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1. 发明授权

US4944894A Ether free organometallic amide compositions 失效
标题翻译：醚游离有机金属酰胺组合物
公开(公告)号：US4944894A
公开(公告)日：1990-07-31
申请号：US160229
申请日：1988-02-25
申请人： Vijay C. Mehta , Terry L. Rathman , Ramiro Sanchez , Robert C. Morrison
发明人： Vijay C. Mehta , Terry L. Rathman , Ramiro Sanchez , Robert C. Morrison
IPC分类号： C07F3/00 , C07F3/02 , C07F7/10
CPC分类号： C07F7/10 , C07F3/003 , C07F3/02
摘要： An ether free magnesium bisorganoamide of the formulaMg[N(R.sup.1) (R.sup.2)].sub.2wherein R.sup.1 and R.sup.2 are independently selected from hydrogen and alkyl groups containing 2 to 20 carbon atoms with the proviso that at least one of R.sup.1 and R.sup.2 is other than hydrogen or R.sup.1 and R.sup.2 taken together form an alkylene chain of 4 to 20 carbon atoms and a method of manufacture. Also disclosed are lithium-magnesiumorganoamides and organosubstituted lithium-magnesiumorganoamide.
摘要翻译：式Mg [N（R 1）（R 2）] 2的无醚自由基二有机酰胺，其中R 1和R 2独立地选自氢和含有2至20个碳原子的烷基，条件是R 1和R 2中的至少一个是其它的氢或R 1和R 2一起形成4至20个碳原子的亚烷基链和制备方法。还公开了锂 - 镁有机酰胺和有机取代的锂 - 镁有机酰胺。

2. 发明授权

US5002689A Preparation of organometallic amide compositions 失效
标题翻译：有机金属酰胺组合物的制备
公开(公告)号：US5002689A
公开(公告)日：1991-03-26
申请号：US160371
申请日：1988-02-25
申请人： Vijay C. Mehta , Terry L. Rathman , Conrad W. Kamienski , Robert C. Morrison , Randy W. Hall
发明人： Vijay C. Mehta , Terry L. Rathman , Conrad W. Kamienski , Robert C. Morrison , Randy W. Hall
IPC分类号： C07F1/08 , C07F1/00 , C07F3/00 , C07F3/02 , C07F3/04 , C07F3/06 , C07F7/10 , C07F9/28 , C07F9/72 , C07F9/74 , C07F19/00
CPC分类号： C07F3/003 , C07F1/005 , C07F7/10
摘要： This invention concerns organometallic amide compositions particularly bimetallic organoamides in liquid hydrocarbon solutions in which one metal is an alkali metal the other an alkaline earth metal, zinc or copper and particularly lithium magnesium bis-diorganoamides, such as lithium magnesium bis-diisopropylamide and processes for preparation of such amides. These novel bimetallic amides have increased solubility in liquid hydrocarbon solvents and improved thermal and precipitation stability at temperatures of 0.degree. C. to 40.degree. C.
摘要翻译：本发明涉及有机金属酰胺组合物，特别是液态烃溶液中的双金属有机酰胺，其中一种金属是碱金属，另一种是碱土金属，锌或铜，特别是锂二异氰酸镁锂，双的这种酰胺。这些新型双金属酰胺在液体烃溶剂中具有增加的溶解度，并且在0℃至40℃的温度下改善了热和沉淀稳定性。

3. 发明授权

US5320774A Preparation of organometallic amide compositions 失效
标题翻译：有机金属酰胺组合物的制备
公开(公告)号：US5320774A
公开(公告)日：1994-06-14
申请号：US334667
申请日：1989-04-06
申请人： Vijay C. Mehta , Terry L. Rathman , Conrad W. Kamienski , Robert C. Morrison , Randy W. Hall
发明人： Vijay C. Mehta , Terry L. Rathman , Conrad W. Kamienski , Robert C. Morrison , Randy W. Hall
IPC分类号： C07F1/08 , C07F1/00 , C07F3/00 , C07F3/02 , C07F3/04 , C07F3/06 , C07F7/10 , C07F9/28 , C07F9/72 , C07F9/74 , C07F19/00 , C09K3/00
CPC分类号： C07F3/003 , C07F1/005 , C07F7/10
摘要： This invention concerns organometallic amide compositions particularly bimetallic organoamides in liquid hydrocarbon solutions in which one metal is an alkali metal the other an alkaline earth metal, zinc or copper and particularly lithium magnesium bis-diorganoamides, such as lithium magnesium bis-diisopropylamide and processes for preparation of such amides. These novel bimetallic amides have increased solubility in liquid hydrocarbon solvents and improved thermal and precipitation stability at temperatures of 0.degree. C. to 40.degree. C.
摘要翻译：本发明涉及有机金属酰胺组合物，特别是液态烃溶液中的双金属有机酰胺，其中一种金属是碱金属，另一种是碱土金属，锌或铜，特别是锂二异氰酸镁锂，双的这种酰胺。这些新型双金属酰胺在液体烃溶剂中具有增加的溶解度，并且在0℃至40℃的温度下改善了热和沉淀稳定性。

4. 发明授权

US6060617A Contaminant free organometallic amide compositions and processes for making same 失效
标题翻译：污染物游离有机金属酰胺组合物及其制备方法
公开(公告)号：US6060617A
公开(公告)日：2000-05-09
申请号：US670348
申请日：1996-06-25
申请人： Randy W. Hall , Bobby J. McElroy , James A. Schwindeman , Conrad W. Kamienski , Terry L. Rathman , Robert C. Morrison
发明人： Randy W. Hall , Bobby J. McElroy , James A. Schwindeman , Conrad W. Kamienski , Terry L. Rathman , Robert C. Morrison
IPC分类号： C07C211/65 , C07F7/10
CPC分类号： C07F7/10 , C07C211/65
摘要： Organometallic amide compositions and processes for preparing the same, for example, by: reacting an alkali metal, alkali metal hydride, or alkali metal amide with a substituted amine in the absence of an electron carrier; reacting an alkali metal with a substituted amine in the presence of an electron carrier in a hydrocarbon solvent; distilling a composition which includes an alkali metal amide and a reduced electron carrier to recover the alkali metal amide; reacting an alkali metal with a substituted amine in the presence of an alkyl halide; and reacting a substituted amine capable of reacting with an alkali metal to form a hydrocarbon insoluble alkali metal amide with an alkali metal in the presence of a substituted amine capable of reacting with an alkali metal to form a hydrocarbon soluble alkali metal amide.
摘要翻译：有机金属酰胺组合物及其制备方法，例如：在不存在电子载体的情况下使碱金属，碱金属氢化物或碱金属氨化物与取代的胺反应; 在电子载体存在下在烃溶剂中使碱金属与取代的胺反应; 蒸馏包含碱金属氨化物和还原电子载体以回收碱金属胺的组合物; 在烷基卤存在下使碱金属与取代的胺反应; 并使能够与碱金属反应的取代的胺与能够与碱金属反应形成烃溶性碱金属氨化物的取代胺存在下与碱金属形成不溶于烃的碱金属胺。

5. 发明授权

US5141667A Preparation of organometallic and organobimetallic compounds 失效
标题翻译：有机金属和有机金属化合物的制备
公开(公告)号：US5141667A
公开(公告)日：1992-08-25
申请号：US567577
申请日：1990-09-10
申请人： Robert C. Morrison , Terry L. Rathman
发明人： Robert C. Morrison , Terry L. Rathman
IPC分类号： C07F1/02 , C07F1/04 , C07F3/02
CPC分类号： C07F1/04 , C07F1/02 , C07F3/02
摘要： A process for producing organometallic compositions by reacting an organohalide with a mixture of two metals; one being an alkali metal, the other being selected from magnesium, calcium, barium and zinc in a hydrocarbon solvent containing 0.5 to 2.0 moles of a Lewis Base per mole of organohalide.
摘要翻译：一种通过使有机卤化物与两种金属的混合物反应制备有机金属组合物的方法; 一种是碱金属，另一种选自镁，钙，钡和锌，在每摩尔有机卤化物中含有0.5至2.0摩尔路易斯碱的烃溶剂中。

6. 发明授权

US4976886A Preparation of organometallic and organobimetallic compounds 失效
标题翻译：有机金属和有机金属化合物的制备
公开(公告)号：US4976886A
公开(公告)日：1990-12-11
申请号：US160388
申请日：1988-02-25
申请人： Robert C. Morrison , Terry L. Rathman
发明人： Robert C. Morrison , Terry L. Rathman
IPC分类号： C07F1/02 , C07F1/04 , C07F3/02 , C07F3/04 , C07F3/06 , C07F5/06
CPC分类号： C07F1/02 , C07F1/04 , C07F3/02
摘要： A process for producing organometallic compositions by reacting an organohalide with a mixture of two metals; one being an alkali metal, the other being selected from magnesium, calcium, barium and zinc in a hydrocarbon solvent containing 0.5 to 2.0 moles of a Lewis Base per mole of organohalide.

7. 发明授权

US4595779A Stable lithium diisopropylamide and method of preparation 失效
标题翻译：稳定的二异丙基氨基锂及其制备方法
公开(公告)号：US4595779A
公开(公告)日：1986-06-17
申请号：US685318
申请日：1984-12-24
申请人： Robert C. Morrison , Randy W. Hall , Terry L. Rathman
发明人： Robert C. Morrison , Randy W. Hall , Terry L. Rathman
IPC分类号： C07C209/90 , C07C67/00 , C07C209/00 , C07C211/65 , C07F1/02 , C07C85/26 , C07C87/123
CPC分类号： C07C209/90
摘要： The present invention provides a nonpyrophoric and thermally stable form of lithium diisopropylamide which is useful as a reagent in the preparation of pharmaceuticals and specialty chemicals. The preferred composition includes lithium diisopropylamide, a limited amount of tetrahydrofuran in an amount not exceeding one mole per mole of lithium diisopropylamide, and at least one C.sub.2 to C.sub.18 amine.
摘要翻译：本发明提供了非制备和热稳定形式的二异丙基氨基锂，其可用作制备药物和特种化学品的试剂。优选的组合物包括二异丙基氨基锂，有限量的四氢呋喃，其量不超过1摩尔/二异丙基氨基锂和至少一种C 2至C 18胺。

8. 发明授权

US5726308A High purity formulations of highly substituted lithium amide bases 失效
标题翻译：高度取代的氨基化锂碱基的高纯度配方
公开(公告)号：US5726308A
公开(公告)日：1998-03-10
申请号：US620587
申请日：1996-03-22
申请人： Randy W. Hall , Robert S. Wedinger , Terry L. Rathman , James A. Schwindeman
发明人： Randy W. Hall , Robert S. Wedinger , Terry L. Rathman , James A. Schwindeman
IPC分类号： C07F1/00 , C07F7/10 , C07F1/02
CPC分类号： C07F7/10 , C07F1/005
摘要： A process for preparing high purity solutions of highly substituted lithium amide bases by direct reaction of lithium metal with highly substituted amine bases alone or in an ether solvent, a hydrocarbon solvent or in a mixed ether/hydrocarbon solvent mixture, optionally in the presence of a catalyst selected from tin salts and transition metal salts of Groups 4B, 5B, 6B, 7B, and 8 of the Periodic Table.
摘要翻译：通过锂金属与高度取代的胺碱单独或在醚溶剂，烃溶剂或混合醚/烃溶剂混合物中直接反应制备高度取代的氨基化锂碱的高纯度溶液的方法，任选地在选自周期表第4B，5B，6B，7B和8族的锡盐和过渡金属盐的催化剂。

9. 发明授权

US4183931A 2-Ketoalkyl-4(3H)-quinazolinones 失效
标题翻译： 2-酮基烷基-4（3H） - 喹唑啉酮
公开(公告)号：US4183931A
公开(公告)日：1980-01-15
申请号：US831446
申请日：1977-09-08
申请人： James F. Wolfe , Terry L. Rathman
发明人： James F. Wolfe , Terry L. Rathman
IPC分类号： C07D239/90 , A61K31/505 , C07D239/91
CPC分类号： C07D239/90
摘要： 2-Ketoalkyl-4(3H)-quinazolinones of the formula ##STR1## wherein R.sub.1 is an aliphatic, cycloaliphatic or hydrocarbon aromatic group of 1-10 carbon atoms;A is divalent alkylene of 1 to 10 carbon atoms;R.sub.2 is an aliphatic, cycloaliphatic, hydrocarbon aromatic or heterocyclic group of 1-10 carbon atoms formed by condensing an acyl ester of the formula R.sub.2 COOR' which can be dissociated to form --COR.sub.2 and R'OH in which R' is the alcoholic portion of said ester; andR.sub.3 and R.sub.4 are each hydrogen, hydroxy, amino, halogen, trifluoromethyl, alkyl, alkoxy, alkylthio or alkylsulfonyl each of 1-4 carbon atoms, the substituents other than hydrogen when present being preferably in the 6- and/or 7-position of the quinazolinone nucleusprovide compounds having useful activity as CNS depressants and anticonvulsants. A process is provided for preparing such compounds by ester condensation of a corresponding 2-alkyl-3-substituted-4(3H) quinazolinone with a condensable ester and excess sodium hydride in the presence of a strong ionization solvent such as refluxing 1,2-dimethoxyethane.
摘要翻译：具有式“IMAGE”的2-酮基烷基-4（3H） - 喹唑啉酮，其中R 1是1-10个碳原子的脂族，脂环族或烃芳族基团; A是1至10个碳原子的二价亚烷基; R2是通过将可分解形成-COR 2和R'OH的式R 2 COOR'的酰基酯缩合形成的1-10个碳原子的脂族，脂环族烃芳族或杂环基团，其中R'是醇的部分所述酯; 并且R 3和R 4各自为1-4个碳原子的氢，羟基，氨基，卤素，三氟甲基，烷基，烷氧基，烷硫基或烷基磺酰基，当存在时除氢之外的取代基优选为6-和/或7-位喹唑啉酮核提供具有CNS抑制剂和抗惊厥药有用活性的化合物。提供了一种通过在强电离溶剂如1,2-二氯乙烷的回流溶剂存在下，通过相应的2-烷基-3-取代-4（3H）喹唑啉酮与可冷凝的酯和过量的氢化钠的酯缩合来制备此类化合物的方法，二甲氧基乙烷。

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