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1. 发明申请

WO2009064752A3 HETEROCYCLIC DERIVATIVES AS MODULATORS OF ION CHANNELS 审中-公开
标题翻译：杂环衍生物作为离子通道的调节剂
公开(公告)号：WO2009064752A3
公开(公告)日：2009-08-27
申请号：PCT/US2008083173
申请日：2008-11-12
申请人： VERTEX PHARMA , STAMOS DEAN , MARTINBOROUGH ESTHER , NEUBERT TIMOTHY , NUMA MEHDI MICHEL DJAMEL , WHITNEY TARA , ZIMMERMANN NICOLE , HAMPTON TARA LEANNE
发明人： STAMOS DEAN , MARTINBOROUGH ESTHER , NEUBERT TIMOTHY , NUMA MEHDI MICHEL DJAMEL , WHITNEY TARA , ZIMMERMANN NICOLE , HAMPTON TARA LEANNE
IPC分类号： C07D417/14 , A61K31/427 , A61K31/4427
CPC分类号： C07D417/14
摘要： The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译：本发明涉及可用作离子通道抑制剂的杂环衍生物。本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。

2. 发明专利

CA2705547A1 HETEROCYCLIC DERIVATIVES AS MODULATORS OF ION CHANNELS 未知
公开(公告)号：CA2705547A1
公开(公告)日：2009-05-22
申请号：CA2705547
申请日：2008-11-12
申请人： VERTEX PHARMA
发明人： STAMOS DEAN , MARTINBOROUGH ESTHER , NEUBERT TIMOTHY , NUMA MEHDI MICHEL DJAMEL , WHITNEY TARA , ZIMMERMANN NICOLE , HAMPTON TARA LEANNE
IPC分类号： C07D417/14 , A61K31/427 , A61K31/4427
摘要： The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

3. 发明专利

MX2010003009A PIRIDIL SULFONAMIDAS COMO MODULADORES DE CANALES IONICOS. 未知
公开(公告)号：MX2010003009A
公开(公告)日：2010-04-30
申请号：MX2010003009
申请日：2008-09-19
申请人： VERTEX PHARMA
发明人： MARTINBOROUGH ESTHER , NEUBERT TIMOTHY , ZIMMERMANN NICOLE , HAMPTON TARA LEANNE
IPC分类号： C07D417/14 , A61K31/33 , A61P25/00
摘要： La presente invenci?n se relaciona con derivados de piridilsulfonamida ?tiles como inhibidores de los canales i?nicos. La invenci?n tambi?n proporciona composiciones farmac?uticamente aceptables que comprenden los compuestos de la invenci?n y con m?todos para usar las composiciones en el tratamiento de diferentes trastornos.

4. 发明专利

AU2008321142A1 Heterocyclic derivatives as modulators of ion channels 未知
公开(公告)号：AU2008321142A1
公开(公告)日：2009-05-22
申请号：AU2008321142
申请日：2008-11-12
申请人： VERTEX PHARMA
发明人： ZIMMERMANN NICOLE , HAMPTON TARA LEANNE , NEUBERT TIMOTHY , NUMA MEHDI MICHEL DJAMEL , MARTINBOROUGH ESTHER , STAMOS DEAN , WHITNEY TARA
IPC分类号： A61K31/427 , A61K31/4427 , C07D417/14
摘要： The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

5. 发明专利

NZ585729A HETEROCYCLIC DERIVATIVES AS MODULATORS OF ION CHANNELS 未知
公开(公告)号：NZ585729A
公开(公告)日：2012-04-27
申请号：NZ58572908
申请日：2008-11-12
申请人： VERTEX PHARMA
发明人： STAMOS DEAN , MARTINBOROUGH ESTHER , NEUBERT TIMOTHY , NUMA MEHDI MICHEL DJAMEL , WHITNEY TARA , ZIMMERMANN NICOLE , HAMPTON TARA LEANNE
IPC分类号： C07D417/14 , A61K31/427 , A61K31/4427
摘要： Disclosed is a compound of formula (I) where the substituents are as disclosed in the specification and examples of compounds of formula (I) are (S)-4-(3-( 6,7-dichloro-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxopyrrolidin-1-yl)-N-(thiazol-2-yl)benzenesulfonamide and (S)-4-(2-oxo-3-(7-( trifluoromethyl)-3,4-dihydroisoquinolin-2(1H)yl)pyrrolidin-1-yl)-N-(thiazol-2-yl)benzenesulfonamide. Also disclosed is a pharmaceutical composition comprising a compound of formula (I) and the use of a compound of formula (I) in the manufacture of a medicament for treating conditions such as arthritis, migraines, pain and epilepsy.

6. 发明专利

MX2010005307A DERIVADOS HETEROCICLICOS COMO MODULADORES DE CANALES DE IONES. 未知
公开(公告)号：MX2010005307A
公开(公告)日：2010-07-28
申请号：MX2010005307
申请日：2008-11-12
申请人： VERTEX PHARMA
发明人： MARTINBOROUGH ESTHER , STAMOS DEAN , NEUBERT TIMOTHY , WHITNEY TARA , ZIMMERMANN NICOLE , HAMPTON TARA LEANNE , NUMA MEHDI MICHEL DJAMEL
IPC分类号： C07D417/14 , A61K31/427 , A61K31/4427
摘要： La presente invención se refiere a derivados heterocíclicos útiles como inhibidores de canales iónicos. La invención también proporciona composiciones farmacéuticamente aceptables que comprenden los compuestos de la invención y métodos para usar las composiciones en el tratamiento de varios trastornos.

7. 发明专利

CA2699892A1 PYRIDYL SULFONAMIDES AS MODULATORS OF ION CHANNELS 未知
公开(公告)号：CA2699892A1
公开(公告)日：2009-03-26
申请号：CA2699892
申请日：2008-09-19
申请人： VERTEX PHARMA
发明人： MARTINBOROUGH ESTHER , ZIMMERMANN NICOLE , NEUBERT TIMOTHY , HAMPTON TARA LEANNE
IPC分类号： C07D417/14 , A61K31/33 , A61P25/00
摘要： The present invention relates to pyridyl sulfonamide derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

8. 发明专利

NZ584009A PYRIDYL SULFONAMIDES AS MODULATORS OF ION CHANNELS 未知
公开(公告)号：NZ584009A
公开(公告)日：2012-03-30
申请号：NZ58400908
申请日：2008-09-19
申请人： VERTEX PHARMA
发明人： MARTINBOROUGH ESTHER , ZIMMERMANN NICOLE , NEUBERT TIMOTHY , HAMPTON TARA LEANNE
IPC分类号： C07D417/14 , A61K31/33 , A61P25/00
摘要： Disclosed are sulfonamide (sulphonamide) compounds also comprising a substituted pyridine ring of formula I, pharmaceutically acceptable salts thereof, and methods for their preparation. Specific examples of compounds of formula I include (S)-6-(3-(4-chloro-5-fluoroindolin-1-yl)-2-oxopyrrolidin-1-yl)-N-(thiazol-2-yl)pyridine-3-sulfonamide, (S)-N-allyl-6-(3-(6-chloro-3,4-dihydroquinolin-1(2H)-yl)-2-oxopyrrolidin-1-yl)-N-(thiazol-2-yl)pyridine-3-sulfonamide, (S)-6-(3-(6-chloro-3,4-dihydroquinolin-1(2H)-yl)-2-oxopyrrolidin-1-yl)-N-(thiazol-2-yl)pyridine-3-sulfonamide, (R)-6-(4-(2-(4-fluoro-1H-indol-1-yl)propanoyl)piperazin-1-yl)-N-(thiazol-2-yl)pyridine-3-sulfonamide, and (R)-6-(4-(2-(6-chloro-1H-indol-1-yl)propanoyl)piperazin-1-yl)-N-(thiazol-2-yl)pyridine-3-sulfonamide. Also disclosed is the use of compound of formula I for treating acute, chronic, neuropathic, or inflammatory pain, arthritis, migraine, cluster headaches, trigeminal neuralgia, herpetic neuralgia, general neuralgias, epilepsy, neurodegenerative disorders, psychiatric disorders, anxiety and depression, dipolar disorder, myotonia, arrhythmia, movement disorders, neuroendocrine disorders, ataxia, multiple sclerosis, irritable bowel syndrome, incontinence, visceral pain, osteoarthritis pain, post therapeutic neuralgia, diabetic neuropathy, radicular pain, sciatica, back pain, head or neck pain, severe or intractable pain, nociceptive pain, breakthrough pain, postsurgical pain, cancer pain, stroke, cerebral ischemia, traumatic brain injury, amyotrophic lateral sclerosis, stress- or exercise induced angina, palpitations, hypertension, migraine, or abnormal gastro-intestinal motility.

9. 发明专利

ZA201003352B HETEROCYCLIC DERIVATIVES AS MODULATORS OF ION CHANNELS 未知
公开(公告)号：ZA201003352B
公开(公告)日：2011-08-31
申请号：ZA201003352
申请日：2010-05-12
申请人： VERTEX PHARMA
发明人： STAMOS DEAN , MARTINBOROUGH ESTHER , NEUBERT TIMOTHY , NUMA MEHDI MICHEL DJAMEL , WHITNEY TARA , ZIMMERMANN NICOLE , HAMPTON TARA LEANNE
IPC分类号： C07D20060101 , A61K20060101
摘要： The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

10. 发明专利

AU2008321142A8 Heterocyclic derivatives as modulators of ion channels 未知
公开(公告)号：AU2008321142A8
公开(公告)日：2010-06-24
申请号：AU2008321142
申请日：2008-11-12
申请人： VERTEX PHARMA
发明人： ZIMMERMANN NICOLE , HAMPTON TARA LEANNE , NEUBERT TIMOTHY , NUMA MEHDI MICHEL DJAMEL , MARTINBOROUGH ESTHER , STAMOS DEAN , WHITNEY TARA
IPC分类号： C07D417/14 , A61K31/427 , A61K31/4427
摘要： The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

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