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1. 发明申请

WO2004093848A2 DEVICES AND PHARMACEUTICAL COMPOSITIONS FOR ENHANCING DOSING EFFICIENCY 审中-公开
标题翻译：用于提高剂量效率的装置和药物组合物
公开(公告)号：WO2004093848A2
公开(公告)日：2004-11-04
申请号：PCT/GB2004/001628
申请日：2004-04-14
申请人： VECTURA LTD , STANIFORTH, John , MORTON, David , TOBYN, Michael , EASON, Stephen , HARMER, Quentin , GANDERTON, David
发明人： STANIFORTH, John , MORTON, David , TOBYN, Michael , EASON, Stephen , HARMER, Quentin , GANDERTON, David
IPC分类号： A61K9/16
CPC分类号： A61K9/0075 , A61K9/1617 , A61K9/1682 , A61M15/0028 , A61M15/0036 , A61M15/0041 , A61M16/207 , A61M2202/064 , A61M2205/073 , A61M2206/16
摘要： The present invention relates to enhancing the dosing efficiency of pharmaceutical dry powder formulations administered by pulmonary inhalation. In particular, the present invention relates to the provision of dry powder inhalers and dry powder compositions which reproducibly achieve a much higher delivered dose of the pharmaceutically active agent than currently achieved.
摘要翻译：本发明涉及提高通过肺部吸入给药的药物干粉制剂的给药效率。特别地，本发明涉及提供干粉吸入器和干粉组合物，其可重复地实现药物活性剂比目前实现的高得多的递送剂量。

2. 发明申请

WO2005025541A2 MANUFACTURE OF PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：包含苯二胺的干粉组合物用于脉搏吸入
公开(公告)号：WO2005025541A2
公开(公告)日：2005-03-24
申请号：PCT/GB2004/003942
申请日：2004-09-15
申请人： VECTURA LIMITED , MORTON, David , GANDERTON, David , STANIFORTH, John , TOBYN, Mike , EASON, Stephen , HARMER, Quentin
发明人： MORTON, David , GANDERTON, David , STANIFORTH, John , TOBYN, Mike , EASON, Stephen , HARMER, Quentin
IPC分类号： A61K9/14
CPC分类号： A61K9/0075 , A61K9/008 , A61K9/16 , A61K9/1617 , A61K9/1623 , A61K9/1694 , A61K9/50 , A61K31/473 , A61K31/55 , A61K31/5513 , A61K31/727 , B02C19/06
摘要： Manufacture of Pharmaceutical Compositions The present invention relates to particles and to methods of making particles. In particular, the invention relates to methods of making composite active particles comprising a pharmaceutically active material for pulmonary inhalation, the method comprising a jet milling process.
摘要翻译：药物组合物的制造本发明涉及颗粒和制备颗粒的方法。特别地，本发明涉及制备包含用于肺部吸入的药物活性物质的复合活性颗粒的方法，所述方法包括喷射研磨方法。

3. 发明申请

WO2005025550A1 PHARMACEUTICAL COMPOSITIONS FOR TREATING PREMATURE EJACULATION BY PULMONARY INHALATION 审中-公开
标题翻译：用于通过脉搏吸入治疗预防性呕吐的药物组合物
公开(公告)号：WO2005025550A1
公开(公告)日：2005-03-24
申请号：PCT/GB2004/003935
申请日：2004-09-15
申请人： VECTURA LIMITED , MORTON, David , STANIFORTH, John , TOBYN, Mike , EASON, Stephen , HARMER, Quentin , GANDERTON, David
发明人： MORTON, David , STANIFORTH, John , TOBYN, Mike , EASON, Stephen , HARMER, Quentin , GANDERTON, David
IPC分类号： A61K9/72
CPC分类号： A61M15/0028 , A61K9/0075 , A61M11/001 , A61M15/0036 , A61M15/004 , A61M15/0091 , A61M15/0093 , A61M2202/064 , A61M2205/073
摘要： The present invention relates to improved formulations for the treatment of premature ejaculation and, in particular, relates to the administration of antidepressants by pulmonary inhalation for treating premature ejaculation. Various types of known antidepressants may be used, including tricyclic antidepressants, such as clomipramine.
摘要翻译：本发明涉及用于治疗早泄的改进制剂，特别涉及通过肺部吸入给予抗抑郁药用于治疗早泄。可以使用各种类型的已知抗抑郁药，包括三环抗抑郁药如氯米帕明。

4. 发明申请

WO2005025540A3 MUCOACTIVE AGENTS FOR TREATING A PULMONARY DISEASE 审中-公开
公开(公告)号：WO2005025540A3
公开(公告)日：2005-03-24
申请号：PCT/GB2004/003932
申请日：2004-09-15
申请人： VECTURA LIMITED , MORTON, David , GANDERTON, David , STANIFORTH, John , KAMLAG, Yorick
发明人： MORTON, David , GANDERTON, David , STANIFORTH, John , KAMLAG, Yorick
IPC分类号： A61K9/12
摘要： The present invention relates to mucoactive agents, such as heparin which are useful in the treatment of diseases where excess mucus is present in the respiratory tract, such as cystic fibrosis and chronic obstructive pulmonary disease. In particular, the invention relates to pharmaceutical compositions for administration by pulmonary inhalation. It also relates to methods for producing particles suitable for pulmonary inhalation, such as spray drying or jet milling.

5. 发明申请

WO2005063203A2 MULTIPARTICULATE FORMULATIONS FOR ORAL DELIVERY 审中-公开
标题翻译：口服给药的多组分制剂
公开(公告)号：WO2005063203A2
公开(公告)日：2005-07-14
申请号：PCT/GB2004/050047
申请日：2004-12-24
申请人： VECTURA LTD , MORTON, David , SIMPSON, David , STANIFORTH, John
发明人： MORTON, David , SIMPSON, David , STANIFORTH, John
IPC分类号： A61K9/00
CPC分类号： A61K9/1652 , A61K9/0056 , A61K9/1623 , A61K9/1635 , A61K9/2077
摘要： The present invention is directed to multiparticulate formulations for oral use, preferably comprising one or more therapeutically active agents. In particular, the present invention relates to fast melt formulations which are capable of masking the taste of the active agent, by virtue of one or more tastemasking measures, whilst retaining the desired drug dissolution profile and good mouthfeel. The multiparticulate formulations of the invention can be used in a multiple dose delivery device which dispenses a unit dose of the powder upon actuation, or can be packaged for dispensation in sachets or like unit dose containers.
摘要翻译：本发明涉及口服使用的多颗粒制剂，优选包含一种或多种治疗活性剂。具体而言，本发明涉及快速熔融制剂，其能够通过一种或多种掩味措施掩蔽活性剂的味道，同时保持所需的药物溶出曲线和良好的口感。本发明的多颗粒制剂可以用于多次剂量递送装置，其在致动时分配单位剂量的粉末，或者可以被包装用于分配在小袋或类似的单位剂量容器中。

6. 发明申请

WO2005025536A3 DRY POWDER COMPOSITION COMPRISING CO-JET MILLED PARTICLES FOR PULMONARY INHALATION 审中-公开
公开(公告)号：WO2005025536A3
公开(公告)日：2005-03-24
申请号：PCT/GB2004/003996
申请日：2004-09-15
申请人： VECTURA LTD , MORTON, David , STANIFORTH, John
发明人： MORTON, David , STANIFORTH, John
IPC分类号： A61K9/14
摘要： The present invention relates to particles and to methods of making particles. In particular, the invention relates to methods of making composite active particles comprising a pharmaceutically active material for pulmonary inhalation, the method comprising a jet milling process.

7. 发明申请

WO2003020197A1 IMPROVEMENTS IN OR RELATING TO THE DELIVERY OF ORAL DRUGS 审中-公开
标题翻译：改善口服药物或提供口服药物
公开(公告)号：WO2003020197A1
公开(公告)日：2003-03-13
申请号：PCT/IB2002/003590
申请日：2002-09-04
申请人： VECTURA LIMITED , TOBYN, Michael , STANIFORTH, John , SIMPSON, David, Bradley, Brook , PATERSON, Graeme, Lindsay, Jonathan , ALTHORPE, Christopher
发明人： TOBYN, Michael , STANIFORTH, John , SIMPSON, David, Bradley, Brook , PATERSON, Graeme, Lindsay, Jonathan , ALTHORPE, Christopher
IPC分类号： A61J7/00
CPC分类号： A61J7/0053 , A61J7/02
摘要： A drug delivery device and method for administering a multiparticulate therapeutic agent into an oral cavity of a human patient for gastrointestinal deposition. The device includes a housing, a delivery unit, a metering unit and an actuator. The housing define a reservoir capable of containing multiple doses of the therapeutic agent. The delivery unit defines a delivery receptacle, is moveable between a closed position and an extended position, and is capable of delivering a unit dose of the therapeutic agent into the oral cavity when the delivery unit is in the extended position. The metering unit defines a dose receptacle and is moveable between a loading position, in which the dose receptacle communicates with the reservoir, and an unloading position, in which the dose receptacle communicates with the delivery receptacle when the delivery unit is in the closed position. The actuator, upon actuation, causes the metering unit to move from the loading to the unloading position so as to meter the unit dose and move the unit dose from the reservoir to the delivery receptacle. The actuator also prevents the delivery unit from being moved from the closed position until after the metering unit has moved from the loading to the unloading position.
摘要翻译：一种用于将多颗粒治疗剂施用于人类患者口腔以用于胃肠道沉积的药物递送装置和方法。该装置包括壳体，输送单元，计量单元和致动器。壳体限定能够容纳多个剂量的治疗剂的贮存器。递送单元限定递送容器，其可在关闭位置和延伸位置之间移动，并且当输送单元处于伸出位置时能够将单位剂量的治疗剂输送到口腔中。计量单元限定剂量容器，并且可以在剂量容器与储存器连通的装载位置和卸载位置之间移动，在卸载位置，当输送单元处于关闭位置时，剂量容器与输送容器连通。致动器在致动时使得计量单元从装载件移动到卸载位置，以便计量单位剂量并将单位剂量从储存器移动到输送容器。致动器还防止输送单元从关闭位置移动直到计量单元从装载位置移动到卸载位置。

8. 发明申请

WO2001064182A3 IMPROVEMENTS IN OR RELATING TO THE DELIVERY OF ORAL DRUGS 审中-公开
公开(公告)号：WO2001064182A3
公开(公告)日：2001-09-07
申请号：PCT/IB2001/000251
申请日：2001-02-26
申请人： VECTURA LIMITED , STANIFORTH, John , TOBYN, Michael
发明人： STANIFORTH, John , TOBYN, Michael
IPC分类号： A61K9/00
摘要： Disclosed is a system for delivery of a drug comprising a multiple unit dosing device comprising a housing and an actuator, said device containing multiple doses of multiparticulates comprising drug particles, said device upon actuation delivering a unit dose of said multiparticulates, said drug particles having a means diameter of greater than 10 μm to about 1 mm such that an effective dose of said drug cannot be delivered into the lower lung of a human patient. Also disclosed are novel methods, devices and dosage forms for delivering a drug.

9. 发明申请

WO2003020241A2 FUNCTIONAL POWDERS FOR ORAL DELIVERY 审中-公开
标题翻译：口粮的功能粉末
公开(公告)号：WO2003020241A2
公开(公告)日：2003-03-13
申请号：PCT/IB2002/004101
申请日：2002-09-05
申请人： VECTURA LIMITED , TOBYN, Michael , STANIFORTH, John , SIMPSON, David, Bradley, Brook
发明人： TOBYN, Michael , STANIFORTH, John , SIMPSON, David, Bradley, Brook
IPC分类号： A61K9/12
CPC分类号： A61K9/5026 , A61K9/0056 , A61K9/1635 , A61K9/1641 , A61K9/5042 , A61K9/5047 , A61K9/5073
摘要： In certain embodiments the invention is directed to a drug formulation for gastrointestinal deposition comprising a non-compressed free flowing plurality of particles comprising a core comprising a drug and a pharmaceutically acceptable excipient, said core overcoated with a functional coating, said drug particles having a mean diameter of greater than 10 µm to about 1 mm.
摘要翻译：在某些实施方案中，本发明涉及用于胃肠沉积的药物制剂，其包含非压缩自由流动的多个颗粒，所述颗粒包含含有药物和药学上可接受的赋形剂的核心，所述核心用功能性所述药物颗粒的平均直径大于10微米至约1毫米

10. 发明申请

WO2008007150A1 PREPARATION OF PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：药物组合物的制备
公开(公告)号：WO2008007150A1
公开(公告)日：2008-01-17
申请号：PCT/GB2007/050407
申请日：2007-07-13
申请人： UNILEVER PLC , ELPHICK, Andrew James , STANIFORTH, John , WANG, Dong , DUNCALF, David John , RANNARD, Steven Paul , LONG, James , FOSTER, Alison Jayne
发明人： ELPHICK, Andrew James , STANIFORTH, John , WANG, Dong , DUNCALF, David John , RANNARD, Steven Paul , LONG, James , FOSTER, Alison Jayne
IPC分类号： A61K9/16 , A61K31/167 , A61K31/192 , A61K31/60
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , Y02A50/411 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： A process for the production of a composition comprising a water-insoluble paracetamol or NSAID which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble paracetamol or NSAID, ii) a water soluble carrier, and iii) a solvent for each of the paracetamol or NSAID and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the paracetamol or NSAID in the carrier.
摘要翻译：一种制备包含水不溶性对乙酰氨基酚或NSAID的组合物的方法，其包括以下步骤：a）提供混合物，其包括：i）水不溶性对乙酰氨基酚或NSAID，ii）水溶性载体，和iii）溶剂，并且b）喷雾干燥该混合物以除去该溶剂或每种溶剂，并获得载体中对乙酰氨基酚或NSAID的基本上无溶剂的纳米分散体。

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