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1. 发明授权

US08546321B2 IL-4-derived peptides for modulation of the chronic inflammatory response and treatment of autoimmune diseases 有权
标题翻译：用于调节慢性炎症反应和治疗自身免疫疾病的IL-4衍生肽
公开(公告)号：US08546321B2
公开(公告)日：2013-10-01
申请号：US13127574
申请日：2009-11-17
申请人： Elisabeth Bock , Vladimir Berezin
发明人： Elisabeth Bock , Vladimir Berezin
IPC分类号： A61K38/00 , A61K38/03
CPC分类号： C07K14/5406 , A61K38/00 , Y02A50/414
摘要： The present invention relates to small peptides derived from a cytokine, interleukin-4 (IL-4), capable of binding to the IL-4 receptors and inhibiting macrophage activation, and thereby preventing the onset of inflammatory response. The invention further relates to use of said peptides for the production of a medicament for the treatment of different pathological conditions, wherein IL-4 plays a prominent role.
摘要翻译：本发明涉及能够结合IL-4受体并抑制巨噬细胞活化的细胞因子，白细胞介素-4（IL-4）的小肽，从而防止炎性反应的发生。本发明还涉及所述肽用于生产用于治疗不同病理状况的药物的用途，其中IL-4起突出作用。

2. 发明授权

US08138148B2 GDNF derived peptides 有权
标题翻译： GDNF衍生肽
公开(公告)号：US08138148B2
公开(公告)日：2012-03-20
申请号：US12064190
申请日：2006-08-15
申请人： Elisabeth Bock , Vladimir Berezin
发明人： Elisabeth Bock , Vladimir Berezin
IPC分类号： A61K38/18 , A61K38/16 , A61K38/03 , A61K38/04
CPC分类号： C07K14/47 , A61K38/00 , C07K14/475 , C07K14/495
摘要： The present invention relates to peptide fragments derived from the proteins belonging to the TGFbeta superfamily, pharmaceutical compositions comprising these peptide fragments and uses thereof for treatment of a disease or condition wherein the effects of stimulating neuronal cell differentiation, neuronal cell survival, stimulating neural plasticity associated with learning and memory and/or inhibiting inflammatory response are beneficial for treatment.
摘要翻译：本发明涉及衍生自属于TGFbeta超家族的蛋白质的肽片段，包含这些肽片段的药物组合物及其用于治疗疾病或病症的用途，其中刺激神经细胞分化，神经元细胞存活，刺激神经可塑性相关的作用学习和记忆和/或抑制炎症反应有利于治疗。

3. 发明申请

US20110300148A1 IL-4-DERIVED PEPTIDES FOR MODULATION OF THE CHRONIC INFLAMMATORY RESPONSE AND TREATMENT OF AUTOIMMUNE DISEASES 有权
标题翻译：用于调节慢性炎症反应和治疗自身免疫性疾病的IL-4衍生肽
公开(公告)号：US20110300148A1
公开(公告)日：2011-12-08
申请号：US13127574
申请日：2009-11-17
申请人： Elisabeth Bock , Vladimir Berezin
发明人： Elisabeth Bock , Vladimir Berezin
IPC分类号： A61K39/395 , A61K38/08 , A61K38/17 , A61P37/00 , C07K7/08 , C07K16/24 , A61P29/00 , A61K38/10 , C07K7/06
CPC分类号： C07K14/5406 , A61K38/00 , Y02A50/414
摘要： The present invention relates to small peptides derived from a cytokine, interleukin-4 (IL-4), capable of binding to the IL-4 receptors and inhibiting macrophage activation, and thereby preventing the onset of inflammatory response. The invention further relates to use of said peptides for the production of a medicament for the treatment of different pathological conditions, wherein IL-4 plays a prominent role.
摘要翻译：本发明涉及能够结合IL-4受体并抑制巨噬细胞活化的细胞因子，白细胞介素-4（IL-4）的小肽，从而防止炎症反应的发生。本发明还涉及所述肽用于生产用于治疗不同病理状况的药物的用途，其中IL-4起突出作用。

4. 发明授权

US07951906B2 Compounds capable of interacting with a cell-surface fibroblast growth factor receptor 有权
标题翻译：能够与细胞表面成纤维细胞生长因子受体相互作用的化合物
公开(公告)号：US07951906B2
公开(公告)日：2011-05-31
申请号：US12370003
申请日：2009-02-12
申请人： Elisabeth Bock , Vladimir Berezin , Morten Albrechtsen
发明人： Elisabeth Bock , Vladimir Berezin , Morten Albrechtsen
IPC分类号： C07K4/00 , G01N33/53
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K16/22 , G01N33/566 , G01N33/74 , G01N2333/50
摘要： The present invention relates to a method for modulating the interaction between at least two proteins, wherein at least one of the two proteins is a functional cell-surface receptor and the other protein is the receptor ligand. The invention features a binding site of said functional cell-surface receptor on the receptor ligand and discloses a series of amino acid sequences, which are part of the structure of said binding site and/or involved in the interaction between the receptor and the ligand. Moreover, the present invention features methods for molecular design and screening of a candidate compound capable of modulating the interaction between the functional cell-surface receptor and receptor ligand through the described binding site, and provides a screening assay for identification of such a compound. The invention further describes an antibody capable of binding to the above binding site and/or to an epitope comprising an amino acid sequence essential for executing the receptor ligand interaction through said binding site. The invention also concerns a variety of uses of the disclosed methods, peptide sequences and antibodies. The invention in preferred embodiments concerns the binding site of the fibroblast growth factor receptor (FGFR) on FGFR ligands, compounds capable of modulating the receptor ligand interaction through said binding site, and antibody capable of recognition of said binding site.
摘要翻译：本发明涉及调节至少两种蛋白质之间的相互作用的方法，其中两种蛋白质中的至少一种是功能性细胞表面受体，而另一种蛋白质是受体配体。本发明的特征在于所述功能性细胞表面受体在受体配体上的结合位点，并公开了一系列氨基酸序列，其是所述结合位点结构的一部分和/或参与受体和配体之间的相互作用。此外，本发明具有分子设计和筛选能够通过所述结合位点调节功能性细胞表面受体和受体配体之间的相互作用的候选化合物的方法，并提供了鉴定这种化合物的筛选试验。本发明还描述了能够结合上述结合位点和/或包含通过所述结合位点执行受体配体相互作用所必需的氨基酸序列的表位的抗体。本发明还涉及所公开的方法，肽序列和抗体的各种用途。本发明在优选实施方案中涉及成纤维细胞生长因子受体（FGFR）对FGFR配体的结合位点，能够通过所述结合位点调节受体配体相互作用的化合物和能够识别所述结合位点的抗体。

5. 发明授权

US06887844B1 NCAM binding compounds 有权
标题翻译： NCAM结合化合物
公开(公告)号：US06887844B1
公开(公告)日：2005-05-03
申请号：US09787443
申请日：1999-09-23
申请人： Lars Christian Ronn , Arne Holm , Marianne Olsen , Soren Ostergaard , Peter H. Jensen , Flemming M. Poulsen , Vladislav Soroka , Igor Ralets , Vladimir Berezin , Elisabeth Bock
发明人： Lars Christian Ronn , Arne Holm , Marianne Olsen , Soren Ostergaard , Peter H. Jensen , Flemming M. Poulsen , Vladislav Soroka , Igor Ralets , Vladimir Berezin , Elisabeth Bock
IPC分类号： C12N15/09 , A61K38/00 , A61K38/39 , A61K39/395 , A61K45/00 , A61P1/00 , A61P1/16 , A61P1/18 , A61P3/10 , A61P9/00 , A61P9/10 , A61P13/12 , A61P15/08 , A61P21/00 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/18 , A61P25/28 , A61P43/00 , C07K7/08 , C07K14/705 , C07K14/78 , C07K16/42 , C07K16/46 , C12P21/08 , A61K38/04 , C07K7/00
CPC分类号： C07K14/70503 , A61K38/00
摘要： The invention provides novel compounds which are capable to stimulate the proliferation or/and the outgrowth from cells presenting the neural cell adhesion molecule (NCAM). Additionally, the invention relates to pharmaceutical compositions, medicaments and methods for treatment of normal, degenerated and damaged NCAM presenting cells.
摘要翻译：本发明提供能够刺激来自呈递神经细胞粘附分子（NCAM）的细胞的增殖和/或生长的新型化合物。此外，本发明涉及用于治疗正常，退化和损伤的NCAM呈递细胞的药物组合物，药物和方法。

6. 发明申请

US20050069537A1 Survical promoting ncam binding and ncam ligand binding compounds 审中-公开
标题翻译：生存促进ncam结合和ncam配体结合化合物
公开(公告)号：US20050069537A1
公开(公告)日：2005-03-31
申请号：US10450150
申请日：2001-12-12
申请人： Vladimir Berezin , Elisabeth Bock , Lene Kohler
发明人： Vladimir Berezin , Elisabeth Bock , Lene Kohler
IPC分类号： A61K38/00 , A61K39/395 , A61P3/10 , A61P9/10 , A61P13/12 , A61P15/00 , A61P21/02 , A61P25/00 , A61P25/02 , A61P25/14 , A61P25/16 , A61P25/28 , C07K14/47 , C07K14/705 , A61K38/08
CPC分类号： C07K14/70503 , A61K38/00 , A61K2039/505
摘要： The present invention relates to compounds capable of stimulating survival of cells presenting the neural cell adhesion molecule (NCAM) or an NCAM-ligand (counter-receptor), such as neurons. Further, the present invention relates to the use of pharmaceutical compositions and medicaments in the treatment or protection of cells presenting NCAM or NCAM ligands. More particularly the invention describes the use of a compound comprising a peptide comprising at least 5 contiguous amino acid residues from an amino acid sequence of NCAM, a fragment thereof, or a variant thereof or a mimic thereof, for the preparation of a medicament for preventing cell death of cells presenting said NCAM or an NCAM ligand.
摘要翻译：本发明涉及能够刺激呈现神经细胞粘附分子（NCAM）的细胞或NCAM-配体（反受体）如神经元的存活的化合物。此外，本发明涉及药物组合物和药物在治疗或保护呈现NCAM或NCAM配体的细胞中的用途。更具体地，本发明描述了使用包含由NCAM的氨基酸序列至少5个连续氨基酸残基的肽组成的化合物，其片段或其变体或其模拟物，用于制备用于预防呈现所述NCAM或NCAM配体的细胞的细胞死亡。

7. 发明授权

US08470964B2 Peptides derived from NCAM (FGLs) 有权
标题翻译：衍生自NCAM（FGL）的肽
公开(公告)号：US08470964B2
公开(公告)日：2013-06-25
申请号：US12745129
申请日：2008-11-28
申请人： Vladimir Berezin , Elisabeth Bock , Soren Ebdrup , Boris Klementiev
发明人： Vladimir Berezin , Elisabeth Bock , Soren Ebdrup , Boris Klementiev
IPC分类号： C07K2/00 , A61K38/00
CPC分类号： C07K14/70503 , A61K38/00
摘要： The present invention relates to novel compounds comprising at most 13 contiguous amino acid residues derived from the fibronectin type 3,11 module of neural cell adhesion molecule (NCAM), or a variant or fragment thereof, capable of interacting with an FGFR and thereby the compounds are capable of inducing differentiation, modulating proliferation, stimulate regeneration, neuronal plasticity or survival of cells. Further, the present invention relates to the use of the compounds for production of a medicament for treatment of conditions and diseases, in which NCAM or FGFR play a prominent role.
摘要翻译：本发明涉及包含至少13个连续氨基酸残基的新化合物，其衍生自神经细胞粘附分子（NCAM）的3型纤连蛋白模块或其变体或片段，其能够与FGFR相互作用，从而使化合物能够诱导分化，调节增殖，刺激再生，神经元可塑性或细胞存活。此外，本发明涉及该化合物用于制备用于治疗NCAM或FGFR起重要作用的病症和疾病的药物的用途。

8. 发明授权

US07847058B2 Method of modulating cell survival, differentiation and/or synaptic plasticity 有权
标题翻译：调节细胞存活，分化和/或突触可塑性的方法
公开(公告)号：US07847058B2
公开(公告)日：2010-12-07
申请号：US10574084
申请日：2004-09-29
申请人： Elisabeth Bock , Vladimir Berezin , Vladyslav Soroka , Christina Kasper , Jette Sandholm Jensen Kastrup
发明人： Elisabeth Bock , Vladimir Berezin , Vladyslav Soroka , Christina Kasper , Jette Sandholm Jensen Kastrup
IPC分类号： A61K38/00 , C07K4/00
CPC分类号： A61K38/00 , C07K5/0819 , C07K14/70503 , C07K2299/00
摘要： The present invention relates to a method of modulating differentiation, adhesion and/or survival of the neural cell adhesion molecule (NCAM) presenting cells by providing compounds capable of modulating the interaction between the Ig1, Ig2 and/or Ig3 modules of NCAM. The invention provides candidate compounds capable of modulating the interaction between the Ig1, Ig2 and/or Ig3 modules of NCAM by using methods for screening and testing described in the application. The invention further relates to pharmaceutical compositions comprising compounds capable of modulating the interaction between the Ig1, Ig2 and/or Ig3 modules of NCAM and to use of the pharmaceutical compositions and compounds for the modulation of differentiation, adhesion and/or survival of NCAM presenting cells.
摘要翻译：本发明涉及通过提供能够调节NCAM的Ig1，Ig2和/或Ig3模块之间的相互作用的化合物来调节呈递细胞的神经细胞粘附分子（NCAM）的分化，粘附和/或存活的方法。本发明提供能够通过应用中描述的筛选和测试方法调节NCAM的Ig1，Ig2和/或Ig3模块之间的相互作用的候选化合物。本发明还涉及包含能够调节NCAM的Ig1，Ig2和/或Ig3模块之间的相互作用的化合物的药物组合物，以及用于调节NCAM呈递细胞的分化，粘附和/或存活的药物组合物和化合物。

9. 发明申请

US20100040623A1 NEURITOGENIC AND NEURONAL SURVIVAL PROMOTING PEPTIDES DERIVED FROM THE FAMILY OF S-100 PROTEINS 审中-公开
标题翻译：从S-100蛋白家族衍生的神经生长因子和神经营养促进肽
公开(公告)号：US20100040623A1
公开(公告)日：2010-02-18
申请号：US12442177
申请日：2006-12-20
申请人： Elisabeth Bock , Vladimir Berezin , Darya Kiryushko
发明人： Elisabeth Bock , Vladimir Berezin , Darya Kiryushko
IPC分类号： A61K39/395 , C07K7/06 , C07K7/08 , C07K14/00 , A61K38/08 , A61K38/10 , A61K38/16 , C07K16/00
CPC分类号： C07K14/4728 , A61K38/00
摘要： The present invention relates to peptide fragments derived from proteins of the S-100 family promoting neural cell survival, differentiation and proliferation. The invention further relates to pharmaceutical compositions comprising said peptide fragments and uses thereof for treatment of diseases and conditions where the effects of stimulating neural cell proliferation, differentiation and/or survival, and/or stimulating neural plasticity associated with learning and memory are beneficial for treatment.
摘要翻译：本发明涉及衍生自S-100家族蛋白质的肽片段，促进神经细胞存活，分化和增殖。本发明还涉及包含所述肽片段的药物组合物及其用于治疗刺激神经细胞增殖，分化和/或存活和/或刺激与学习和记忆相关的神经可塑性的作用对治疗有益的疾病和病症的用途。

10. 发明申请

US20090197801A1 NEURITOGENIC PEPTIDES 有权
标题翻译：神经细胞肽
公开(公告)号：US20090197801A1
公开(公告)日：2009-08-06
申请号：US11913954
申请日：2006-05-08
申请人： Vladimir Berezin , Elisabeth Bock
发明人： Vladimir Berezin , Elisabeth Bock
IPC分类号： A61K38/20 , C07K7/00 , C07K14/54 , C07K14/555 , A61K38/21 , A61K38/10 , C07K16/24 , C07K16/22 , C07K16/18 , A61K38/08 , C07K14/435 , A61P25/16 , A61P25/28
CPC分类号： A61K38/07 , A61K38/00 , A61K38/08 , A61K38/10 , C07K14/505
摘要： The present invention relates to peptide compounds that are capable of stimulating neuronal differentiation, neurite outgrowth and survival of neural cells, and enhancing synaptic plasticity, learning and memory, methods of treating diseases and conditions of nervous system by administration of compositions comprising said compounds. The compounds and compositions of the invention include peptide sequences that are derived from the sequence of human erythropoietin or proteins that are homologous of human erythropoietin.
摘要翻译：本发明涉及能够刺激神经元分化，神经突生长和神经细胞存活的肽化合物，以及通过施用包含所述化合物的组合物来增强突触可塑性，学习和记忆，治疗神经系统的疾病和病症的方法。本发明的化合物和组合物包括衍生自人促红细胞生成素序列或与促红细胞生成素同源的蛋白质的肽序列。

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