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1. 发明授权

US5252465A Avian erythroblastosis virus vectors for integration and expression of heterologous genes in avian cells 失效
标题翻译：禽类红细胞生成病毒载体用于在鸟类细胞中整合和表达异源基因
公开(公告)号：US5252465A
公开(公告)日：1993-10-12
申请号：US477833
申请日：1990-06-25
申请人： Victor-Marc Nigon , Gerard Verdier , Yahia Chebloune , Francois-Loic Cosset , Catherine Legras , Astrid Reyss-Brion , Mustapha Belakebi , Francois Mallet , Pierre Savatier , Pierrick Thoraval , Jacques Samarut , Didier Poncet , Claude Bagnis , Miloud Benchaibi
发明人： Victor-Marc Nigon , Gerard Verdier , Yahia Chebloune , Francois-Loic Cosset , Catherine Legras , Astrid Reyss-Brion , Mustapha Belakebi , Francois Mallet , Pierre Savatier , Pierrick Thoraval , Jacques Samarut , Didier Poncet , Claude Bagnis , Miloud Benchaibi
IPC分类号： C12N15/09 , C12N15/867 , C12P21/00 , C12R1/19 , C12N15/86 , C12N5/10 , C12N7/01
CPC分类号： C12N15/86 , C12N2740/11043
摘要： A viral vector for the integration and expression of at least one heterologous gene in fowl pest cells consists wholly or in part of the proviral genome of fowl pest erythroblastosis or of a related virus in which said heterologous gene(s) replace(s) the v-erbA gene and/or the v-erB gene. Said gene(s) is(are) controlled either by an LTR promoter of the same virus, in which case the heterologous gene(s); mimics(s) the gene(s) it(they) replace, or by a heterologous promoter, in which case the additional att sequence is situated upstream of said heterologous promoter.
摘要翻译： PCT No.PCT / FR88 / 00487 Sec。 371日期：1990年6月25日 102（e）1990年6月25日PCT PCT日期为1988年10月3日。用于在家禽有害细胞中整合和表达至少一个异源基因的病毒载体全部或部分地由家禽有害成虫的前病毒基因组或其中所述异源基因替换v-erbA基因和/或v-erB基因的相关病毒。所述基因由相同病毒的LTR启动子控制，在这种情况下，该异源基因; 模拟它们（或它们）取代的基因，或通过异源启动子，在这种情况下，额外的att序列位于所述异源启动子的上游。

2. 发明授权

US4957865A Cloning or expression vectors containing the avian erythroblastosis virus genome and cells transfected by these vectors 失效
标题翻译：含有禽类成红细胞病毒病毒基因组和由这些载体转染的细胞的克隆或表达载体
公开(公告)号：US4957865A
公开(公告)日：1990-09-18
申请号：US879103
申请日：1986-06-04
申请人： Jacques Samarut , Gerard Verdier , Miloud Benchaibi , Pierre Savatier , Didier Poncet , Frederic Flamant , Jiao-Hao Xiao , Pierrick Thoraval , Frederique Chambonnet , Victor Nigon
发明人： Jacques Samarut , Gerard Verdier , Miloud Benchaibi , Pierre Savatier , Didier Poncet , Frederic Flamant , Jiao-Hao Xiao , Pierrick Thoraval , Frederique Chambonnet , Victor Nigon
IPC分类号： C12N15/00 , C12N5/00 , C12N5/02 , C12N5/10 , C12N7/00 , C12N15/09 , C12N15/867 , C12P21/02 , C12R1/91
CPC分类号： C12N15/86 , C12N2740/15043
摘要： The invention relates to a virus for cloning or expression of a foreign gene, characterized in that it consists of all or part of the genome of avian erythroblastosis virus and contains at least one foreign gene situated between the 3 LTR sequences.
摘要翻译： PCT No.PCT / FR85 / 00293 Sec。 371日期1986年6月4日第 102（e）日期1986年6月4日PCT提交1985年10月15日PCT公布。公开号WO86 / 02380 日本1984年4月24日。本发明涉及用于克隆或表达外源基因的病毒，其特征在于，其由全部或部分的禽类成红细胞病毒基因组组成，并且含有位于3LTR之间的至少一个外源基因序列。

3. 发明授权

US08246621B2 Reamer guide for revision procedure 有权
标题翻译：铰刀指南修订程序
公开(公告)号：US08246621B2
公开(公告)日：2012-08-21
申请号：US12110919
申请日：2008-04-28
申请人： Didier Poncet
发明人： Didier Poncet
IPC分类号： A61B17/00
CPC分类号： A61B17/1684 , A61B17/1778
摘要： An instrument kit is provided for reaming bone around a head of a bone, the bone including an implanted epiphysis component. The instrument kit includes a reaming guide and a reamer. The reaming guide is couplable to the epiphysis component and has a first reamer support feature and a second reamer support feature. The reamer is couplable to one of the first reamer support feature and the second support feature to ream bone around the epiphysis component.
摘要翻译：提供了一种仪器套件，用于在骨头周围扩展骨骼，骨骼包括植入的骨ysis组件。仪器套件包括扩孔引导件和铰刀。扩孔引导件可连接到骨ysis部件，并具有第一铰刀支撑特征和第二铰刀支撑特征。铰刀可以连接到第一铰刀支撑特征之一和第二支撑特征，以在骨ysis构件周围引导骨骼。

4. 发明授权

US09622869B2 Modular humeral prosthesis for an inverted shoulder prosthesis 有权
公开(公告)号：US09622869B2
公开(公告)日：2017-04-18
申请号：US11577966
申请日：2005-10-25
申请人： Cecile Nerot , Didier Capon , Ludwig Seebauer , Anders Ekelund , Lieven De Wilde , Michael Wirth , David Collins , Laurent Lafosse , Didier Poncet
发明人： Cecile Nerot , Didier Capon , Ludwig Seebauer , Anders Ekelund , Lieven De Wilde , Michael Wirth , David Collins , Laurent Lafosse , Didier Poncet
IPC分类号： A61F2/40 , A61F2/30
CPC分类号： A61F2/4014 , A61F2/30767 , A61F2/40 , A61F2/4059 , A61F2002/30355 , A61F2002/30428 , A61F2002/30433 , A61F2002/3054 , A61F2002/30604 , A61F2002/30617 , A61F2002/30714 , A61F2002/30774 , A61F2002/30828 , A61F2002/30879 , A61F2002/4022 , A61F2002/4051 , A61F2002/4074 , A61F2250/0089 , A61F2250/0097
摘要： The invention relates to a modular humeral prosthesis for an inverse shoulder prosthesis, comprising an anatomical shaft (1) and a separable epiphyseal head (2) which may be angularly orientated by rotation about the longitudinal axis (XX) of the anatomical shaft. The anatomical shaft and the epiphyseal head comprise complementary angular indexing means (11, 28) for relative rotational fixation.

5. 发明申请

US20090270867A1 REAMER GUIDE FOR REVISION PROCEDURE 有权
标题翻译：修订程序指引
公开(公告)号：US20090270867A1
公开(公告)日：2009-10-29
申请号：US12110919
申请日：2008-04-28
申请人： Didier Poncet
发明人： Didier Poncet
IPC分类号： A61B17/00 , A61B17/56
CPC分类号： A61B17/1684 , A61B17/1778
摘要： An instrument kit is provided for reaming bone around a head of a bone, the bone including an implanted epiphysis component. The instrument kit includes a reaming guide and a reamer. The reaming guide is couplable to the epiphysis component and has a first reamer support feature and a second reamer support feature. The reamer is couplable to one of the first reamer support feature and the second support feature to ream bone around the epiphysis component.
摘要翻译：提供了一种仪器套件，用于在骨头周围扩展骨骼，骨骼包括植入的骨ysis组件。仪器套件包括扩孔引导件和铰刀。扩孔引导件可连接到骨ysis部件，并具有第一铰刀支撑特征和第二铰刀支撑特征。铰刀可以连接到第一铰刀支撑特征之一和第二支撑特征，以在骨ysis构件周围引导骨骼。

6. 发明申请

US20140188231A1 IMPLANT INSERTION TOOL FOR USE IN A SURGICAL PROCEDURE TO IMPLANT A STEMLESS HUMERAL COMPONENT 审中-公开
标题翻译：用于植入手术的植入式插入工具，用于植入一个不起眼的成年人
公开(公告)号：US20140188231A1
公开(公告)日：2014-07-03
申请号：US13803533
申请日：2013-03-14
申请人： Didier Poncet , David M. Warlop , Laurent Zanchin
发明人： Didier Poncet , David M. Warlop , Laurent Zanchin
IPC分类号： A61F2/46
CPC分类号： A61F2/4612 , A61B17/15 , A61B17/16 , A61B17/1604 , A61B17/1684 , A61B17/1739 , A61B17/1778 , A61B17/32053 , A61B17/842 , A61B90/06 , A61B90/50 , A61B2090/034 , A61B2090/3945 , A61F2/40 , A61F2/4003 , A61F2/4014 , A61F2/4637 , A61F2/4684 , A61F2002/30235 , A61F2002/30332 , A61F2002/30574 , A61F2002/30579 , A61F2002/30604 , A61F2002/30616 , A61F2002/30772 , A61F2002/30904 , A61F2002/4007 , A61F2002/4018 , A61F2002/4022 , A61F2002/4029 , A61F2002/4033 , A61F2002/4037 , A61F2002/4619 , A61F2002/4624 , A61F2002/4627 , A61F2002/4628 , A61F2002/4629 , A61F2002/4658 , A61F2002/4681
摘要： A stemless humeral component for replacing the humeral head of a patient's humerus includes a support flange having a number of cantilevered legs extending distally away from a bottom surface thereof. Instruments and methods for surgically installing the stemless humeral component are also disclosed.
摘要翻译：用于更换患者肱骨的肱骨头的无肱骨部件包括具有多个从其底表面向远侧延伸的悬臂的支撑凸缘。还公开了用于手术安装无茎肱骨组件的仪器和方法。

7. 发明申请

US20130004991A1 POSITIVE CYTOMODULINES TO IMPROVE BIOREACTOR PRODUCTIVITY 审中-公开
标题翻译：积极的细胞色素改善生物反应器生产力
公开(公告)号：US20130004991A1
公开(公告)日：2013-01-03
申请号：US12374618
申请日：2007-07-19
申请人： Bertrand Cosson , Vincent Legagneux , Luc Paillard , Howard Beverley Osborne , Didier Poncet , Cécile Keryer-Bibens
发明人： Bertrand Cosson , Vincent Legagneux , Luc Paillard , Howard Beverley Osborne , Didier Poncet , Cécile Keryer-Bibens
IPC分类号： C12P21/00 , C07K14/00 , C07K19/00 , C12N15/62
CPC分类号： C12N15/67 , C07K14/005 , C07K2319/03 , C07K2319/85 , C12N15/85 , C12N2720/12322 , C12N2840/105
摘要： The present invention relates to the activation of the protein synthesis by controlling the post-transcriptional steps of mRNA translation into proteins. A polypeptide is provided, which is capable of activating said protein translation. The principal industrial application of the invention is the control of recombinant protein production in cultured cells including in bioreactors.
摘要翻译：本发明涉及通过控制mRNA翻译成蛋白质的转录后步骤来激活蛋白质合成。提供能够激活所述蛋白质翻译的多肽。本发明的主要工业应用是控制包括生物反应器在内的培养细胞中重组蛋白的产生。

8. 发明授权

US08197487B2 Reaming guide alignment instrument 有权
标题翻译：铰孔导轨对准仪
公开(公告)号：US08197487B2
公开(公告)日：2012-06-12
申请号：US12110882
申请日：2008-04-28
申请人： Didier Poncet , Robin Maisonneuve
发明人： Didier Poncet , Robin Maisonneuve
IPC分类号： A61F5/00
CPC分类号： A61B17/164 , A61B17/1659 , A61B17/1684 , A61B17/1725 , A61B17/1778 , A61B2090/061
摘要： An alignment system for aligning a reaming guide during insertion into a cavity of a bone is provided. The bone has a resected surface and the cavity defines a cavity axis. The system includes a reaming guide that includes an elongate stem portion having a stem axis, a neck portion extending from the stem portion at an incline with respect to the stem axis, and an alignment instrument. The alignment instrument includes a handle defining a handle axis, the handle being releasably couplable to the reaming guide such that the handle axis is in a predetermined relationship with the stem axis. The alignment instrument further comprises a plane finder slidably coupled to the handle, the plane finder comprising a surface defined by a plane that intersects the axis of the handle at an angle having a predetermined relationship with the angle at which a resection surface of the bone intersects the cavity axis.
摘要翻译：提供了一种用于在插入到骨的腔中时将扩孔引导件对准的对准系统。骨头具有切除的表面，腔体限定腔体轴线。该系统包括扩孔引导件，其包括具有杆轴的细长杆部分，从杆部分相对于杆轴线倾斜延伸的颈部部分和对准仪器。对准仪器包括限定手柄轴线的手柄，手柄可释放地联接到扩孔引导件，使得手柄轴线与杆轴线成预定关系。对准仪器还包括可滑动地联接到手柄的平面取景器，平面取景器包括由与手柄的轴线相交的平面限定的表面，该角度与骨的切除面相交的角度具有预定的关系腔轴。

9. 发明申请

US20090270866A1 VARIABLE OFFSET REAMER ASSEMBLY FOR MODULAR HUMERAL COMPONENT 有权
标题翻译：用于模块化的HUMERAL COMPONENT的可变偏移组件
公开(公告)号：US20090270866A1
公开(公告)日：2009-10-29
申请号：US12110895
申请日：2008-04-28
申请人： Didier Poncet
发明人： Didier Poncet
IPC分类号： A61F5/00 , A61B17/00
CPC分类号： A61B17/1684 , A61B17/1717 , A61B17/1778
摘要： An instrument kit for reaming a cavity within a resected head of a bone is provided. The kit includes a reaming guide, at least two adaptor sleeves and a reamer. The reaming guide includes an elongate stem portion insertable into a cavity extending into the bone from a resection surface at the head of the bone and a neck portion. The at least two adapter sleeves are mountable upon the reaming guide. Each adapter sleeve has a longitudinal axis, being generally cylindrical and a bore configured to receive part of the neck portion of the reaming guide. When the adapter sleeve is mounted upon the neck portion of a reaming guide inserted into a cavity in a bone the reamer is arranged to ream a cavity into the resection surface of the bone around the neck portion.
摘要翻译：提供了一种用于在骨切割的头部内部扩孔的仪器套件。套件包括铰孔导轨，至少两个适配器套筒和铰刀。扩孔引导件包括细长的杆部分，其可从骨头头部的切除表面和颈部部分插入到延伸到骨中的腔中。至少两个适配器套筒可安装在扩孔引导件上。每个适配器套筒具有纵向轴线，其大致为圆柱形，并且构造成容纳扩孔导向件颈部的一部分的孔。当将适配器套筒安装在插入到骨头中的空腔中的扩孔引导件的颈部上时，铰刀布置成将空腔引导到围绕颈部的骨的切除表面中。

10. 发明授权

US09610165B2 Humeral component of a shoulder joint prosthesis 有权
公开(公告)号：US09610165B2
公开(公告)日：2017-04-04
申请号：US12088907
申请日：2006-10-02
申请人： Didier Poncet , Cecile Nerot , Didier Capon , Ludwig Seebauer , Anders Ekelund , Lieven De Wilde , Michael Wirth , David Collins , Laurent Lafosse
发明人： Didier Poncet , Cecile Nerot , Didier Capon , Ludwig Seebauer , Anders Ekelund , Lieven De Wilde , Michael Wirth , David Collins , Laurent Lafosse
IPC分类号： A61F2/40 , A61F2/30
CPC分类号： A61F2/4059 , A61F2/4014 , A61F2002/30253 , A61F2002/30331 , A61F2002/30487 , A61F2002/305 , A61F2002/30507 , A61F2002/30512 , A61F2002/30538 , A61F2002/3054 , A61F2002/30604 , A61F2002/30616 , A61F2002/30617 , A61F2002/3082 , A61F2002/30884 , A61F2002/4022 , A61F2002/4037 , A61F2002/4044 , A61F2002/4051 , A61F2220/0025 , A61F2220/0033 , A61F2230/0076 , A61F2250/0006 , A61F2250/0097 , A61F2310/00011
摘要： A humeral component of a reverse shoulder prosthesis includes a stem part configured for location within the intramedullary cavity of the humerus, the stem part having a stem axis, an epiphyseal part connected to the elongate stem part and having a concave bearing surface defining an epiphyseal axis, and wherein the epiphyseal axis is offset posteriorly relative to the stem axis.

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