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1. 发明授权

US10421798B2 Factor VIII compositions and methods of making and using same 有权
公开(公告)号：US10421798B2
公开(公告)日：2019-09-24
申请号：US14379192
申请日：2012-07-11
申请人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Sheng Ding , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Volker Schellenberger , Nathan Geething , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei
发明人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Sheng Ding , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Nathan Geething , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei
IPC分类号： C07K14/755 , A61K38/00
摘要： The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.

2. 发明申请

US20150158929A1 FACTOR VIII COMPOSITIONS AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：要素VIII组成及其制备方法和使用方法
公开(公告)号：US20150158929A1
公开(公告)日：2015-06-11
申请号：US14379192
申请日：2012-07-11
申请人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Sheng Ding , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Nathan Geething , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei
发明人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Sheng Ding , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Nathan Geething , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei
IPC分类号： C07K14/755
摘要： The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.
摘要翻译：本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VIII凝血因子的组合物，编码组合物的分离的核酸和含有它们的载体和宿主细胞，以及制备和使用这些组合物治疗因子VIII相关的方法疾病，病症和状况。

3. 发明申请

US20130017997A1 Factor VIII Compositions and Methods of Making and Using Same 审中-公开
标题翻译：因子VIII组合物和制备和使用方法
公开(公告)号：US20130017997A1
公开(公告)日：2013-01-17
申请号：US13365166
申请日：2012-02-02
申请人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei , Joshua Silverman , Chia-Wei Wang , Benjamin Spink , Nathan Geething
发明人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei , Joshua Silverman , Chia-Wei Wang , Benjamin Spink , Nathan Geething
IPC分类号： C07K19/00 , A61P7/04 , A61K38/37
CPC分类号： C07K14/755 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/21 , C07K2319/31 , C07K2319/41 , C07K2319/50 , C07K2319/95
摘要： The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.
摘要翻译：本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VIII凝血因子的组合物，编码组合物的分离的核酸和含有它们的载体和宿主细胞，以及制备和使用这些组合物治疗因子VIII相关的方法疾病，病症和状况。

4. 发明申请

US20130108629A1 Factor VIII-Fc Chimeric and Hybrid Polypeptides, and Methods of Use Thereof 有权
标题翻译：因子VIII-Fc嵌合和杂交多肽及其使用方法
公开(公告)号：US20130108629A1
公开(公告)日：2013-05-02
申请号：US13513424
申请日：2010-12-06
申请人： Jennifer A. Dumont , Susan Low , Alan J. Bitonti , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron McKinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
发明人： Jennifer A. Dumont , Susan Low , Alan J. Bitonti , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron McKinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
IPC分类号： C07K14/755 , C07K16/46
CPC分类号： A61K38/37 , A61K47/643 , A61K47/6811 , C07K14/755 , C07K16/46 , C07K2319/30
摘要： The present invention provides methods of administering Factor VIII; methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
摘要翻译：本发明提供了施用因子VIII的方法; 包含因子VIII的嵌合和杂交多肽的施用方法; 包含因子VIII的嵌合和杂合多肽; 编码这种嵌合和杂交多肽的多核苷酸; 包含这种多核苷酸的细胞; 以及使用这种细胞产生这种嵌合和杂合多肽的方法。

5. 发明授权

US10010622B2 Factor VIII chimeric and hybrid polypeptides, and methods of use thereof 有权
公开(公告)号：US10010622B2
公开(公告)日：2018-07-03
申请号：US14131600
申请日：2012-07-06
申请人： Jennifer A. Dumont , Susan Low , Alan J. Bitoni , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron McKinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
发明人： Jennifer A. Dumont , Susan Low , Alan J. Bitoni , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron McKinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
IPC分类号： C07K14/755 , A61K47/48 , A61K38/37 , G01N33/86 , A61K47/60 , A61K47/68
CPC分类号： A61K47/6803 , A61K38/37 , A61K47/60 , A61K47/68 , C07K14/755 , C07K2319/00 , C07K2319/31 , G01N33/86
摘要： The present invention provides methods of administering Factor VIII (processed FVIII, single chain FVIII, or a combination thereof); methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.

6. 发明授权

US09050318B2 Factor VIII-Fc chimeric and hybrid polypeptides, and methods of use thereof 有权
标题翻译：因子VIII-Fc嵌合和杂交多肽及其使用方法
公开(公告)号：US09050318B2
公开(公告)日：2015-06-09
申请号：US13513424
申请日：2010-12-06
申请人： Jennifer A. Dumont , Susan Low , Alan J. Bitonti , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron McKinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
发明人： Jennifer A. Dumont , Susan Low , Alan J. Bitonti , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron McKinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
IPC分类号： A61K39/395 , A61K38/37 , A61K47/48 , C07K14/755 , C07K16/46
CPC分类号： A61K38/37 , A61K47/643 , A61K47/6811 , C07K14/755 , C07K16/46 , C07K2319/30
摘要： The present invention provides methods of administering Factor VIII; methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
摘要翻译：本发明提供了施用因子VIII的方法; 包含因子VIII的嵌合和杂交多肽的施用方法; 包含因子VIII的嵌合和杂合多肽; 编码这种嵌合和杂交多肽的多核苷酸; 包含这种多核苷酸的细胞; 以及使用这种细胞产生这种嵌合和杂合多肽的方法。

7. 发明申请

US20140294821A1 FACTOR VIII CHIMERIC AND HYBRID POLYPEPTIDES, AND METHODS OF USE THEREOF 有权
标题翻译：因子VIII二元和混合多聚物及其使用方法
公开(公告)号：US20140294821A1
公开(公告)日：2014-10-02
申请号：US14131600
申请日：2012-07-06
申请人： Jennifer A. Dumont , Susan Low , Alan J. Bitonti , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron Mckinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
发明人： Jennifer A. Dumont , Susan Low , Alan J. Bitonti , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron Mckinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
IPC分类号： A61K47/48 , A61K38/37
CPC分类号： A61K47/6803 , A61K38/37 , A61K47/60 , A61K47/68 , C07K14/755 , C07K2319/00 , C07K2319/31 , G01N33/86
摘要： The present invention provides methods of administering Factor VIII (processed FVIII, single chain FVIII, or a combination thereof); methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells
摘要翻译：本发明提供了施用因子VIII（加工的FVIII，单链FVIII或其组合）的方法; 包含因子VIII的嵌合和杂交多肽的施用方法; 包含因子VIII的嵌合和杂合多肽; 编码这种嵌合和杂交多肽的多核苷酸; 包含这种多核苷酸的细胞; 以及使用这种细胞产生这种嵌合和杂合多肽的方法

8. 发明授权

US07306147B2 Systems and methods for package sortation and delivery using radio frequency identification technology 有权
标题翻译：使用射频识别技术进行封装分拣和交付的系统和方法
公开(公告)号：US07306147B2
公开(公告)日：2007-12-11
申请号：US11465216
申请日：2006-08-17
申请人： Anthony Baldassari , Robert Peters
发明人： Anthony Baldassari , Robert Peters
IPC分类号： G07B15/02
CPC分类号： G06K17/00 , B07C3/10 , G06K2017/0045 , G06K2017/0048 , G06Q10/08 , G06Q10/087 , G06Q10/0875 , G06Q50/30
摘要： A disclosed method comprises scanning a radio-frequency identification (RFID) tag on a package to generate scanned data, and generating a handling instruction for the package based on the scanned data. The handling instruction can be executed to route the package to a tip position within a hub facility for directing the package to the next location along its route, and/or to pre-load the package in a vehicle for delivery to the package's final destination. Related systems and computer-readable media are also disclosed.
摘要翻译：所公开的方法包括扫描包装上的射频识别（RFID）标签以产生扫描数据，以及基于扫描数据生成针对包的处理指令。可以执行处理指令以将包裹路由到集线器设备内的尖端位置，以将包装沿着其路线引导到下一个位置，和/或将包装预先装载在车辆中以便传送到包裹的最终目的地。还公开了相关系统和计算机可读介质。

9. 发明申请

US20070063704A1 METHOD AND APPARATUS FOR FAST SPIN ECHO (FSE) PRESCAN PHASE CORRECTION 有权
标题翻译：用于快速旋转（FSE）预相位校正的方法和装置
公开(公告)号：US20070063704A1
公开(公告)日：2007-03-22
申请号：US11162704
申请日：2005-09-20
申请人： Robert Peters
发明人： Robert Peters
IPC分类号： G01V3/00
CPC分类号： G01R33/5617 , G01R33/56554
摘要： A method and apparatus for prescan phase correction analyzes the phase profile of the first echo sampled in a prescan and the phase profile corresponding to the lope echo of an impending FSE acquisition to determine appropriate phase correction settings of the FSE scan.
摘要翻译：用于预扫描相位校正的方法和装置分析在预扫描中采样的第一回波的相位分布和对应于即将到来的FSE采集的波形回波的相位曲线，以确定FSE扫描的适当的相位校正设置。

10. 发明授权

US07104892B2 Coupling 有权
标题翻译：耦合
公开(公告)号：US07104892B2
公开(公告)日：2006-09-12
申请号：US10620482
申请日：2003-07-16
申请人： Detlef Cordts , Robert Peters , Christian Meyer
发明人： Detlef Cordts , Robert Peters , Christian Meyer
IPC分类号： F16D3/70
CPC分类号： F16D3/70 , F16D3/28 , F16D3/62
摘要： A coupling for connecting a driving machine part and a driven machine part, such as shafts, wheel hubs or the like, includes an intermediate shaft and articulated lever couplings situated at the ends of the intermediate shaft. Each articulated lever coupling has at least three identical articulated levers, which engage via elastic joints situated at their ends with the intermediate shaft and with the adjacent machine parts to be connected. The axes of the elastic joints of each articulated lever are oriented perpendicularly to an axial plane, the axial plane being parallel to the articulated lever and intersecting the axis of the intermediate shaft and the axes of the machine parts to be connected.
摘要翻译：用于连接驱动机器部件和从动机器部件（例如轴，轮毂等）的联接器包括位于中间轴的端部处的中间轴和铰接杆联接器。每个铰接杆联接器具有至少三个相同的铰接杆，其通过位于其端部的弹性接头与中间轴以及相邻的待连接的机器部件接合。每个铰接杆的弹性接头的轴线垂直于轴向平面定向，轴向平面与铰接杆平行，并与中间轴的轴线和要连接的机器部件的轴线相交。

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