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1. 发明申请

US20050059803A1 Immunosuppressant target proteins 审中-公开
标题翻译：免疫抑制剂靶蛋白
公开(公告)号：US20050059803A1
公开(公告)日：2005-03-17
申请号：US10877320
申请日：2004-06-24
申请人： Vivian Berlin , Maria Chiu , Guillaume Cottarel , Veronique Damagnez
发明人： Vivian Berlin , Maria Chiu , Guillaume Cottarel , Veronique Damagnez
IPC分类号： G01N33/53 , C07K14/40 , C07K14/47 , C07K16/18 , C12N1/19 , C12N1/21 , C12N9/00 , C12N9/12 , C12N15/09 , C12N15/12 , C12N15/31 , C12N15/62 , C12N15/81 , C12P21/02 , C12Q1/25 , C12Q1/68 , G01N33/566 , G01N33/68 , G01N33/94 , C07K14/74
CPC分类号： G01N33/5091 , A01K2217/05 , C07K14/40 , C07K14/4702 , C07K2319/00 , C12N9/1205 , C12N9/93 , C12Q1/25 , C12Q1/6883 , C12Q1/6897 , C12Q2600/158 , G01N33/5005 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/68 , G01N33/6845 , G01N33/9493 , G01N2500/00
摘要： The present invention relates to the discovery of novel proteins of mammalian origin which are immediate downstream targets for FKBP/rapamycin complexes.
摘要翻译：本发明涉及哺乳动物来源的新型蛋白质的发现，其是FKBP /雷帕霉素复合物的即时下游靶标。

2. 发明授权

US06068982A Ubiquitin conjugating enzymes 失效
标题翻译：泛素缀合酶
公开(公告)号：US06068982A
公开(公告)日：2000-05-30
申请号：US767942
申请日：1996-12-17
申请人： Mark Rolfe , Maria Isabel Chiu , Guillaume Cottarel , Vivian Berlin , Veronique Damagnez , Giulio Draetta
发明人： Mark Rolfe , Maria Isabel Chiu , Guillaume Cottarel , Vivian Berlin , Veronique Damagnez , Giulio Draetta
IPC分类号： G01N33/48 , C07K16/40 , C12N9/00 , C12N15/00 , C12N15/09 , C12Q1/25 , C12Q1/68 , C12R1/91 , G01N33/53 , G01N33/68
CPC分类号： G01N33/6842 , C12N9/93 , C12Q1/25 , G01N33/68 , A01K2217/05
摘要： The present invention relates to drug screening assays which provide a systematic and practical approach for the identification of candidate agents able to inhibit ubiquitin-mediated degradation of a cell-cycle regulatory protein, such as p53, p27, myc, fos, MAT.alpha.2, or cyclins. The invention further relates to novel ubiquitin-conjugating enzymes, and uses related thereto.
摘要翻译：本发明涉及药物筛选测定法，其提供了用于鉴定能够抑制泛素介导的细胞周期调节蛋白如p53，p27，myc，fos，MATα2等的降解的候选试剂的系统和实用的方法。或细胞周期蛋白。本发明还涉及新的泛素结合酶及其相关用途。

3. 发明授权

US06509152B1 Immunosuppressant target proteins 失效
标题翻译：免疫抑制剂靶蛋白
公开(公告)号：US06509152B1
公开(公告)日：2003-01-21
申请号：US09012399
申请日：1998-01-23
申请人： Vivian Berlin , Maria Isabel Chiu , Guillaume Cottarel , Veronique Damagnez
发明人： Vivian Berlin , Maria Isabel Chiu , Guillaume Cottarel , Veronique Damagnez
IPC分类号： C12Q168
CPC分类号： G01N33/5091 , A01K2217/05 , C07K14/40 , C07K14/4702 , C07K2319/00 , C12N9/1205 , C12N9/93 , C12Q1/25 , C12Q1/6883 , C12Q1/6897 , C12Q2600/158 , G01N33/5005 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/68 , G01N33/6845 , G01N33/9493 , G01N2500/00
摘要： The present invention relates to the discovery of novel proteins of mammalian origin which are immediate downstream targets for FKBP/rapamycin complexes.
摘要翻译：本发明涉及哺乳动物来源的新型蛋白质的发现，其是FKBP /雷帕霉素复合物的即时下游靶标。

4. 发明授权

US5968761A Ubiquitin conjugating enzymes 失效
公开(公告)号：US5968761A
公开(公告)日：1999-10-19
申请号：US486663
申请日：1995-06-07
申请人： Mark Rolfe , Maria Isabel Chiu , Guillaume Cottarel , Vivian Berlin , Veronique Damagnez , Giulio Draetta
发明人： Mark Rolfe , Maria Isabel Chiu , Guillaume Cottarel , Vivian Berlin , Veronique Damagnez , Giulio Draetta
IPC分类号： G01N33/48 , C07K16/40 , C12N9/00 , C12N15/00 , C12N15/09 , C12Q1/25 , C12Q1/68 , C12R1/91 , G01N33/53 , G01N33/68 , C12Q1/48 , C12N9/10
CPC分类号： G01N33/6842 , C12N9/93 , C12Q1/25 , G01N33/68 , A01K2217/05
摘要： The present invention relates to drug screening assays which provide a systematic and practical approach for the identification of candidate agents able to inhibit ubiquitin-mediated degradation of a cell-cycle regulatory protein, such as p53, p27, myc, fos, MAT.alpha.2, or cyclins. The invention further relates to novel ubiquitin-conjugating enzymes, and uses related thereto.

5. 发明申请

US20110065898A1 Immunosuppressant Target Proteins 审中-公开
标题翻译：免疫抑制剂靶蛋白
公开(公告)号：US20110065898A1
公开(公告)日：2011-03-17
申请号：US12625940
申请日：2009-11-25
申请人： Vivian Berlin , Maria Isabel Chiu , Guillaume Cottarel , Veronique Damagnez
发明人： Vivian Berlin , Maria Isabel Chiu , Guillaume Cottarel , Veronique Damagnez
IPC分类号： C07K14/00 , C07H21/04
CPC分类号： G01N33/5091 , A01K2217/05 , C07K14/40 , C07K14/4702 , C07K2319/00 , C12N9/1205 , C12N9/93 , C12Q1/25 , C12Q1/6883 , C12Q1/6897 , C12Q2600/158 , G01N33/5005 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/68 , G01N33/6845 , G01N33/9493 , G01N2500/00
摘要： The present invention relates to the discovery of novel proteins of mammalian origin which are immediate downstream targets for FKBP/rapamycin complexes.
摘要翻译：本发明涉及哺乳动物来源的新型蛋白质的发现，其是FKBP /雷帕霉素复合物的即时下游靶标。

6. 发明授权

US6127521A Immunosuppressant target proteins 失效
公开(公告)号：US6127521A
公开(公告)日：2000-10-03
申请号：US12515
申请日：1998-01-23
申请人： Vivian Berlin , Maria Isabel Chiu , Guillaume Cottarel , Veronique Damagnez
发明人： Vivian Berlin , Maria Isabel Chiu , Guillaume Cottarel , Veronique Damagnez
IPC分类号： G01N33/53 , C07K14/40 , C07K14/47 , C07K16/18 , C12N1/19 , C12N1/21 , C12N9/00 , C12N9/12 , C12N15/09 , C12N15/12 , C12N15/31 , C12N15/62 , C12N15/81 , C12P21/02 , C12Q1/25 , C12Q1/68 , G01N33/566 , G01N33/68 , G01N33/94 , C07K19/00 , C07K11/00 , C07K14/00
CPC分类号： G01N33/5091 , C07K14/40 , C07K14/4702 , C12N9/1205 , C12N9/93 , C12Q1/25 , C12Q1/6883 , C12Q1/6897 , G01N33/5005 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/68 , G01N33/6845 , G01N33/9493 , A01K2217/05 , C07K2319/00 , C12Q2600/158 , G01N2500/00
摘要： The present invention relates to the discovery of novel proteins of mammalian origin which are immediate downstream targets for FKBP/rapamycin complexes.

7. 发明授权

US06464974B1 Immunosuppressant target proteins 失效
标题翻译：免疫抑制剂靶蛋白
公开(公告)号：US06464974B1
公开(公告)日：2002-10-15
申请号：US09012504
申请日：1998-01-23
申请人： Vivian Berlin , Maria Isabel Chiu , Guillaume Cottarel , Veronique Damagnez
发明人： Vivian Berlin , Maria Isabel Chiu , Guillaume Cottarel , Veronique Damagnez
IPC分类号： C07K1600
CPC分类号： G01N33/5091 , A01K2217/05 , C07K14/40 , C07K14/4702 , C07K2319/00 , C12N9/1205 , C12N9/93 , C12Q1/25 , C12Q1/6883 , C12Q1/6897 , C12Q2600/158 , G01N33/5005 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/68 , G01N33/6845 , G01N33/9493 , G01N2500/00
摘要： The present invention relates to the discovery of novel proteins of mammalian origin which are immediate downstream targets for FKBP/rapamycin complexes and provides, e.g., isolated polypeptides, nucleic acids encoding such, antibodies, screening methods, and diagnostic and therepeutic methods.
摘要翻译：本发明涉及哺乳动物来源的新型蛋白质的发现，其是FKBP /雷帕霉素复合物的即时下游靶标，并提供例如分离的多肽，编码此类核酸，抗体，筛选方法以及诊断和方法。

8. 发明授权

US6150137A Immunosuppressant target proteins 失效
公开(公告)号：US6150137A
公开(公告)日：2000-11-21
申请号：US360144
申请日：1994-12-20
申请人： Vivian Berlin , Maria Isabel Chiu , Guillaume Cottarel , Veronique Damagnez
发明人： Vivian Berlin , Maria Isabel Chiu , Guillaume Cottarel , Veronique Damagnez
IPC分类号： G01N33/53 , C07K14/40 , C07K14/47 , C07K16/18 , C12N1/19 , C12N1/21 , C12N9/00 , C12N9/12 , C12N15/09 , C12N15/12 , C12N15/31 , C12N15/62 , C12N15/81 , C12P21/02 , C12Q1/25 , C12Q1/68 , G01N33/566 , G01N33/68 , G01N33/94 , C07H21/04
CPC分类号： G01N33/5091 , C07K14/40 , C07K14/4702 , C12N9/1205 , C12N9/93 , C12Q1/25 , C12Q1/6883 , C12Q1/6897 , G01N33/5005 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/68 , G01N33/6845 , G01N33/9493 , A01K2217/05 , C07K2319/00 , C12Q2600/158 , G01N2500/00
摘要： The present invention relates to the discovery of novel proteins of mammalian origin which are immediate downstream targets for FKBP/rapamycin complexes.

9. 发明授权

US06251585B1 Assay and reagents for identifying anti-proliferative agents 失效
标题翻译：用于鉴定抗增殖剂的测定和试剂
公开(公告)号：US06251585B1
公开(公告)日：2001-06-26
申请号：US08428762
申请日：1995-04-24
申请人： Giulio Draetta , Guillaume Cottarel , Veronique Damagnez
发明人： Giulio Draetta , Guillaume Cottarel , Veronique Damagnez
IPC分类号： C12Q168
CPC分类号： G01N33/5011 , C12N9/16
摘要： The present invention makes available assays and reagents for identifying anti-proliferative agents, such as mitotic and meiotic inhibitors. The present assay provides a simple and rapid screening test which relies on scoring for positive cellular proliferation as indicative of anti-mitotic or anti-meiotic activity, and comprises contacting a candidate agent with a cell which has an impaired cell-cycle checkpoint and measuring the level of proliferation in the presence and absence of the agent. The checkpoint impairment is such that it either causes premature progression of the cell through at least a portion of a cell-cycle or inhibition of normal progression of the cell through at least a portion of a cell-cycle, but can be off-set by the action of an agent which inhibits at least one regulatory protein of the cell-cycle in a manner which counter-balances the effect of the impairment.
摘要翻译：本发明提供用于鉴定抗增殖剂（如有丝分裂和减数分裂抑制剂）的测定和试剂。本测定提供了一种简单快速的筛选试验，其依赖于阳性细胞增殖的评分作为抗有丝分裂或抗减数分裂活性的指示，并且包括使候选试剂与具有受损的细胞周期检查点的细胞接触并测量药剂存在和不存在时的增殖水平。检查点受损使得其通过细胞周期的至少一部分或者通过细胞周期的至少一部分抑制细胞的正常进展来导致细胞过早进展，但是可以通过抑制细胞周期的至少一种调节蛋白的药物的作用，其以抵消该损伤的作用的方式。

10. 发明授权

US5443962A Methods of identifying inhibitors of cdc25 phosphatase 失效
标题翻译：鉴定cdc25磷酸酶抑制剂的方法
公开(公告)号：US5443962A
公开(公告)日：1995-08-22
申请号：US73383
申请日：1993-06-04
申请人： Giulio Draetta , Guillaume Cottarel , Veronique Damagnez
发明人： Giulio Draetta , Guillaume Cottarel , Veronique Damagnez
IPC分类号： G01N33/15 , A61K38/45 , A61K45/00 , A61P43/00 , C12N1/15 , C12N1/19 , C12N9/16 , C12N15/09 , C12Q1/18 , C12R1/645 , G01N33/50 , C12Q1/02 , C12Q1/42 , C12Q1/68
CPC分类号： G01N33/5011 , C12N9/16
摘要： The present invention makes available assays and reagents for identifying anti-proliferative agents, such as mitotic and meiotic inhibitors, especially inhibitors of cdc25 phosphatase. The present assay provides a simple and rapid screening test which relies on scoring for positive cellular proliferation as indicative of anti-mitotic or anti-meiotic activity, and comprises contacting a candidate agent with a cell which has an impaired cell-cycle checkpoint and measuring the level of proliferation in the presence and absence of the agent. The checkpoint impairment is such that it either causes premature progression of the cell through at least a portion of a cell-cycle or inhibition of normal progression of the cell through at least a portion of a cell-cycle, but can be off-set by the action of an agent which inhibits at least one regulatory protein of the cell-cycle in a manner which counter-balances the effect of the impairment.
摘要翻译：本发明提供用于鉴定抗增殖剂的测定和试剂，例如有丝分裂和减数分裂抑制剂，特别是cdc25磷酸酶的抑制剂。本测定提供了一种简单快速的筛选试验，其依赖于阳性细胞增殖的评分作为抗有丝分裂或抗减数分裂活性的指示，并且包括使候选试剂与具有受损的细胞周期检查点的细胞接触并测量药剂存在和不存在时的增殖水平。检查点受损使得其通过细胞周期的至少一部分或者通过细胞周期的至少一部分抑制细胞的正常进展来导致细胞过早进展，但是可以通过抑制细胞周期的至少一种调节蛋白的药物的作用，其以抵消该损伤的作用的方式。

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