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1. 发明申请

WO2011006354A8 POLYMERIC BASED AND SURFACE TREATED METALLIC HYBRID MATERIALS AND FABRICATION METHODS THEREOF 审中-公开
标题翻译：聚合物和表面处理金属杂化材料及其制备方法
公开(公告)号：WO2011006354A8
公开(公告)日：2012-02-02
申请号：PCT/CN2010001053
申请日：2010-07-14
申请人： VERSITECH LTD , UNIV CITY HONG KONG , WONG HOIMAN KAREN , YEUNG WAIKWOK KELVIN , CHEUNG MANCHEE , LUK DIPKEI KEITH , LAM KINON JOHN , CHU KIMHO PAUL
发明人： WONG HOIMAN KAREN , YEUNG WAIKWOK KELVIN , CHEUNG MANCHEE , LUK DIPKEI KEITH , LAM KINON JOHN , CHU KIMHO PAUL
IPC分类号： A61L27/36 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/34 , A61L27/60
CPC分类号： A61L27/58 , A61L27/446 , A61L2400/18 , C08L67/04
摘要： Novel hybrid materials and fabrication methods thereof are provided. The novel hybrid materials can include a biodegradable polymer and a biodegradable metallic material. The hybrid material can also include a coupling agent between the biodegradable metallic material and the biodegradable polymer. A method of fabricating a hybrid material can include performing a surface treatment process on the biodegradable metallic material, and then either performing a solvent formation method or a thermal formation method.
摘要翻译：提供了新颖的混合材料及其制造方法。新型混合材料可以包括可生物降解的聚合物和可生物降解的金属材料。混合材料还可以包括可生物降解的金属材料和可生物降解的聚合物之间的偶联剂。制造混合材料的方法可以包括对可生物降解的金属材料进行表面处理，然后进行溶剂形成法或热成形法。

2. 发明申请

WO2010094212A2 ANTIBACTERIAL SURFACE AND METHOD OF FABRICATION 审中-公开
标题翻译：抗菌表面和制造方法
公开(公告)号：WO2010094212A2
公开(公告)日：2010-08-26
申请号：PCT/CN2010000216
申请日：2010-02-18
申请人： VERSITECH LTD , UNIV CITY HONG KONG , YEUNG WAIKWOK KELVIN , CHEUNG MANCHEE , LUK DIPKEI KEITH , YEUNG CHEYAN , KAO YITSUN RICHARD , CHU KIMHO PAUL
发明人： YEUNG WAIKWOK KELVIN , CHEUNG MANCHEE , LUK DIPKEI KEITH , YEUNG CHEYAN , KAO YITSUN RICHARD , CHU KIMHO PAUL
IPC分类号： A61L27/34
CPC分类号： A61L27/06 , A61L27/34 , A61L27/54 , A61L2300/25 , A61L2300/404 , A61L2300/602 , A61L2300/606 , C08L89/00
摘要： This invention involves a plasma treated and controllable release antimicrobial peptide coated titanium alloy for surgical implantation, where the alloy with antimicrobial properties is fabricated using surface techniques without adversely compromising its biocompatibility and original mechanical properties. The surface techniques form antimicrobial layers on the alloy capable of resisting microbial adhesion and proliferation, while allowing mammalian cell adhesion and proliferation when the alloy is implanted to human body. In one embodiment, PIII&D is applied to incorporate ions, electrons, free radicals, atoms or molecules on a titanium alloy substrate. A pressurized hydrothermal treatment can be carried out to establish reactive functional groups for antimicrobial purpose or for connecting the substrate and external antimicrobial molecules. An outermost layer of the titanium alloy includes antibacterial peptides possessing a controllable release mechanism, and is fabricated alone or in an assembly of the aforementioned basal surface layers. The controllable release mechanism is able to withstand long-term deep tissue infection after surgery, and in an embodiment comprises APTES as a linker molecule.
摘要翻译：本发明涉及用于手术植入的等离子体处理和可控释放的抗微生物肽包被的钛合金，其中具有抗微生物性质的合金使用表面技术制造而不会不利地损害其生物相容性和原始机械性能。表面技术在能够抵抗微生物粘附和增殖的合金上形成抗微生物层，同时当将合金植入人体时允许哺乳动物细胞粘附和增殖。在一个实施方案中，应用PIII和D将离子，电子，自由基，原子或分子结合到钛合金基底上。可以进行加压水热处理以建立用于抗微生物目的的反应性官能团或用于连接底物和外部抗微生物分子。钛合金的最外层包括具有可控释放机构的抗菌肽，并且单独制造或在上述基础表面层的组装中制造。可释放机制能够经受手术后的长期深部组织感染，并且在一个实施方案中包含作为连接分子的APTES。

3. 发明公开

EP2398517A4 ANTIBACTERIAL SURFACE AND METHOD OF FABRICATION 有权
标题翻译：抗菌表面及其制备方法
公开(公告)号：EP2398517A4
公开(公告)日：2013-10-16
申请号：EP10743393
申请日：2010-02-18
申请人： VERSITECH LTD , UNIV CITY HONG KONG
发明人： YEUNG WAIKWOK KELVIN , CHEUNG MANCHEE , LUK DIPKEI KEITH , YEUNG CHEYAN , KAO YITSUN RICHARD , CHU KIMHO PAUL
IPC分类号： A61L27/22 , A61L27/06 , A61L27/54
CPC分类号： A61L27/06 , A61L27/34 , A61L27/54 , A61L2300/25 , A61L2300/404 , A61L2300/602 , A61L2300/606 , C08L89/00

4. 发明公开

EP2453935A4 POLYMERIC BASED AND SURFACE TREATED METALLIC HYBRID MATERIALS AND FABRICATION METHODS THEREOF 有权转让
标题翻译：在基于聚合物的表面处理的金属混合材料及其制造方法
公开(公告)号：EP2453935A4
公开(公告)日：2013-12-25
申请号：EP10799352
申请日：2010-07-14
申请人： VERSITECH LTD , UNIV CITY HONG KONG
发明人： WONG HOIMAN KAREN , YEUNG WAIKWOK KELVIN , CHEUNG MANCHEE , LUK DIPKEI KEITH , LAM KINON JOHN , CHU KIMHO PAUL
IPC分类号： A61L27/36 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/34 , A61L27/44 , A61L27/58 , A61L27/60
CPC分类号： A61L27/58 , A61L27/446 , A61L2400/18 , C08L67/04
摘要： Novel hybrid materials and fabrication methods thereof are provided. The novel hybrid materials can include a biodegradable polymer and a biodegradable metallic material. The hybrid material can also include a coupling agent between the biodegradable metallic material and the biodegradable polymer. A method of fabricating a hybrid material can include performing a surface treatment process on the biodegradable metallic material, and then either performing a solvent formation method or a thermal formation method.

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