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1. 发明授权

US4762943A Aromatization process 失效
公开(公告)号：US4762943A
公开(公告)日：1988-08-09
申请号：US880070
申请日：1986-06-30
申请人： Venkataraman Ramachandran , John R. Maloney
发明人： Venkataraman Ramachandran , John R. Maloney
IPC分类号： C07B35/04 , B01J23/02 , B01J27/232 , B01J31/00 , B01J31/02 , C07B31/00 , C07B61/00 , C07C67/00 , C07C241/00 , C07C253/00 , C07C253/30 , C07C255/52 , C07C255/53 , C07C255/54 , C07C291/08 , C07C121/62
CPC分类号： C07C255/00
摘要： A dihydroaromatic compound is aromatized by intimately contacting it with a base selected from alkali metal, alkaline earth metal, and tetraalkylammonium hydroxides, alkoxides, carbonates, and bicarbonates in the presence of a hydrogen acceptor. In a preferred embodiment of the invention, the dihydroaromatic compound is a dihydronaphthalene bearing an electron-withdrawing substituent, e.g., a cyanodihydronaphthalene.

2. 发明授权

US4590012A Process for preparing alpha-arylacrylonitriles 失效
标题翻译：制备α-芳基丙烯腈的方法
公开(公告)号：US4590012A
公开(公告)日：1986-05-20
申请号：US735148
申请日：1985-05-17
申请人： Venkataraman Ramachandran
发明人： Venkataraman Ramachandran
IPC分类号： C07C255/34 , C07C121/75 , C07C121/62 , C07C121/70
CPC分类号： C07C255/00
摘要： An alpha-arylacrylonitrile is prepared by reacting an aryl ketone having a removable hydrogen alpha to the carbonyl group with an alkali metal cyanide and a Lewis acid other than aluminum chloride, preferably in the presence of a solvent. In a preferred embodiment, the aryl ketone is a tetralone, the cyanide is sodium cyanide, the Lewis acid is boron trifluoride, and the product is a 1-cyano-3,4-dihydronaphthalene.
摘要翻译：优选在溶剂存在下，使具有可除去的氢的芳基酮与羰基的碱金属氰化物和除氯化铝以外的路易斯酸反应制备α-芳基丙烯腈。在优选的实施方案中，芳基酮是四氢萘酮，氰化物是氰化钠，路易斯酸是三氟化硼，产物是1-氰基-3,4-二氢萘。

3. 发明授权

US5574183A Preparation of optically active aliphatic carboxylic acids 失效
标题翻译：光学活性脂族羧酸的制备
公开(公告)号：US5574183A
公开(公告)日：1996-11-12
申请号：US378049
申请日：1995-01-24
申请人： Deepak R. Patil , Venkataraman Ramachandran
发明人： Deepak R. Patil , Venkataraman Ramachandran
IPC分类号： C07B57/00 , C07C51/487 , C07C57/30 , C07C57/58 , C07C59/64 , C07B55/00
CPC分类号： C07B57/00 , C07C51/487
摘要： A process for the separation of a racemic mixture of certain aliphatic carboxylic acids or esters thereof is disclosed. The process comprises i) forming a diastereomeric salt by reaction comprising said racemic mixture of a C.sub.1 to C.sub.6 linear or branched aliphatic carboxylic acid and an amount of a chiral organic base sufficient to react with one of the enantiomers of the racemic mixture; ii) precipitating from the reaction solution formed in step i) the diastereomeric salt; iii) separating said precipitated diastereomeric salt; iv) decomposing the salt into its enantiomeric component and its organic base component; and v) isolating a substantially pure enantiomer from said decomposed salt.
摘要翻译：公开了分离某些脂族羧酸或其酯的外消旋混合物的方法。该方法包括i）通过包含C1-C6直链或支链脂族羧酸的外消旋混合物和足以与外消旋混合物的一种对映异构体反应的量的手性有机碱的反应形成非对映体盐; ii）从步骤i）中形成的反应溶液沉淀非对映体盐; iii）分离所述沉淀的非对映体盐; iv）将盐分解成其对映体组分及其有机碱组分; 和v）从所述分解的盐分离基本上纯的对映异构体。

4. 发明授权

US5073552A Substituted benzophenone dicarboxylic acids 失效
标题翻译：取代的二苯甲酮二羧酸
公开(公告)号：US5073552A
公开(公告)日：1991-12-17
申请号：US576849
申请日：1990-09-04
申请人： Mark W. Beltz , Venkataraman Ramachandran
发明人： Mark W. Beltz , Venkataraman Ramachandran
IPC分类号： C07C205/38 , C07C217/90
CPC分类号： C07C217/90 , C07C205/38
摘要： Substituted benzophenones are disclosed having the following formula ##STR1## where R.sub.A and R.sub.B are each independently COOH, C.sub.1 to C.sub.12 linear or branched alkyl or taken together to form an anhydride ring, R is nitro or amino unsubstituted or substituted with at least one C.sub.1 to C.sub.6 linear or branched alkyl, phenyl or substituted phenyl, the substituents being one or more C.sub.1 to C.sub.6 linear or branched alkyl or C.sub.6 to C.sub.10 aryl, Y and Y' are the same or different and are a chemical bond ##STR2## and m is 0 or 1 with the proviso that both R.sub.A and R.sub.B can not be hydrogen.Processes to produce these benzophenones are also disclosed.
摘要翻译：公开了具有下列结构式的取代的二苯甲酮，其中RA和RB各自独立地为COOH，C1至C12直链或支链烷基或一起形成酸酐环，R为硝基或未取代的氨基或被至少一个C1至 C6直链或支链烷基，苯基或取代的苯基，取代基是一个或多个C 1至C 6直链或支链烷基或C 6至C 10芳基，Y和Y'相同或不同，并且是化学键。）2，C（CF 3）2或Si（CH 3）2，m为0或1，条件是RA和RB都不能为氢。还公开了制备这些二苯甲酮的方法。

5. 发明授权

US4590013A Process for preparing alpha arylacrylonitriles 失效
标题翻译：制备α-芳基丙烯腈的方法
公开(公告)号：US4590013A
公开(公告)日：1986-05-20
申请号：US735151
申请日：1985-05-17
申请人： John R. Maloney , Venkataraman Ramachandran
发明人： John R. Maloney , Venkataraman Ramachandran
IPC分类号： C07C255/32 , C07C121/75 , C07C121/62 , C07C121/70
CPC分类号： C07C255/00
摘要： An alpha-arylacrylonitrile is prepared by reacting an aryl ketone having a removable hydrogen alpha to the carbonyl group with a cyanide ion source which is free of radicals that would stabilize a cyanohydrin corresponding to the aryl ketone and with a Lewis acid, preferably in the presence of a solvent. In a preferred embodiment, the aryl ketone is a tetralone, the cyanide ion source is hydrogen cyanide, the Lewis acid is aluminum chloride, and the product is a 1-cyano-3,4-dihydronaphthalene.
摘要翻译：通过使具有可除去的氢的芳基酮与羰基与氰离子源反应来制备α-芳基丙烯腈，所述氰离子源不含能够稳定对应于芳基酮的氰醇和路易斯酸的自由基，优选在存在下的溶剂。在优选的实施方案中，芳基酮是四氢萘酮，氰化物离子源是氰化氢，路易斯酸是氯化铝，产物是1-氰基-3,4-二氢萘。

6. 发明授权

US4539397A (Alkoxydiazo)halobenzeneacetonitriles 失效
标题翻译：（Alkoxydiazo）卤代苯乙腈
公开(公告)号：US4539397A
公开(公告)日：1985-09-03
申请号：US635215
申请日：1984-07-27
申请人： Venkataraman Ramachandran
发明人： Venkataraman Ramachandran
IPC分类号： C07C113/00 , C07C120/00 , C07C121/66 , C07C121/68
CPC分类号： C07C255/00
摘要： The coupling of an aminohalobenzeneacetonitrile with a benzene compound in the presence of an alkyl nitrite to form a halobiphenylacetonitrile via a diazo intermediate is improved by conducting the reaction at a temperature of about 0.degree.-15.degree. C. until diazotization of the aminohalobenzeneacetonitrile is substantially complete. Use of the low diazotization temperature leads to an increased yield of halobiphenylacetonitrile.
摘要翻译：在亚硝酸烷基酯存在下，通过重氮中间体与偶氮苯乙腈的偶联反应，可以通过在约0℃-15℃的温度下进行反应，直至氨基卤代苯乙腈的重氮化基本完全。使用低重氮化温度导致卤代二苯乙腈的产率增加。

7. 发明授权

US5847225A Production of naphthyl-substituted ketones from naphthaldehydes 失效
标题翻译：由萘醛生产萘基取代的酮
公开(公告)号：US5847225A
公开(公告)日：1998-12-08
申请号：US846220
申请日：1997-04-25
申请人： Venkataraman Ramachandran , Stephen E. Belmont
发明人： Venkataraman Ramachandran , Stephen E. Belmont
IPC分类号： C07C45/62 , C07C45/74 , C07C49/255 , C07C49/215
CPC分类号： C07C49/255 , C07C45/62 , C07C45/74
摘要： A mixture formed from 2-naphthaldehyde (e.g., 6-methoxy-2-naphthaldehyde) and a dihydrocarbyl ketone having at least one hydrogen atom in the .alpha.-position (e.g., acetone) is heated in the presence of a heterogeneous basic catalyst (e.g., basic alumina) such that the unsaturated 2-naphthyl ketone is formed. The unsaturated ketone can be hydrogenated using, for example, a Pd/C catalyst to form the corresponding saturated ketone. The process enables efficient production of nabumetone and related pharmaceuticals by a clean reaction.
摘要翻译：将由2-萘甲醛（例如6-甲氧基-2-萘甲醛）和在α-位上具有至少一个氢原子的二烃基酮（例如丙酮）形成的混合物在非均相碱性催化剂（例如，，碱性氧化铝），使得形成不饱和的2-萘基酮。可以使用例如Pd / C催化剂氢化不饱和酮以形成相应的饱和酮。该方法可以通过清洁反应有效地生产萘丁美酮和相关药物。

8. 发明授权

US5705039A Process for purifying a 2,6-dialkylphenol 失效
标题翻译：纯化2,6-二烷基苯酚的方法
公开(公告)号：US5705039A
公开(公告)日：1998-01-06
申请号：US542612
申请日：1995-10-13
申请人： Sam F. Clarke , Venkataraman Ramachandran , J. Steve Staton , Paul L. Wiggins
发明人： Sam F. Clarke , Venkataraman Ramachandran , J. Steve Staton , Paul L. Wiggins
IPC分类号： B01D3/14 , C07C37/74 , B01D3/00 , C07C37/68
CPC分类号： B01D3/146 , C07C37/685 , C07C37/74 , Y10S203/07 , Y10S203/09
摘要： Impure 2,6-diisopropylphenol (DIP) is purified by use of a distillation process in which a single distillation column is used. The process comprises: (a) subjecting the impure DIP to a first continuous distillation in the column in an inert environment to distill off lower boiling components and produce first column bottoms enriched in DIP; (b) collecting, cooling and storing the first column bottoms while continuously maintaining them in an inert environment; (c) discontinuing the first continuous distillation; (d) subjecting the first column bottoms to a second continuous distillation in an inert environment in the same column to produce a second overhead distillate composed of purified DIP. The process avoids the formation in the distilling mixtures of dose boiling impurities due to seepage of air through standard pipe flanges and fittings and consequent oxidation reactions which occur under the conditions needed for batch distillations conducted in typical industrial distillation facilities. These impurities include 2,6-diisopropylbenzoquinone, 2-isopropyl-6-isopropenylphenol, 2,6-diisopropenylphenol and 2,2-dimethyl-4-isopropyl-1,3-benzodioxole. The capital investment needed for a conventional continuous distillation facility is also avoided.
摘要翻译：不纯的2,6-二异丙基苯酚（DIP）通过使用其中使用单个蒸馏塔的蒸馏方法纯化。该方法包括：（a）使惰性DIP在惰性环境中在柱中进行第一次连续蒸馏以蒸馏掉低沸点组分并产生富含DIP的第一塔底物; （b）收集，冷却和储存第一塔底，同时将其保持在惰性环境中; （c）停止第一次连续蒸馏; （d）在同一塔的惰性环境中对第一塔底部进行第二次连续蒸馏以产生由纯化的DIP组成的第二塔顶馏出物。该过程避免了在典型工业蒸馏设备中进行的批次蒸馏所需的条件下，由于通过标准管道法兰和配件的空气渗漏导致的沸腾杂质的蒸馏混合物中的形成以及随之而来的氧化反应。这些杂质包括2,6-二异丙基苯醌，2-异丙基-6-异丙烯基苯酚，2,6-二异丙烯基苯酚和2,2-二甲基-4-异丙基-1,3-苯并间二氧杂环戊烯。也避免了常规连续蒸馏设备所需的投资。

9. 发明授权

US5118839A Nitro-substituted polyarylketones 失效
标题翻译：硝基取代的聚芳基酮
公开(公告)号：US5118839A
公开(公告)日：1992-06-02
申请号：US576850
申请日：1990-09-04
申请人： Allan A. Eisenbraun , Venkataraman Ramachandran
发明人： Allan A. Eisenbraun , Venkataraman Ramachandran
IPC分类号： C07C51/373 , C07C205/38 , C07C205/45 , C07C217/90
CPC分类号： C07C201/12 , C07C213/02 , C07C51/373
摘要： A process for preparing nitro substituted polyarylketones of the formula: ##STR1## is disclosed. The process involves the condensation of ##STR2## where R.sub.A is hydrogen, --COOH, or C.sup.1 to C.sub.12 linear or branched alkyl, Y and Y' are the same or different and are a chemical bond ##STR3## or --Si(CH.sub.3).sub.2 -- and m is 0 or 1 and X is halo. These nitro groups of these compounds can be reduced to provide the corresponding amines, which are useful for the preparation of thermally stable high melting polyimides.
摘要翻译：公开了制备下式的硝基取代的聚芳基酮的方法：＆lt; IMAGE＆gt; + TR＆lt; IMAGE＆gt;。该方法涉及与RA图像是氢，-COOH或C 1〜C 12直链或支链烷基的Y IMAF缩合，Y和Y'相同或不同，并且是化学键 CF2，C （CF 3）2或-Si（CH 3）2 - ，m为0或1，X为卤素。这些化合物的这些硝基可以被还原以提供相应的胺，其可用于制备热稳定的高熔点聚酰亚胺。

10. 发明授权

US4824988A Process for recovering cuprous iodide catalyst used in synthesis of (trifluoromethyl)napthalenes 失效
标题翻译：回收用于（三氟甲基）萘的合成中使用的碘化亚铜催化剂的方法
公开(公告)号：US4824988A
公开(公告)日：1989-04-25
申请号：US112398
申请日：1987-10-26
申请人： Ronny W. Lin , Venkataraman Ramachandran
发明人： Ronny W. Lin , Venkataraman Ramachandran
IPC分类号： C07C255/54 , C07C121/62 , C07C69/76
CPC分类号： C07C255/54
摘要： In a process for preparing a (trifluoromethyl)napthalene by reacting a halonapthalene with a trifluoroacetate in the presence of cuprous iodide and a dipolar aprotic solvent and separating out the inorganic ingredients of the final reaction mixture in the recovery of the product, the cuprous iodide is recovered by washing the separated inorganic ingredients with an alcohol and a carboxylic acid and then with water to purify the cuprous iodide.
摘要翻译：在碘化亚铜和偶极非质子溶剂的存在下，通过卤代萘与三氟乙酸盐反应制备（三氟甲基）萘的方法，在回收产物时分离出最终反应混合物中的无机成分，碘化亚铜是通过用醇和羧酸洗涤分离的无机成分，然后用水回收以净化碘化亚铜。

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