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1. 发明申请

US20050261838A1 Matched filtration with experimental noise determination for denoising, peak picking and quantitation in lc-ms 失效
标题翻译：匹配滤波，实验噪声测定用于去噪，峰值采集和定量在lc-ms
公开(公告)号：US20050261838A1
公开(公告)日：2005-11-24
申请号：US10510992
申请日：2003-04-11
申请人： Victor Andreev , Tomas Rejtar , Barry Karger
发明人： Victor Andreev , Tomas Rejtar , Barry Karger
IPC分类号： G01N20060101 , G06F19/00
CPC分类号： H01J49/004 , G01N30/8603 , G01N30/8617 , G06F19/703 , H01J49/0036
摘要： An improved system and method of analyzing sample data that increases the reliability of peak (compound) detection and identification in the presence of chemical and/or random noise. The sample analysis system includes a compound-separating unit for separating constituent compounds in a sample mixture, a compound-analyzing unit for identifying and quantitating at least one of the separated compounds, and a computer for acquiring data from the compound-separating and compound-analyzing units, for generating a multi-dimensional data set incorporating the acquired data, for executing an algorithm for reducing noise in the data set and for detecting peaks (compounds) in the noise-reduced data set, and for identifying/quantitating the detected compounds.
摘要翻译：一种改进的系统和方法，用于分析样本数据，提高在存在化学和/或随机噪声的情况下峰（复合）检测和识别的可靠性。样品分析系统包括用于分离样品混合物中的组分化合物的化合物分离单元，用于鉴定和定量分离的化合物中的至少一种的化合物分析单元，以及用于从化合物分离和化合物分离单元中获取数据的计算机，分析单元，用于生成包含所获取的数据的多维数据集，用于执行用于减少数据集中的噪声并且用于检测噪声减小的数据集中的峰值（化合物）的算法，以及用于识别/定量检测到的化合物。

2. 发明申请

US20070172887A1 Monoclonal antibody based biomarker discovery and development platform 有权
标题翻译：基于单克隆抗体的生物标志物发现和开发平台
公开(公告)号：US20070172887A1
公开(公告)日：2007-07-26
申请号：US10588392
申请日：2005-02-09
申请人： Laszlo Takacs , Andras Guttrman , William Hancock , Barry Karger , Manuel Duval , Patrick Berna
发明人： Laszlo Takacs , Andras Guttrman , William Hancock , Barry Karger , Manuel Duval , Patrick Berna
IPC分类号： G01N33/53 , C12M3/00
CPC分类号： G01N33/6854 , B01L3/5027 , C07K16/18 , G01N33/54386 , G01N33/577 , G01N33/6845 , G01N2500/00
摘要： A method or platform for monoclonal antibody based biomarker discovery is disclosed. The method according to the invention provides for the integration of analyte collection, hybridoma screening and nanovolume integrated mass spectrometry (NVIMS) to achieve a robust screening system that is capable, for example, of cutting 4-6 years off of the classical biomarker discovery and development process. The invention provides a platform for the rapid, high-throughput production, isolation and characterization of, e.g., disease specific biomarkers together with highly specific monoclonal antibodies. The method of the invention has a variety of applications such as, but not limited to, drug testing, biohazard applications, ecological applications, physiological applications and/or pathology screening applications. The method of the invention is also capable of being performed or used as or with a high-throughput screening process or system of the invention.
摘要翻译：公开了用于基于单克隆抗体的生物标志物发现的方法或平台。根据本发明的方法提供了分析物收集，杂交瘤筛选和纳瓦级综合质谱（NVIMS）的整合，以实现强大的筛选系统，其能够例如从经典生物标志物发现开始4-6年，开发过程。本发明提供了用于快速，高通量生产，分离和表征例如疾病特异性生物标志物以及高度特异性单克隆抗体的平台。本发明的方法具有多种应用，例如但不限于药物测试，生物危害应用，生态应用，生理应用和/或病理学筛选应用。本发明的方法还能够作为或与本发明的高通量筛选方法或系统一起使用或使用。

3. 发明申请

US20070117212A1 Method for efficient transport of small liquid volumes to, from or within microfluidic devices 失效
标题翻译：微流体装置内或从微流体装置内有效输送小液体体积的方法
公开(公告)号：US20070117212A1
公开(公告)日：2007-05-24
申请号：US10582599
申请日：2004-12-10
申请人： Roger Kautz , Barry Karger
发明人： Roger Kautz , Barry Karger
IPC分类号： G01N33/22
CPC分类号： G01R33/307 , B01L3/502784 , B01L2200/027 , B01L2200/0673 , B01L2300/0838 , B01L2300/165 , G01N35/1095 , G01R33/302 , Y10T436/117497 , Y10T436/208339 , Y10T436/24 , Y10T436/25 , Y10T436/2575
摘要： Methods are presented for realizing zero-dispersion segmented flow for transfer of small microfluidic samples onto or within microfluidic analysis or processing devices. Where fluidic systems are in whole or in part made of materials favorable to the zero-dispersion conditions for an indicated solvent/carrier fluid system, the system may be covalently coated to impart the necessary surface properties. This invention is demonstrated in an embodiment where 1 microliter samples (6) are robotically prepared and transferred through 3 meters of capillary tubing (4) to a microcoil NMR probe.
摘要翻译：提出了用于实现零分散分段流的方法，用于将微流体样品转移到微流体分析或处理装置之上或之内。如果流体系统全部或部分地由对于指定的溶剂/载体流体系统的零分散条件有利的材料制成，则该系统可以共价涂覆以赋予必要的表面性质。本发明在其中1微升样品（6）被机器人制备并通过3米毛细管（4）转移到微线圈NMR探针上的实施例中得到证明。

4. 发明申请

US20070243540A1 Kits and Methods for Identification, Assessment, Prevention and Therapy of Breast Cancer 审中-公开
标题翻译：乳腺癌鉴别，评估，预防和治疗的试剂盒和方法
公开(公告)号：US20070243540A1
公开(公告)日：2007-10-18
申请号：US11597159
申请日：2005-05-23
申请人： Jo Tsai , William Hancock , Barry Karger
发明人： Jo Tsai , William Hancock , Barry Karger
IPC分类号： G01N33/53 , C12Q1/68
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136
摘要： Disclosed herein are methods for detecting and identifying potential breast cancer biomarkers in an individual patient. Also disclosed are newly discovered breast cancer markers set forth in Tables I, II and III, associated with the cancerous state of breast cells. It has been discovered that a higher than normal level of expression of any of these markers or combination of these markers correlates with breast cancer in a patient. Methods are provided for detecting the presence of breast cancer in a sample, the absence of breast cancer in a sample, the stage of breast cancer, assessing whether a breast cancer has metastasized, predicting the likely clinical outcome of a breast cancer patient, and with other characteristics of breast cancer that are relevant to prevention, diagnosis, characterization, and therapy of breast cancer in a patient.
摘要翻译：本文公开了用于检测和鉴定个体患者中的潜在乳腺癌生物标志物的方法。还公开了与乳腺细胞的癌症状态相关的新发现的表I，II和III中列出的乳腺癌标志物。已经发现，这些标记物或这些标记物的组合的高于正常水平的表达与患者的乳腺癌相关。提供了用于检测样品中乳腺癌存在的方法，样品中没有乳腺癌，乳腺癌阶段，评估乳腺癌是否转移，预测乳腺癌患者可能的临床结果，以及用与患者乳腺癌的预防，诊断，表征和治疗相关的乳腺癌的其他特征。

5. 发明申请

US20070012627A1 Narrow I.D. monolithic capillary columns for high efficiency separation and high sensitivity analysis of biomolecules 失效
标题翻译：狭窄的用于高效分离的单片毛细管柱和生物分子的高灵敏度分析
公开(公告)号：US20070012627A1
公开(公告)日：2007-01-18
申请号：US11409415
申请日：2006-04-21
申请人： Alexander Ivanov , Li Zang , Barry Karger
发明人： Alexander Ivanov , Li Zang , Barry Karger
IPC分类号： B01D15/08
CPC分类号： B01J20/28042 , B01J20/26 , B01J20/261 , B01J20/267 , B01J20/28014 , B01J20/285 , B01J2220/58 , B01J2220/82 , B01J2220/84 , G01N30/52 , G01N30/6095 , G01N2030/528
摘要： A method of preparing an ultra-nanoscale-LC monolithic separation medium for use in capillary columns, or channels in microfabricated devices (microchips), and capillaries prepared by the method are disclosed. The application of moderate positive pressure to both ends of the capillary during the monolith polymerization process permits the preparation of monolithic capillary columns having very low i.d., e.g., 25 μm and smaller, with enhanced mass transfer properties and low back pressures, and excellent column-to-column reproducibility of retention times.
摘要翻译：公开了一种制备用于毛细管柱或微细加工装置（微芯片）中的通道的超级纳米级LC整体式分离介质和通过该方法制备的毛细管的方法。在整料聚合过程中，对毛细管两端施加适度的正压允许制备具有非常低的id，例如25μm和更小，具有增强的传质性能和低背压的单片毛细管柱，保留时间至柱重现性。

6. 发明申请

US20050247701A1 Analysis apparatus having improved temperature control unit 有权
标题翻译：分析装置具有改进的温度控制单元
公开(公告)号：US20050247701A1
公开(公告)日：2005-11-10
申请号：US10828929
申请日：2004-04-21
申请人： Chiranjit Deka , Arthur Miller , Sunil Deliwala , Barry Karger
发明人： Chiranjit Deka , Arthur Miller , Sunil Deliwala , Barry Karger
IPC分类号： B01L7/00 , B01L9/00 , G01N27/447 , H05B3/68
CPC分类号： B01L9/527 , B01L7/52 , B01L2300/043 , B01L2300/1805 , B01L2400/0406
摘要： An apparatus for use in controlling the temperature of one or more substances passing through one or more microfluidics channels in an analysis device is set forth. The apparatus comprises a heating unit having first and second surfaces. The first surface of the heating unit is constructed so that it is at least partially exposed for cooling of the heating unit. The apparatus also comprises a thermally conductive medium that is disposed proximate the second surface of the heating unit. The one or more microfluidics channels are disposed in the thermally conductive medium. In one embodiment, the one or more microfluidics channels are in the form of a plurality of capillary columns, such as those used in instruments for capillary electrophoresis. Each capillary columns is substantially surrounded by the material forming the thermally conductive medium. In another embodiment, the thermally conductive medium, along with the corresponding plurality of capillary columns, can be easily disengaged from the heating unit in a non-destructive manner thereby allowing the heating unit to be reused.
摘要翻译：阐述了一种用于控制分析装置中通过一个或多个微流体通道的一种或多种物质的温度的装置。该装置包括具有第一和第二表面的加热单元。加热单元的第一表面被构造成使其至少部分地暴露以用于加热单元的冷却。该设备还包括靠近加热单元的第二表面设置的导热介质。一个或多个微流体通道设置在导热介质中。在一个实施方案中，一个或多个微流体通道为多个毛细管柱的形式，例如用于毛细管电泳仪器中的那些。每个毛细管柱基本上被形成导热介质的材料包围。在另一个实施例中，导热介质以及相应的多个毛细管柱可以以非破坏性的方式容易地从加热单元脱离，从而允许加热单元被再次使用。

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