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1. 发明授权

US08251958B2 Medicament microdevice delivery system, cartridge and method of use 有权
标题翻译：药物微装置输送系统，药筒和使用方法
公开(公告)号：US08251958B2
公开(公告)日：2012-08-28
申请号：US12965278
申请日：2010-12-10
申请人： Vincent J. Sullivan , Ronald J. Pettis , John A. Mikszta , John P. Dekker, III , Wendy D. Woodley , Anjana Bhuta Wills , Matthew S. Ferriter , C. Robin Hwang
发明人： Vincent J. Sullivan , Ronald J. Pettis , John A. Mikszta , John P. Dekker, III , Wendy D. Woodley , Anjana Bhuta Wills , Matthew S. Ferriter , C. Robin Hwang
IPC分类号： A61M5/00 , A61M37/00 , A61M31/00
CPC分类号： A61M37/0015 , A61M11/003 , A61M11/008 , A61M15/0028 , A61M15/0031 , A61M15/0033 , A61M2202/064 , A61M2205/073 , A61M2205/075 , B05B11/061 , B05B11/062
摘要： A method and device for intradermal delivery of a reconstituted medicament. The device includes a chamber, which is in fluid communication with a microdevice, e.g. microabrader or one or more microneedles. A cartridge containing the medicament may be located within said chamber. At least one burstable membrane retains a medicament within the housing. The method involves the steps of positioning the device at a delivery site on the skin of a patient and intradermally administering the medicament by dispensing a diluent from a diluent source an through inlet port to rupture the membranes, reconstitute the medicament and deliver the reconstituted medicament through the microdevice to the dermal region of the skin.
摘要翻译：用于皮内递送重组药物的方法和装置。该装置包括与微型装置例如流体连通的腔室。微型抛光机或一个或多个微针。容纳药物的药筒可以位于所述腔室内。至少一个可爆破膜在壳体内保持药物。该方法包括以下步骤：将装置定位在患者皮肤上的递送部位，并通过从稀释剂源通过入口端口分配稀释剂来皮内施用药物，以破裂膜，重建药物并将重组的药物通过皮肤的皮肤区域的微型装置。

2. 发明申请

US20110251546A1 MEDICAMENT MICRODEVICE DELIVERY SYSTEM, CARTRIDGE AND METHOD OF USE 有权
标题翻译：药物MICRODEVICE传递系统，盒子和使用方法
公开(公告)号：US20110251546A1
公开(公告)日：2011-10-13
申请号：US12965278
申请日：2010-12-10
申请人： Vincent J. Sullivan , Ronald J. Pettis , John A. Mikszta , John P. Dekker, III , Wendy D. Woodley , Anjana Bhuta Wills , Matthew S. Ferriter , C. Robin Hwang
发明人： Vincent J. Sullivan , Ronald J. Pettis , John A. Mikszta , John P. Dekker, III , Wendy D. Woodley , Anjana Bhuta Wills , Matthew S. Ferriter , C. Robin Hwang
IPC分类号： A61M5/31 , A61M37/00
CPC分类号： A61M37/0015 , A61M11/003 , A61M11/008 , A61M15/0028 , A61M15/0031 , A61M15/0033 , A61M2202/064 , A61M2205/073 , A61M2205/075 , B05B11/061 , B05B11/062
摘要： A method and device for intradermal delivery of a reconstituted medicament. The device includes a chamber, which is in fluid communication with a microdevice, e.g. microabrader or one or more microneedles. A cartridge containing the medicament may be located within said chamber. At least one burstable membrane retains a medicament within the housing. The method involves the steps of positioning the device at a delivery site on the skin of a patient and intradermally administering the medicament by dispensing a diluent from a diluent source an through inlet port to rupture the membranes, reconstitute the medicament and deliver the reconstituted medicament through the microdevice to the dermal region of the skin.
摘要翻译：用于皮内递送重组药物的方法和装置。该装置包括与微型装置例如流体连通的腔室。微型抛光机或一个或多个微针。容纳药物的药筒可以位于所述腔室内。至少一个可爆破的膜在壳体内保持药物。该方法包括以下步骤：将装置定位在患者皮肤上的递送部位，并通过从稀释剂源通过入口端口分配稀释剂来皮内施用药物，以破裂膜，重建药物并将重组的药物通过皮肤的皮肤区域的微型装置。

3. 发明授权

US07850663B2 Medicament microdevice delivery system, cartridge and method of use 有权
标题翻译：药物微装置输送系统，药筒和使用方法
公开(公告)号：US07850663B2
公开(公告)日：2010-12-14
申请号：US10858447
申请日：2004-06-01
申请人： Vincent J. Sullivan , Ronald J. Pettis , John A. Mikszta , John P. Dekker, III , Wendy D. Woodley , Anjana Bhuta Wills , Matthew S. Ferriter , C. Robin Hwang
发明人： Vincent J. Sullivan , Ronald J. Pettis , John A. Mikszta , John P. Dekker, III , Wendy D. Woodley , Anjana Bhuta Wills , Matthew S. Ferriter , C. Robin Hwang
IPC分类号： A61M5/00
CPC分类号： A61M37/0015 , A61M11/003 , A61M11/008 , A61M15/0028 , A61M15/0031 , A61M15/0033 , A61M2202/064 , A61M2205/073 , A61M2205/075 , B05B11/061 , B05B11/062
摘要： A method and device for intradermal delivery of a reconstituted powdered medicament. The device includes a chamber, which is in fluid communication with a microdevice, e.g. microabrader or one or more microneedles. A cartridge containing the powdered medicament may be located within said chamber. At least one burstable membrane retains a powdered medicament within the housing. The method involves the steps of positioning the device at a delivery site on the skin of a patient and intradermally administering the medicament by dispensing a diluent from a diluent source an through inlet port to rupture the membranes, reconstitute the powdered medicament and deliver the reconstituted medicament through the microdevice to the dermal region of the skin.
摘要翻译：用于皮内递送重构粉末状药物的方法和装置。该装置包括与微型装置例如流体连通的腔室。微型抛光机或一个或多个微针。含有粉末状药物的药筒可以位于所述腔室内。至少一个可爆破膜在壳体内保持粉末状药物。该方法包括以下步骤：将装置定位在患者皮肤上的递送部位，并通过从稀释剂源通过入口端口分配稀释剂来皮内施用药物，以破裂膜，重构粉末状药物并递送重组的药物通过微型装置到皮肤的皮肤区域。

4. 发明授权

US07588774B2 Molecules enhancing dermal delivery of influenza vaccines 有权
标题翻译：分子增强流感疫苗的皮肤输送
公开(公告)号：US07588774B2
公开(公告)日：2009-09-15
申请号：US11006422
申请日：2004-12-06
申请人： Robert L. Campbell , Kevin G. Dolan , Wendy D. Woodley
发明人： Robert L. Campbell , Kevin G. Dolan , Wendy D. Woodley
IPC分类号： A61K39/00 , A61K39/39 , A61K39/12 , A61K39/02
CPC分类号： A61K9/0021 , A61K39/12 , A61K39/145 , A61K39/39 , A61K2039/54 , A61K2039/55555 , A61K2039/55583 , A61K2039/70 , C12N2760/16134 , C12N2760/16234 , Y02A50/386
摘要： The present invention relates to dermal vaccine formulations, designed for targeted delivery of an immunogenic composition to a dermal compartment of skin including the intradermal and epidermal compartments. The dermal vaccine formulations of the invention comprise an antigenic or immunogenic agent, and at least one molecule, e.g., a chemical agent, which enhances the presentation and/or availability of the antigenic or immunogenic agent to the immune cells of the intradermal compartment or epidermal compartment resulting in an enhanced immune response. The dermal vaccine formulations of the invention have enhanced efficacy as the antigenic or immunogenic agent is delivered to the intradermal compartment or epidermal compartment with enhanced presentation and/or availability to the immune cells that reside therein. The enhanced efficacy of the dermal vaccine formulations results in a therapeutically effective immune response after a single intradermal or epidermal dose, with lower doses of antigenic or immunogenic agent than conventionally used, and without the need for booster immunizations.
摘要翻译：本发明涉及真皮疫苗制剂，其设计用于将免疫原性组合物靶向递送至包括皮内和表皮隔层的皮肤皮肤隔室。本发明的真皮疫苗制剂包含抗原或免疫原性试剂和至少一种分子，例如化学试剂，其增强抗原或免疫原性试剂对皮内隔室或表皮的免疫细胞的呈递和/或可用性隔室导致增强的免疫应答。本发明的真皮疫苗制剂具有增强的功效，因为将抗原性或免疫原性药物递送至真皮内室或表皮隔室，其中存在于其中的免疫细胞具有增强的呈递和/或可用性。真皮疫苗制剂的增强功效在单次真皮内或表皮剂量后产生治疗有效的免疫应答，其具有比常规使用的更低剂量的抗原性或免疫原性剂量，并且不需要加强免疫。

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