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1. 发明授权

US07163960B2 Treatment and prevention of inflammatory disorders 有权
标题翻译：治疗和预防炎症性疾病
公开(公告)号：US07163960B2
公开(公告)日：2007-01-16
申请号：US10384369
申请日：2003-03-07
申请人： Virginia Ursin , Michael J. James
发明人： Virginia Ursin , Michael J. James
IPC分类号： A61K31/20
CPC分类号： A23K50/45 , A23D7/0056 , A23D9/007 , A23K20/158 , A23L33/12 , A61K31/185 , A61K31/202
摘要： The invention relates to methods of treating and preventing disorders associated with elevated TNF-α and/or IL-1β by administering therapeutic amounts of stearidonic acid. Further provided are methods for down-regulating TNF-α and/or IL-1β and assays for determining the presence, absence, or quantity of TNF-α and/or IL-1β in a subject in conjunction with a regimen of stearidonic acid administration.
摘要翻译：本发明涉及通过施用治疗量的十八碳四烯酸治疗和预防与升高的TNF-α和/或IL-1β相关的疾病的方法。还提供了用于下调TNF-α和/或IL-1β的方法和用于测定受试者中的TNF-α和/或IL-1β的存在，不存在或数量的测定以及十八碳四烯酸给药方案。

2. 发明授权

US4681192A Dual-wheel casters with positive lock mechanism 失效
标题翻译：双轮脚轮具有正锁定机构
公开(公告)号：US4681192A
公开(公告)日：1987-07-21
申请号：US662063
申请日：1984-10-18
申请人： Michael J. James
发明人： Michael J. James
IPC分类号： B60B33/00 , B60B33/02
CPC分类号： B60B33/0042 , B60B33/021 , Y10T16/195
摘要： A braked twin-wheel caster assembly consists of five components--a body, two indentical wheels, a metal wheel spindle and a locking lever. A molded brake lever, rockable between a wheel-locking position and an unlocking position in which the wheels are free to turn, has an intermediate mounting portion which pivots in a bearing recess in the moulded body. The bearing recess is disposed towards the trailing end of the body, and it is open at an outer aperture and also at an inner aperture. An outer end portion of the locking lever projects through the outer aperture to provide an operating member for external operation. An inner end portion of the locking lever projects from said inner aperture to provide a locking member for engagement with the caster wheels. The intermediate portion of the locking lever is molded so that it can be resiliently compressed sufficiently for it to be inserted into the bearing recess through the outer aperture.
摘要翻译：制动的双轮脚轮组件由五个部件组成：主体，两个独立的轮子，金属轮轴和锁定杆。在车轮锁定位置和车轮自由转动的解锁位置之间摆动的模制制动杆具有在模制体中的轴承凹部中枢枢转的中间安装部。轴承凹槽朝向主体的后端设置，并且其在外孔和内孔处开口。锁定杆的外端部突出穿过外孔，以提供用于外部操作的操作构件。锁定杆的内端部从所述内孔突出，以提供用于与脚轮接合的锁定构件。锁定杆的中间部分被模制，使得其能够被充分地弹性压缩，以使其通过外孔插入到轴承凹部中。

3. 发明授权

US4491353A Reciprocatory devices 失效
标题翻译：往复式装置
公开(公告)号：US4491353A
公开(公告)日：1985-01-01
申请号：US490299
申请日：1983-05-02
申请人： Michael J. James
发明人： Michael J. James
IPC分类号： E05C19/04 , E05C19/02
CPC分类号： E05C19/04 , Y10S292/22 , Y10S292/38 , Y10S292/60 , Y10S292/62 , Y10T292/0879
摘要： A reciprocatory device in the form of a roller door catch has a reciprocatory plunger slidable in a fixed tubular housing and retained therein by an adjustment member. The plunger is urged to a normal resting position by a compression return spring. At its outer end the plunger rotatably supports a catch roller engageable with a recessed keeper mounted on the door frame. The adjustment member has a stem portion which projects into a blind bore at the inner end of the plunger, and this stem has radial stub projections which engage with a helical rib providing a screw thread within said bore, with a clearance in the axial direction approximating to the normal range of plunger reciprocation on door opening and closure. The adjustment member has a head portion with a frusto-conical clutch face which frictionally engages a mating clutch face at the inner end of the housing. The plunger is restrained against rotation within the housing, and a small amount of clutch slip as said clutch faces interengage on door opening provides an auto-set facility which compensates for variations in the gap between the door and the door frame at the shut face.
摘要翻译：滚轮门锁的形式的往复运动装置具有可在固定管状壳体中滑动并且由调节构件保持在其中的往复式柱塞。柱塞通过压缩复位弹簧被推动到正常的静止位置。在其外端，柱塞可旋转地支撑可与安装在门框上的嵌入式保持器接合的止动辊。调节构件具有在柱塞的内端处突入盲孔的杆部分，并且该杆具有径向短柱突起，其与在所述孔内提供螺纹的螺旋肋接合，轴向间隙近似到门开启和关闭时柱塞往复运动的正常范围。调节构件具有头部，其具有截头圆锥形离合器面，其在壳体的内端处与配合离合器面摩擦接合。柱塞被限制在壳体内旋转，并且当所述离合器面对门开口提供时，少量的离合器滑动提供了一种自动设定装置，其补偿在关闭面处的门和门框之间的间隙的变化。

4. 发明授权

US5050956A Optical fiber attenuator and connecting element 失效
标题翻译：光纤衰减器和连接元件
公开(公告)号：US5050956A
公开(公告)日：1991-09-24
申请号：US585504
申请日：1990-09-20
申请人： P. Kevin Carpenter , Michael J. James
发明人： P. Kevin Carpenter , Michael J. James
IPC分类号： G02B6/26
CPC分类号： G02B6/266
摘要： The attenuator includes an externally threaded sleeve for receiving standard ferrules within its bore at opposite ends, an internally threaded adjuster for threaded engagement about the sleeve and a ferrule locking nut threadedly engageable about the adjuster for clamping a ferrule at one end of the sleeve between the adjuster and ferrule locking nut. By relatively threading the sleeve and adjuster, the ferrule may be displaced relative to the sleeve whereby the end face of the optical fiber carried thereby is adjustably spaced from the end face of an optical fiber carried by a ferrule fixed on the sleeve at the opposite end thereof.
摘要翻译：衰减器包括外螺纹套筒，用于在其相对端处的孔内容纳标准套圈，用于螺纹接合套筒的内螺纹调节器，以及能够围绕调节器螺纹接合的套圈锁紧螺母，用于在套筒的一端处夹紧套圈调节器和套圈锁紧螺母。通过相对于套筒和调节器穿线，套圈可以相对于套筒移动，由此承载的光纤的端面可调节地与固定在套筒上的套圈的相反端的由光纤承载的光纤的端面间隔开其中。

5. 发明授权

US4664231A Braked castors 失效
标题翻译：制动脚轮
公开(公告)号：US4664231A
公开(公告)日：1987-05-12
申请号：US789333
申请日：1985-10-21
申请人： Michael J. James
发明人： Michael J. James
IPC分类号： B60B33/00 , B60B33/02 , B62B5/04 , B62C7/02
CPC分类号： B60B33/0042 , B60B33/021 , B62B5/0461 , Y10T16/1853 , Y10T16/195
摘要： A twin-wheel castor incorporates brake means comprising an externally-operable brake member which is rockably mounted in a body of the castor for engagement with the wheels of the castor to lock the wheels against rotation. The brake member has a detent projection engageable with a formation of the body to retain the brake member in the braking position, and projecting locking stubs which are engageable between internally projecting webs of the wheels to lock the latter against rotation. The locking stubs are resiliently mounted so that their connection to the main body of the locking member on which the detent projection is mounted will yield, should locking movement of the locking stubs be blocked by engagement with the edge of one of the webs, thus allowing the detent projection to engage the body formation and retain the locking member in the locking position. Thus, as soon as the wheel concerned turns, the resilient mounting of the locking stubs causes the latter to move into a wheel-locking position.
摘要翻译：双轮脚轮包括制动装置，其包括外部可操作的制动构件，该制动构件可摇动地安装在脚轮的主体中，用于与脚轮的车轮接合以将车轮锁定以防止旋转。制动构件具有可与主体的形式接合的制动突起，以将制动构件保持在制动位置，以及突出的锁定杆，其可在车轮的内部突出的腹板之间接合以将其锁定以防旋转。锁定桩被弹性地安装，使得它们与锁定构件的主体的连接，其上安置有止动突起将会产生锁定桩的锁定运动，通过与一个腹板的边缘接合来阻止，从而允许所述制动突起接合所述主体结构并将所述锁定构件保持在所述锁定位置。因此，一旦轮子转动，锁定杆的弹性安装就会使其移动到车轮锁定位置。

6. 发明授权

US4243369A Mould closing, clamping and opening means 失效
标题翻译：闭模，夹紧和开启手段
公开(公告)号：US4243369A
公开(公告)日：1981-01-06
申请号：US966557
申请日：1978-12-05
申请人： Michael J. James
发明人： Michael J. James
IPC分类号： B29C45/67 , B29F1/00
CPC分类号： B29C45/6714
摘要： Mould closing, clamping and opening means for the split mould of a pressure moulding machine comprises a pair of elongated arms each pivotally attached to the moving platen of the machine at one end and free at the other end, and extending lengthwise between the moving platen and a hydraulic rear clamping platen. During a mould operation the free ends of the arms engage the rear clamping platen so as to act as struts between the rear clamping platen and the moving platen during a mould clamping operation, but during a mould opening operation the arms are swung by an hydraulic cylinder to a position in which they register with openings in the rear clamping platen so that the arms may pass rearwardly through the openings as the mould opens.
摘要翻译：用于压模机的分模的闭模，夹紧和打开装置包括一对细长臂，每个细长臂在一端枢转地附接到机器的移动压板并在另一端自由，并且在移动压板和液压后夹板。在模具操作期间，臂的自由端接合后夹紧台板，以便在模具夹紧操作期间用作后夹板和移动压板之间的支柱，但是在模具打开操作期间，臂由液压缸在其中它们与后夹紧压板中的开口对准的位置，使得当模具打开时，臂可以向后通过开口。

7. 发明授权

US4173810A Twin-wheel castor 失效
标题翻译：双轮脚轮
公开(公告)号：US4173810A
公开(公告)日：1979-11-13
申请号：US914292
申请日：1978-06-09
申请人： Michael J. James
发明人： Michael J. James
IPC分类号： B60B33/00
CPC分类号： B60B33/0042 , B60B33/0028 , Y10T16/1853
摘要： A twin-wheel castor has a moulded body with a through bearing bore in which stub axles of twin moulded wheels are received. The axles have circumferential grooves respectively engaged by two axially-spaced circumferential series of internal body projections moulded within the through bore of the body. The projections are arranged with the two series thereof angularly staggered so that in axial projection no two projections overlap. The engagement of the projections with the axle grooves provides positive retention of the wheels with snap-on assembly thereof to the body.
摘要翻译：双轮脚轮具有带有贯穿轴承孔的成型体，其中接收双模轮的短轴。轴具有分别由在主体的通孔内模制的两个轴向间隔开的周向系列的内部主体突起接合的圆周槽。这些突起被布置成两个系列成角度地交错，使得在轴向投影中没有两个突起重叠。突起与轴槽的接合使得车轮的卡扣组装能正确地保持在车身上。

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