专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20090305963A1 Lipocalin 2 for the Treatment, Prevention, and Management of Cancer Metastasis, Angiogenesis, and Fibrosis 审中-公开
标题翻译： Lipocalin 2用于治疗，预防和控制癌症转移，血管生成和纤维化
公开(公告)号：US20090305963A1
公开(公告)日：2009-12-10
申请号：US11795392
申请日：2006-01-19
申请人： Vikas P. Sukhatme , S. Ananth Karumanchi , Pankaj Seth , Junichi Hanai , Tadanori Mammoto , Jonathan Barasch , Kiyoshi Mori
发明人： Vikas P. Sukhatme , S. Ananth Karumanchi , Pankaj Seth , Junichi Hanai , Tadanori Mammoto , Jonathan Barasch , Kiyoshi Mori
IPC分类号： A61K38/17 , A61P35/00 , C12Q1/68 , G01N33/574 , A61P7/04
CPC分类号： A61K38/1703 , A61K38/164 , A61K2300/00
摘要： The invention features methods and compositions for treating and preventing cancer metastasis, angiogenic disorders, and fibrotic disorders using lipocalin 2 compounds.
摘要翻译：本发明的特征在于使用脂质运载蛋白2化合物治疗和预防癌症转移，血管生成障碍和纤维化病症的方法和组合物。

2. 发明申请

US20090117588A1 Methods of diagnosing pre-eclampsia or eclampsia 有权
标题翻译：诊断先兆子痫或子痫的方法
公开(公告)号：US20090117588A1
公开(公告)日：2009-05-07
申请号：US12220245
申请日：2008-07-23
申请人： S. Ananth Karumanchi , Vikas P. Sukhatme
发明人： S. Ananth Karumanchi , Vikas P. Sukhatme
IPC分类号： G01N33/53
CPC分类号： G01N33/689 , A61K31/522 , A61K2039/505 , C07K16/1217 , C07K16/2863 , C12Q1/485 , G01N33/6893 , G01N33/74 , G01N2500/00 , G01N2800/368
摘要： Disclosed herein are kits for diagnosing pre-eclampsia and eclampsia or a propensity to develop pre-eclampsia or eclampsia that include agents for the detection of levels of free placental growth factor in a subject.
摘要翻译：本文公开了用于诊断先兆子痫和子痫或倾向于发展先兆子痫或子痫的试剂盒，其包括用于检测受试者中游离胎盘生长因子水平的试剂。

3. 发明申请

US20090004669A1 Methods of diagnosing pre-eclampsia or eclampsia 有权
标题翻译：诊断先兆子痫或子痫的方法
公开(公告)号：US20090004669A1
公开(公告)日：2009-01-01
申请号：US12221623
申请日：2008-08-04
申请人： S. Ananth Karumanchi , Sharon Maynard , Vikas P. Sukhatme
发明人： S. Ananth Karumanchi , Sharon Maynard , Vikas P. Sukhatme
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/542
CPC分类号： C07K16/1217 , A61K31/522 , A61K38/1866 , A61K38/1891 , A61K2039/505 , C07K16/2863 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12Q1/485 , G01N33/6893 , G01N33/74 , G01N2500/00 , G01N2800/368
摘要： Disclosed herein are methods for diagnosing pre-eclampsia and eclampsia. Also disclosed herein are methods for treating pre-eclampsia and eclampsia using compounds that increase VEGF or PlGF levels or compounds that decrease sFlt-1 levels. Compounds that inhibit the binding of VEGF or PlGF to sFlt1- are also disclosed herein for the treatment of pre-eclampsia or eclampsia.
摘要翻译：本文公开了诊断先兆子痫和子痫的方法。本文还公开了使用增加VEGF或PlGF水平的化合物或降低sFlt-1水平的化合物治疗先兆子痫和子痫的方法。本文还公开了抑制VEGF或PlGF与sFlt1结合的化合物用于治疗先兆子痫或子痫。

4. 发明授权

US09518992B2 Kits for the diagnosis of pre-eclampsia or eclampsia 有权
标题翻译：用于诊断先兆子痫或子痫的试剂盒
公开(公告)号：US09518992B2
公开(公告)日：2016-12-13
申请号：US12220245
申请日：2008-07-23
申请人： S. Ananth Karumanchi , Vikas P. Sukhatme
发明人： S. Ananth Karumanchi , Vikas P. Sukhatme
IPC分类号： G01N33/68 , G01N33/74 , C07K16/28 , C12Q1/48 , A61K31/522 , C07K16/12 , A61K39/00
CPC分类号： G01N33/689 , A61K31/522 , A61K2039/505 , C07K16/1217 , C07K16/2863 , C12Q1/485 , G01N33/6893 , G01N33/74 , G01N2500/00 , G01N2800/368
摘要： Disclosed herein are kits for diagnosing pre-eclampsia and eclampsia or a propensity to develop pre-eclampsia or eclampsia that include agents for the detection of levels of free placental growth factor in a subject.
摘要翻译：本文公开了用于诊断先兆子痫和子痫或倾向于发展先兆子痫或子痫的试剂盒，其包括用于检测受试者中游离胎盘生长因子水平的试剂。

5. 发明授权

US07947449B2 Methods of diagnosing pre-eclampsia or eclampsia 有权
标题翻译：诊断先兆子痫或子痫的方法
公开(公告)号：US07947449B2
公开(公告)日：2011-05-24
申请号：US12221623
申请日：2008-08-04
申请人： S. Ananth Karumanchi , Sharon Maynard , Vikas P. Sukhatme
发明人： S. Ananth Karumanchi , Sharon Maynard , Vikas P. Sukhatme
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/542
CPC分类号： C07K16/1217 , A61K31/522 , A61K38/1866 , A61K38/1891 , A61K2039/505 , C07K16/2863 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12Q1/485 , G01N33/6893 , G01N33/74 , G01N2500/00 , G01N2800/368
摘要： Disclosed herein are methods for diagnosing pre-eclampsia and eclampsia. Also disclosed herein are methods for treating pre-eclampsia and eclampsia using compounds that increase VEGF or PlGF levels or compounds that decrease sFlt-1 levels. Compounds that inhibit the binding of VEGF or PlGF to sFlt1- are also disclosed herein for the treatment of pre-eclampsia or eclampsia.
摘要翻译：本文公开了诊断先兆子痫和子痫的方法。本文还公开了使用增加VEGF或PlGF水平的化合物或降低sFlt-1水平的化合物治疗先兆子痫和子痫的方法。本文还公开了抑制VEGF或PlGF与sFlt1结合的化合物用于治疗先兆子痫或子痫。

6. 发明授权

US07740849B2 Use of compounds that bind soluble endoglin and SFLT-1 for the treatment of pregnancy related hypertensive disorders 有权
标题翻译：使用结合可溶内皮糖蛋白和SFLT-1的化合物治疗妊娠相关的高血压疾病
公开(公告)号：US07740849B2
公开(公告)日：2010-06-22
申请号：US11443920
申请日：2006-05-31
申请人： S. Ananth Karumanchi , Vikas P. Sukhatme , Mourad Toporsian , Michelle V. Letarte
发明人： S. Ananth Karumanchi , Vikas P. Sukhatme , Mourad Toporsian , Michelle V. Letarte
IPC分类号： A61K39/395
CPC分类号： A61K31/4439 , A61K31/455 , A61K31/513 , A61K31/522 , A61K38/13 , A61K38/1841 , A61K38/1866 , A61K38/1875 , A61K38/22 , G01N2800/368 , A61K2300/00
摘要： Disclosed herein are methods for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using combinations of compounds that alter soluble endoglin and sFlt-1 expression levels or biological activity. Also disclosed are methods for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using compounds that increase endothelial nitric oxide synthase levels or biological activity.
摘要翻译：本文公开了使用改变可溶内皮糖蛋白和sFlt-1表达水平或生物活性的化合物的组合来治疗怀孕相关的高血压病症（例如先兆子痫和子痫）的方法。还公开了使用增加内皮一氧化氮合酶水平或生物活性的化合物治疗怀孕相关的高血压病症如先兆子痫和子痫的方法。

7. 发明授权

US07955805B2 Nucleic acids and polypeptides useful for diagnosing complications of pregnancy 有权
标题翻译：用于诊断怀孕并发症的核酸和多肽
公开(公告)号：US07955805B2
公开(公告)日：2011-06-07
申请号：US11300928
申请日：2005-12-15
申请人： S. Ananth Karumanchi , Vikas P. Sukhatme
发明人： S. Ananth Karumanchi , Vikas P. Sukhatme
IPC分类号： G01N33/53
CPC分类号： G01N33/689 , C12Q1/6883 , C12Q2600/158 , G01N33/6893 , G01N2800/321 , G01N2800/368
摘要： Disclosed herein are methods for diagnosing or treating pregnancy related hypertensive disorders that include the use of a polypeptide or a nucleic acid encoding a polypeptide selected from the following: follistatin related protein, interleukin 8, inhibin A, VEGF-C, angiogenin, beta fertilin, hypothetical protein, leukocyte associated Ig-like receptor secreted protein, erythroid differentiation protein, adipogenesis inhibitory factor, corticotropin releasing factor binding protein, alpha-1 anti-chymotrypsin, insulin-like growth factor binding protein-5, CD33L, cytokine receptor like factor 1, platelet derived endothelial growth factor, lysyl hydroxylase isoform 2, stanniocalcin precursor, secreted frizzled related protein, galectin-3, alpha defensin, ADAM-TS3, cholecystokinin precursor, interferon stimulated T-cell alpha chemoattractant precursor, azurocidin, sperminine oxidase, UDP glycosyltransferase 2 family polypeptide B28, neurotrophic tyrosine kinase receptor 2, neutral endopeptidase, CDC28 protein kinase regulatory subunit 2, beta glucosidase, lanosterol synthase, calcium/calmodulin-dependent serine protein kinase, estrogen receptor-alternatively spliced transcript H, chemokine (CX3C motif) receptor 1, tyrosinase-related protein 1, hydoxy-delta-5-steroid dehyrogenase, dihydropyramidinase-like-4, and cytochrome P450-family 11.
摘要翻译：本文公开了用于诊断或治疗怀孕相关性高血压病症的方法，其包括使用多肽或编码选自以下的多肽的核酸：卵泡抑素相关蛋白，白细胞介素8，抑制素A，VEGF-C，血管生成素，假性蛋白，白细胞相关的Ig样受体分泌蛋白，红细胞分化蛋白，脂肪形成抑制因子，促肾上腺皮质激素释放因子结合蛋白，α-1抗糜蛋白酶，胰岛素样生长因子结合蛋白-5，CD33L，细胞因子受体样因子1 ，血小板衍生的内皮生长因子，赖氨酰羟化酶同种型2，斯诺钙钙前体，分泌性卷曲相关蛋白，半乳凝素-3，α-防御素，ADAM-TS3，缩胆囊素前体，干扰素刺激的T细胞α化学引诱物前体，azurocidin，精氨酸氧化酶，UDP糖基转移酶 2家族多肽B28，神经营养性酪氨酸激酶受体2，中性endopept 雌激素受体 - 可变剪接的转录物H，趋化因子（CX3C基序）受体1，酪氨酸酶相关蛋白1，羟基-δ-蛋白激酶调控亚单位2，β-葡糖苷酶，羊毛甾醇合酶，钙/钙调蛋白依赖性丝氨酸蛋白激酶， 5-类固醇脱氢酶，二氢吡喃脒酶-4和细胞色素P450-家族11。

8. 发明申请

US20110014197A1 METHODS OF TREATING PRE-ECLAMPSIA OR ECLAMPSIA 审中-公开
标题翻译：治疗前列腺炎或ECLAMPSIA的方法
公开(公告)号：US20110014197A1
公开(公告)日：2011-01-20
申请号：US12892652
申请日：2010-09-28
申请人： S. Ananth Karumanchi , Sharon Maynard , Vikas P. Sukhatme
发明人： S. Ananth Karumanchi , Sharon Maynard , Vikas P. Sukhatme
IPC分类号： A61K39/395 , A61K38/18 , A61K33/20 , G01N33/573 , G01N33/68 , A61P15/00
CPC分类号： A61K39/3955 , A61K31/522 , A61K38/1866 , A61K38/1891 , A61K45/06 , A61K2039/505 , C07K16/1217 , C07K16/18 , C07K16/2863 , C07K16/40 , C07K2317/76 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12Q1/485 , G01N33/689 , G01N33/6893 , G01N33/74 , G01N2500/00 , G01N2800/368
摘要： Disclosed herein are methods for treating pre-eclampsia and eclampsia using compounds that increase VEGF or PlGF levels or compounds that decrease sFlt-1 levels. Compounds that inhibit the binding of VEGF or PlGF to sFlt1—are also disclosed herein for the treatment of pre-eclampsia or eclampsia.
摘要翻译：本文公开了使用增加VEGF或PlGF水平的化合物或降低sFlt-1水平的化合物治疗先兆子痫和子痫的方法。抑制VEGF或PlGF与sFlt1结合的化合物也在本文中公开用于治疗先兆子痫或子痫。

9. 发明申请

US20090170767A1 Soluble Endoglin Compounds for the Treatment and Prevention of Cancer 审中-公开
标题翻译：可溶内皮糖蛋白化合物治疗和预防癌症
公开(公告)号：US20090170767A1
公开(公告)日：2009-07-02
申请号：US12227546
申请日：2007-05-31
申请人： S. Ananth Karumanchi , Vikas P. Sukhatme
发明人： S. Ananth Karumanchi , Vikas P. Sukhatme
IPC分类号： A61K38/16 , C12N5/06 , C07H21/04
CPC分类号： A61K31/439 , A61K31/455 , A61K31/513 , A61K31/522 , A61K38/179 , A61K45/06 , C07K14/70596 , A61K2300/00
摘要： Disclosed herein are soluble endoglin compounds and kits, pharmaceutical compositions, and articles of manufacture containing soluble endoglin compounds. Also disclosed herein are methods for treating an angiogenesis disorder, such as cancer, using soluble endoglin compounds, provided alone or in combination with a chemotherapeutic agent, an angiogenesis inhibitor, or an antiproliferative compound.
摘要翻译：本文公开了可溶内皮糖蛋白化合物和试剂盒，药物组合物和含有可溶内皮糖蛋白化合物的制品。本文还公开了使用可单独或与化疗剂，血管发生抑制剂或抗增殖化合物组合提供的可溶内皮糖蛋白化合物治疗血管生成障碍（例如癌症）的方法。

10. 发明授权

US07407659B2 Methods of diagnosing pre-eclampsia or eclampsia 有权
标题翻译：诊断先兆子痫或子痫的方法
公开(公告)号：US07407659B2
公开(公告)日：2008-08-05
申请号：US10624809
申请日：2003-07-21
申请人： S. Ananth Karumanchi , Sharon Maynard , Vikas P. Sukhatme
发明人： S. Ananth Karumanchi , Sharon Maynard , Vikas P. Sukhatme
IPC分类号： A61K38/00 , A61K39/00 , G01N33/53 , C07K17/00
CPC分类号： C07K16/1217 , A61K31/522 , A61K38/1866 , A61K38/1891 , A61K2039/505 , C07K16/2863 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12Q1/485 , G01N33/6893 , G01N33/74 , G01N2500/00 , G01N2800/368
摘要： Disclosed herein are methods for diagnosing pre-eclampsia and eclampsia. Also disclosed herein are methods for treating pre-eclampsia and eclampsia using compounds that increase VEGF or PlGF levels or compounds that decrease sFlt-1 levels. Compounds that inhibit the binding of VEGF or PlGF to sFlt1—are also disclosed herein for the treatment of pre-eclampsia or eclampsia.
摘要翻译：本文公开了诊断先兆子痫和子痫的方法。本文还公开了使用增加VEGF或PlGF水平的化合物或降低sFlt-1水平的化合物治疗先兆子痫和子痫的方法。抑制VEGF或PlGF与sFlt1结合的化合物也在本文中公开用于治疗先兆子痫或子痫。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式