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1. 发明申请

WO2008079521A2 TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASE 审中-公开
标题翻译：用于JANUS KINASE抑制剂的三环类化合物
公开(公告)号：WO2008079521A2
公开(公告)日：2008-07-03
申请号：PCT/US2007083134
申请日：2007-10-31
申请人： VERTEX PHARMA , BENNANI YOUSSEFF , WANG TIANSHENG , SALITURO FRANCESCO , DUFFY JOHN
发明人： BENNANI YOUSSEFF , WANG TIANSHENG , SALITURO FRANCESCO , DUFFY JOHN
CPC分类号： C07D471/16 , C07D471/22 , C07D487/16
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译：本发明涉及用作蛋白激酶抑制剂，特别是JAK家族激酶抑制剂的化合物。本发明还提供了包含所述化合物的药学上可接受的组合物以及使用该组合物治疗各种疾病，病症或障碍的方法。

2. 发明申请

WO2007041130A3 DEAZAPURINES USEFUL AS INHIBITORS OF JANUS KINASES 审中-公开
标题翻译： DEAZAPURINES有用作JANK KINASES的抑制剂
公开(公告)号：WO2007041130A3
公开(公告)日：2010-01-21
申请号：PCT/US2006037593
申请日：2006-09-28
申请人： VERTEX PHARMA , SALITURO FRANCESCO , FARMER LUC , WANG TIANSHENG , WANG JIAN , BETHIEL RANDY , WANNAMAKER MARION , MARTINEZ-BOTELLA GABRIEL , DUFFY JOHN , ARONOV ALEXANDER , LAUFFER DAVID , PIERCE ALBERT
发明人： SALITURO FRANCESCO , FARMER LUC , WANG TIANSHENG , WANG JIAN , BETHIEL RANDY , WANNAMAKER MARION , MARTINEZ-BOTELLA GABRIEL , DUFFY JOHN , ARONOV ALEXANDER , LAUFFER DAVID , PIERCE ALBERT
IPC分类号： C07D487/04 , A61K31/495 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/00 , C07D519/00
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of formula (I) useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译：本发明涉及用作蛋白激酶抑制剂，特别是JAK家族激酶的抑制剂的式（I）化合物。本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。

3. 发明专利

GB191410563A Improvements in Decompressors or Release Valves for Internal Combustion Engines. 未知
公开(公告)号：GB191410563A
公开(公告)日：1915-02-25
申请号：GB191410563D
申请日：1914-04-29
申请人： RICHARDS ROBERT WILLIAM , DUFFY JOHN
发明人： RICHARDS ROBERT WILLIAM , DUFFY JOHN
摘要： 10,563. Richards, R. W., and Duffy, J., [trading as V.T.S. Manufacturing Co.]. April 29. Actuating:-A beat or lift valve 5 serving to relieve compression in an internal-combustion engine is opened through the movement of the casing member of a Bowden mechanism, the cable being attached to a fixed pin 10.

4. 发明专利

GB2360301B Post support assembly 未知
公开(公告)号：GB2360301B
公开(公告)日：2003-06-04
申请号：GB0025001
申请日：2000-10-12
申请人： DUFFY JOHN
发明人： DUFFY JOHN
IPC分类号： E04H12/22

5. 发明专利

GB191408518A New or Improved Means for Preventing Leakage at Engine or other Bearings. 未知
公开(公告)号：GB191408518A
公开(公告)日：1915-02-18
申请号：GB191408518D
申请日：1914-04-04
申请人： RICHARDS ROBERT WILLIAM , DUFFY JOHN
发明人： RICHARDS ROBERT WILLIAM , DUFFY JOHN
IPC分类号： F02B75/02 , F02F11/00
摘要： 8518. Richards, R. W., and Duffy, J., [trading as V.T.S. Manufacturing Co.]. April 4. Stuffing-boxes, substitutes for.-A packing- device, which is particularly applicable for twostroke-cycle internal-combustion engines in which the crank chamber is used for compression, comprises a cup 8 which has an internal flange 9 and is pressed against the hub of the fly-wheel 2 by a spring 10 and packed at its periphery by one or more spring rings 11. Where several rings 11 are employed, they may be contained in a single groove.

6. 发明专利

GB2330328A Jigsaw blade guide and support assembly 未知
公开(公告)号：GB2330328A
公开(公告)日：1999-04-21
申请号：GB9721766
申请日：1997-10-15
申请人： DUFFY JOHN
发明人： DUFFY JOHN
IPC分类号： B23D51/02 , B27B11/02
摘要： An electric jig saw blade guide and support assembly consists of a support fin 1 which is secured to the body of the saw 2. The support fin connects to the free end of the blade 4 via a blade guide assembly 5 which allows the blade to move in the plane of it's reciprocating motion but prevent lateral movement. As the sawing action progresses the fin passes though the saw cut thus assisting in the maintenance of correct alignment of the saw to the workpiece. The guide assembly 5, eg a roller, may be attached to the saw-blade or the fin.

7. 发明专利

CA195448A FUEL MIXER 未知
公开(公告)号：CA195448A
公开(公告)日：1919-12-30
申请号：CA195448D
申请日：1919-06-16
申请人： DUFFY JOHN
发明人： DUFFY JOHN

8. 发明专利

GB2360301A Fence post support 未知
公开(公告)号：GB2360301A
公开(公告)日：2001-09-19
申请号：GB0025001
申请日：2000-10-12
申请人： DUFFY JOHN
发明人： DUFFY JOHN
IPC分类号： E04H12/22
摘要： A fence post support has a foot (2) that contacts the ground, where the foot (2) may have on one side a socket (6) for receiving a fence post (1). A spike (4), separate from the foot (2), is secured to one side of the foot (2) and extends from the other side into the ground. The post (1) may be sealed in the socket (6) with a weather resistant material. Preferably, guides are provided to position and align the spikes (4) as they are driven into the ground and temporary anchor stakes (7, fig 2) may be used to position the foot (2) during erection of the post support.

9. 发明专利

GB191410648A Improvements in the Lubrication of Internal Combustion Engines. 未知
公开(公告)号：GB191410648A
公开(公告)日：1914-11-19
申请号：GB191410648D
申请日：1914-04-30
申请人： RICHARDS ROBERT WILLIAM , DUFFY JOHN
发明人： RICHARDS ROBERT WILLIAM , DUFFY JOHN
IPC分类号： F01M1/04
摘要： 10,648. Richards, R. W., and Duffy, J., [trading as V. T. S. Manufacturing Co.]. April 30. Channels in cylinders, pistons, connecting- rods, cranks and engine crank casings.-An internal-combustion engine, particularly of the two-stroke-cycle type, is lubricated by oil which is supplied to a duct in the cylinder wall and distributed by changes of pressure in the crank case. Oil is supplied to an annular chamber 1 formed at the upper part of the crank case 2, the inner side of the chamber being closed by the spigot 3 of the cylinder. The oil is sucked in through two openings 4, and passes along passages and grooves 5, 6, 14, 10 to lubricate the crank-shaft and crank-pin bearings. Oil from the chamber 1 also passes through holes 17 in the cylinder wall and is received and distributed by one or more grooves 18 in the piston. The holes 17 may be at different levels, and the groove 18 may be helical. Oil draining from the cylinder is caught in grooves 33 formed in projecting parts 32 of the crank case, and passes to the crank-shaft bearings. A non-return valve is placed in the pipe that supplies the chamber 1, and at periods of high pressure in the crank case oil is forced from the chamber up a passage 19 fitted with a regulating-valve 22. This oil is delivered through an opening 20 to a hollow gudgeon 23, and passes through openings 28 to a groove 31 in the connecting-rod bearing. The openings 28 and groove 31 are in register only during the down-stroke of the piston. A ball valve 26, engaging conical seats at both ends of the gudgeon, controls the leakage of gas through the inlet port 21 of the engine and through the gudgeon, enabling the oil to be delivered through the passage 19. Oil which accumulates in the spaces at the ends of the gudgeon enters short distributing grooves arranged on each side of the piston. In place of the ball valve 26, a ball valve may be arranged on the pipe 19 to prevent the oil from being sucked back into the chamber 1. Fig. 6 shows a modification in which.a ball valve 26 engaging two conical seats is mounted in the cylinder wall at the end of the gudgeon opposite to that at which the oil enters. Besides controlling the lubrication, this valve, when uncovered by the piston, allows air to be sucked into the crank case while the throttle valve is shut; this air assists in cooling the engine.

10. 发明专利

GB190415238A Improvements in Sash Pulleys. 未知
公开(公告)号：GB190415238A
公开(公告)日：1904-08-25
申请号：GB190415238D
申请日：1904-07-07
申请人： DUFFY JOHN
发明人： DUFFY JOHN
摘要： 15,238. Duffy, J. July 7. Pulleys, axle.-A sash pulley is formed from two sheet-metal discs 4, Fig. 2. From a central aperture in each disc, tongues 5 project inwards, forming a spring support for the hub 6, Fig. 3. The hub is secured in position by forming an annular flange 7 near each end. In one or both discs, a number of cross-slits are cut, and the tongues 9 thus formed are passed through circular holes in the opposite disc and clamped down to lock the discs together. The pulley is mounted on an axle in a casing, shown in side and top views in Figs. 5 and 8, made from one piece of sheet metal, and consisting of the face-plate 11 and corrugated sides 10. Holes or slits 10 separate the corrugations from the straight portions 13. The case is fitted into a mortice having straight sides and rounded ends, or consisting of a series of intersecting holes corresponding in shape to the corrugations. In the abutting top and bottom edges are made indentations 14, arranged as shown in Fig. 8 to engage the wood of the window frame. An inward flange 15 is made around the edge of the slot in the face-plate 11. The outer ends of the top and bottom portions are slit, forming tongues 16 which are driven into the wood by a blow of a punch. Fig. 17 shows a modification adapted to fit in the mortice flush with the frame. The ends 17 of the face-plate are slightly turned in, and inclined cuts 18 are made, leaving tapered shoulders to support the ends of the face-plate. To close in the pulley and prevent the rope from jumping, the inner ends of the corrugations are bent to form bevels 20. Two corrugations only may be made on each side, separated by a flat panel with a bevelled edge 20 . Fig. 19 shows a modification in which the abutting top and bottom edges have tongues 21 overlapping the adjacent edges. Each side has a single elongated slot, and the parts of the sides below the slots are bent into close proximity to the sides of the pulley.

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