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1. 发明申请

US20070179368A1 Method of recognizing abnormal tissue using the detection of early increase in microvascular blood content 审中-公开
标题翻译：使用检测微血管血液含量早期增加来识别异常组织的方法
公开(公告)号：US20070179368A1
公开(公告)日：2007-08-02
申请号：US11604653
申请日：2006-11-27
申请人： Vadim Backman , Hemant Roy , Ramesh Wali , Young Kim , Michael Siegel , Vladimir Turzhitsky
发明人： Vadim Backman , Hemant Roy , Ramesh Wali , Young Kim , Michael Siegel , Vladimir Turzhitsky
IPC分类号： A61B5/00
CPC分类号： A61B5/0261 , A61B5/0075 , A61B5/0084 , A61B5/0091 , A61B5/1459
摘要： The present invention, in one aspect, relates to a method for examining a target for tumors or lesions using what is referred to as “Early Increase in microvascular Blood Supply” (EIBS) that exists in tissues that are close to, but are not themselves, the abnormal tissue and in tissues that precede the development of such lesions or tumors. While the abnormal tissue can be a lesion or tumor, the abnormal tissue can also be tissue that precedes formation of a lesion or tumor, such as a precancerous adenoma, aberrant crypt foci, tissues that precede the development of dysplastic lesions that themselves do not yet exhibit dysplastic phenotype, and tissues in the vicinity of these lesions or pre-dysplastic tissues.
摘要翻译：本发明在一个方面涉及使用所谓的“微血管供血的早期增加”（EIBS）来检查肿瘤或病变的靶标的方法，所述方法存在于接近但不是本身的组织中，异常组织和在这些损伤或肿瘤的发展之前的组织中。虽然异常组织可以是病变或肿瘤，但是异常组织也可以是在形成病变或肿瘤之前的组织，例如癌前腺瘤，异常隐窝灶，在发育不良的病变之前的组织，其本身还没有表现出发育不良的表型，以及这些损伤或发育不良前组织附近的组织。

2. 发明申请

US20060155178A1 Multi-dimensional elastic light scattering 审中-公开
标题翻译：多维弹性光散射
公开(公告)号：US20060155178A1
公开(公告)日：2006-07-13
申请号：US11261452
申请日：2005-10-27
申请人： Vadim Backman , Hemant Roy , Ramesh Wali , Young Kim , Yang Liu , Guillermo Ameer , Jian Yang , Antonio Webb , Josephine Allen
发明人： Vadim Backman , Hemant Roy , Ramesh Wali , Young Kim , Yang Liu , Guillermo Ameer , Jian Yang , Antonio Webb , Josephine Allen
IPC分类号： A61B5/00
CPC分类号： G01N33/48
摘要： A method of examining a sample includes measuring, as function of wavelength of light elastically scattered from the sample, at least 2 properties, selected from the group consisting of scattering angle theta of the light, scattering angle phi of the light, and polarization of the light. The scattering angle theta is an angle between backward direction and direction of propagation of the light, and scattering angle phi is an angle between incident light polarization and projection of direction of the light propagation onto a plane in which incident electric field oscillates.
摘要翻译：检查样品的方法包括测量作为从样品弹性散射的光的波长的函数，至少选自由光的散射角度θ，光的散射角度phi和光的偏振度光。散射角θ是光的向后方向和传播方向之间的角度，散射角φi是入射光偏振与入射电场振荡的平面上的光传播方向的投影之间的角度。

3. 发明授权

US07652772B2 Systems, methods, and apparatuses of low-coherence enhanced backscattering spectroscopy 有权
标题翻译：低相干增强后向散射光谱的系统，方法和装置
公开(公告)号：US07652772B2
公开(公告)日：2010-01-26
申请号：US11803029
申请日：2007-05-11
申请人： Vadim Backman , Hemant Roy , Young Kim , Yang Liu , Vladimir Turzhitsky , Jeremy Rogers
发明人： Vadim Backman , Hemant Roy , Young Kim , Yang Liu , Vladimir Turzhitsky , Jeremy Rogers
IPC分类号： G01B9/02
CPC分类号： G01J3/4412 , G01J3/02 , G01J3/0221 , G01J3/0224 , G01J3/10 , G01N21/31 , G01N21/47 , G01N2021/4709
摘要： Systems, methods, and apparatuses of low-coherence enhanced backscattering spectroscopy are described within this application. One embodiment includes providing incident light comprising at least one spectral component having low coherence, wherein the incident light is to be illuminated on a target object in vivo. An intensity of one or more of at least one spectral component and at least one angular component of backscattering angle of backscattered light is recorded, wherein the backscattered light is to be backscattered from illumination of the incident light on the target object and wherein the backscattering angle is an angle between incident light propagation direction and backscattered light propagation direction. The intensity of the at least one spectral component and the at least one backscattering angle of backscattered light is analyzed, to obtain one or more optical markers of the backscattered light, toward evaluating said properties.
摘要翻译：本申请中描述了低相干增强后向散射光谱的系统，方法和装置。一个实施例包括提供包括具有低相干性的至少一个光谱分量的入射光，其中入射光将在体内照射在目标物体上。记录至少一个光谱分量中的一个或多个光束分量和至少一个后向散射光的后向散射角度的角度分量的强度，其中后向散射光将从目标物体上入射光的照射反向散射，并且其中后向散射角是入射光传播方向和反向散射光传播方向之间的角度。分析至少一个光谱分量的强度和背散射光的至少一个后向散射角度，以获得反向散射光的一个或多个光学标记，以评估所述性质。

4. 发明申请

US20080037024A1 Systems, methods, and apparatuses of low-coherence enhanced backscattering spectroscopy 有权
标题翻译：低相干增强后向散射光谱的系统，方法和装置
公开(公告)号：US20080037024A1
公开(公告)日：2008-02-14
申请号：US11803029
申请日：2007-05-11
申请人： Vadim Backman , Hermant Roy , Young Kim , Yang Liu , Vladimir Turzhitsky , Jeremy Rogers
发明人： Vadim Backman , Hermant Roy , Young Kim , Yang Liu , Vladimir Turzhitsky , Jeremy Rogers
IPC分类号： G01N21/47
CPC分类号： G01J3/4412 , G01J3/02 , G01J3/0221 , G01J3/0224 , G01J3/10 , G01N21/31 , G01N21/47 , G01N2021/4709
摘要： Systems, methods, and apparatuses of low-coherence enhanced backscattering spectroscopy are described within this application. One embodiment includes providing incident light comprising at least one spectral component having low coherence, wherein the incident light is to be illuminated on a target object in vivo. An intensity of one or more of at least one spectral component and at least one angular component of backscattering angle of backscattered light is recorded, wherein the backscattered light is to be backscattered from illumination of the incident light on the target object and wherein the backscattering angle is an angle between incident light propagation direction and backscattered light propagation direction. The intensity of the at least one spectral component and the at least one backscattering angle of backscattered light is analyzed, to obtain one or more optical markers of the backscattered light, toward evaluating said properties.
摘要翻译：本申请中描述了低相干增强后向散射光谱的系统，方法和装置。一个实施例包括提供包括具有低相干性的至少一个光谱分量的入射光，其中入射光将在体内照射在目标物体上。记录至少一个光谱分量中的一个或多个光束分量和至少一个后向散射光的后向散射角度的角度分量的强度，其中后向散射光将从目标物体上入射光的照射反向散射，并且其中后向散射角是入射光传播方向和反向散射光传播方向之间的角度。分析至少一个光谱分量的强度和背散射光的至少一个后向散射角度，以获得反向散射光的一个或多个光学标记，以评估所述性质。

5. 发明申请

US20080278713A1 Method for identifying refractive-index fluctuations of a target 有权
$Method for identifying refractive-index fluctuations of a target$
标题翻译：用于识别目标的折射率波动的方法
公开(公告)号：US20080278713A1
公开(公告)日：2008-11-13
申请号：US11891877
申请日：2007-08-13
申请人： Vadim Backman , Yang Liu , Young Kim , Hemant Roy , Michael Goldberg , Randall Brand , Prabhakar Pradhan , Hariharan Subramanian
发明人： Vadim Backman , Yang Liu , Young Kim , Hemant Roy , Michael Goldberg , Randall Brand , Prabhakar Pradhan , Hariharan Subramanian
IPC分类号： G01N21/41 , G01N21/55
CPC分类号： G01N21/49 , A61B5/0062 , A61B5/0068 , A61B5/0075 , A61B5/0084 , G01N2021/4709
摘要： Systems and methods for identifying refractive-index fluctuations of a target are described in this application. One embodiment includes identifying one or more properties of emergent light, the emergent light to be emergent from a target, and determining refractive-index fluctuations of the target based on the one or more properties of the emergent light. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive-index fluctuations and the spatial correlation length of the refractive-index fluctuations. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive-index fluctuations and the spatial correlation length of the refractive-index fluctuations.
摘要翻译：在本申请中描述了用于识别目标的折射率波动的系统和方法。一个实施例包括识别出射光的一个或多个属性，从目标出射的出射光，以及基于出射光的一个或多个属性来确定目标的折射率波动。确定折射率波动还包括确定折射率波动的方差和折射率波动的空间相关长度的一个或多个。确定折射率波动还包括确定折射率波动的方差和折射率波动的空间相关长度的一个或多个。

6. 发明授权

US07800746B2 Method for identifying refractive-index fluctuations of a target 有权
$Method for identifying refractive-index fluctuations of a target$
标题翻译：用于识别目标的折射率波动的方法
公开(公告)号：US07800746B2
公开(公告)日：2010-09-21
申请号：US11891877
申请日：2007-08-13
申请人： Vadim Backman , Yang Liu , Young Kim , Hemant Roy , Michael Goldberg , Randall Brand , Prabhakar Pradhan , Hariharan Subramanian
发明人： Vadim Backman , Yang Liu , Young Kim , Hemant Roy , Michael Goldberg , Randall Brand , Prabhakar Pradhan , Hariharan Subramanian
IPC分类号： G01N21/41
CPC分类号： G01N21/49 , A61B5/0062 , A61B5/0068 , A61B5/0075 , A61B5/0084 , G01N2021/4709
摘要： Systems and methods for identifying refractive-index fluctuations of a target are described in this application. One embodiment includes identifying one or more properties of emergent light, the emergent light to be emergent from a target, and determining refractive-index fluctuations of the target based on the one or more properties of the emergent light. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive-index fluctuations and the spatial correlation length of the refractive-index fluctuations. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive-index fluctuations and the spatial correlation length of the refractive-index fluctuations.
摘要翻译：在本申请中描述了用于识别目标的折射率波动的系统和方法。一个实施例包括识别出射光的一个或多个属性，从目标出射的出射光，以及基于出射光的一个或多个属性来确定目标的折射率波动。确定折射率波动还包括确定折射率波动的方差和折射率波动的空间相关长度的一个或多个。确定折射率波动还包括确定折射率波动的方差和折射率波动的空间相关长度的一个或多个。

7. 发明申请

US20070129615A1 Apparatus for recognizing abnormal tissue using the detection of early increase in microvascular blood content 审中-公开
标题翻译：使用检测微血管血液含量的早期增加识别异常组织的装置
公开(公告)号：US20070129615A1
公开(公告)日：2007-06-07
申请号：US11604659
申请日：2006-11-27
申请人： Vadim Backman , Hemant Roy , Young Kim , Yang Liu
发明人： Vadim Backman , Hemant Roy , Young Kim , Yang Liu
IPC分类号： A61B5/00
CPC分类号： A61B5/0261 , A61B5/0075 , A61B5/0084 , A61B5/0091 , A61B5/1459 , A61B2560/0443 , A61B2562/0242 , G01N33/48
摘要： The present invention relates to probe apparatuses and component combinations thereof that are used to recognize possibly abnormal living tissue using a detected early increase in microvascular blood supply and corresponding applications. In one embodiment there is disclosed an apparatus that emits broadband light obtained from a light source onto microvasculature of tissue disposed within a human body and receives interacted light that is obtained from interaction of the broadband light with the microvasculature for transmission to a receiver. Different further embodiments include combinations of optical fibers, polarizers and lenses that assist in the selection of a predetermined depth profile of interacted light. In another embodiment, a kit apparatus is described that has various probe tips and/or light transmission elements that provide for various combinations of predetermined depth profiles of interacted light. In a further embodiment, a method of making a spectral data probe for a depth range detection selectivity for detection of blood within microvasculature of tissue is described.
摘要翻译：本发明涉及用于利用检测到的微血管血液供应的早期增加和相应应用来识别可能的异常活体组织的探针装置及其组分组合。在一个实施例中，公开了一种将从光源发射的宽带光发射到设置在人体内的组织的微血管上的装置，并且接收从宽带光与微血管系统的相互作用获得的相互作用的光，以便传输到接收器。不同的另外的实施例包括有助于选择相互作用的光的预定深度分布的光纤，偏振器和透镜的组合。在另一个实施例中，描述了具有各种探针尖端和/或光透射元件的套件装置，其提供了相互作用的光的预定深度分布的各种组合。在另一个实施方案中，描述了制备用于检测组织微血管内的血液的深度范围检测选择性的光谱数据探针的方法。

8. 发明申请

US20080180664A1 System for identifying refractive-index fluctuations of a target 有权
$System for identifying refractive-index fluctuations of a target$
标题翻译：用于识别目标的折射率波动的系统
公开(公告)号：US20080180664A1
公开(公告)日：2008-07-31
申请号：US11891884
申请日：2007-08-13
申请人： Vadim Backman , Yang Liu , Young Kim
发明人： Vadim Backman , Yang Liu , Young Kim
IPC分类号： G01J3/30
CPC分类号： G01N21/49 , A61B5/0062 , A61B5/0068 , A61B5/0075 , A61B5/0084 , G01N2021/4709
摘要： Systems and methods for identifying refractive-index fluctuations of a target are described in this application. One embodiment includes identifying one or more properties of emergent light, the emergent light to be emergent from a target, and determining refractive-index fluctuations of the target based on the one or more properties of the emergent light. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive-index fluctuations and the spatial correlation length of the refractive-index fluctuations. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive-index fluctuations and the spatial correlation length of the refractive-index fluctuations.
摘要翻译：在本申请中描述了用于识别目标的折射率波动的系统和方法。一个实施例包括识别出射光的一个或多个属性，从目标出射的出射光，以及基于出射光的一个或多个属性来确定目标的折射率波动。确定折射率波动还包括确定折射率波动的方差和折射率波动的空间相关长度的一个或多个。确定折射率波动还包括确定折射率波动的方差和折射率波动的空间相关长度的一个或多个。

9. 发明授权

US07667832B2 System for identifying refractive-index fluctuations of a target 有权
$System for identifying refractive-index fluctuations of a target$
标题翻译：用于识别目标的折射率波动的系统
公开(公告)号：US07667832B2
公开(公告)日：2010-02-23
申请号：US11891884
申请日：2007-08-13
申请人： Vadim Backman , Yang Liu , Young Kim
发明人： Vadim Backman , Yang Liu , Young Kim
IPC分类号： G01N21/41
CPC分类号： G01N21/49 , A61B5/0062 , A61B5/0068 , A61B5/0075 , A61B5/0084 , G01N2021/4709
摘要： Systems and methods for identifying refractive-index fluctuations of a target are described in this application. One embodiment includes identifying one or more properties of emergent light, the emergent light to be emergent from a target, and determining refractive-index fluctuations of the target based on the one or more properties of the emergent light. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive-index fluctuations and the spatial correlation length of the refractive-index fluctuations. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive-index fluctuations and the spatial correlation length of the refractive-index fluctuations.
摘要翻译：在本申请中描述了用于识别目标的折射率波动的系统和方法。一个实施例包括识别出射光的一个或多个属性，从目标出射的出射光，以及基于出射光的一个或多个属性来确定目标的折射率波动。确定折射率波动还包括确定折射率波动的方差和折射率波动的空间相关长度的一个或多个。确定折射率波动还包括确定折射率波动的方差和折射率波动的空间相关长度的一个或多个。

10. 发明申请

US20070212965A1 SCRUB PAD WITH PRINTED RIGID PLATES AND ASSOCIATED METHODS 审中-公开
标题翻译：具有印刷刚性板的SCRUB PAD和相关方法
公开(公告)号：US20070212965A1
公开(公告)日：2007-09-13
申请号：US11748941
申请日：2007-05-15
申请人： Nicole Smith , Young Kim , Hong Ji , Young Kim
发明人： Nicole Smith , Young Kim , Hong Ji , Young Kim
IPC分类号： B32B5/18 , B32B5/22
CPC分类号： B32B5/26 , A41D31/245 , A45D2200/1018 , A45D2200/1054 , A45D2200/1063 , A47L13/16 , A47L23/266 , B32B3/08 , B32B2038/0076 , B32B2305/18 , B32B2307/554 , D06N3/183 , D06N3/186 , D06N7/0092 , D06N2201/02 , D06N2201/042 , D06N2203/041 , D06N2205/04 , D06N2205/20 , F41H5/0492 , Y10T442/3325 , Y10T442/3472 , Y10T442/3846
摘要： The invention relates to a flexible scrubbing material that combines at least two discrete components. One component is a continuous flexible substrate. A second component is a discontinuous abrasive layer affixed to the flexible substrate. The abrasive layer is a set of plates formed from a material different than the continuous flexible substrate. One or two flexible substrates with affixed plates can be combined with an intermediate layer such as sponge or terry cloth. The gaps between plates are relatively large and are generally larger than one-third the largest plate dimension. The flexible substrate can be tightly woven fabric that can be printed with visually attractive colors, patterns and images. The plate material is a printable material that subsequently solidifies, such as epoxy. The inventions include associated methods of use and manufacture.
摘要翻译：本发明涉及组合至少两个分立组件的柔性洗涤材料。一个组件是连续的柔性基板。第二组分是固定在柔性基底上的不连续磨料层。研磨层是由不同于连续柔性基底的材料形成的一组板。具有固定板的一个或两个柔性基底可以与诸如海绵或毛圈布之类的中间层组合。板之间的间隙相对较大并且通常大于最大板尺寸的三分之一。柔性基底可以是可以用视觉吸引人的颜色，图案和图像打印的紧密织物。板材是随后固化的可印刷材料，例如环氧树脂。本发明包括相关的使用和制造方法。

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