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1. 发明授权

US06309886B1 High throughput analysis of samples in flowing liquid 失效
标题翻译：流动液中样品的高通量分析
公开(公告)号：US06309886B1
公开(公告)日：2001-10-30
申请号：US09449280
申请日：1999-11-24
申请人： W. Patrick Ambrose , W. Kevin Grace , Peter M. Goodwin , James H. Jett , Alan Van Orden , Richard A. Keller
发明人： W. Patrick Ambrose , W. Kevin Grace , Peter M. Goodwin , James H. Jett , Alan Van Orden , Richard A. Keller
IPC分类号： G01N2164
CPC分类号： G01N21/6456 , G01N15/1434 , G01N15/1459 , G01N21/6458 , G01N2015/1006
摘要： Apparatus and method enable imaging multiple fluorescent sample particles in a single flow channel. A flow channel defines a flow direction for samples in a flow stream and has a viewing plane perpendicular to the flow direction. A laser beam is formed as a ribbon having a width effective to cover the viewing plane. Imaging optics are arranged to view the viewing plane to form an image of the fluorescent sample particles in the flow stream, and a camera records the image formed by the imaging optics.
摘要翻译：装置和方法能够在单个流动通道中成像多个荧光样品颗粒。流动通道限定流动流中的样品的流动方向，并且具有垂直于流动方向的观察平面。激光束形成为具有有效覆盖观察平面的宽度的带状物。成像光学器件被布置成观看观察平面以形成流动流中的荧光样品颗粒的图像，并且相机记录由成像光学元件形成的图像。

2. 发明授权

US4884886A Biological particle identification apparatus 失效
标题翻译：生物颗粒识别装置
公开(公告)号：US4884886A
公开(公告)日：1989-12-05
申请号：US302036
申请日：1989-01-26
申请人： Gary C. Salzman , Charles T. Gregg , W. Kevin Grace , Richard D. Hiebert
发明人： Gary C. Salzman , Charles T. Gregg , W. Kevin Grace , Richard D. Hiebert
IPC分类号： G01N15/02 , G01N21/21 , G01N21/47
CPC分类号： G01N21/21 , G01N21/47 , G01N15/0211
摘要： An apparatus and method for making multiparameter light scattering measurements from suspensions of biological particles is described. Fourteen of the sixteen Mueller matrix elements describing the particles under investigation can be substantially individually determined as a function of scattering angle and probing radiations wavelength, eight elements simultaneously for each of two apparatus configurations using an apparatus which incluees, in its simplest form, two polarization modulators each operating at a chosen frequency, one polarizer, a source of monochromatic electromagnetic radiation, a detector sensitive to the wavelength of radiation employed, eight phase-sensitive detectors, and appropriate electronics. A database of known biological particle suspensions can be assembled, and unknown samples can be quickly identified once measurements are performed on it according to the teachings of the subject invention, and a comparison is made with the database.
摘要翻译：描述了用于从生物颗粒的悬浮液制造多参数光散射测量的装置和方法。描述所研究的颗粒的十六个Mueller矩阵元素中的十四个可以基本上单独地确定为散射角和探测辐射波长的函数，对于两个装置配置中的每一个，使用一种装置，其以最简单的形式显示出两个极化每个以所选频率工作的调制器，一个偏振器，单色电磁辐射源，对所使用的辐射波长敏感的检测器，八个相敏检测器和适当的电子器件。可以组装已知生物颗粒悬浮液的数据库，并且根据本发明的教导对其进行测量后可以快速识别未知样品，并且与数据库进行比较。

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