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1. 发明申请

US20220236265A1 SEQUENTIAL LATERAL FLOW DEVICE 有权
公开(公告)号：US20220236265A1
公开(公告)日：2022-07-28
申请号：US17713181
申请日：2022-04-04
申请人： Verax Biomedical Incorporated
发明人： Gregory M. Lawrence , Adam P. Lousararian , Yli Remo Vallejo , Lisa Shinefeld
IPC分类号： G01N33/543 , G01N33/53 , B01L3/00 , G01N33/577 , G01N33/569 , G01N33/566 , G01N33/558
摘要： The present disclosure provides methods and lateral flow devices for detecting a plurality of target analytes in a liquid sample. In some implementations, the disclosed lateral flow device comprises a housing unit, a capillary flow bed, a sample-receiving zone, a buffer-receiving zone, and a capture zone. The device is configured to control the flow of the sample and reagent buffer in a sequential manner with minimal mixing. In some implementations, the disclosed method is capable of detecting a plurality of target analytes in an assay by applying the binding agents and the signaling agents in separate or sequential steps.

2. 发明申请

US20190079085A1 SEQUENTIAL LATERAL FLOW DEVICE 审中-公开
公开(公告)号：US20190079085A1
公开(公告)日：2019-03-14
申请号：US16047980
申请日：2018-07-27
申请人： Verax Biomedical Incorporated
发明人： Gregory M. Lawrence , Yli Remo Vallejo , Adam P. Lousararian , Lisa Shinefeld
IPC分类号： G01N33/543 , G01N33/53 , G01N33/566 , G01N33/577 , G01N33/569 , B01L3/00
摘要： The present disclosure provides methods and lateral flow devices for detecting a plurality of target analytes in a liquid sample. In some implementations, the disclosed lateral flow device comprises a housing unit, a capillary flow bed, a sample-receiving zone, a buffer-receiving zone, and a capture zone. The device is configured to control the flow of the sample and reagent buffer in a sequential manner with minimal mixing. In some implementations, the disclosed method is capable of detecting a plurality of target analytes in an assay by applying the binding agents and the signaling agents in separate or sequential steps.

3. 发明申请

US20150241424A1 MULTI-ANALYTE ASSAY 审中-公开
标题翻译：多分析测定
公开(公告)号：US20150241424A1
公开(公告)日：2015-08-27
申请号：US14433370
申请日：2013-10-07
申请人： Gregory M. LAWRENCE , Lisa SHINEFELD , VERAX BIOMEDICAL INCORPORATED
发明人： Gregory M. Lawrence , Lisa Shinefeld
IPC分类号： G01N33/543 , G01N33/569 , G01N33/553
CPC分类号： G01N33/54353 , G01N33/553 , G01N33/558 , G01N33/56911 , G01N33/585 , G01N2333/195 , G01N2400/50 , G01N2405/04
摘要： The present invention is directed to devices and methods using pan-generic antibodies to detect bacteria in a sample.
摘要翻译：本发明涉及使用泛泛型抗体检测样品中细菌的装置和方法。

4. 发明授权

US11293922B2 Sequential lateral flow device 有权
公开(公告)号：US11293922B2
公开(公告)日：2022-04-05
申请号：US16047980
申请日：2018-07-27
申请人： Verax Biomedical Incorporated
发明人： Yli Remo Vallejo , Gregory M. Lawrence , Adam P. Lousararian , Lisa Shinefeld
IPC分类号： G01N33/566 , G01N33/543 , G01N33/53 , B01L3/00 , G01N33/577 , G01N33/569 , G01N33/558
摘要： The present disclosure provides methods and lateral flow devices for detecting a plurality of target analytes in a liquid sample. In some implementations, the disclosed lateral flow device comprises a housing unit, a capillary flow bed, a sample-receiving zone, a buffer-receiving zone, and a capture zone. The device is configured to control the flow of the sample and reagent buffer in a sequential manner with minimal mixing. In some implementations, the disclosed method is capable of detecting a plurality of target analytes in an assay by applying the binding agents and the signaling agents in separate or sequential steps.

5. 发明申请

US20160011185A1 MULTI-ANALYTE ASSAY 审中-公开
标题翻译：多分析测定
公开(公告)号：US20160011185A1
公开(公告)日：2016-01-14
申请号：US14772657
申请日：2014-03-04
申请人： Gregory M. LAWRENCE , Lisa SHINEFELD , VERAX BIOMEDICAL INCORPORATED
发明人： Gregory M. Lawrence , Lisa Shinefeld
IPC分类号： G01N33/543
CPC分类号： G01N33/54366 , C07K17/14 , C12Q1/04 , G01N33/54353 , G01N33/54393 , G01N33/558
摘要： The present invention is directed to devices and methods using pan-generic antibodies to detect bacteria in a sample. The invention relates to binding assays, especially immunoassays, utilizing a multivalent binding agent immobilized on a particle. The invention also relates to the surprising discovery that increasing the size of the particles improves the sensitivity of the screen. The invention provides, inter alia, a lateral flow device for detecting bacteria in a sample, the device comprising a flow path for the sample and further comprising a pan-generic binding agent specific for other or more bacterial antigens, wherein the pan-generic binding agent is immobilized via a linker on a population of particularly-sized detectable particles; and a capture binding agent that captures the population of particles bound to bacterial antigens, wherein the capture binding agent is immobilized on the flow path, and wherein the population of detectable particles are disposed along the flow path such that the sample contacts the population of detectable particles before contacting the capture binding agent.
摘要翻译：本发明涉及使用泛泛型抗体检测样品中细菌的装置和方法。本发明涉及使用固定在颗粒上的多价结合剂的结合测定法，特别是免疫测定法。本发明还涉及令人惊奇的发现，即增加颗粒的尺寸提高了屏幕的灵敏度。本发明尤其提供了一种用于检测样品中的细菌的侧流装置，该装置包括用于样品的流动路径，并且还包括对其它或更多细菌抗原特异的泛泛型结合剂，其中泛泛型结合试剂通过接头固定在特别大小的可检测颗粒群上; 捕获结合剂捕获与细菌抗原结合的颗粒群体，其中捕获结合剂固定在流动路径上，并且其中可检测颗粒群沿着流动路径设置，使得样品接触可检测群体在接触捕获结合剂之前的颗粒。

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