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1. 发明申请

WO2010079427A1 MODULAR PERCUTANEOUS VALVE STRUCTURE AND DELIVERY METHOD 审中-公开
标题翻译：模块化的经皮瓣膜结构与输送方法
公开(公告)号：WO2010079427A1
公开(公告)日：2010-07-15
申请号：PCT/IB2010/000052
申请日：2010-01-13
申请人： VALVE MEDICAL LTD , RICHTER, Yoram , RICHTER, Jacob
发明人： RICHTER, Yoram , RICHTER, Jacob
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2412 , A61F2/2439 , A61F2220/0033 , A61F2230/0091 , A61F2250/0004 , A61F2250/0008 , A61F2250/006 , Y10T29/49826
摘要： A modular prosthetic valve device for implantation in a patient is disclosed. The valve device is designed as two or more modules to be delivered unassembled and combined into an assembled valve device in the body - e.g., in the body at or near the site where implantation occurs. The two or more modules may be a support structure and a valve assembly. The valve assembly may be formed from two or more valve sections. Because the valve device of the invention is deliverable as modules, it may have a smaller delivery diameter than pre-assembled percutaneous valves and permits use of a delivery device of reduced diameter. Delivering the valve device as modules increases the flexibility of the valve device during delivery, compared to percutaneous valve devices in the art. The invention further provides a system for and method of delivering such a modular valve device and assembling it in vivo. The modules of the valve device may be connected by pull wires for delivery sequentially to or near the implantation site in the body lumen, and then assembled by remote manipulation using the pull wires. The system may further include a temporary valve that may be deployed to maintain valvular function while the device modules are assembled. The temporary valve may be attached to the delivery device and deployed either before or after the support structure is expanded, or the temporary valve may be attached to the support structure and deployed when the support structure is expanded. Various locking mechanisms are provided for attaching the device modules together.
摘要翻译：公开了一种用于植入患者体内的模块化假体瓣膜装置。该阀装置被设计为两个或更多个未组装的组件并且被组合成体内组装的阀装置 - 例如在发生植入的部位处或附近的体内。两个或更多个模块可以是支撑结构和阀组件。阀组件可以由两个或更多个阀部分形成。因为本发明的阀装置可作为模块输送，所以其可具有比预组装的经皮瓣膜更小的输送直径，并且允许使用直径减小的输送装置。与本领域中的经皮瓣膜装置相比，作为模块递送瓣膜装置增加了瓣膜装置在输送期间的灵活性。本发明还提供了一种用于输送这种模块化阀装置并在体内进行装配的系统和方法。阀装置的模块可以通过拉线连接，以顺序地输送到体腔内的植入部位或其附近，然后通过使用拉线的远程操作来组装。该系统可以进一步包括临时阀，该临时阀可以被部署以在装置模块被组装时保持瓣膜功能。临时阀可以连接到输送装置并且在支撑结构扩张之前或之后展开，或者临时阀可以连接到支撑结构并且在支撑结构扩张时展开。提供各种锁定机构用于将设备模块连接在一起。

2. 发明申请

WO2011086401A1 SELF-ASSEMBLING MODULAR PERCUTANEOUS VALVE AND METHODS OF FOLDING, ASSEMBLY AND DELIVERY 审中-公开
标题翻译：自组装模块式阀门及折叠，组装和运输方法
公开(公告)号：WO2011086401A1
公开(公告)日：2011-07-21
申请号：PCT/IB2010/000049
申请日：2010-01-13
申请人： VALVE MEDICAL LTD , RICHTER, Yoram , RICHTER, Jacob , WEISZ, Ety
发明人： RICHTER, Yoram , RICHTER, Jacob , WEISZ, Ety
IPC分类号： A61F2/24
CPC分类号： A61F2/2415 , A61F2/24 , A61F2/2406 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2/844 , A61F2210/0014 , A61F2230/0091 , A61F2250/006
摘要： The present invention provides a modular prosthetic valve device designed as two or more device modules that may be delivered to a body lumen unassembled and then assembled into the assembled valve device in the body at least in part using a self-assembly member at or near the site of valve implantation. The device modules may include a support structure and a valve module. The valve module may be delivered in an unassembled, folded delivery configuration, and unfolded and assembled into a working configuration via the self-assembly member. In its unassembled form, the valve module may be a single-piece leaflets substructure or a plurality of valve sections. The self-assembly member has a delivery configuration and a preset configuration, and may be triggered to revert to the preset configuration to assemble the valve module. The modular valve device may be folded in a manner not possible with current valve devices, for example, by rolling the unassembled valve module along its circumferential axis in the direction of its height, so that the diameter of the folded valve module may be equivalent to that of one rolled leaflet. This feature of the invention provides a percutaneous valve device having a smaller delivery diameter than pre-assembled valve devices. This in turn permits use of a delivery device of reduced diameter and increases the flexibility of the loaded delivery device compared to percutaneous valve devices in the art. The invention further provides a system for and method of folding and delivering such a modular valve device and assembling it using the self-assembly member, preferably in the body.
摘要翻译：本发明提供了一种设计为两个或更多个装置模块的模块化假体瓣膜装置，其可以被输送到未被组装的身体腔体，然后至少部分地使用位于或靠近该组件的自组装构件瓣膜植入部位。装置模块可以包括支撑结构和阀模块。阀模块可以以未组装的折叠输送构造递送，并且经由自组装构件展开并组装成工作构型。在其组装形式中，阀模块可以是单件式叶片子结构或多个阀部分。自组装构件具有输送配置和预设配置，并且可以被触发以恢复到预设配置以组装阀模块。模块化阀装置可以以当前阀装置不可能的方式进行折叠，例如通过沿着其周向轴线在其高度方向上滚动未组装的阀模块，使得折叠的阀模块的直径可以等于一个滚动的小叶。本发明的该特征提供了一种具有比预组装阀装置更小的输送直径的经皮瓣膜装置。这又允许使用减小直径的输送装置，并且与本领域中的经皮瓣膜装置相比增加了装载的输送装置的灵活性。本发明还提供了一种用于折叠和传送这种模块化阀装置的系统和方法，并且使用自组装构件优选地在身体中组装它。

3. 发明申请

WO2010079425A1 SYSTEM AND METHOD FOR PLACING A PERCUTANEOUS VALVE DEVICE 审中-公开
标题翻译：用于配置胰腺瓣装置的系统和方法
公开(公告)号：WO2010079425A1
公开(公告)日：2010-07-15
申请号：PCT/IB2010/000048
申请日：2010-01-13
申请人： VALVE MEDICAL LTD , RICHTER, Yoram , RICHTER, Jacob
发明人： RICHTER, Yoram , RICHTER, Jacob
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2439 , A61F2250/006
摘要： A system and process for placing a percutaneous valve device in a body lumen at the location of implantation is provided. The placement system and method are simple and enhance the accuracy of the placement of the valve device. Anchors and placement wires or sutures are used to fix the implantation target and guide the device to the implantation site. The system and method are applicable to pre-assembled percutaneous valve devices as well as a modular prosthetic valve device, which modular device is also provided. The modular valve device comprises two or more device modules and is designed to be delivered unassembled and then assembled in the body lumen at or near the site where implantation occurs. The device modules may be assembled before or after the implantation target is fixed with the anchor, and then placed using the placement system in a manner similar to how a pre-assembled percutaneous valve device may be placed in accordance with the invention.
摘要翻译：提供了一种用于将经皮瓣膜装置置于植入位置的体腔内的系统和方法。放置系统和方法简单，提高了阀门装置的放置精度。使用锚和放置线或缝线来固定植入物并将装置引导到植入部位。该系统和方法适用于预先组装的经皮瓣膜装置以及还提供了模块化装置的组合式假体瓣膜装置。模块化阀装置包括两个或更多个装置模块，并被设计成未被组装地输送，然后在植入发生的位置处或附近组装在体腔中。装置模块可以在植入对象与锚固件固定之前或之后组装，然后以类似于根据本发明放置预组装的经皮瓣膜装置的方式放置在放置系统中。

4. 发明申请

WO2010079426A1 METHOD AND APPARATUS FOR FINE ADJUSTMENT OF A PERCUTANEOUS VALVE STRUCTURE 审中-公开
标题翻译：精密调节阀门结构的方法和装置
公开(公告)号：WO2010079426A1
公开(公告)日：2010-07-15
申请号：PCT/IB2010/000051
申请日：2010-01-13
申请人： VALVE MEDICAL LTD , RICHTER, Yoram , RICHTER, Jacob , WEISZ, Ety
发明人： RICHTER, Yoram , RICHTER, Jacob , WEISZ, Ety
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2427 , A61F2230/0013 , A61F2250/0006 , A61F2250/0008 , A61F2250/006
摘要： The invention provides a device for fine adjustment of a prosthetic valve device and a method of adjusting the position of a prosthetic valve after implantation. The adjustment mechanism includes complementary structures on a valve member and device frame that cooperate to provide relative axial and/or angular motion between the valve member and device frame (and thus the native vessel). The adjustment mechanism of the invention may also include a means for selectively maintaining the relative position of the valve member and device frame. The device and method are particularly applicable for use with a modular prosthetic valve device that is assembled in the body lumen.
摘要翻译：本发明提供了一种用于精细调节假体瓣膜装置的装置和调节植入后假体瓣膜位置的方法。调节机构包括在阀构件和装置框架上的互补结构，其协作以在阀构件和装置框架之间提供相对的轴向和/或角运动（因此也是本机容器）。本发明的调节机构还可以包括用于选择性地保持阀构件和装置框架的相对位置的装置。该装置和方法特别适用于组装在体腔中的模块化的人造瓣膜装置。

5. 发明授权

EP3061421B1 APPARATUS FOR FINE ADJUSTMENT OF A PERCUTANEOUS VALVE STRUCTURE 有权
公开(公告)号：EP3061421B1
公开(公告)日：2020-07-08
申请号：EP16164467.9
申请日：2010-01-13
申请人： VALVE MEDICAL LTD.
发明人： RICHTER, Yoram , RICHTER, Jacob , WEISZ, Ety
IPC分类号： A61F2/24

6. 发明授权

EP3111890B1 SELF-ASSEMBLING MODULAR PERCUTANEOUS VALVE AND METHODS OF FOLDING, ASSEMBLY AND DELIVERY 有权
公开(公告)号：EP3111890B1
公开(公告)日：2019-05-08
申请号：EP16183064.1
申请日：2010-01-13
申请人： VALVE MEDICAL LTD.
发明人： RICHTER, Yoram , RICHTER, Jacob , WEISZ, Ety
IPC分类号： A61F2/24

7. 发明授权

EP2379010B2 APPARATUS FOR FINE ADJUSTMENT OF A PERCUTANEOUS VALVE STRUCTURE 有权转让
标题翻译：精密调整经皮瓣膜结构的装置
公开(公告)号：EP2379010B2
公开(公告)日：2018-04-04
申请号：EP10702540.5
申请日：2010-01-13
申请人： VALVE MEDICAL LTD.
发明人： RICHTER, Yoram , RICHTER, Jacob , WEISZ, Ety
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2427 , A61F2230/0013 , A61F2250/0006 , A61F2250/0008 , A61F2250/006
摘要： The invention provides a device for fine adjustment of a prosthetic valve device and a method of adjusting the position of a prosthetic valve after implantation. The adjustment mechanism includes complementary structures on a valve member and device frame that cooperate to provide relative axial and/or angular motion between the valve member and device frame (and thus the native vessel). The adjustment mechanism of the invention may also include a means for selectively maintaining the relative position of the valve member and device frame. The device and method are particularly applicable for use with a modular prosthetic valve device that is assembled in the body lumen.

8. 发明授权

EP2982338B1 MODULAR PERCUTANEOUS VALVE STRUCTURE 有权
标题翻译：模块化的经皮瓣膜结构
公开(公告)号：EP2982338B1
公开(公告)日：2017-11-01
申请号：EP15182656.7
申请日：2010-01-13
申请人： VALVE MEDICAL LTD.
发明人： RICHTER, Jacob , RICHTER, Yoram
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2412 , A61F2/2439 , A61F2220/0033 , A61F2230/0091 , A61F2250/0004 , A61F2250/0008 , A61F2250/006 , Y10T29/49826

9. 发明公开

EP2379011A1 MODULAR PERCUTANEOUS VALVE STRUCTURE AND DELIVERY METHOD 有权转让
标题翻译： MODULARE PERKUTANE KLAPPENSTRUKTUR SOWIE EINSATZVERFAHRENDAFÜR
公开(公告)号：EP2379011A1
公开(公告)日：2011-10-26
申请号：EP10702541.3
申请日：2010-01-13
申请人： Valve Medical Ltd
发明人： RICHTER, Yoram , RICHTER, Jacob
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2412 , A61F2/2439 , A61F2220/0033 , A61F2230/0091 , A61F2250/0004 , A61F2250/0008 , A61F2250/006 , Y10T29/49826
摘要： A modular prosthetic valve device for implantation in a patient is disclosed. The valve device is designed as two or more modules to be delivered unassembled and combined into an assembled valve device in the body - e.g., in the body at or near the site where implantation occurs. The two or more modules may be a support structure and a valve assembly. The valve assembly may be formed from two or more valve sections. Because the valve device of the invention is deliverable as modules, it may have a smaller delivery diameter than pre-assembled percutaneous valves and permits use of a delivery device of reduced diameter. Delivering the valve device as modules increases the flexibility of the valve device during delivery, compared to percutaneous valve devices in the art. The invention further provides a system for and method of delivering such a modular valve device and assembling it in vivo. The modules of the valve device may be connected by pull wires for delivery sequentially to or near the implantation site in the body lumen, and then assembled by remote manipulation using the pull wires. The system may further include a temporary valve that may be deployed to maintain valvular function while the device modules are assembled. The temporary valve may be attached to the delivery device and deployed either before or after the support structure is expanded, or the temporary valve may be attached to the support structure and deployed when the support structure is expanded. Various locking mechanisms are provided for attaching the device modules together.
摘要翻译：公开了一种用于植入患者体内的组合式假体瓣膜装置。阀装置被设计为两个或更多个模块，其被未组装地输送并组合到主体中的组装的阀装置中，例如在植入发生的位置处或附近的身体中。两个或更多个模块可以是支撑结构和阀组件。阀组件可以由两个或更多个阀部分形成。因为本发明的阀装置作为模块可输送，所以它可以具有比预组装的经皮瓣更小的输送直径，并允许使用减小直径的输送装置。与本领域的经皮瓣膜装置相比，将阀装置作为模块递送增加了瓣膜装置在输送过程中的灵活性。本发明还提供了一种递送这种模块化阀装置并在体内组装它的系统和方法。阀装置的模块可以通过拉线连接以顺序地输送到体腔内的植入部位或其附近，然后通过使用拉线进行远程操作来组装。该系统还可以包括临时阀，其可以部署以在装置模块组装时维持阀瓣功能。临时阀可以附接到输送装置并且在支撑结构膨胀之前或之后展开，或者临时阀可以附接到支撑结构并且在支撑结构膨胀时展开。提供了各种锁定机构用于将装置模块连接在一起。

10. 发明公开

EP3061421A1 APPARATUS FOR FINE ADJUSTMENT OF A PERCUTANEOUS VALVE STRUCTURE 有权
标题翻译： VORRICHTUNG ZUR FEINEINSTELLUNG EINER PERKUTANEN KLAPPENSTRUKTUR
公开(公告)号：EP3061421A1
公开(公告)日：2016-08-31
申请号：EP16164467.9
申请日：2010-01-13
申请人： VALVE MEDICAL LTD.
发明人： RICHTER, Yoram , RICHTER, Jacob , WEISZ, Ety
IPC分类号： A61F2/24
摘要： The invention provides a device for fine adjustment of a prosthetic valve device and a method of adjusting the position of a prosthetic valve after implantation. The adjustment mechanism includes complementary structures on a valve member and device frame that cooperate to provide relative axial and/or angular motion between the valve member and device frame (and thus the native vessel). The adjustment mechanism of the invention may also include a means for selectively maintaining the relative position of the valve member and device frame. The device and method are particularly applicable for use with a modular prosthetic valve device that is assembled in the body lumen.
摘要翻译：本发明提供了一种用于精细调节假体瓣膜装置的装置和调节植入后假体瓣膜位置的方法。调节机构包括在阀构件和装置框架上的互补结构，其协作以在阀构件和装置框架（以及因此的天然容器）之间提供相对的轴向和/或角运动。本发明的调节机构还可以包括用于选择性地保持阀构件和装置框架的相对位置的装置。该装置和方法特别适用于组装在体腔中的组合式假体瓣膜装置。

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