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1. 发明申请

WO2006031285A2 COILED LADDER STENT 审中-公开
标题翻译：绞线梯子
公开(公告)号：WO2006031285A2
公开(公告)日：2006-03-23
申请号：PCT/US2005/024539
申请日：2005-07-11
申请人： VASCULAR ARCHITECTS, INC. , OLSON, Jonathan, M. , ROSARIO, Peter, E. , RAVICHANDRAN, Guruswami , TSURUDA, Marshall
发明人： OLSON, Jonathan, M. , ROSARIO, Peter, E. , RAVICHANDRAN, Guruswami , TSURUDA, Marshall
IPC分类号： A61F2/06
CPC分类号： A61F2/88 , A61F2/91 , A61F2/915 , A61F2002/9155
摘要： A coiled ladder stent (12) comprises side rails (14, 16) and rungs (18) connecting the rails. At least one rung has lower strength portion (24) or is an enhanced flexibility (28) rung, or both. The lower strength portion is positioned at a reduced strength fracture location (26) along the rung so to promote any fracture of the ladder stmt at the fracture location along the rung to help prevent fracture of a rail. One way to make the lower strength portion is to make the cross-sectional area of the lower strength portion less than the average cross-sectional area of the rung. The enhanced flexibility aspect helps to accommodate relative movement between the side rails. Doing so helps to prevent fracture of the rails and rungs. In some embodiments of the invention the enhanced flexibility rung comprises one or more nonlinear, such as generally S-shaped or generally U-shaped, portions.
摘要翻译：螺旋式梯架（12）包括侧轨（14,16）和连接轨道的梯级（18）。至少一个梯级具有较低的强度部分（24）或是增强的柔性（28）梯级，或两者。较低强度部分位于沿着梯级的减小的强度断裂位置（26）处，以便促进沿着梯级的断裂位置处的梯子桩的任何断裂，以有助于防止轨道断裂。制造低强度部分的一种方式是使下部强度部分的横截面面积小于横梁的平均横截面面积。增强的灵活性方面有助于适应侧轨之间的相对运动。这样做有助于防止轨道和梯级断裂。在本发明的一些实施例中，增强的柔性梯级包括一个或多个非线性，例如大致S形或大致U形的部分。

2. 发明申请

WO2006068856A3 COILED ENDOLUMINAL PROSTHESIS SYSTEM, DELIVERY CATHETER AND METHOD 审中-公开
公开(公告)号：WO2006068856A3
公开(公告)日：2006-06-29
申请号：PCT/US2005/044575
申请日：2005-12-09
申请人： VASCULAR ARCHITECTS, INC. , HERMANN, George, D. , OLSON, Jonathan, M. , TSURUDA, Marshall , MODESITT, Bruce, D. , ROSARIO, Peter, E. , CABALUNA, Donald, J. , RAVICHANDRAN, Guruswami
发明人： HERMANN, George, D. , OLSON, Jonathan, M. , TSURUDA, Marshall , MODESITT, Bruce, D. , ROSARIO, Peter, E. , CABALUNA, Donald, J. , RAVICHANDRAN, Guruswami
IPC分类号： A61F2/06
摘要： A delivery assembly includes a catheter, a generally helical endoluminal prosthesis, placeable in a radially contracted state on the catheter, means for engaging portions of the prosthesis to maintain it in the contracted state, and means for controllably releasing the portions so the prosthesis controllably expands. A delivery catheter comprises a first, flexible, polymer-based tube and a second, metal tube with flexibility enhancing relief areas to enhance the bending flexibility while retaining good torsional stiffness. A coiled endoluminal prosthesis system may include means for rotating a delivery catheter while axially releasing the prosthesis. A release element may be retracted simultaneously with rotation of the delivery catheter. The prosthesis may be configured to reduce or eliminate any difference between the length of the prosthesis when expanded and contracted.

3. 发明申请

WO2006031284A2 COVERED STENT WITH CONTROLLED THERAPEUTIC AGENT DIFFUSION 审中-公开
标题翻译：覆盖支架控制治疗药物扩散
公开(公告)号：WO2006031284A2
公开(公告)日：2006-03-23
申请号：PCT/US2005/024183
申请日：2005-07-11
申请人： VASCULAR ARCHITECTS, INC. , IKI, Kobi , TSURUDA, Marshall
发明人： IKI, Kobi , TSURUDA, Marshall
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/88 , A61F2250/0068
摘要： A covered stent (18) includes a generally tubular stent body (16) having inner and outer stent body surfaces (26, 24). A sleeve of porous material (20) encloses the stent body and has inner and outer portions (40, 42) opposed to the inner and outer stent body surfaces. A therapeutic agent is located along the stent body, the agent being diffusible through the material. A diffusion barrier (30) is located between the inner material portion and the agent along the stent. The diffusion barrier prevents passage of at least a significant amount the agent through the inner portion of the sleeve of porous material. A diffusion restrictor (32) is located between the outer portion of the sleeve of porous material and the agent along the stent. The diffusion restrictor permits passage of the agent through the inner material portion at a therapeutic level.
摘要翻译：覆膜支架（18）包括具有内支架主体表面（26）和外支架主体表面（24）的大致管状支架主体（16）。多孔材料的套管（20）包围支架主体，并具有与内部和外部支架主体表面相对的内部和外部（40,42）。治疗剂沿着支架体定位，该试剂可扩散穿过材料。扩散屏障（30）沿支架位于内部材料部分和制剂之间。扩散阻挡层防止至少显着量的试剂通过多孔材料套筒的内部部分。扩散限制器（32）位于多孔材料套管的外部与沿着支架的制剂之间。扩散限制器允许药剂以治疗水平通过内部材料部分。

4. 发明公开

EP1830744A2 COILED ENDOLUMINAL PROSTHESIS SYSTEM, DELIVERY CATHETER AND METHOD 审中-公开
标题翻译：冷轧腔内移植物系统，储存导管和方法
公开(公告)号：EP1830744A2
公开(公告)日：2007-09-12
申请号：EP05853481.9
申请日：2005-12-09
申请人： Vascular Architects, Inc.
发明人： HERMANN, George, D. , OLSON, Jonathan, M. , TSURUDA, Marshall , MODESITT, Bruce, D. , ROSARIO, Peter, E. , CABALUNA, Donald, J. , RAVICHANDRAN, Guruswami
IPC分类号： A61F2/06
CPC分类号： A61F2/92 , A61F2/95 , A61F2002/9511 , A61F2002/9517
摘要： A delivery assembly includes a catheter, a generally helical endoluminal prosthesis, placeable in a radially contracted state on the catheter, means for engaging portions of the prosthesis to maintain it in the contracted state, and means for controllably releasing the portions so the prosthesis controllably expands. A delivery catheter comprises a first, flexible, polymer-based tube and a second, metal tube with flexibility enhancing relief areas to enhance the bending flexibility while retaining good torsional stiffness. A coiled endoluminal prosthesis system may include means for rotating a delivery catheter while axially releasing the prosthesis. A release element may be retracted simultaneously with rotation of the delivery catheter. The prosthesis may be configured to reduce or eliminate any difference between the length of the prosthesis when expanded and contracted.

5. 发明公开

EP1799150A2 COVERED STENT WITH CONTROLLED THERAPEUTIC AGENT DIFFUSION 审中-公开
标题翻译：与治疗剂的受控扩散涂层支架
公开(公告)号：EP1799150A2
公开(公告)日：2007-06-27
申请号：EP05779525.4
申请日：2005-07-11
申请人： Vascular Architects, Inc.
发明人： IKI, Kobi , TSURUDA, Marshall
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/88 , A61F2250/0068
摘要： A covered stent (18) includes a generally tubular stent body (16) having inner and outer stent body surfaces (26, 24). A sleeve of porous material (20) encloses the stent body and has inner and outer portions (40, 42) opposed to the inner and outer stent body surfaces. A therapeutic agent is located along the stent body, the agent being diffusible through the material. A diffusion barrier (30) is located between the inner material portion and the agent along the stent. The diffusion barrier prevents passage of at least a significant amount the agent through the inner portion of the sleeve of porous material. A diffusion restrictor (32) is located between the outer portion of the sleeve of porous material and the agent along the stent. The diffusion restrictor permits passage of the agent through the inner material portion at a therapeutic level.

6. 发明公开

EP1799149A2 COILED LADDER STENT 审中-公开
标题翻译：螺旋梯形支架
公开(公告)号：EP1799149A2
公开(公告)日：2007-06-27
申请号：EP05770205.2
申请日：2005-07-11
申请人： Vascular Architects, Inc.
发明人： OLSON, Jonathan, M. , ROSARIO, Peter, E. , RAVICHANDRAN, Guruswami , TSURUDA, Marshall
IPC分类号： A61F2/06
CPC分类号： A61F2/88 , A61F2/91 , A61F2/915 , A61F2002/9155
摘要： A coiled ladder stent (12) comprises side rails (14, 16) and rungs (18) connecting the rails. At least one rung has lower strength portion (24) or is an enhanced flexibility (28) rung, or both. The lower strength portion is positioned at a reduced strength fracture location (26) along the rung so to promote any fracture of the ladder stmt at the fracture location along the rung to help prevent fracture of a rail. One way to make the lower strength portion is to make the cross-sectional area of the lower strength portion less than the average cross-sectional area of the rung. The enhanced flexibility aspect helps to accommodate relative movement between the side rails. Doing so helps to prevent fracture of the rails and rungs. In some embodiments of the invention the enhanced flexibility rung comprises one or more nonlinear, such as generally S-shaped or generally U-shaped, portions.

7. 发明申请

WO2010011698A1 TETHER-ANCHOR ASSEMBLIES 审中-公开
公开(公告)号：WO2010011698A1
公开(公告)日：2010-01-28
申请号：PCT/US2009/051322
申请日：2009-07-21
申请人： GUIDED DELIVERY SYSTEMS INC. , JOHANSSON, Peter, K. , TSURUDA, Marshall
发明人： JOHANSSON, Peter, K. , TSURUDA, Marshall
IPC分类号： A61B17/03
CPC分类号： A61B17/0401 , A61B17/00234 , A61B17/06166 , A61B17/064 , A61B17/068 , A61B17/0682 , A61B17/072 , A61B2017/00243 , A61B2017/00783 , A61B2017/00867 , A61B2017/0409 , A61B2017/0414 , A61B2017/0437 , A61B2017/0464 , A61B2017/07221 , A61F2/2445 , Y10T29/49826
摘要： Anchors, tethers, knot configurations and other coupling mechanisms used to secure tethers to anchors or other implants are described. The knot configurations described may provide enhanced knot security and/or tensile strength, while also occupying relatively little volume. In some variations, the surfaces of a tether and/or an anchor or other implant may be at least partially coated with one or more agents and/or may be at least partially textured.
摘要翻译：描述了锚固件，系绳，结结构和用于将系绳固定到锚固件或其它植入物的其它联接机构。所描述的结结构可以提供增强的结安全性和/或拉伸强度，同时也占据相对较小的体积。在一些变型中，系绳和/或锚固件或其它植入物的表面可以至少部分地涂覆有一种或多种试剂和/或可以至少部分地织构化。

8. 发明申请

WO2006118757A3 METHOD FOR MAKING A COVERED DRUG-ELUTING STENT 审中-公开
公开(公告)号：WO2006118757A3
公开(公告)日：2006-11-09
申请号：PCT/US2006/013523
申请日：2006-04-12
申请人： THE WALLACE ENTERPRISES, INC. , IKI, Kobi , TSURUDA, Marshall , TECSON, Teodoro , ALVARADO, Angelica , BADESHA, Jasbir
发明人： IKI, Kobi , TSURUDA, Marshall , TECSON, Teodoro , ALVARADO, Angelica , BADESHA, Jasbir
IPC分类号： A61L33/00 , A61F2/06
摘要： A stent, having openings, is mounted onto a mandrel. An agent-containing film is applied onto the stent and the two are pressed against one another so that at least a portion of the film is pressed at least partially into the openings. The film is adhered to the stent. Any excess film is removed to create a stent/film combination which is removed from the mandrel and enclosed within a sleeve of porous material to create a covered agent-eluting stent.

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