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2. 发明申请

WO2003043415A1 SYSTEME D'EXPRESSION DE PROTEINES EXOGENES DANS UN SYSTEME AVIAIRE 审中-公开
标题翻译： AVIAN系统中外源蛋白表达系统
公开(公告)号：WO2003043415A1
公开(公告)日：2003-05-30
申请号：PCT/FR2002/003992
申请日：2002-11-21
申请人： VIVALIS , INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , ENS - ECOLE NORMALE SUPERIEURE DE LYON , PAIN, Bertrand , SAMARUT, Jacques , VALARCHE, Isabelle , CHAMPION-ARNAUD, Patrick , SOBCZYK, André , KUNITA, Ryota
发明人： PAIN, Bertrand , SAMARUT, Jacques , VALARCHE, Isabelle , CHAMPION-ARNAUD, Patrick , SOBCZYK, André , KUNITA, Ryota
IPC分类号： A01K67/027
CPC分类号： A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2227/30 , A01K2267/01 , A23L15/20 , C12N15/8509 , C12N15/902 , C12N2830/008 , C12N2830/32 , C12N2830/90 , C12N2840/20 , C12N2840/203
摘要： La présente invention se rapporte à l'utilisation d'une cellule aviaire pour la production d'une protéine exogène d'intérêt dans un animal appartenant à l'espèce aviaire, ladite cellule étant transformée par un vecteur d'expression comprenant le gène codant pour ladite protéine, ladite cellule étant introduite soit dans la cavité sub-germinale d'un embryon, la circulation sanguine de l'embryon ou servant de source de noyau pour le transfert nucléaire dans un ovocyte énuclée ou non, ou dont les chromosomes ont été détruits.
摘要翻译：本发明涉及禽类细胞在属于禽类物种的动物中用于产生感兴趣的外源蛋白质的用途，所述细胞由包含编码所述蛋白质的基因的表达载体转化，所述细胞被引入次生物胚胎的空腔，胚胎的血液或被用作核转移到核蛋白的核蛋白来源或其染色体已被破坏的核心来源。

3. 发明公开

EP1446004A1 SYSTEME D'EXPRESSION DE PROTEINES EXOGENES DANS UN SYSTEME AVIAIRE 有权
标题翻译：禽流感表达系统外源蛋白
公开(公告)号：EP1446004A1
公开(公告)日：2004-08-18
申请号：EP02796854.4
申请日：2002-11-21
申请人： Vivalis , Institut National de la Recherche Agronomique (INRA) , Centre National de la Recherche Scientifique - CNRS , Ens - Ecole Normale Superieure de Lyon
发明人： PAIN, Bertrand , SAMARUT, Jacques , VALARCHE, Isabelle , CHAMPION-ARNAUD, Patrick , SOBCZYK, André , KUNITA, Ryota
IPC分类号： A01K67/027 , C12N15/90 , C12N15/63 , C12N15/06 , C12P21/00
CPC分类号： A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2227/30 , A01K2267/01 , A23L15/20 , C12N15/8509 , C12N15/902 , C12N2830/008 , C12N2830/32 , C12N2830/90 , C12N2840/20 , C12N2840/203
摘要： The invention concerns the use of an avian cell for producing an exogenous protein of interest in an animal belonging to the avian species, said cell being transformed by an expression vector comprising the gene coding for said protein, said cell being introduced in the sub-germinal cavity of an embryo, the blood stream of the embryo or being used as nucleus source for nuclear transfer into an avian egg enucleated or not, or whereof the chromosomes have been destroyed.

4. 发明申请

WO2009112592A1 IN VITRO METHOD TO DETERMINE WHETHER A DRUG CANDIDATE ACTIVE AGAINST A TARGET PROTEIN IS ACTIVE AGAINST A VARIANT OF SAID PROTEIN 审中-公开
标题翻译： PROCESS <我
公开(公告)号：WO2009112592A1
公开(公告)日：2009-09-17
申请号：PCT/EP2009/053101
申请日：2009-03-16
申请人： VIVALIS , LAHMAR, Medhi , VALARCHE, Isabelle , MEHTALI, Majid
发明人： LAHMAR, Medhi , VALARCHE, Isabelle , MEHTALI, Majid
IPC分类号： G01N33/50 , G01N33/576 , G01N33/68
CPC分类号： G01N33/5008 , G01N33/5767 , G01N33/6845 , G01N2333/16 , G01N2333/70567
摘要： The present invention relates to the field of virology. More precisely, the invention provides a method of determining the ability of a test compound to modulate the biological activity of a variant of a target protein, wherein said test compound is previously known to modulate the biological activity of said protein. This invention is useful to determine whether a drug candidate, such as anti-viral compounds (eg. against hepatitis C virus: NS5B, NS3), active against a target protein is active against a variant of said protein (eg. polymorphisms, genotypes or mutants).
摘要翻译：本发明涉及病毒学领域。更具体地说，本发明涉及一种确定测试化合物调节靶蛋白的变体的生物学活性的能力的方法，所述测试化合物是先前已知调节活动生物的所述蛋白。本发明是有用的，用于确定候选药物，如抗病毒化合物（例如抗丙型肝炎病毒：NS5B，NS3）是否针对靶蛋白活性是有效对抗所述蛋白质的变体（例如，多态性，基因型或突变体）。

5. 发明申请

WO2008017704A1 METHOD OF PRODUCTION OF TRANSGENIC AVIAN USING EMBRYONIC STEM CELLS 审中-公开
标题翻译：使用胚胎干细胞生产转基因禽的方法
公开(公告)号：WO2008017704A1
公开(公告)日：2008-02-14
申请号：PCT/EP2007/058263
申请日：2007-08-09
申请人： VIVALIS , VALARCHE, Isabelle , BATARD, Luc , MEHTALI, Majid
发明人： VALARCHE, Isabelle , BATARD, Luc , MEHTALI, Majid
IPC分类号： C12N5/06
CPC分类号： C12N5/0606 , A01K2217/00 , A01K2227/30 , C12N2501/10 , C12N2501/105 , C12N2501/115 , C12N2501/125 , C12N2501/13 , C12N2501/23 , C12N2501/2306 , C12N2502/13
摘要： The present invention concerns a method of culturing embryonic stem (ES) cells of avian, comprising the steps of: a) suspending ES cells originating from the blastoderm disk of fertilized un-incubated avian egg(s) in a basal culture medium supplemented with: insulin-like growth factor-1 (IGF-1) and ciliary neurotrophic factor (CNTF); and animal serum; and optionally, at least one growth factors selected in the group comprising interleukin 6 (Il-6), interleukin 6 receptor (Il-6R), stem cell factor (SCF), fibroblast growth factor (FGF), leukaemia inhibitory factor (LIF), interleukin 11 (Il-11), oncostatin and cardiotrophin; b) seeding the suspension of ES cells obtained in step a) on a layer of feeder cells and further culturing the ES cells for at least between 2 to 10 passages; c) optionally removing at least one growth factors selected SCF, FGF, Il-6, Il-6R, LIF, oncostatin and cardiotrophin and Il-11 from the culture medium; d) further culturing the ES cells in the medium of step c) on a layer of feeder cells.
摘要翻译：本发明涉及一种培养禽类胚胎干（ES）细胞的方法，包括以下步骤：a）将源自受精培养未孵化禽鸟卵胚细胞盘的ES细胞悬浮在补充以下物质的基础培养基中：胰岛素样生长因子-1（IGF-1）和睫状神经营养因子（CNTF）; 和动物血清; 并且任选地，选自包含白细胞介素6（II-6），白细胞介素6受体（II-6R），干细胞因子（SCF），成纤维细胞生长因子（FGF），白血病抑制因子（LIF））的组中的至少一种生长因子，，白介素11（Il-11），制瘤素和心肌营养素; b）将步骤a）中获得的ES细胞的悬浮液接种在饲养细胞层上，并进一步培养ES细胞至少2至10代; c）任选地从培养基中除去选自SCF，FGF，II-6，II-6R，LIF，制瘤素和心肌营养素和II-11的至少一种生长因子; d）在步骤c）的培养基中进一步培养ES细胞在饲养细胞层上。

6. 发明申请

WO2011004018A1 SUBSTITUTED PYRROLIDINONE AS INHIBITORS OF HEPATITIS C NS5B POLYMERASE, THE PHARMACEUTICAL COMPOSITION THEREOF AND THEIR THERAPEUTIC USE 审中-公开
标题翻译：取代的吡咯烷酮作为丙型肝炎病毒NS5B聚合酶，其药物组合物及其治疗用途的抑制剂
公开(公告)号：WO2011004018A1
公开(公告)日：2011-01-13
申请号：PCT/EP2010/059921
申请日：2010-07-09
申请人： VIVALIS , BERECIBAR, Amaya , GUEDAT, Philippe , VALARCHE, Isabelle , MOHAMED-ARAB, Céline , MATT, Christophe
发明人： BERECIBAR, Amaya , GUEDAT, Philippe , VALARCHE, Isabelle , MOHAMED-ARAB, Céline , MATT, Christophe
IPC分类号： A61K31/427 , A61K31/428 , A61K31/433 , A61K31/4402 , A61K31/4406 , A61K31/4409 , C07D417/04 , A61P31/12
CPC分类号： C07D417/04 , C07D417/14
摘要： The present invention concerns a substituted pyrrolidinone of the following formula I or a salt, solvate, tautomer, isotope, enantiomer, diastereoisomer or racemic mixture thereof:(I), for the treatment of hepatitis C.
摘要翻译：本发明涉及下式I的取代的吡咯烷酮或其盐，溶剂化物，互变异构体，同位素，对映体，非对映异构体或外消旋混合物：（I），用于治疗丙型肝炎

7. 发明公开

EP2054507A1 METHOD OF PRODUCTION OF TRANSGENIC AVIAN USING EMBRYONIC STEM CELLS 审中-公开
标题翻译：法生产转基因鸟类胚胎干细胞
公开(公告)号：EP2054507A1
公开(公告)日：2009-05-06
申请号：EP07802553.3
申请日：2007-08-09
申请人： Vivalis
发明人： VALARCHE, Isabelle , BATARD, Luc , MEHTALI, Majid
IPC分类号： C12N5/06
CPC分类号： C12N5/0606 , A01K2217/00 , A01K2227/30 , C12N2501/10 , C12N2501/105 , C12N2501/115 , C12N2501/125 , C12N2501/13 , C12N2501/23 , C12N2501/2306 , C12N2502/13
摘要： The present invention concerns a method of culturing embryonic stem (ES) cells of avian, comprising the steps of: a) suspending ES cells originating from the blastoderm disk of fertilized un-incubated avian egg(s) in a basal culture medium supplemented with: insulin-like growth factor-1 (IGF-1) and ciliary neurotrophic factor (CNTF); and animal serum; and optionally, at least one growth factors selected in the group comprising interleukin 6 (Il-6), interleukin 6 receptor (Il-6R), stem cell factor (SCF), fibroblast growth factor (FGF), leukaemia inhibitory factor (LIF), interleukin 11 (Il-11), oncostatin and cardiotrophin; b) seeding the suspension of ES cells obtained in step a) on a layer of feeder cells and further culturing the ES cells for at least between 2 to 10 passages; c) optionally removing at least one growth factors selected SCF, FGF, Il-6, Il-6R, LIF, oncostatin and cardiotrophin and Il-11 from the culture medium; d) further culturing the ES cells in the medium of step c) on a layer of feeder cells.

8. 发明公开

EP2451453A1 SUBSTITUTED PYRROLIDINONE AS INHIBITORS OF HEPATITIS C NS5B POLYMERASE, THE PHARMACEUTICAL COMPOSITION THEREOF AND THEIR THERAPEUTIC USE 审中-公开
标题翻译：取代吡咯烷酮作为其丙型肝炎NS5B聚合酶的抑制剂，药物组合物及其治疗用途
公开(公告)号：EP2451453A1
公开(公告)日：2012-05-16
申请号：EP10732354.5
申请日：2010-07-09
申请人： Vivalis
发明人： BERECIBAR, Amaya , GUEDAT, Philippe , VALARCHE, Isabelle , MOHAMED-ARAB, Céline , MATT, Christophe
IPC分类号： A61K31/427 , A61K31/428 , A61K31/433 , A61K31/4402 , A61K31/4406 , A61K31/4409 , C07D417/04 , A61P31/12
CPC分类号： C07D417/04 , C07D417/14
摘要： The present invention concerns a substituted pyrrolidinone of the following formula I or a salt, solvate, tautomer, isotope, enantiomer, diastereoisomer or racemic mixture thereof: (I), for the treatment of hepatitis C.

9. 发明公开

EP2271936A1 IN VITRO METHOD TO DETERMINE WHETHER A DRUG CANDIDATE ACTIVE AGAINST A TARGET PROTEIN IS ACTIVE AGAINST A VARIANT OF SAID PROTEIN 有权
标题翻译： IS体外方法以判断是否针对靶蛋白质活性区域的候选药物对蛋白质活性的变体
公开(公告)号：EP2271936A1
公开(公告)日：2011-01-12
申请号：EP09721044.7
申请日：2009-03-16
申请人： Vivalis
发明人： LAHMAR, Medhi , VALARCHE, Isabelle , MEHTALI, Majid
IPC分类号： G01N33/50 , G01N33/576 , G01N33/68
CPC分类号： G01N33/5008 , G01N33/5767 , G01N33/6845 , G01N2333/16 , G01N2333/70567
摘要： The present invention relates to the field of virology. More precisely, the invention provides a method of determining the ability of a test compound to modulate the biological activity of a variant of a target protein, wherein said test compound is previously known to modulate the biological activity of said protein. This invention is useful to determine whether a drug candidate, such as anti-viral compounds (e.g. against hepatitis C virus: NS5B, NS3), active against a target protein is active against a variant of said protein (e.g. polymorphisms, genotypes or mutants).

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