专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100240653A1 BIPHENYL SULFONYL AND PHENYL-HETEROARYL SULFONYL MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 审中-公开
标题翻译：用于治疗相关疾病的组胺H3受体的联苯磺隆和苯并噻吩磺酸盐调节剂
公开(公告)号：US20100240653A1
公开(公告)日：2010-09-23
申请号：US12445795
申请日：2007-10-16
申请人： Vincent J. Santora , Ryan M. Hart , Jason B. Ibarra , Douglas M. Park , Albert S. Ren , Graeme Semple , Jeffrey A. Schultz , Brian M. Smith , Jeffrey Smith
发明人： Vincent J. Santora , Ryan M. Hart , Jason B. Ibarra , Douglas M. Park , Albert S. Ren , Graeme Semple , Jeffrey A. Schultz , Brian M. Smith , Jeffrey Smith
IPC分类号： A61K31/4025 , A61K31/5377 , A61K31/506 , A61K31/454 , A61K31/4439 , A61K31/40 , C07D413/12 , C07D403/10 , C07D401/12 , C07D401/10 , C07D409/10 , C07D207/06 , A61P25/28 , C07D405/10 , A61P25/00 , A61P25/24 , A61P3/04 , A61P25/18 , A61P37/08 , A61P11/00
CPC分类号： C07D207/06 , C07D401/12 , C07D403/10 , C07D405/12 , C07D409/10 , C07D417/10
摘要： The present invention relates to certain biphenyl sulfonamide derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the histamine H3-receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of histamine H3-associated disorders, such as, cognitive disorders, epilepsy, brain trauma, depression, obesity, disorders of sleep and wakefulness such as narcolepsy, shift-work syndrome, drowsiness as a side effect from a medication, maintenance of vigilance to aid in completion of tasks and the like, cataplexy, hypersomnia, somnolence syndrome, jet lag, sleep apnea and the like, attention deficit hyperactivity disorder (ADHD), schizophrenia, allergies, allergic responses in the upper airway, allergic rhinitis, nasal congestion, dementia, Alzheimer's disease and the like.
摘要翻译：本发明涉及式（Ia）的某些联苯磺酰胺衍生物及其药物组合物，其调节组胺H3受体的活性。本发明的化合物及其药物组合物涉及可用于治疗组胺H3相关疾病例如认知障碍，癫痫，脑外伤，抑郁症，肥胖症，睡眠障碍和觉醒症如发作性睡眠，工作综合征，作为药物副作用的睡意，维持警惕以完成任务等，猝倒，睡眠过多，嗜睡症，时差，睡眠呼吸暂停等，注意力缺陷多动障碍（ADHD），精神分裂症过敏，上呼吸道过敏反应，过敏性鼻炎，鼻塞，痴呆，阿尔茨海默氏病等。

2. 发明申请

US20080119477A1 N-Biaryl and N-Arylheteroaryl Piperazine Derivatives as Modulators of the 5Ht2c Receptor Useful For the Treatment of Disorders Related Thereto 审中-公开
标题翻译： N-二芳基和N-芳基杂芳基哌嗪衍生物作为用于治疗相关疾病的5Ht2c受体的调节剂
公开(公告)号：US20080119477A1
公开(公告)日：2008-05-22
申请号：US11792894
申请日：2005-12-09
申请人： Brian M. Smith , Vincent J. Santora , Rena Hayashi , Jason B. Ibarra , Jeffrey A. Schultz , Scott A. Estrada
发明人： Brian M. Smith , Vincent J. Santora , Rena Hayashi , Jason B. Ibarra , Jeffrey A. Schultz , Scott A. Estrada
IPC分类号： A61K31/496 , A61K31/495 , C07D409/02 , C07D403/02 , C07D405/02
CPC分类号： C07D295/073 , C07D213/38 , C07D295/096 , C07D307/52 , C07D333/20
摘要： The present invention relates to certain biarylz and arylheteroaryl piperazine derivatives of Formula (Ia) that are modulators of the 5HT2c receptor. Accordingly, compounds of the present invention are useful for the treatment of 5HT2c receptor associated diseases or disorders, such as, obesity, Alzheimer Disease, erectile dysfunction and related disorders.
摘要翻译：本发明涉及作为5HT 2C受体的调节剂的式（Ia）的某些双芳基和芳基杂芳基哌嗪衍生物。因此，本发明的化合物可用于治疗5HT 2C受体相关疾病或病症，例如肥胖症，阿尔茨海默病，勃起功能障碍和相关疾病。

3. 发明申请

US20100331312A1 MODULATORS OF THE HISTAMINE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 审中-公开
标题翻译：用于治疗相关疾病的组胺H3受体的调节剂
公开(公告)号：US20100331312A1
公开(公告)日：2010-12-30
申请号：US12867570
申请日：2009-02-18
申请人： Vincent J. Santora , Brian J. Hofilena , Michelle Pulley , Graeme Semple , Yun Shan , Brian M. Smith
发明人： Vincent J. Santora , Brian J. Hofilena , Michelle Pulley , Graeme Semple , Yun Shan , Brian M. Smith
IPC分类号： A61K31/55 , C07D401/10 , C07D403/10 , A61P25/08 , A61P25/24 , A61P3/04 , A61P25/18 , A61P25/28 , A61P11/02 , A61K31/506 , C07D401/14 , A61K31/4725
CPC分类号： C07D401/10 , C07D217/14 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/14
摘要： Amide derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the histamine H3 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of histamine H3-associated disorders, such as cognitive disorders, epilepsy, brain trauma, depression, obesity, disorders of sleep and wakefulness such as excessive daytime sleepiness, narcolepsy, shift-work sleep disorder, drowsiness as a side effect from a medication, maintenance of vigilance to aid in the completion of tasks and the like, cataplexy, hypersomnia, somnolence syndrome, jet lag, sleep apnea and the like, attention deficit hyperactivity disorder (ADHD), schizophrenia, allergies, allergic responses in the upper airway, allergic rhinitis, nasal congestion, dementia, Alzheimer's disease, pain and the like.
摘要翻译：式（Ia）的酰胺衍生物及其药物组合物，其调节组胺H3受体的活性。本发明化合物及其药物组合物涉及可用于治疗组胺H3相关疾病如认知障碍，癫痫，脑外伤，抑郁症，肥胖症，睡眠障碍和觉醒症如白天过度嗜睡，发作性睡病的方法，换班工作睡眠障碍，作为药物副作用的嗜睡，维持警惕以帮助完成任务等，猝倒，睡眠过多，嗜睡综合征，时差，睡眠呼吸暂停等，注意力缺陷多动障碍（ADHD），精神分裂症，过敏，上呼吸道过敏反应，过敏性鼻炎，鼻塞，痴呆，阿尔茨海默病，疼痛等。

4. 发明申请

US20130217700A1 PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 审中-公开
标题翻译：作为用于治疗与相关疾病相关的疾病的5-HT2A丝氨酸受体的调节剂的吡唑衍生物
公开(公告)号：US20130217700A1
公开(公告)日：2013-08-22
申请号：US13614537
申请日：2012-09-13
申请人： Yifeng Xiong , Martin C. Cherrier , Jin Sun Karoline Choi , Peter I. Dosa , Brian M. Smith , Sonja Strah-Pleynet , Brett Ullman , Bradley Teegarden
发明人： Yifeng Xiong , Martin C. Cherrier , Jin Sun Karoline Choi , Peter I. Dosa , Brian M. Smith , Sonja Strah-Pleynet , Brett Ullman , Bradley Teegarden
IPC分类号： C07D231/14 , C07D403/06 , C07D405/04 , C07D403/12
CPC分类号： C07D231/16 , C07D231/14 , C07D231/54 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/04
摘要： Pyrazole derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the serotonin 5HT2A receptor. Formula (Ia). Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of insomnia and related sleep disorders, platelet aggregation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, reducing the risk of blood clot formation, asthma or symptoms thereof, agitation or symptoms thereof, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de la Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic disorders, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizophrenia and related disorders, diabetic-related disorders, progressive multifocal leukoencephalopathy and the like. The present invention also relates to the methods for the treatment of 5-IIT2A serotonin receptor mediated disorders in combination with other pharmaceutical agents administered separately or together.
摘要翻译：式（Ia）的吡唑衍生物及其药物组合物，其调节5-羟色胺5HT2A受体的活性。式（Ia）。化合物及其药物组合物涉及可用于治疗失眠和相关睡眠障碍，血小板聚集，冠状动脉疾病，心肌梗死，短暂性脑缺血发作，心绞痛，中风，心房颤动，降低血块形成风险，哮喘的方法精神病，精神病，急性精神分裂症，慢性精神分裂症，精神分裂症，精神分裂症，精神分裂症及相关疾病，以及其他症状，症状或症状，激动或其症状，行为障碍，药物诱发的精神病，兴奋性精神病，糖尿病相关疾病，进行性多灶性脑白质病等。本发明还涉及与单独或一起施用的其它药剂组合治疗5-IIT2A 5-羟色胺受体介导的病症的方法。

5. 发明授权

US5427740A Tin oxide gas sensors 失效
标题翻译：氧化锡气体传感器
公开(公告)号：US5427740A
公开(公告)日：1995-06-27
申请号：US129085
申请日：1993-10-07
申请人： Gary S. V. Coles , Geraint Williams , Brian M. Smith
发明人： Gary S. V. Coles , Geraint Williams , Brian M. Smith
IPC分类号： G01N27/12 , G01N33/00
CPC分类号： G01N27/125 , G01N27/123 , Y10T436/20 , Y10T436/209163 , Y10T436/22
摘要： Tin oxide sensors are made by mixing antimony bearing material with tin oxide powder and formation of the sensor by deposition of a slurry of the mixture onto a substrate and drying and sintering the slurry, the antimony bearing material being present in an amount sufficient to render the sensitivity of the sensor to one or more of the gases H.sub.2, CO, or CH.sub.4 , relatively independent of the concentration of oxygen in the range P.sub.O2 10.sup.-1 -1 atm. A further type of a tin oxide gas sensor is disclosed having a resistivity that at a measuring temperature increases with concentration of at least one gas to be measured, the sensor is made by calcining the tin oxide in air at a temperature in excess of 1400.degree. C., or otherwise treating the tin oxide so that it has a state of physical aggregation consistent with being formed in such manner. At a second measuring temperature the resistivity of the sensor to said one gas decreases with increasing gas concentration. The resistivity of the sensor is dependent on the concentration of several gases, the dependence at differing measuring temperatures being such that by measuring the resistivity of the sensor at several different measuring temperatures the composition of a gas to which the sensor is exposed may be calculated. An array of such tin oxide gas sensors may be mounted on a single substrate having heater means to maintain the sensors at differing temperatures. Such an array may also include an antimony bearing sensor as disclosed or other tin oxide sensors.
摘要翻译： PCT No.PCT / GB92 / 00604 Sec。 371日期：1993年10月7日 102（e）日期1993年10月7日PCT提交1992年4月3日PCT公布。第WO92 / 17773号公报日期：1992年10月15日。氧化物传感器通过将锑轴承材料与氧化锡粉末混合并通过将混合物的浆料沉积到基底上并形成干燥和烧结浆料而制成，所述锑轴承材料存在其量足以使传感器对一种或多种气体H2，CO或CH4的灵敏度相对独立于PO2 10-1-1大气压范围内的氧浓度。公开了另一种类型的氧化锡气体传感器，其具有在测量温度下随着至少一种待测气体的浓度而增加的电阻率，该传感器是通过在超过1400℃的温度下在空气中煅烧氧化锡制成的。 C.或以其他方式处理氧化锡，使得其具有与以这种方式形成的物理聚集状态。在第二测量温度下，传感器对所述一种气体的电阻率随着气体浓度的增加而降低。传感器的电阻率取决于几种气体的浓度，在不同测量温度下的依赖性使得通过在几个不同的测量温度下测量传感器的电阻率，可以计算传感器暴露于其中的气体的组成。这种氧化锡气体传感器的阵列可以安装在具有加热器装置的单个基板上，以将传感器保持在不同的温度。这样的阵列还可以包括所公开的锑承载传感器或其它氧化锡传感器。

6. 发明授权

US08153621B2 5ht2C receptor modulator compositions 有权
标题翻译： 5ht2C受体调节剂组合物
公开(公告)号：US08153621B2
公开(公告)日：2012-04-10
申请号：US11793941
申请日：2005-12-21
申请人： Dominic P. Behan , Brian M. Smith , Christina Bjenning
发明人： Dominic P. Behan , Brian M. Smith , Christina Bjenning
IPC分类号： A61K31/55
CPC分类号： A61K31/55 , A61K31/135 , A61K31/137
摘要： The present invention relates to a composition comprising phentermine and a selective 5HT-2C receptor agonist. In addition, the invention relates to a composition comprising phentermine and a selective 5HT-2C receptor agonist having Formula (I): or a pharmaceutically acceptable salt, solvate or hydrate thereof. These compositions are useful in pharmaceutical compositions whose use includes the treatment of obesity.
摘要翻译：本发明涉及包含苯丁胺和选择性5HT-2C受体激动剂的组合物。此外，本发明涉及包含苯丁胺和具有式（I）的选择性5HT-2C受体激动剂或其药学上可接受的盐，溶剂合物或水合物的组合物。这些组合物可用于其用途包括治疗肥胖症的药物组合物中。

7. 发明申请

US20090197868A1 5ht2c receptor modulator compositions and methods of use 有权
标题翻译： 5ht2c受体调节剂组合物和使用方法
公开(公告)号：US20090197868A1
公开(公告)日：2009-08-06
申请号：US11793941
申请日：2005-12-21
申请人： Dominic P. Behan , Brian M. Smith , Christina Bjenning
发明人： Dominic P. Behan , Brian M. Smith , Christina Bjenning
IPC分类号： A61K31/55 , A61K31/137 , A61K31/495
CPC分类号： A61K31/55 , A61K31/135 , A61K31/137
摘要： The present invention relates to a composition comprising phentermine and a selective 5HT-2C receptor agonist. In addition, the invention relates to a composition comprising phentermine and a selective 5HT-2C receptor agonist having Formula (I): or a pharmaceutically acceptable salt, solvate or hydrate thereof. These compositions are useful in pharmaceutical compositions whose use includes the treatment of obesity.
摘要翻译：本发明涉及包含苯丁胺和选择性5HT-2C受体激动剂的组合物。此外，本发明涉及包含苯丁胺和具有式（I）的选择性5HT-2C受体激动剂或其药学上可接受的盐，溶剂合物或水合物的组合物。这些组合物可用于其用途包括治疗肥胖症的药物组合物中。

8. 发明授权

US09434692B2 Pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto 有权
标题翻译：吡唑衍生物作为可用于治疗与其相关的疾病的5-HT2A 5-羟色胺受体的调节剂
公开(公告)号：US09434692B2
公开(公告)日：2016-09-06
申请号：US12444098
申请日：2007-10-02
申请人： Yifeng Xiong , Martin C. Cherrier , Jin Sun Karoline Choi , Peter I. Dosa , Brian M. Smith , Sonja Strah-Pleynet , Brett Ullman , Bradley Teegarden
发明人： Yifeng Xiong , Martin C. Cherrier , Jin Sun Karoline Choi , Peter I. Dosa , Brian M. Smith , Sonja Strah-Pleynet , Brett Ullman , Bradley Teegarden
IPC分类号： C07D231/14 , C07D403/06 , C07D403/12 , C07D405/04 , C07D231/16 , C07D231/54 , C07D403/14
CPC分类号： C07D231/16 , C07D231/14 , C07D231/54 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/04
摘要： Pyrazole derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the serotonin 5HT2A receptor. Formula (Ia). Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of insomnia and related sleep disorders, platelet aggregation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, reducing the risk of blood clot formation, asthma or symptoms thereof, agitation or symptoms thereof, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de Ia Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic disorders, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizophrenia and related disorders, diabetic-related disorders, progressive multifocal leukoencephalopathy and the like. The present invention also relates to the methods for the treatment of 5-HT2A serotonin receptor mediated disorders in combination with other pharmaceutical agents administered separately or together.

9. 发明申请

US20150087634A1 5HT2C RECEPTOR MODULATOR COMPOSITIONS 审中-公开
标题翻译： 5HT2C受体调节剂组合物
公开(公告)号：US20150087634A1
公开(公告)日：2015-03-26
申请号：US14259748
申请日：2014-04-23
申请人： Dominic P. Behan , Brian M. Smith , Christina Bjenning
发明人： Dominic P. Behan , Brian M. Smith , Christina Bjenning
IPC分类号： A61K31/55 , A61K31/137
CPC分类号： A61K31/55 , A61K31/135 , A61K31/137
摘要： The present invention relates to a composition comprising phentermine and a selective 5HT-2C receptor agonist. In addition, the invention relates to a composition comprising phentermine and a selective 5HT-2C receptor agonist having Formula (I): or a pharmaceutically acceptable salt, solvate or hydrate thereof. These compositions are useful in pharmaceutical compositions whose use includes the treatment of obesity.
摘要翻译：本发明涉及包含苯丁胺和选择性5HT-2C受体激动剂的组合物。此外，本发明涉及包含苯丁胺和具有式（I）的选择性5HT-2C受体激动剂或其药学上可接受的盐，溶剂合物或水合物的组合物。这些组合物可用于其用途包括治疗肥胖症的药物组合物中。

10. 发明授权

US4620761A High density chip socket 失效
标题翻译：高密度芯片插座
公开(公告)号：US4620761A
公开(公告)日：1986-11-04
申请号：US696663
申请日：1985-01-30
申请人： Brian M. Smith , Emanuel D. Torti
发明人： Brian M. Smith , Emanuel D. Torti
IPC分类号： H01R12/51 , H05K7/10 , H01R9/09
CPC分类号： H05K7/1069 , H01L2924/00013
摘要： An interconnection system for high density I/O sites on an I.C. Interconnection substrate allowing field replacement thereof has a socket body with an array of contact springs adapted to be removably biased into engagement with conductive pads on the bottom surface of the substrate. The contact springs have a tail portion depending from the socket body which are affixed to a printed board. The substrate is locked into place on the socket body by removable latches.
摘要翻译：用于ITS上高密度I / O站点的互连系统允许其进行现场更换的互连基板具有插座主体，其具有接触弹簧阵列，其适于可拆卸地偏置成与基板的底表面上的导电焊盘接合。接触弹簧具有从插座主体垂下的尾部，该尾部固定在印刷电路板上。基板通过可拆卸的锁扣锁定在插座主体上的适当位置。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式