专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5204464A High bulk density, crystalline 3-cyano-2-morpholino-5-pyrid-4-yl)-pyridine 失效
标题翻译：高密度密度，结晶3-氰基-2-吗啉基-5-吡啶-4-基） - 吡啶
公开(公告)号：US5204464A
公开(公告)日：1993-04-20
申请号：US665681
申请日：1991-03-07
申请人： Volker Hagen , Gunter Reck , Brigitte Gentsch , Hans-Joachim Heidrich , Hans-Joachim Jansch , Ingrid Wielop , Dieter Lohmann
发明人： Volker Hagen , Gunter Reck , Brigitte Gentsch , Hans-Joachim Heidrich , Hans-Joachim Jansch , Ingrid Wielop , Dieter Lohmann
IPC分类号： A61K31/535 , A61K31/5377 , A61P9/04 , A61P9/08 , C07B63/00 , C07D213/85 , C07D413/14
CPC分类号： C07D213/85
摘要： A method for preparing high bulk density crystalline 3-cyano-2-morpholino-5-(pyrid-4-yl)-pyridine which comprises precipitating a high bulk density crystaline 3-cyano-2-morpholino-5-(pyrid-4-yl)-pyridine from a starting material that is(a) a solution in an inorganic or organic acid, and precipitating with a base, or(b) a solution in a chlorinated hydrocarbon, and precipitating with an aliphatic hydrocarbon, or(c) from an aliphatic ester of an aliphatic carboxylic acid and an aliphatic alcohol.The compact, crystalline 3-cyano-2-morpholino-5-(pyrid-4-yl)-pyridine, so obtained, has a bulk density of from about 220 to about 360 g/l and is most suitable for pharmaceutical preparations.
摘要翻译：一种制备高体积密度结晶3-氰基-2-吗啉代-5-（吡啶-4-基） - 吡啶的方法，其包括沉淀高体积密度的3-氰基-2-吗啉代-5-（吡啶-4-基）（a）无机或有机酸溶液，并用碱沉淀的原料，或（b）氯代烃中的溶液，并用脂族烃沉淀，或（c）由脂肪族羧酸和脂肪族醇的脂肪族酯组成。如此获得的紧密结晶的3-氰基-2-吗啉代-5-（吡啶-4-基） - 吡啶的堆积密度为约220至约360g / l，最适用于药物制剂。

2. 发明授权

US5281705A Method for making high bulk density crystalline 3-cyano-2-morpholino-5-(pyrid-4yl)-pyridine 失效
标题翻译：制备高密度结晶3-氰基-2-吗啉代-5-（吡啶-4-基） - 吡啶的方法
公开(公告)号：US5281705A
公开(公告)日：1994-01-25
申请号：US971297
申请日：1992-11-04
申请人： Volker Hagen , Gunter Reck , Brigitte Gentsch , Hans-Joachim Heidrich , Hans-Joachim Jansch , Ingrid Wielop , Dieter Lohmann
发明人： Volker Hagen , Gunter Reck , Brigitte Gentsch , Hans-Joachim Heidrich , Hans-Joachim Jansch , Ingrid Wielop , Dieter Lohmann
IPC分类号： A61K31/535 , A61K31/5377 , A61P9/04 , A61P9/08 , C07B63/00 , C07D213/85 , C07D413/14
CPC分类号： C07D213/85
摘要： A method for preparing high bulk density crystalline 3-cyano-2-morpholino-5-(pyrid-4-yl)-pyridine which comprises precipitating a high bulk density crystalline 3-cyano-2-morpholino-5-(pyrid-4-yl)-pyridine from a starting material that is(a) a solution in an inorganic or organic acid, and precipitating with a base, or(b) a solution in a chlorinated hydrocarbon, and precipitating with an aliphatic hydrocarbon, or(c) from an aliphatic ester of an aliphatic carboxylic acid and an aliphatic alcohol.The compact, crystalline 3-cyano-2-morpholino-5-(pyrid-4-yl)-pyridine, so obtained, has a bulk density of from about 220 to about 360 g/l and is most suitable for pharmaceutical preparations.
摘要翻译：一种制备高体积密度晶体3-氰基-2-吗啉代-5-（吡啶-4-基） - 吡啶的方法，其包括沉淀高体积密度的结晶3-氰基-2-吗啉代-5-（吡啶-4-基）（a）无机或有机酸溶液，并用碱沉淀的原料，或（b）氯代烃中的溶液，并用脂族烃沉淀，或（c）由脂肪族羧酸和脂肪族醇的脂肪族酯组成。如此获得的紧密结晶的3-氰基-2-吗啉代-5-（吡啶-4-基） - 吡啶的堆积密度为约220至约360g / l，最适用于药物制剂。

3. 发明授权

US5162533A 3-cyano-5,4'-bipyridine-1'-oxide compounds and pharmaceutical compositions and methods containing the same 失效
标题翻译： 3-氰基-5,4'-联吡啶-1'-氧化物化合物和药物组合物及其含有的方法
公开(公告)号：US5162533A
公开(公告)日：1992-11-10
申请号：US665682
申请日：1991-03-07
申请人： Erhard Klauschenz , Volker Hagen , Angela Hagen , Peter Muschick , Brigitte Schlegel , Sabine Heer , Gottfried Faust , Hans-Joachim Jansch
发明人： Erhard Klauschenz , Volker Hagen , Angela Hagen , Peter Muschick , Brigitte Schlegel , Sabine Heer , Gottfried Faust , Hans-Joachim Jansch
IPC分类号： A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4412 , A61K31/444 , A61K31/495 , A61K31/535 , A61P9/04 , A61P9/08 , C07D213/89
CPC分类号： C07D213/89
摘要： A 3-cyano-5,4'-bipyridine-1'-oxide of the formula ##STR1## and their pharmaceutically acceptable acid addition salts, wherein R is an amino, alkoxy, oxyalkoxy or chloro residue, have heart stimulating cardiotonic and vasodiolatory properties. They can be preparaed by (a) converting an R-substituted-3-cyano-bipyridine to its corresponding N-oxide, or (b) by substituting an R-residue or an R-unsubstituted precursor of the conpound of fomula (i), and if required, converting the product into its pharmaceutically acceptable acid addition salt.
摘要翻译：式（I）的3-氰基-5,4'-联吡啶-1'-氧化物及其药学上可接受的酸加成盐，其中R是氨基，烷氧基，氧代烷氧基或氯代残基，具有心脏刺激强心剂和血管舒张特性。它们可以通过（a）将R-取代的3-氰基 - 联吡啶转化成其相应的N-氧化物来制备，或（b）通过用式（ⅰ）的R-残基或R-未取代的前体代替，，如果需要，将产物转化为其药学上可接受的酸加成盐。

4. 发明授权

US5912359A Dimaleinimido-substituted dihydroxyalkanes which can be used as crosslinking reagents and process for their preparation 失效
标题翻译：二亚氨基亚氨基取代的二羟基烷烃，可用作交联剂及其制备方法
公开(公告)号：US5912359A
公开(公告)日：1999-06-15
申请号：US43263
申请日：1998-08-27
申请人： Paul J. Bauer , Volker Hagen
发明人： Paul J. Bauer , Volker Hagen
IPC分类号： C07D207/44 , C07D207/452 , C08F8/30 , C08J3/24 , C07D207/404 , C07D207/408 , C07K1/10
CPC分类号： C07D207/452 , C08F8/30
摘要： The invention relates to novel dimaleinimido-substituted dihydroxyalkanes, to a process for their preparation as well as to their use as cross-linking reagents, e.g. in analytical methods. A disadvantage of the cleavable bismaleinimido derivatives used so far, which react with SH groups, is that the subsequent cleavage of the cross-linking reagents from the proteins must take place in acidic or alkaline media. The objective of the invention is to prepare novel cleavable cross-linking reagents which react with SH groups or proteins and which form cross-links which can be cleaved under mild conditions not requiring strongly acidic or basic media. This objective is sought through the preparation and use of dimaleinimido-substituted dihydroxyalkanes having the general formula I ##STR1## where n=1 to 6, preferably 1 or 2.
摘要翻译： PCT No.PCT / DE96 / 01742 Sec。 371日期1998年8月27日第 102（e）1998年8月27日PCT PCT 1996年9月11日PCT公布。公开号WO97 / 10209 日期1997年3月20日本发明涉及新的二亚氨基亚氨基取代的二羟基烷烃，其制备方法以及它们作为交联剂的用途，例如，在分析方法。迄今使用的可切割双马来酰亚胺衍生物与SH基团反应的缺点是随后从蛋白质中切割交联剂必须在酸性或碱性介质中进行。本发明的目的是制备与SH基团或蛋白质反应的新的可切割交联试剂，并形成可在不需要强酸性或碱性介质的温和条件下切割的交联。通过制备和使用具有通式I的二亚氨基亚氨基取代的二羟基烷烃，其中n = 1至6，优选1或2，寻求该目的。

5. 发明申请

US20070249822A1 Photolabile Coumarinylmethyl Esters of Cyclic Nucleotides, Methods for their Preparation and Their Use 审中-公开
标题翻译：环状核苷酸的光不稳定香豆素甲酯，其制备方法及其用途
公开(公告)号：US20070249822A1
公开(公告)日：2007-10-25
申请号：US10257793
申请日：2001-03-26
申请人： Volker Hagen , Ulrich Kaupp , Jurgen Bendig , Burghard Wiesner
发明人： Volker Hagen , Ulrich Kaupp , Jurgen Bendig , Burghard Wiesner
IPC分类号： C07H19/16
CPC分类号： C07H19/20
摘要： The invention relates to new photolabile coumarinylmethyl esters of cyclic nucleotides of general formula I wherein R1 represents hydrogen, bromine or p-chlorophenylthio R4 represents 7-carboxymethoxy, 6,7-, 5,7- or 7,8-bis-(carboxymethoxy), 7-C1-C3-alkoxycarbonylmethoxy, 6,7-bis(C1-C3-alkoxycarbonylmethoxy), 5,7-bis(C1-C3-alkoxy-carbonylmethoxy), or 7,8-bis(C1-C3-alkoxycarbonylmethoxy), R2 represents —NH2 and R3 is hydrogen (adenine residue), or R2 represents —OH and R3 represents NH2 (guanine residue) The inventive compounds are biologically inactive and exhibit high solubility in aqueous buffer solutions, high efficiency in photocleavage and rapid kinetics of liberation, together with high resistance to solvolysis.
摘要翻译：本发明涉及通式I的环状核苷酸的新的光不稳定香豆素甲酯，其中R 1表示氢，溴或对氯苯硫基R 4代表7-羧甲氧基，6,7 - ，5,7-或7,8-双 - （羧基甲氧基），7-C 1 -C 3 - 烷氧基羰基甲氧基，6,7-双（C < （C 1 -C 3 - 烷氧基羰基甲氧基），5,7-双（C 1 -C 3 - 烷氧基羰基甲氧基），或7,8-双（C 1 -C 3 - 烷氧基羰基甲氧基），R 2表示-NH 2 >和R 3是氢（腺嘌呤残基），或R 2表示-OH，R 3表示NH 2 >（鸟嘌呤残基）本发明化合物在生物学上无活性并且在缓冲溶液水溶液中表现出高溶解度，光切割效率高，释放快速动力学以及高溶解溶解性。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式