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1. 发明申请

WO2011139792A3 ANTIBODY-NANOPARTICLE CONJUGATES AND METHODS FOR MAKING AND USING SUCH CONJUGATES 审中-公开
标题翻译：抗体 - 纳米颗粒结合体和制备和使用这种结合体的方法
公开(公告)号：WO2011139792A3
公开(公告)日：2012-04-26
申请号：PCT/US2011034190
申请日：2011-04-27
申请人： VENTANA MED SYST INC , ASHWORTH-SHARPE JULIA , YUN CHOL STEVEN , ZHILINA ZHANNA , MURILLO ADRIAN E , JOHNSON DONALD D , FARRELL MICHAEL , KOSMEDER JEROME W , BIENIARZ CHRISTOPHER
发明人： ASHWORTH-SHARPE JULIA , YUN CHOL STEVEN , ZHILINA ZHANNA , MURILLO ADRIAN E , JOHNSON DONALD D , FARRELL MICHAEL , KOSMEDER JEROME W , BIENIARZ CHRISTOPHER
IPC分类号： G01N33/68 , C07F1/00 , C07F9/12 , C07F9/50 , C07F9/572 , C07F9/655 , G01N33/531 , G01N33/543 , G01N33/58
CPC分类号： G01N33/54346 , C07F9/12 , C07F9/5004 , C07F9/5022 , C07F9/5045 , C07F9/5728 , C07F9/65515 , C07F9/65517 , C07F9/65522 , G01N33/531 , G01N33/553 , G01N33/587 , G01N33/6854 , G01N2333/916
摘要： Disclosed herein are antibody-nanoparticle conjugates that include two or more nanoparticles (such as gold, palladium, platinum, silver, copper, nickel, cobalt, iridium, or an alloy of two or more thereof) directly linked to an antibody or fragment thereof through a metal-thiol bond. Methods of making the antibody- nanoparticle conjugates disclosed herein include reacting an arylphosphine-nanoparticle composite with a reduced antibody to produce an antibody-nanoparticle conjugate. Also disclosed herein are methods for detecting a target molecule in a sample that include using an antibody-nanoparticle conjugate (such as the antibody- nanoparticle conjugates described herein) and kits for detecting target molecules utilizing the methods disclosed herein.
摘要翻译：本文公开了抗体 - 纳米颗粒缀合物，其包括直接连接到抗体或其片段的两个或更多个纳米颗粒（例如金，钯，铂，银，铜，镍，钴，铱或其两个或更多个的合金）金属硫醇键。本文公开的制备抗体 - 纳米颗粒缀合物的方法包括使芳基膦 - 纳米颗粒复合物与还原抗体反应以产生抗体 - 纳米颗粒缀合物。本文还公开了用于检测样品中靶分子的方法，其包括使用抗体 - 纳米颗粒缀合物（例如本文所述的抗体 - 纳米颗粒缀合物）和利用本文公开的方法检测靶分子的试剂盒。

2. 发明申请

WO2006116628A3 ENZYMES CONJUGATED TO ANTIOBODIES VIA A PEG HETEROBIFUCTIONAL LINKER 审中-公开
标题翻译：通过PEG疏水连接剂与酶联合使用的酶
公开(公告)号：WO2006116628A3
公开(公告)日：2007-12-13
申请号：PCT/US2006016087
申请日：2006-04-27
申请人： VENTANA MED SYST INC , BIENIARZ CHRISTOPHER , WONG JENNIFER , LEFEVER MARK , KOSMEDER JEROME W , ASHWORTH-SHARPE JULIA , KERNAG CASEY A
发明人： BIENIARZ CHRISTOPHER , WONG JENNIFER , LEFEVER MARK , KOSMEDER JEROME W , ASHWORTH-SHARPE JULIA , KERNAG CASEY A
IPC分类号： A61K47/48
CPC分类号： G01N33/535 , A61K47/65 , A61K47/6815 , C07K16/42 , C07K16/44 , C07K2317/76 , C12N9/0065 , C12N9/16 , C12N9/96
摘要： Antibody/signal-generating moiety conjugates are disclosed that include an antibody covalently linked to a signal-generating moiety through a heterobifunctional polyalkyleneglycol linker. The disclosed conjugates show exceptional signal-generation in immunohistochemical and in situ hybridization assays on tissue sections and cytology samples. In one embodiment, enzyme-metallographic detection of nucleic acid sequences with hapten-labeled probes can be accomplished using the disclosed conjugates as a primary antibody without amplification.
摘要翻译：公开了抗体/信号产生部分缀合物，其包括通过异双功能聚亚烷基二醇连接体与产生信号的部分共价连接的抗体。所公开的缀合物在组织切片和细胞学样品的免疫组织化学和原位杂交测定中显示出异常的信号产生。在一个实施方案中，用半抗原标记的探针对核酸序列的酶 - 金相检测可以使用所公开的缀合物作为一级抗体而无需扩增来完成。

3. 发明申请

WO2010078376A3 FC-SPECIFIC POLYMER-CONJUGATED ANTIBODIES AND THEIR DIAGNOSTIC USE 审中-公开
标题翻译： FC特异性聚合物联合抗体及其诊断用途
公开(公告)号：WO2010078376A3
公开(公告)日：2010-09-16
申请号：PCT/US2009069748
申请日：2009-12-29
申请人： VENTANA MED SYST INC , KERNAG CASEY A , BIENIARZ CHRISTOPHER , BRANDS DANIELLE , ASHWORTH-SHARPE JULIA
发明人： KERNAG CASEY A , BIENIARZ CHRISTOPHER , BRANDS DANIELLE , ASHWORTH-SHARPE JULIA
IPC分类号： G01N33/58 , G01N33/68
CPC分类号： G01N33/6854 , G01N33/58
摘要： The present invention provides molecular conjugates of antibodies and hydrophilic, non-immunogenic polymers. More particularly, the present invention provides Fc-specific polymer-conjugated antibody signal- generating moiety conjugates and methods for making and using the conjugates.
摘要翻译：本发明提供抗体和亲水性，非免疫原性聚合物的分子缀合物。更具体地，本发明提供了Fc特异性聚合物缀合的抗体产生信号的部分缀合物以及用于制备和使用缀合物的方法。

4. 发明授权

EP2564203B1 ANTIBODY-NANOPARTICLE CONJUGATES AND METHODS FOR MAKING AND USING SUCH CONJUGATES 有权
标题翻译： MITANTIKÖRPERNKONJUGIERTE NANOPARTIKEL，DEREN PRODUKTION UND DEREN VERWENDUNG
公开(公告)号：EP2564203B1
公开(公告)日：2017-06-07
申请号：EP11721853
申请日：2011-04-27
申请人： VENTANA MED SYST INC
发明人： ASHWORTH-SHARPE JULIA , YUN CHOL STEVEN , ZHILINA ZHANNA , MURILLO ADRIAN E , JOHNSON DONALD D , FARRELL MICHAEL , KOSMEDER JEROME W , BIENIARZ CHRISTOPHER
IPC分类号： G01N33/68 , C07F1/00 , C07F9/12 , C07F9/50 , C07F9/572 , C07F9/655 , G01N33/531 , G01N33/543 , G01N33/58
CPC分类号： G01N33/54346 , C07F9/12 , C07F9/5004 , C07F9/5022 , C07F9/5045 , C07F9/5728 , C07F9/65515 , C07F9/65517 , C07F9/65522 , G01N33/531 , G01N33/553 , G01N33/587 , G01N33/6854 , G01N2333/916
摘要： Disclosed herein are antibody-nanoparticle conjugates that include two or more nanoparticles (such as gold, palladium, platinum, silver, copper, nickel, cobalt, iridium, or an alloy of two or more thereof) directly linked to an antibody or fragment thereof through a metal-thiol bond. Methods of making the antibody-nanoparticle conjugates disclosed herein include reacting an arylphosphine-nanoparticle composite with a reduced antibody to produce an antibody-nanoparticle conjugate. Also disclosed herein are methods for detecting a target molecule in a sample that include using an antibody-nanoparticle conjugate (such as the antibody-nanoparticle conjugates described herein) and kits for detecting target molecules utilizing the methods disclosed herein.
摘要翻译：本文公开了抗体 - 纳米颗粒缀合物，其包括直接连接至抗体或其片段的两个或更多个纳米颗粒（例如金，钯，铂，银，铜，镍，钴，铱或其两种或更多种的合金）金属硫醇键。制备本文公开的抗体 - 纳米颗粒缀合物的方法包括使芳基膦 - 纳米颗粒复合物与还原的抗体反应以产生抗体 - 纳米颗粒缀合物。本文还公开了用于检测样品中的靶分子的方法，其包括使用本文公开的方法使用抗体 - 纳米颗粒缀合物（例如本文所述的抗体 - 纳米颗粒缀合物）和用于检测靶分子的试剂盒。

5. 发明专利

AU2020202647B2 Quinone methide analog signal amplification 未知
公开(公告)号：AU2020202647B2
公开(公告)日：2021-01-21
申请号：AU2020202647
申请日：2020-04-20
申请人： VENTANA MED SYST INC
发明人： BIENIARZ CHRISTOPHER , ASHWORTH-SHARPE JULIA , KELLY BRIAN D , POLASKE NATHAN
IPC分类号： C07C27/00 , G01N33/58
摘要： QUINONE METHIDE ANALOG SIGNAL AMPLIFICATION Abstract 110 ~LG ' a _1__-N 1 HN 40 0'0 HN 0 ,. O IG -D aH Disclosed herein are novel quinone methide analog precursors and embodiments of a method and a kit of using the same for detecting one or more targets in a biological sample. The method of detection comprises contacting the sample with a detection probe, then contacting the sample with a labeling conjugate that comprises an enzyme. The enzyme interacts with a quinone methide analog precursor comprising a detectable label, forming a reactive quinone methide analog, which binds to the biological sample proximally to or directly on the target. The detectable label is then detected. In some embodiments, multiple targets can be detected by multiple quinone methide analog precursors interacting with different enzymes without the need for an enzyme deactivation step.

6. 发明专利

ES2713438T3 Amplificación de señal de análogos de quinona metidas 未知
公开(公告)号：ES2713438T3
公开(公告)日：2019-05-21
申请号：ES15706439
申请日：2015-02-20
申请人： VENTANA MED SYST INC
发明人： BIENIARZ CHRISTOPHER , ASHWORTH-SHARPE JULIA , KELLY BRIAN D , POLASKE NATHAN
IPC分类号： G01N33/58 , C07C27/00
摘要： Un compuesto, que tiene una fórmula **Fórmula** o una sal o solvato del mismo, en la que: Z es O, S o NRª y R1 es un fosfato, o ZR1 es un fosfato; R8 es -C(LG)(R5)(R3R4); R9, R11 y R12 son cada uno independientemente hidrógeno, halo, ciano, alifático, alcoxi, NO2, N(Rc)2, arilo, haloalquilo, -C(O)alquilo, -C(S)alquilo, -C(O)OH, -C(O)Oalquilo, -C(O)NHRc, -C(O)N(Rc)2, -R3R4 o dos grupos adyacentes conjuntamente forman un anillo alifático o anillo arilo; R10 es hidrógeno, halo, ciano, alifático, alcoxi, NO2, N(Rc)2, arilo, haloalquilo, -C(O)alquilo, -C(S)alquilo, -C(O)OH, -C(O)Oalquilo, -C(O)NHRc, -C(O)N(Rc)2, -R3R4, -C(LG)(R5)(R6) o con uno de R9 o R11 forman un anillo alifático o anillo arilo; LG es un grupo saliente R3 es un conector o un enlace; R4 es un marcador detectable; cada R5 es independientemente hidrógeno, halo, ciano, alquilo inferior, haloalquilo inferior, -C(O)alquilo, -C(S)alquilo, -C(O)OH, -C(O)Oalquilo, -C(O)NHRc o -C(O)N(Rc)2; cada R6 es independientemente hidrógeno, halo, ciano, alquilo inferior, haloalquilo inferior, -C(O)alquilo, -C(S)alquilo, -C(O)OH, -C(O)Oalquilo, -C(O)NHRc o -C(O)N(Rc)2; Rª es hidrógeno o alifático; cada Rc independientemente es hidrógeno, arilo, alifático o heteroalifático, o dos restos Rc conjuntamente forman un anillo heteroalifático; y al menos uno de R8 y R10 comprende LG, y al menos uno de R8 y R10 comprende R3R4; y si LG es halo, entonces R5 y R6 no son halo.

8. 发明专利

DK1877101T3 ENZYMER KONJUGERET TIL ANTISTOFFER VIA EN PEG HETEROBIFUNKTIONEL LINKER 未知
公开(公告)号：DK1877101T3
公开(公告)日：2017-01-09
申请号：DK06758689
申请日：2006-04-27
申请人： VENTANA MED SYST INC
发明人： BIENIARZ CHRISTOPHER , KOSMEDER JEROME W , ASHWORTH-SHARPE JULIA , WONG JENNIFER , LEFEVER MARK , KERNAG CASEY A
IPC分类号： G01N33/535 , G01N33/58

9. 发明专利

AU2015220750A1 Quinone methide analog signal amplification 未知
公开(公告)号：AU2015220750A1
公开(公告)日：2016-07-21
申请号：AU2015220750
申请日：2015-02-20
申请人： VENTANA MED SYST INC
发明人： BIENIARZ CHRISTOPHER , ASHWORTH-SHARPE JULIA , KELLY BRIAN D , POLASKE NATHAN
IPC分类号： G01N33/58 , C07C27/00
摘要： Disclosed herein are novel quinone methide analog precursors and embodiments of a method and a kit of using the same for detecting one or more targets in a biological sample. The method of detection comprises contacting the sample with a detection probe, then contacting the sample with a labeling conjugate that comprises an enzyme. The enzyme interacts with a quinone methide analog precursor comprising a detectable label, forming a reactive quinone methide analog, which binds to the biological sample proximally to or directly on the target. The detectable label is then detected. In some embodiments, multiple targets can be detected by multiple quinone methide analog precursors interacting with different enzymes without the need for an enzyme deactivation step.

10. 发明专利

AU2012222506B2 Application of quantum dots for nuclear staining 未知
公开(公告)号：AU2012222506B2
公开(公告)日：2015-08-20
申请号：AU2012222506
申请日：2012-02-27
申请人： VENTANA MED SYST INC
发明人： YUN CHOL S , KELLY BRIAN D , ASHWORTH-SHARPE JULIA , BIENIARZ CHRISTOPHER , BAMFORD PASCAL , MURILLO ADRIAN E
IPC分类号： C12Q1/68 , B82Y15/00 , G01N33/533 , G01N33/58
摘要： Embodiments of a system, method, and kit for visualizing a nucleus are disclosed. A tissue sample is pretreated with a protease to permeabilize the nucleus, and then incubated with a nanoparticle/DNA-binding moiety conjugate. The DNA-binding moiety includes at least one DNA-binding molecule. The conjugate binds to DNA within the nucleus, and the nanoparticle is visualized, thereby visualizing the nucleus. Computer and image analysis techniques are used to evaluate nuclear features such as chromosomal distribution, ploidy, shape, size, texture features, and/or contextual features. The method may be used in combination with other multiplexed tests on the tissue sample, including fluorescence in situ hybridization. Kits for performing the method include a protease enzyme composition, a nanoparticle/DNA-binding moiety conjugate, and a reaction buffer.

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