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1. 发明授权

US07060192B2 Methods of fabricating physiological sample collection devices 有权
公开(公告)号：US07060192B2
公开(公告)日：2006-06-13
申请号：US10143127
申请日：2002-05-09
申请人： Vadim V Yuzhakov , Devin V. McAllister , Lorin Olson , Koon-wah Leong , Maria Teodorczyk , Ernest Kiser
发明人： Vadim V Yuzhakov , Devin V. McAllister , Lorin Olson , Koon-wah Leong , Maria Teodorczyk , Ernest Kiser
IPC分类号： B32B31/00 , C03C25/68
CPC分类号： A61B5/15146 , A61B5/150022 , A61B5/150068 , A61B5/150099 , A61B5/150282 , A61B5/150358 , A61B5/150419 , A61B5/150435 , A61B5/150954 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15153 , A61B5/15184 , A61B5/1519 , A61B5/15194 , A61B5/157
摘要： Methods of fabricating devices for collecting a sample of physiological and for measuring a characteristic, e.g., an analyte concentration, of the sampled physiological sample. The devices are in the form of a test strip which include a biosensor and at least one skin-piercing element which is a planar extension of a portion of the biosensor. The fabrication methods provide various or forming the test strip and the skin-piercing element.

2. 发明申请

US20060100656A1 Compact lancing device 审中-公开
标题翻译：紧凑型穿刺装置
公开(公告)号：US20060100656A1
公开(公告)日：2006-05-11
申请号：US10975517
申请日：2004-10-28
申请人： Lorin Olson , Koon-Wah Leong
发明人： Lorin Olson , Koon-Wah Leong
IPC分类号： A61B17/32
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/150152 , A61B5/150183 , A61B5/150259 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150824 , A61B5/15113 , A61B5/15117 , A61B5/1513 , A61B5/1519 , A61B5/15194 , A61B17/32093
摘要： A compact lancing includes a housing, a moveable lancet holder disposed within the housing and configured to hold a lancet, a launching mechanism disposed within the housing, and arming and trigger mechanisms disposed at least partially within the housing. In addition, the launching mechanism includes a launch spring and a retraction spring. The lancet holder, launching mechanism, arming mechanism and trigger mechanism are operatively connected to lance a target site with a lancet held by the moveable lancet holder. In addition, the retraction spring is configured in an essentially concentric arrangement with the launch spring, thereby providing for compactness in design.
摘要翻译：小型穿刺包括壳体，可移动的柳叶刀夹持器，其设置在壳体内并且构造成保持刺血针，设置在壳体内的发射机构，以及至少部分地设置在壳体内的布置和触发机构。此外，发射机构包括发射弹簧和缩回弹簧。柳叶刀座，发射机构，布防机构和触发机构可操作地连接到用可移动的刺血针保持器保持的刺血针的目标位置。此外，缩回弹簧被构造成与发射弹簧基本上同心的布置，从而提供设计的紧凑性。

3. 发明申请

US20060100655A1 Combined lancing and auxiliary device 审中-公开
标题翻译：组合穿刺和辅助装置
公开(公告)号：US20060100655A1
公开(公告)日：2006-05-11
申请号：US10975234
申请日：2004-10-28
申请人： Koon-Wah Leong , Priya Talreja , Lorin Olson
发明人： Koon-Wah Leong , Priya Talreja , Lorin Olson
IPC分类号： A61B17/32
CPC分类号： A61B5/15186
摘要： A combined lancing and auxiliary device includes a lancing device with a lancing auxiliary device attached thereto. The lancing auxiliary device can be, for example, a compartment for securely and removably containing items associated or unassociated with lancing, a timer or personal digital assistant device for assisting in documentation, or an illumination device for illuminating a target site. The lancing auxiliary device can be permanently or removably attached to the lancing device.
摘要翻译：组合的穿刺和辅助装置包括具有连接到其上的穿刺辅助装置的穿刺装置。穿刺辅助装置可以是例如用于牢固地和可移除地包含与穿刺相关联或不相关的物品的隔室，用于辅助文件的定时器或个人数字助理装置或用于照射目标地点的照明装置。穿刺辅助装置可以永久地或可拆卸地附接到穿刺装置。

4. 发明授权

US07097631B2 Self-actuating applicator for microprojection array 有权
标题翻译：用于微喷射阵列的自动执行器
公开(公告)号：US07097631B2
公开(公告)日：2006-08-29
申请号：US10971871
申请日：2004-10-21
申请人： Joseph C. Trautman , Lorin Olson
发明人： Joseph C. Trautman , Lorin Olson
IPC分类号： A61B17/20
CPC分类号： A61M37/0015 , A61B17/205 , A61B2017/925 , A61M2037/0023 , A61M2037/0038 , A61M2037/0046
摘要： An applicator for applying a microprojection member to the stratum corneum of a patient having a housing, a piston moveable within the housing and a cap adapted to activate the applicator. The applicator is self-setting and auto-triggering, which allows the applicator to be used by patient's having neither the strength, nor the manual dexterity to pre-set and activate other types of applicator devices.
摘要翻译：一种用于将微突出物构件施加到具有壳体的患者的角质层的施加器，可在壳体内移动的活塞和适于激活施用器的帽。施用器是自设置和自动触发，其允许患者既不具有强度也不使用手动灵巧来使用施用器来预先设定和激活其它类型的施用器具。

5. 发明授权

US06866822B1 Gimbaled bladder actuator for use with test strips 有权
标题翻译：平衡式气囊执行器，用于测试条
公开(公告)号：US06866822B1
公开(公告)日：2005-03-15
申请号：US09637504
申请日：2000-08-11
申请人： Allen House , Lorin Olson
发明人： Allen House , Lorin Olson
IPC分类号： G01N1/00 , B01L3/00 , B01L9/00 , G01N21/01 , G01N21/11 , G01N21/59 , G01N35/04 , G01N35/10 , G01N37/00 , G01N33/48
CPC分类号： B01L3/50273 , B01L9/52 , B01L2300/0825 , B01L2300/0864 , B01L2400/0481 , B01L2400/0688 , Y10T436/114165
摘要： Gimbaled bladder actuators and methods for their use in compressing bladders present on test strips are provided. The subject actuators are characterized by the presence of a gimbaled compression pad under movement control of an actuating means, preferably an automated actuating means. Also provided are meters for reading test strips that include bladders, where the meters include the subject gimbaled bladder actuators.
摘要翻译：提供了平衡式膀胱致动器及其用于压缩测试条上存在的气囊的方法。主体致动器的特征在于在致动装置的运动控制下存在万向压缩垫，优选地是自动致动装置。还提供了用于读取包括气囊的测试条的仪表，其中仪表包括主体万向气囊致动器。

6. 发明授权

US06652814B1 Strip holder for use in a test strip meter 失效
标题翻译：带状支架用于试纸表
公开(公告)号：US06652814B1
公开(公告)日：2003-11-25
申请号：US09637466
申请日：2000-08-11
申请人： Allen House , Lorin Olson
发明人： Allen House , Lorin Olson
IPC分类号： B01L900
CPC分类号： G01N21/8483 , B01L3/5027 , B01L9/52 , B01L2200/025 , B01L2200/141 , B01L2300/0822 , B01L2400/0406 , Y10T436/25
摘要： Test strip holders for use with test strip meters are provided. The subject test strip holders include at least an opening and a lip associated with the opening. The lip element of the subject holders is capable of forming a liquid seal with the upper surface of a test strip upon insertion of the test strip into the opening. In many embodiments, the strip holder is configured to at least partially encompass a sample application region of a test strip upon insertion of the strip into the opening. Also provided are meters on which the subject test holders are present, as well as methods for using the same.
摘要翻译：提供用于测试条表的测试条夹。被测试条保持器至少包括与开口相关联的开口和唇缘。当将测试条插入开口时，被检体保持器的唇部元件能够与测试条的上表面形成液体密封。在许多实施例中，条带保持器构造成在将带插入开口中时至少部分地包围测试条的样本施加区域。还提供了目标测试持有人所在的仪表，以及使用它们的方法。

7. 发明授权

US07303726B2 Minimal procedure analyte test system 有权
标题翻译：最小程序分析物测试系统
公开(公告)号：US07303726B2
公开(公告)日：2007-12-04
申请号：US10142443
申请日：2002-05-09
申请人： Devin McAllister , Lorin Olson , Borzu Sohrab
发明人： Devin McAllister , Lorin Olson , Borzu Sohrab
IPC分类号： G01N33/49
CPC分类号： A61B5/14532 , A61B5/150022 , A61B5/15019 , A61B5/150198 , A61B5/150259 , A61B5/150358 , A61B5/150419 , A61B5/150427 , A61B5/150435 , A61B5/150824 , A61B5/15111 , A61B5/15117 , A61B5/15153 , A61B5/15174 , A61B5/15176 , A61B5/1518 , A61B5/15182 , A61B5/15184 , A61B5/157 , G06F19/00
摘要： A system employing an integrated analyte test strip including a biosensor and lancet is disclosed. The integration of lancet and the sensor elements eliminates the need to align the sensor to the biologic fluid sample after a lancet and lancing device are used in combination to pierce the skin. The system preferably includes a device comprising two body portions that slide relative to each other to both cock and fire a test strip at a target site. Meter reading and test strip disposal may be accomplished by removing the device from the target site. The device preferably employs a magazine loaded with test strips, with one strip being taken from the magazine each time the device is actuated. It preferably also includes a magazine in a cap to store spent test strips for disposal. The device may be turned on an off simply by removal and return of the cap.
摘要翻译：公开了一种采用包括生物传感器和刺血针的综合分析物测试条的系统。柳叶刀和传感器元件的集成消除了在将刺血针和穿刺装置组合用于刺穿皮肤之后将传感器对准生物液体样品的需要。该系统优选地包括一个装置，该装置包括相对于彼此滑动的两个主体部分，以在目标位置处旋转并起火测试条。仪表读数和测试条处理可以通过从目标位置移除设备来实现。该装置优选地采用装载有测试条的仓库，每当该装置被致动时，一个条带从该仓中取出。它还优选地还包括一个盖子中的杂志，以存储用于处置的用过的测试条。可以简单地通过去除和返回盖来关闭装置。

8. 发明申请

US20050085839A1 Lancing device with a floating probe for control of penetration depth 有权
标题翻译：采用浮动探头对穿刺深度进行控制
公开(公告)号：US20050085839A1
公开(公告)日：2005-04-21
申请号：US10690083
申请日：2003-10-20
申请人： John Allen , Lorin Olson , Alan Doop
发明人： John Allen , Lorin Olson , Alan Doop
IPC分类号： A61B5/151 , A61B5/15 , A61B17/00 , A61B17/3211 , A61M5/46 , A61M5/48 , A61B17/32
CPC分类号： A61B5/15194 , A61B5/150022 , A61B5/150068 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/15113 , A61B5/15117 , A61B5/1519
摘要： A lancing device includes a lancing mechanism, a floating probe and a pressure tip. The lancing mechanism includes a lancet carriage, a lancet holder slidably connected to the lancet carriage, and a lancet attached to the lancet holder. The pressure tip of the lancing device is configured for engaging a target site and creating a target site bulge. The floating probe is adapted to floatably contact the target site bulge and to operatively interact with the lance carriage to control a penetration depth of the lancet into the target site bulge. A method for lancing a target site includes providing the lancing device describe above and contacting the pressure tip of the lancing device with the target site. The pressure tip is then urged towards the target site to create a target site bulge with the floating probe of the lancing device floating on a surface of the target site bulge. Next, the target site bulge is lanced while the floating probe operatively interacts with the lance carriage to control a penetration depth of the lancet.
摘要翻译：采血装置包括采血机构，浮动探头和压力尖。所述切断机构包括：柳叶刀托架，可与所述柳叶刀托架滑动连接的刺血针托架，以及连接于所述刺血针托架的刺血针。穿刺装置的压力尖端被配置用于接合目标部位并创建目标部位凸起。浮动探针适于与目标部位凸起浮动接触并且与喷枪托架可操作地相互作用以控制刺血针进入目标部位凸起的穿透深度。用于穿刺目标部位的方法包括提供上述描述的穿刺装置，并将穿刺装置的压力尖端与目标部位接触。然后将压力尖端朝向目标部位推动以产生目标部位隆起，其中穿刺装置的浮动探针浮在目标部位隆起物的表面上。接下来，在浮动探针与喷枪托架可操作地相互作用以控制刺血针的穿透深度的同时，靶部位凸起被拉平。

9. 发明授权

US06749792B2 Micro-needles and methods of manufacture and use thereof 失效
标题翻译：微针及其制造方法及其应用
公开(公告)号：US06749792B2
公开(公告)日：2004-06-15
申请号：US09901535
申请日：2001-07-09
申请人： Lorin Olson
发明人： Lorin Olson
IPC分类号： B29C4500
CPC分类号： A61M37/0015 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150282 , A61B5/150984 , A61B2010/008 , A61M2037/003 , A61M2037/0053
摘要： A micro-needle is provided which is particularly useful for the minimally invasive sampling of a biological fluid and/or the minimally invasive delivery of a drug or other formulation across the skin. The micro-needle has a structure having a base at a proximal end and a vertex at a distal end, and an open lumen extending there through and through which fluid may be transferred. The structure defines a structural axis that intersects the lumenal axis defined by the open lumen. The point of intersection between these axes is at a point below the vertex of the micro-needle to provide a sharp apex at the distal end of the micro-needle and defines the general configuration of the distal end of the micro-needle, which may be selected or customized depending on the intended use of the microneedle. The micro-needle may be integral with a measurement device for measuring the concentration of a constituent within sampled biological fluid and/or with a fluid reservoir for containing a fluid to be delivered, and may also be used in conjunction with a remote control means. Methods of making and using the micro-needle of the present invention as well as kits comprising one or more of the micro-needles are also provided.
摘要翻译：提供了一种微针，其特别适用于生物流体的微创取样和/或通过皮肤的药物或其它制剂的微创输送。微针具有在近端具有基部并且在远端具有顶点的结构，以及在其上延伸并且流体可被传送的开放腔。该结构限定了与由开口腔限定的内腔轴相交的结构轴线。这些轴之间的交点位于微针的顶点以下，在微针的远端处提供尖锐的尖端，并且限定了微针的远端的一般结构，根据微针的预期用途进行选择或定制。微针可以与用于测量采样的生物流体中的组分浓度和/或用于容纳要输送的流体的流体储存器的测量装置成一体，并且还可以与遥控装置结合使用。还提供了制造和使用本发明的微针的方法以及包括一个或多个微针的试剂盒。

10. 发明授权

US6119295A Brush assembly apparatus 有权
标题翻译：刷子装配装置
公开(公告)号：US6119295A
公开(公告)日：2000-09-19
申请号：US285356
申请日：1999-04-02
申请人： Thomas R. Gockel , Lorin Olson , Lynn Ryle , Brett A. Whitelaw
发明人： Thomas R. Gockel , Lorin Olson , Lynn Ryle , Brett A. Whitelaw
IPC分类号： H01L21/304 , A46B13/02 , B08B1/04 , B24B29/02 , B24B37/04 , H01L21/00 , B08B11/00 , B08B13/00
CPC分类号： H01L21/67046 , B08B1/04 , B24B29/02 , B24B37/04 , H01L21/67028
摘要： A semiconductor processing system, such as a system for scrubbing both sides of a wafer at the same time, that includes a brush box containment apparatus for use with highly-acidic or other volatile chemical solutions, a roller positioning apparatus and a (brush) placement device.
摘要翻译：半导体处理系统，例如用于同时洗涤晶片的两侧的系统，其包括用于与高酸性或其它挥发性化学溶液一起使用的刷盒容纳装置，辊定位装置和（刷）放置设备。

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