专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050176698A1 Neuropeptide Y antagonists 失效
公开(公告)号：US20050176698A1
公开(公告)日：2005-08-11
申请号：US11100938
申请日：2005-04-07
申请人： Volker Breu , Frank Dautzenberg , Philippe Guerry , Matthias Nettekoven , Philippe Pflieger
发明人： Volker Breu , Frank Dautzenberg , Philippe Guerry , Matthias Nettekoven , Philippe Pflieger
IPC分类号： C07D239/94 , A61K31/365 , A61K31/4709 , A61K31/4725 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/55 , A61K45/00 , A61P1/14 , A61P3/00 , A61P3/04 , A61P3/10 , A61P9/00 , A61P13/12 , A61P19/02 , A61P43/00 , C07D215/00 , C07D215/42 , C07D239/84 , C07D401/04 , C07D409/04 , C07D41/04 , C07D43/04
CPC分类号： C07D401/04 , C07D215/42 , C07D239/84 , C07D409/04
摘要： Quinoline and quinazoline derivatives can be used in the form of pharmaceutical preparations as Neuropeptide Y antagonists for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders and obesity.

2. 发明授权

US06900226B2 Neuropeptide Y antagonists 失效
标题翻译：神经肽Y拮抗剂
公开(公告)号：US06900226B2
公开(公告)日：2005-05-31
申请号：US09939883
申请日：2001-08-27
申请人： Volker Breu , Frank Dautzenberg , Philippe Guerry , Matthias Heinrich Nettekoven , Philippe Pflieger
发明人： Volker Breu , Frank Dautzenberg , Philippe Guerry , Matthias Heinrich Nettekoven , Philippe Pflieger
IPC分类号： C07D239/94 , A61K31/365 , A61K31/4709 , A61K31/4725 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/55 , A61K45/00 , A61P1/14 , A61P3/00 , A61P3/04 , A61P3/10 , A61P9/00 , A61P13/12 , A61P19/02 , A61P43/00 , C07D215/00 , C07D215/42 , C07D239/84 , C07D401/04 , C07D409/04 , C07D215/38 , C07D403/00 , C07D419/00
CPC分类号： C07D401/04 , C07D215/42 , C07D239/84 , C07D409/04
摘要： Quinoline and quinazoline derivatives can be used in the form of pharmaceutical preparations as Neuropeptide Y antagonists for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders and obesity.
摘要翻译：喹啉和喹唑啉衍生物可以药物制剂的形式用作神经肽Y拮抗剂，用于治疗或预防关节炎，心血管疾病，糖尿病，肾衰竭，进食障碍和肥胖症。

3. 发明授权

US07265125B2 Neuropeptide Y antagonists 失效
标题翻译：神经肽Y拮抗剂
公开(公告)号：US07265125B2
公开(公告)日：2007-09-04
申请号：US11100938
申请日：2005-04-07
申请人： Volker Breu , Frank Dautzenberg , Philippe Guerry , Matthias Heinrich Nettekoven , Philippe Pflieger
发明人： Volker Breu , Frank Dautzenberg , Philippe Guerry , Matthias Heinrich Nettekoven , Philippe Pflieger
IPC分类号： A61P3/04 , A61K31/55 , A61K31/517 , C07D403/00
CPC分类号： C07D401/04 , C07D215/42 , C07D239/84 , C07D409/04
摘要： Quinoline and quinazoline derivatives can be used in the form of pharmaceutical preparations as Neuropeptide Y antagonists for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders and obesity.
摘要翻译：喹啉和喹唑啉衍生物可以药物制剂的形式用作神经肽Y拮抗剂，用于治疗或预防关节炎，心血管疾病，糖尿病，肾衰竭，进食障碍和肥胖症。

4. 发明授权

US06657060B2 Pyrimidine derivatives 失效
公开(公告)号：US06657060B2
公开(公告)日：2003-12-02
申请号：US10008166
申请日：2001-11-08
申请人： Volker Breu , Frank Dautzenberg , Patrizio Mattei , Werner Neidhart , Philippe Pflieger
发明人： Volker Breu , Frank Dautzenberg , Patrizio Mattei , Werner Neidhart , Philippe Pflieger
IPC分类号： C07D40304
CPC分类号： C07D239/42 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/06 , C07D409/06
摘要： Pyrimidine derivatives have been found to be useful as neuropeptide Y receptor ligands and particularly as antagonists. These pyrimidine derivatives may be used in the form of pharmaceutical preparations for the treatment or prevention of arthritis, diabetes, eating disorders, and obesity.

5. 发明授权

US06821980B1 Substituted 5-benzyl-2,4-diaminopyrimidines 失效
标题翻译：取代的5-苄基-2,4-二氨基嘧啶
公开(公告)号：US06821980B1
公开(公告)日：2004-11-23
申请号：US10129461
申请日：2002-07-18
申请人： Philippe Guerry , Peter Mohr , Marc Muller , Werner Mueller , Philippe Pflieger
发明人： Philippe Guerry , Peter Mohr , Marc Muller , Werner Mueller , Philippe Pflieger
IPC分类号： A61K31505
CPC分类号： C07D239/49 , A61K31/505
摘要： The invention relates to substituted 5-benzyl-2,4-diaminopyrimidines of general formula (A) wherein R1 is C2-C3 alkyl an R2 is heterocyclyl, phenyl or naphthyl, bonded by one of its C-atoms and R3 is C2-C6 alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, heterocyclylalkyl, alkylsulfonyl, cycloalkylsulfonyl, cycloalkylalkylsulfamoyl, heterocyclysylfonyl, heterocyclylalkylsulfonyl or dialkylsulfamoyl; wherein alkyl, cycloalkyl and alyenyl can carry up to 6 carbon atoms alone or in compositions and can carry up to 6 ring members heterocyclically, alone, or in compositions and the groups R2 and R3 can be substituted; and to acid addition salts of compounds. The invention also relates to a method for producing the above 5-benzyl-2,4-diaminopyrimidines, to the intermediate. products that are produced, to corresponding medicaments and to the use of 5-benzyl-2,4-diaminopyrimidines as medicinal preparations. The products have antibiotic properties and are useful for combating or preventing infectious diseases.
摘要翻译：本发明涉及通式（A）的取代的5-苄基-2,4-二氨基嘧啶，其中R 1是C 2 -C 3烷基，R 2是其一个C原子键合的杂环基，苯基或萘基， R 3为C 2 -C 6烷基，烯基，环烷基，环烷基烷基，杂环基烷基，烷基磺酰基，环烷基磺酰基，环烷基烷基氨磺酰基，杂芳基磺酰基，杂环基烷基磺酰基或二烷基氨磺酰基。其中烷基，环烷基和亚烯基可以单独或组合物中携带多达6个碳原子，并且可以单独携带多达6个环成员，或者在组合物中并且基团R 2和R 3可以被取代; 和化合物的酸加成盐。本发明还涉及制备上述5-苄基-2,4-二氨基嘧啶的方法。生产的产品，相应的药物和使用5-苄基-2,4-二氨基嘧啶作为药物制剂。该产品具有抗生素特性，可用于对抗或预防传染病。

6. 发明申请

US20060063758A1 QUINOLINE DERIVATIVES 失效
标题翻译：喹啉衍生物
公开(公告)号：US20060063758A1
公开(公告)日：2006-03-23
申请号：US11272207
申请日：2005-11-10
申请人： Michael Klug , Patrizio Mattei , Werner Mueller , Werner Neidhart , Matthias Nettekoven , Philippe Pflieger , Jean-Marc Plancher
发明人： Michael Klug , Patrizio Mattei , Werner Mueller , Werner Neidhart , Matthias Nettekoven , Philippe Pflieger , Jean-Marc Plancher
IPC分类号： A61K31/55 , A61K31/4709 , C07D401/02
CPC分类号： C07D401/04 , C04B35/632 , C07D215/42 , C07D401/12 , C07D405/14
摘要： Compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein R1, R2, R3, A1 and A2 have the significance given in claim 1, can be used in the form of pharmaceutical preparations for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders and obesity.
摘要翻译：式I化合物

7. 发明申请

US20060148794A1 Quinoline derivatives 失效
标题翻译：喹啉衍生物
公开(公告)号：US20060148794A1
公开(公告)日：2006-07-06
申请号：US11376976
申请日：2006-03-16
申请人： Michael Klug , Patrizio Mattei , Werner Mueller , Werner Neidhart , Matthias Nettekoven , Philippe Pflieger , Jean-Marc Plancher
发明人： Michael Klug , Patrizio Mattei , Werner Mueller , Werner Neidhart , Matthias Nettekoven , Philippe Pflieger , Jean-Marc Plancher
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4709
CPC分类号： C07D401/04 , C04B35/632 , C07D215/42 , C07D401/12 , C07D405/14
摘要： Compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein R1, R2, R3, A1 and A2 have the significance given in claim 1, can be used in the form of pharmaceutical preparations for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders and obesity.
摘要翻译：式I化合物及其药学上可接受的盐和酯，其中R 1，R 2，R 3，A 1，具有权利要求1给出的意义的化合物可以以用于治疗或预防关节炎，心血管疾病，糖尿病，肾功能衰竭，饮食失调的药物制剂的形式使用，肥胖。

8. 发明申请

US20050038089A1 Thiazole derivatives 失效
标题翻译：噻唑衍生物
公开(公告)号：US20050038089A1
公开(公告)日：2005-02-17
申请号：US10915199
申请日：2004-08-10
申请人： Werner Neidhart , Matthias Nettekoven , Philippe Pflieger
发明人： Werner Neidhart , Matthias Nettekoven , Philippe Pflieger
IPC分类号： A61P3/04 , C07D277/42 , C07D277/56 , C07D417/12 , A61K31/426
CPC分类号： C07D417/12 , C07D277/42
摘要： Thiazole derivatives of formula I are provided as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R5, a and b have the significance given in the specification. The compounds are neuropeptide Y Y5 receptor antagonists which can be used for the treatment of obesity.
摘要翻译：提供式I的噻唑衍生物以及其药学上可接受的盐和酯，其中R 1至R 5，a和b具有说明书中给出的含义。该化合物是可用于治疗肥胖症的神经肽Y Y5受体拮抗剂。

9. 发明申请

US20050038073A1 Thiazole derivatives 失效
标题翻译：噻唑衍生物
公开(公告)号：US20050038073A1
公开(公告)日：2005-02-17
申请号：US10915190
申请日：2004-08-10
申请人： Werner Neidhart , Matthias Nettekoven , Philippe Pflieger , Sven Taylor
发明人： Werner Neidhart , Matthias Nettekoven , Philippe Pflieger , Sven Taylor
IPC分类号： A61P19/02 , C07D417/12 , C07D417/14 , A61K31/4545 , A61K31/454
CPC分类号： C07D417/14 , C07D417/12
摘要： Compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein the substituents have the significance given in the specification, and the compounds are neuropeptide Y(NPY) antagonists which are useful in the treatment of obesity.
摘要翻译：式I化合物及其药学上可接受的盐和酯，其中取代基具有说明书中给出的意义，并且该化合物是可用于治疗肥胖症的神经肽Y（NPY）拮抗剂。

10. 发明授权

US09452980B2 Substituted benzamides 有权
标题翻译：取代苯甲酰胺
公开(公告)号：US09452980B2
公开(公告)日：2016-09-27
申请号：US12969613
申请日：2010-12-16
申请人： Katrin Groebke Zbinden , Roger Norcross , Philippe Pflieger
发明人： Katrin Groebke Zbinden , Roger Norcross , Philippe Pflieger
IPC分类号： C07D207/09 , C07D207/10 , C07D207/12 , C07D211/26 , C07D241/04 , C07D265/30 , C07D267/08 , C07D295/135 , C07D401/04 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/40 , A61K31/495 , A61K31/496 , A61K31/454 , A61K31/553 , A61P25/00 , A61P25/24 , A61P25/18 , A61P25/16 , A61P25/22 , A61K9/20
CPC分类号： C07D207/09 , A61K9/2018 , C07D207/10 , C07D207/12 , C07D211/26 , C07D241/04 , C07D263/32 , C07D265/30 , C07D267/08 , C07D267/10 , C07D295/135 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04
摘要： The invention relates to compounds of formula wherein R, R1, R2, X, and Y are as defined herein and to a pharmaceutically suitable acid addition salt thereof. Compounds of formula I have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1. The compounds can be used for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.
摘要翻译：式I化合物对微量胺相关受体（TAAR）具有良好的亲和力，特别是TAAR1。这些化合物可用于治疗抑郁症，焦虑障碍，双相情感障碍，注意力缺陷多动障碍（ADHD），应激相关疾病，精神病性精神障碍如精神分裂症，神经系统疾病如帕金森病，神经退行性疾病如阿尔茨海默病，癫痫，偏头痛，高血压，药物滥用和代谢障碍如进食障碍，糖尿病，糖尿病并发症，肥胖症，血脂异常，能量消耗和同化障碍，体温平衡紊乱和失调，睡眠和昼夜节律紊乱以及心血管疾病。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式