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1. 发明申请

WO2003040705A3 A MANIFOLD DEVICE COMPRISING A PLURALITY OF FLOW CELLS AND FIBER-OPTIC PROBES FOR DISSOLUTION SYSTEMS, AND METHOD 审中-公开
公开(公告)号：WO2003040705A3
公开(公告)日：2003-05-15
申请号：PCT/US2002/034251
申请日：2002-10-25
申请人： VARIAN, INC.
发明人： FERNANDO, C., J., Anthony , SWON, James, E. , HOFER, Henry, Z.
IPC分类号： G01N21/03
摘要： A dissolution system (10) provides remote flow cells (F1-F6) integrated into a manifold device (150). The manifold device (150) communicates with liquid input (IL1-IL6) and output lines (OL1-OL6) associated with each flow cell (F1-F6), as well as fiber-optic input and output lines (DP1-DP6) associated with each flow cell (F1-F6). Liquid samples are respectively drawn from dissolution vessels, optically-related measurements are taken, and the samples are thereafter returned their respective vessels (V1-V6). The manifold device (150) can be adapted to receive probe-type instruments (DP1-DP6) that incorporate the fiber-optics, wherein each probe-type instrument (DP1-DP6) is associated with each flow cell (F1-F6). Alternatively, each corresponding pair of fiberoptic input and output lines (DP1-DP6) are disposed in opposing, optically-aligned relation and probe-type instruments are not used. The gap between the ends of the opposing fiber-optic lines (DP1-DP6) provides a light path across the corresponding flow cell (F1-F6). Calibration procedures using blank and/or standard media (BV, SV) are performed using the same flow cells (F1-F6), with provisions (M1, M2, S13, S14) made for bypassing the vessels (V1-V6) in which the samples to be analyzed are held.

2. 发明授权

EP1293108B1 WATERLESS VESSEL HEATING SYSTEM AND METHOD 有权
标题翻译：水箱无氧化加热系统和关联方法
公开(公告)号：EP1293108B1
公开(公告)日：2007-12-26
申请号：EP01941968.8
申请日：2001-06-04
申请人： Varian, Inc.
发明人： FERNANDO, C., J., Anthony , SWON, James, E. , HAW, Michael, F.
IPC分类号： H05B1/02 , H05B3/36 , H05B3/84
CPC分类号： G01N13/00 , B01F1/00 , B01F1/0011 , B01F2215/0037 , B01J19/0013 , B01J2219/00011 , B01J2219/00038 , B01J2219/00063 , B01J2219/00135 , B01J2219/002 , B01J2219/00213 , B01J2219/00238 , B01L7/00 , B01L2300/1805 , G01N33/15 , G01N2013/006 , H05B3/00 , H05B3/34 , H05B3/54 , H05B2203/005 , H05B2203/014 , H05B2203/017 , H05B2203/037
摘要： A dissolution testing system comprises a vessel plate on which a plurality of vessels are mounted. Each vessel including a lateral wall having an outer surface around which a plurality of flexible heater elements are attached. Each heater element includes a transparent surface area, a heat conductive element extending along the transparent surface area, a temperature sensing element extending along the transparent surface area, and an electrical contact element connected to the heat conductive element and the temperature sensing element. The transparent heater element allows unobstructed view into the interior of its vessel, and reduces the time required to achieve a stabilized set point temperature in the vessel. A heater control system communicates with each heat conductive element and each temperature sensing element through a corresponding one of the electrical contact elements. The heater control system permits each vessel to be controlled independently of the other vessels.

3. 发明申请

WO2003087901A2 FIBER-OPTIC CHANNEL SELECTING APPARATUS 审中-公开
标题翻译：光纤通道选择装置
公开(公告)号：WO2003087901A2
公开(公告)日：2003-10-23
申请号：PCT/US2002/027872
申请日：2002-09-03
申请人： VARIAN, INC.
发明人： FERNANDO, Anthony, C., J. , SWON, James, E.
IPC分类号： G02B6/00
CPC分类号： G02B6/3504 , G02B6/3558 , G02B6/3574 , G02B6/3582
摘要： An optical channel selection device comprises a barrel, an internal optical fiber disposed within the barrel, a first bearing coaxially disposed around the barrel, and a first bearing sleeve coaxially disposed around the first bearing. The barrel is rotatable about a central axis, and comprises a first end surface and a second opposing end surface. The internal optical fiber includes a first fiber end and a second fiber end. The first fiber end is exposed on the first end surface at a radially offset distance from the central axis. The second fiber end is exposed on the second end surface collinearly with the central axis. The first bearing sleeve has a plurality of first bearing sleeve apertures circumferentially spaced from each other. Each first bearing sleeve aperture is disposed in the first bearing sleeve at the radially offset distance, and is selectively optically aligned with the second fiber end through incremental rotation of the barrel.
摘要翻译：光通道选择装置包括筒体，设置在筒体内的内部光纤，围绕筒体同轴设置的第一轴承以及围绕第一轴承同轴设置的第一轴承套筒。筒可围绕中心轴线旋转，并且包括第一端面和第二相对端面。内部光纤包括第一光纤端和第二光纤端。第一光纤端部在第一端面上以与中心轴线径向偏移的距离露出。第二纤维端部在与中心轴线共线的第二端面上露出。第一轴承套筒具有彼此周向间隔开的多个第一轴承套筒孔。每个第一轴承套孔在径向偏移的距离处设置在第一轴承套筒中，并且通过筒的增量旋转与第二纤维端选择性地光学对准。

4. 发明申请

WO2003010999A3 WATERLESS VESSEL HEATING SYSTEM AND METHOD 审中-公开
公开(公告)号：WO2003010999A3
公开(公告)日：2003-02-06
申请号：PCT/US2002/023022
申请日：2002-07-19
申请人： VARIAN, INC.
发明人： FERNANDO, C., J., Anthony , SWON, James, E. , HAW, Michael, F.
IPC分类号： H05B1/02
摘要： A dissolution testing system comprises a vessel plate on which a plurality of vessels are mounted. Each vessel includes a lateral wall having an outer surface around which a plurality of flexible heater elements are attached. Each heater element includes a transparent surface area, a heat conductive element extending along the transparent surface area, a temperature sensing element extending along the transparent surface area, and an electrical contact element connected to the heat conductive element and the temperature sensing element. The heater element can have more than one heating zone, with at least one of the heating zones being selectively energizable. The transparent heater element allows unobstructed view into the interior of its vessel, and reduces the time required to achieve a stabilized set point temperature in the vessel. A heater control system communicates with each heat conductive element and each temperature sensing element through a corresponding one of the electrical contact elements. The heater control system permits each vessel to be controlled independently of the other vessels.

5. 发明申请

WO2002034392A3 VESSEL CENTERING SYSTEM AND METHOD 审中-公开
公开(公告)号：WO2002034392A3
公开(公告)日：2002-05-02
申请号：PCT/US2001/031324
申请日：2001-10-05
申请人： VARIAN, INC.
发明人： DEAN, Stephen, D. , FERNANDO, C., J., Anthony , SWON, James, E.
IPC分类号： B01L9/06
摘要： A vessel centering system comprises a vessel, an annular, spacer member, a fastening element, and an elastomeric component. The vessel includes an outer surface and a vessel groove formed on a circumference of the vessel outer surface. The spacer member is fitted in the vessel groove and extends outwardly with respect to the vessel. The first and second lateral end surfaces define a spacing therebetween. The spacer member includes a tangential bore and an annular groove. The tangential bore extends along a line generally tangential to a curvature of the spacer member. The fastening element, which could be a screw, is disposed in the tangential bore in engagement with the ring member and extends across the ring spacing. The elastometric component, which could be a gasket or O-ring, is disposed in the annular groove. A plurality of biased bearings can be provided instead of the elastomeric component. When the vessel is installed in the aperture of a vessel plate, concentricity between the inner surfaces of the vessel and a shaft extending into the vessel is easily obtained.

6. 发明授权

EP1333927B1 VESSEL CENTERING SYSTEM AND METHOD 有权
标题翻译：系统和方法定心货柜的
公开(公告)号：EP1333927B1
公开(公告)日：2011-01-12
申请号：EP01977556.8
申请日：2001-10-05
申请人： Varian, Inc.
发明人： DEAN, Stephen, D. , FERNANDO, C., J., Anthony , SWON, James, E.
IPC分类号： B01L9/06 , B65D23/00 , B01F11/00 , B01F15/00 , B01L3/14
CPC分类号： B01L3/5082 , B01F7/1605 , B01L9/06 , G01N13/00 , G01N33/15 , G01N2013/006
摘要： A vessel centering system comprises a vessel, an annular, spacer member, a fastening element, and an elastomeric component. The vessel includes an outer surface and a vessel groove formed on a circumference of the vessel outer surface. The spacer member is fitted in the vessel groove and extends outwardly with respect to the vessel. The first and second lateral end surfaces define a spacing therebetween. The spacer member includes a tangential bore and an annular groove. The tangential bore extends along a line generally tangential to a curvature of the spacer member. The fastening element, which could be a screw, is disposed in the tangential bore in engagement with the ring member and extends across the ring spacing. The elastometric component, which could be a gasket or O-ring, is disposed in the annular groove. A plurality of biased bearings can be provided instead of the elastomeric component. When the vessel is installed in the aperture of a vessel plate, concentricity between the inner surfaces of the vessel and a shaft extending into the vessel is easily obtained.

7. 发明授权

EP1474714B1 FIBER-OPTIC CHANNEL SELECTING APPARATUS 有权
标题翻译：光纤通道选择装置
公开(公告)号：EP1474714B1
公开(公告)日：2008-05-07
申请号：EP02806831.0
申请日：2002-09-03
申请人： Varian, Inc.
发明人： FERNANDO, Anthony, C., J. , SWON, James, E.
IPC分类号： G02B6/36 , G02B6/35
CPC分类号： G02B6/3504 , G02B6/3558 , G02B6/3574 , G02B6/3582
摘要： An optical channel selection device comprises a barrel, an internal optical fiber disposed within the barrel, a first bearing coaxially disposed around the barrel, and a first bearing sleeve coaxially disposed around the first bearing. The barrel is rotatable about a central axis, and comprises a first end surface and a second opposing end surface. The internal optical fiber includes a first fiber end and a second fiber end. The first fiber end is exposed on the first end surface at a radially offset distance from the central axis. The second fiber end is exposed on the second end surface collinearly with the central axis. The first bearing sleeve has a plurality of first bearing sleeve apertures circumferentially spaced from each other. Each first bearing sleeve aperture is disposed in the first bearing sleeve at the radially offset distance, and is selectively optically aligned with the second fiber end through incremental rotation of the barrel.
摘要翻译：一种光学通道选择装置包括：筒体，设置在筒体内的内部光纤，围绕筒体同轴设置的第一轴承以及围绕第一轴承同轴设置的第一轴承套筒。枪管可围绕中心轴线旋转，并且包括第一端面和第二相对端面。内部光纤包括第一光纤端和第二光纤端。第一光纤端部在距离中心轴线的径向偏移距离处暴露在第一端面上。第二光纤端部在与中心轴线共线的第二端面上暴露。第一轴承套筒具有彼此周向间隔开的多个第一轴承套筒孔。每个第一轴承套筒孔以径向偏移距离设置在第一轴承套筒中，并且通过筒体的增量旋转选择性地与第二光纤端部光学对准。

8. 发明授权

EP1417862B1 WATERLESS VESSEL HEATING SYSTEM AND METHOD 有权
标题翻译：水箱无氧化加热系统和关联方法
公开(公告)号：EP1417862B1
公开(公告)日：2005-11-09
申请号：EP02753399.1
申请日：2002-07-19
申请人： Varian, Inc.
发明人： FERNANDO, C., J., Anthony , SWON, James, E. , HAW, Michael, F.
IPC分类号： H05B1/02 , H05B3/26 , H05B3/28
CPC分类号： H05B1/025 , B01F1/00 , B01F1/0011 , B01F2215/0037 , B01J19/0013 , B01J2219/00011 , B01J2219/00038 , B01J2219/00063 , B01J2219/00135 , B01J2219/002 , B01J2219/00213 , B01J2219/00238 , B01L7/00 , B01L2300/1805 , G01N13/00 , G01N33/15 , G01N2013/006 , H05B3/00 , H05B3/34 , H05B3/54 , H05B2203/005 , H05B2203/014 , H05B2203/017 , H05B2203/037
摘要： A dissolution testing system comprises a vessel plate on which a plurality of vessels are mounted. Each vessel includes a lateral wall having an outer surface around which a plurality of flexible heater elements are attached. Each heater element includes a transparent surface area, a heat conductive element extending along the transparent surface area, a temperature sensing element extending along the transparent surface area, and an electrical contact element connected to the heat conductive element and the temperature sensing element. The heater element can have more than one heating zone, with at least one of the heating zones being selectively energizable. The transparent heater element allows unobstructed view into the interior of its vessel, and reduces the time required to achieve a stabilized set point temperature in the vessel. A heater control system communicates with each heat conductive element and each temperature sensing element through a corresponding one of the electrical contact elements. The heater control system permits each vessel to be controlled independently of the other vessels.

9. 发明公开

EP1446651A2 A MANIFOLD DEVICE COMPRISING A PLURALITY OF FLOW CELLS AND FIBER-OPTIC PROBES FOR DISSOLUTION SYSTEMS, AND METHOD 审中-公开
标题翻译：随着对DISSOLUTIONSSYSTEME液流电池和光纤传感器的品种，如任何电器本体
公开(公告)号：EP1446651A2
公开(公告)日：2004-08-18
申请号：EP02780528.2
申请日：2002-10-25
申请人： Varian, Inc.
发明人： FERNANDO, C., J., Anthony , SWON, James, E. , HOFER, Henry, Z.
IPC分类号： G01N21/03 , G01N21/05 , G01N21/25 , G01N33/15
CPC分类号： G01N21/8507 , G01N13/00 , G01N21/253 , G01N33/15 , G01N2013/006 , G01N2021/8521 , G01N2021/8528 , Y10T436/117497 , Y10T436/2575
摘要： A dissolution system (10) provides remote flow cells (F1-F6) integrated into a manifold device (150). The manifold device (150) communicates with liquid input (IL1-IL6) and output lines (OL1-OL6) associated with each flow cell (F1-F6), as well as fiber-optic input and output lines (DP1-DP6) associated with each flow cell (F1-F6). Liquid samples are respectively drawn from dissolution vessels, optically-related measurements are taken, and the samples are thereafter returned their respective vessels (V1-V6). The manifold device (150) can be adapted to receive probe-type instruments (DP1-DP6) that incorporate the fiber-optics, wherein each probe-type instrument (DP1-DP6) is associated with each flow cell (F1-F6). Alternatively, each corresponding pair of fiberoptic input and output lines (DP1-DP6) are disposed in opposing, optically-aligned relation and probe-type instruments are not used. The gap between the ends of the opposing fiber-optic lines (DP1-DP6) provides a light path across the corresponding flow cell (F1-F6). Calibration procedures using blank and/or standard media (BV, SV) are performed using the same flow cells (F1-F6), with provisions (M1, M2, S13, S14) made for bypassing the vessels (V1-V6) in which the samples to be analyzed are held.

10. 发明申请

WO2005105277A1 APPARATUS AND METHOD FOR AGITATING A SAMPLE DURING IN VITRO TESTING 审中-公开
标题翻译：用于在体外测试中测定样品的装置和方法
公开(公告)号：WO2005105277A1
公开(公告)日：2005-11-10
申请号：PCT/US2005/013568
申请日：2005-04-21
申请人： VARIAN, INC. , SWON, James, E. , FERNANDO, C., J., Anthony
发明人： SWON, James, E. , FERNANDO, C., J., Anthony
IPC分类号： B01F1/00
CPC分类号： B01F11/0082 , B01F13/0818 , B01L99/00
摘要： In an apparatus and method for agitating a sample during dissolution or other in vitro testing, a movable component is disposed in a container for reciprocating or rotating a sample carrier such as a dosage form or stent through a medium in the container. The apparatus can include a closure member to seal the container for substantially preventing loss of contents during movement of the sample carrier. The movable component can be actuated by a driving source in a non-contacting manner. The movable component can include a magnet drivable by a source external to the container. The container can include first and second container sections having different volumes, in which case actuation of the movable component causes agitation of the sample carrier through a medium contained in one of the container sections. The container can include a hole at or near the bottom for filling the container, using instruments, and the like.
摘要翻译：在用于在溶解或其它体外测试期间搅拌样品的装置和方法中，可移动部件设置在用于通过容器中的介质往复或旋转样品载体（例如剂型或支架）的容器中。该装置可以包括封闭构件以密封容器，用于在样品载体移动期间基本上防止内容物的损失。可移动部件可以以非接触的方式由驱动源致动。可移动部件可以包括可由容器外部的源驱动的磁体。容器可以包括具有不同体积的第一和第二容器部分，在这种情况下，活动部件的致动引起样品载体通过容纳在其中一个容器部分中的介质的搅动。容器可以在底部或附近包括用于填充容器的孔，使用仪器等。

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