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1. 发明授权

US6026323A Tissue diagnostic system 失效
标题翻译：组织诊断系统
公开(公告)号：US6026323A
公开(公告)日：2000-02-15
申请号：US934152
申请日：1997-09-23
申请人： Victor Skladnev , Richard Thompson , Irwin Wunderman , David Bull , Neil Edwards , Stephen Rowe , Gregory Smart , Megan Smith
发明人： Victor Skladnev , Richard Thompson , Irwin Wunderman , David Bull , Neil Edwards , Stephen Rowe , Gregory Smart , Megan Smith
IPC分类号： A61B5/00 , A61B5/05 , A61B5/053
CPC分类号： A61B5/0538 , A61B5/0084 , A61B5/05 , A61B5/053 , A61B5/4331 , A61B5/7264 , A61B2562/085 , A61B5/0088 , A61B5/441 , A61B5/7203
摘要： A probe type instrument to characterize tissue type that combines optical and electrical tests in a single device capable of providing data of both types almost simultaneously from very small, e.g. 3-10 mm diameter, areas of tissue surface. Key to this approach is an instrument capable of making almost simultaneous electrical and optical measurements on the same small areas of tissue, before being moved to scan adjacent tissue areas. In the preferred operation of the system fourteen measurement cycles are performed per second and each measurement involves a complex sequence of events, including (1) three optical and fifteen electrical tissue stimulations with subsequent detection, filtering and digitization of the tissue response; (2) extraction of specific parameters from the optical and electrical signals; (3) checking for errors, and subsequent classification of the extracted parameters into various tissue type categories; and (4) feedback to the system operator. Thus on the order of 15,000 measurements are made per one minute patient examination.
摘要翻译：用于表征组织类型的探针型仪器，其在单个装置中组合光学和电学测试，能够从非常小的例如几乎同时提供两种类型的数据。 3-10毫米直径，组织表面的区域。该方法的关键是能够在被移动到扫描相邻组织区域之前，在组织的相同小区域上进行几乎同时的电和光学测量的仪器。在系统的优选操作中，每秒执行十四个测量周期，每个测量涉及复杂的事件序列，包括（1）三个光学和十五个电组织刺激，随后检测，滤波和数字化组织响应; （2）从光电信号中提取具体参数; （3）检查错误，以及随后将提取的参数分类成各种组织类型类别; 和（4）反馈给系统操作员。因此，在每一分钟的病人检查中进行15,000次测量。

2. 发明授权

US5830146A Sheathed probes for tissue type recognition 失效
标题翻译：护套探针用于组织型识别
公开(公告)号：US5830146A
公开(公告)日：1998-11-03
申请号：US823660
申请日：1997-03-17
申请人： Victor N. Skladnev , Richard L. Thompson , Irwin Wunderman
发明人： Victor N. Skladnev , Richard L. Thompson , Irwin Wunderman
IPC分类号： A61B1/00 , A61B5/00
CPC分类号： A61B5/0084 , A61B5/4331
摘要： The invention incorporates electrodes in the tip of the sheath cover for a diagnostic probe that makes both electric and optical measurements of tissue contacted by the sheath. The electrodes are positioned relative to the optical window in such a way as to ensure that sealing is not compromised by the presence of the electrodes. The electrodes are close by to ensure that both the optical and electrical measurements are made on the same area of tissue. The invention uses the hoop tension in the sheath to apply the needed spring force to the electrode contact. In addition the invention provides a piece of turbid material such as a polymer of controlled composition as a built-in calibrator attached to the outside of the tip of the sheath.
摘要翻译：本发明在用于诊断探针的护套盖的尖端中结合电极，其使得由护套接触的组织进行电学和光学测量。电极相对于光学窗口定位，以确保密封不会被电极的存在所影响。电极靠近，以确保光学和电学测量都在相同的组织区域上进行。本发明使用护套中的环向张力将所需的弹簧力施加到电极接触件。此外，本发明提供了一片浑浊的材料，例如作为内置校准器的受控组合物的聚合物，其连接到护套的尖端的外部。

3. 发明授权

US6122042A Devices and methods for optically identifying characteristics of material objects 失效
标题翻译：用于光学识别材料物体特征的装置和方法
公开(公告)号：US6122042A
公开(公告)日：2000-09-19
申请号：US886561
申请日：1997-07-01
申请人： Irwin Wunderman , Adolph E. Smith , Vijay K. Lumba
发明人： Irwin Wunderman , Adolph E. Smith , Vijay K. Lumba
IPC分类号： A61B5/00 , A61B5/103 , G01N21/31 , G01N21/49 , G01N21/00
CPC分类号： G01N21/49 , A61B1/05 , A61B1/0607 , A61B1/0638 , A61B1/0684 , A61B5/0048 , A61B5/0059 , A61B5/0071 , A61B5/0075 , A61B5/411 , A61B5/415 , A61B5/418 , A61B5/444 , A61B5/445 , G01N21/3151 , A61B2562/0242 , A61B5/7267
摘要： An apparatus for photometric analysis and/or identification of properties of a material object comprises a collection of light sources having substantially distinct wavelength envelopes and activated in a rapid sequence of distinct combinations. The apparatus comprises a collection of spatially distributed light detectors which detect radiation from the object and produce detected signals. A signal processor for controlling the light sources and analyzing the detected signals synchronizes the detected signals with the activation of the sequence of distinct combinations of the light sources to produce associated combinations of detected signals which are then analyzed to determine a physical property of the object and/or compared for similarity to previously detected signals from known objects. The photometric data may be combined and correlated with other measured data to enhance identification.
摘要翻译：用于光度分析和/或材料物体的性质鉴定的装置包括具有基本上不同的波长包络并以不同组合的快速序列激活的光源的集合。该装置包括空间分布的光检测器的集合，其检测来自物体的辐射并产生检测信号。用于控制光源并分析检测到的信号的信号处理器使检测到的信号与光源的不同组合的序列的激活同步，以产生检测信号的相关联的组合，然后对其进行分析，以确定物体的物理属性， /或与来自已知对象的先前检测到的信号的相似性进行比较。光度数据可以组合并与其他测量数据相关联以增强识别。

4. 发明授权

US06487439B1 Glove-mounted hybrid probe for tissue type recognition 失效
标题翻译：用于组织型识别的手套式混合探针
公开(公告)号：US06487439B1
公开(公告)日：2002-11-26
申请号：US08818915
申请日：1997-03-17
申请人： Victor N. Skladnev , Richard L. Thompson , Irwin Wunderman , David J. Bull
发明人： Victor N. Skladnev , Richard L. Thompson , Irwin Wunderman , David J. Bull
IPC分类号： A61B500
CPC分类号： A61B5/0059 , A61B5/05 , A61B5/6806
摘要： A probe configured as a finger tip of a glove used to recognize tissue types in a human patient and adapted to perform both optical and electrical measurements to diagnose tissue type while scanned over the surface of the tissue. Hybrid electronic technology reduces the size of the diagnostic elements. The necessary electrical connections are led down the finger and the glove to a remotely positioned control unit. The control unit provides power to the diagnostic device and analyzes the signals received from the device.
摘要翻译：被配置为用于识别人类患者中的组织类型的手套的指尖的探针，并且适于执行光学和电学测量以在组织表面扫描时诊断组织类型的探针。混合电子技术减少诊断元件的尺寸。所需的电气连接将手指和手套导向远程定位的控制单元。控制单元为诊断装置提供电力并分析从设备接收的信号。

5. 发明授权

US5941834A Sheath for a side view probe 失效
标题翻译：护套用于侧视探头
公开(公告)号：US5941834A
公开(公告)日：1999-08-24
申请号：US818921
申请日：1997-03-17
申请人： Victor N. Skladnev , Richard L. Thompson , Irwin Wunderman
发明人： Victor N. Skladnev , Richard L. Thompson , Irwin Wunderman
IPC分类号： A61B5/00 , A61B5/042 , A61B5/103
CPC分类号： A61B1/00177 , A61B5/0084 , A61B5/0422 , A61B2560/0233 , A61B2562/0209 , A61B2562/043 , A61B5/1495
摘要： A sheath for a side view probe having at least two complete hybrid optical and electrode systems on opposite faces of a cylinder, in order to obviate the need to manipulate the probe through more than a half revolution during examination by the doctor. The sheath covers the probe but allows both electrical and optical measurements to be made by the underlying probe on the same areas of tissue. The invention uses the hoop tension in the sheath to apply the needed spring force to maintain electrode contact. In addition, the probe and its sheath are shaped to ensure both good electrical contact and reliable optical pathways. A built-in means of calibration of the sheath enclosed probe is achieved by attaching to the outside of the tip of the sheath a tube or blocks of a turbid material such as a polymer of controlled composition. The tube or blocks of turbid material are removed prior to using the probe on a patient.
摘要翻译：用于侧视探针的护套，其具有在气缸的相对面上的至少两个完全混合的光学和电极系统，以避免在由医生检查期间将探针操纵超过半转的需要。护套覆盖探头，但允许在相同的组织区域上的底层探针进行电和光学测量。本发明使用护套中的环向张力来施加所需的弹簧力以保持电极接触。此外，探头及其护套的形状可确保良好的电接触和可靠的光学路径。护套封闭式探针的内置校准方法是通过将护套尖端的外部附着到诸如受控组合物的聚合物的混浊物质的管子或块来实现。在患者使用探头之前，先除去管状或混浊物质块。

6. 发明授权

US5941822A Apparatus for tissue type recognition within a body canal 失效
标题翻译：用于体内组织类型识别的装置
公开(公告)号：US5941822A
公开(公告)日：1999-08-24
申请号：US818930
申请日：1997-03-17
申请人： Victor N. Skladnev , Richard L. Thompson , Irwin Wunderman , David J. Bull
发明人： Victor N. Skladnev , Richard L. Thompson , Irwin Wunderman , David J. Bull
IPC分类号： A61B5/00
CPC分类号： A61B5/0084 , A61B5/4331
摘要： A method and apparatus for tissue type recognition for use within the narrow confines of body canals and which can quickly produce an objective identification of the tissue types including the presence of pre-cancerous and cancerous activity. Possible configurations for the probe include endocervical probe configurations which make measurements in directions orthogonal to the long axis of the probe and configurations where multiple probe "tips" are arranged in a "wood drill" configuration. The apparatus has a measurement section that has at least one source of electromagnetic radiation such as a light emitting diode, a barrier which acts to confine the direction that the radiation can take and a detector such as a photodiode beyond the barrier, which is able to detect the radiation after it has been backscattered from tissue in close proximity to the surface of the cylinder. In the vicinity of these components one or more electrodes may also be positioned on the surface of the cylinder such that they are able to contact the tissue under examination thereby enabling simultaneous electrical property measurements to be made. The radiation source and the electrodes receive electrical signals produced by a programmed controller. The radiation detector and the electrode signals are processed by the controller. Comparator means in the controller are used to compare the signals with known values to thereby identify the tissue type.
摘要翻译：用于组织型识别的方法和装置，其用于体内运河的狭窄范围内，并且可以快速产生包括癌前和癌性活动的组织类型的客观鉴定。探针的可能配置包括子宫颈探针配置，其在与探针的长轴正交的方向上进行测量，并且以“木钻”配置布置多个探针“尖端”的配置。该装置具有测量部分，其具有至少一个电磁辐射源，例如发光二极管，用于限制辐射可以采取的方向的屏障和诸如光电二极管之类的检测器超出屏障，其能够在辐射已经从组织背面散射到紧邻气缸表面之后检测辐射。在这些部件附近，也可以将一个或多个电极定位在圆筒的表面上，使得它们能够接触被检查的组织，从而实现同时的电性能测量。辐射源和电极接收由编程的控制器产生的电信号。辐射检测器和电极信号由控制器处理。控制器中的比较器装置用于将信号与已知值进行比较，从而识别组织类型。

7. 发明授权

US5852494A Apparatus for checking the calibration of optical probes 失效
标题翻译：用于检查光学探针校准的装置
公开(公告)号：US5852494A
公开(公告)日：1998-12-22
申请号：US819107
申请日：1997-03-17
申请人： Victor N. Skladnev , Richard L. Thompson , Irwin Wunderman
发明人： Victor N. Skladnev , Richard L. Thompson , Irwin Wunderman
IPC分类号： A61B5/00 , G01J1/04 , G01J1/08 , G01N21/47 , G01J1/02
CPC分类号： G01N21/4785 , A61B5/1495 , A61B2560/0233 , G01J1/08
摘要： An apparatus which permits an analytical probe to be calibrated by pressing the tip against a block of material of controlled characteristics. A transparent elastomer is used into which has been incorporated a light-scattering material. Elastomer calibrators may also be made part of a preassembled probe component such as a disposable sheath. In that case the turbid elastomer is assembled on the tip with the other components of the sheath and is removed after calibrating the system and before the probe put into use. An additional film of flexible polymer having optical characteristics analogous to the material to be detected by the probe may be placed on top to simulate the structure of the material that is to be measured.
摘要翻译：允许通过将尖端压靠受控特征材料块来校准分析探针的装置。使用透明弹性体，其中掺入光散射材料。弹性体校准器也可以制成预组装的探针组件的一部分，例如一次性护套。在这种情况下，浑浊的弹性体与护套的其他部件组装在尖端上，并且在校准系统之后并且在探头投入使用之前被去除。具有类似于由探针检测的材料的光学特性的柔性聚合物的另外的膜可以放置在顶部以模拟要被测量的材料的结构。

8. 发明授权

US5855551A Integral sheathing apparatus for tissue recognition probes 失效
标题翻译：用于组织识别探针的整体护套装置
公开(公告)号：US5855551A
公开(公告)日：1999-01-05
申请号：US818910
申请日：1997-03-17
申请人： Victor N. Sklandnev , Richard L. Thompson , Irwin Wunderman
发明人： Victor N. Sklandnev , Richard L. Thompson , Irwin Wunderman
IPC分类号： A61B10/00 , A61B5/00 , A61B5/103
CPC分类号： A61B5/445 , A61B5/0059 , A61B5/1455 , A61B2560/0233
摘要： The invention incorporates an opto-electronic section in the tip of the sheath cover for a diagnostic probe that makes both electric and optical measurements of tissue contacted by the sheath. In addition the invention provides a piece of turbid material such as a polymer of controlled composition as a built-in calibrator attached to the outside of the tip of the sheath. In one embodiment the probe sheath in fabricated from a flexible material which can be rolled up prior to fitting and when fitted to the tip of the probe can be rolled down the shaft of the probe for use and then rolled back off the shaft for disposal.
摘要翻译：本发明在用于诊断探针的护套盖的尖端中结合有光电子部分，其对由鞘接触的组织进行电和光学测量。此外，本发明提供了一片浑浊的材料，例如作为内置校准器的受控组合物的聚合物，其连接到护套的尖端的外部。在一个实施例中，由柔性材料制成的探针护套可以在配合之前被卷起并且当安装到探针的尖端时被卷绕在探针的轴上用于使用，然后从轴上回退以便处置。

9. 发明授权

US5792053A Hybrid probe for tissue type recognition 失效
标题翻译：用于组织型识别的混合探针
公开(公告)号：US5792053A
公开(公告)日：1998-08-11
申请号：US818912
申请日：1997-03-17
申请人： Victor N. Skladnev , Richard N. Thompson , Irwin Wunderman , David J. Bull
发明人： Victor N. Skladnev , Richard N. Thompson , Irwin Wunderman , David J. Bull
IPC分类号： G01N33/48 , A61B1/00 , A61B1/06 , A61B5/00 , A61B5/0408 , A61B5/0478 , A61B5/0492 , A61B5/05 , A61B10/00
CPC分类号： A61B5/0084
摘要： A hybrid probe in which the optical pathway and the optical sensors comprise elements located within a compact hybrid chip structure. The full optical system of the hybrid probe is located at its tip. No fibers are required to bring the light to and from the tip of the probe. This is achieved in part by mounting one or more LED dice on a substrate at the probe tip. Appropriate connections are made to these dice which are powered from electronics in the handle of the probe.
摘要翻译：一种混合探针，其中光学路径和光学传感器包括位于紧凑型混合芯片结构内的元件。混合探针的全光学系统位于其尖端。不需要光纤将光线从探头的尖端引出。这部分地通过在探针尖端处将一个或多个LED骰子安装在基底上来实现。对这些骰子进行适当的连接，这些骰子由探头手柄中的电子元件供电。

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