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1. 发明申请

WO2004111625A1 VEHICLE MOUNTED INSPECTION SYSTEMS AND METHODS 审中-公开
标题翻译：车辆安装检查系统和方法
公开(公告)号：WO2004111625A1
公开(公告)日：2004-12-23
申请号：PCT/US2004/017532
申请日：2004-06-03
申请人： VARIAN MEDICAL SYSTEMS TECHNOLOGIES, INC. , JOHNSON, James, H. , BJORKHOLM, Paul
发明人： JOHNSON, James, H. , BJORKHOLM, Paul
IPC分类号： G01N23/04
CPC分类号： G01V5/0016 , G01N23/04
摘要： Radiation scanning systems to inspect objects are disclosed comprising a first vehicle supporting a radiation source. A second vehicle supports a detector. The source and the detector may be moved to scan an object, such as a cargo conveyance, between the vehicles. The first and second vehicles may having an expandable length and the source and detector may be moved across the expandable length, to scan long objects. The radiation source may be adapted to emit a vertically diverging beam of radiation, such as a fan beam. The radiation may be X-ray radiation, for example. The vehicle may comprise a truck and an expandable trailer releasably coupled to the truck. The trailer may comprise telescoping rails. The first and second vehicles may be driven to an inspection site, where they may be rapidly deployed. Methods of inspecting objects are disclosed, as well.
摘要翻译：公开了用于检查物体的辐射扫描系统，其包括支撑辐射源的第一车辆。第二车辆支持检测器。源和检测器可以被移动以在车辆之间扫描诸如货物运输工具之类的物体。第一和第二车辆可以具有可扩展的长度，并且源和检测器可以在可扩展的长度上移动，以扫描长的物体。辐射源可以适于发射垂直发散的辐射束，例如扇形光束。辐射可以是例如X射线辐射。车辆可以包括卡车和可释放地联接到卡车的可膨胀拖车。拖车可以包括伸缩轨道。第一和第二车辆可以被驱动到检查现场，在那里它们可以被快速部署。还公开了检查对象的方法。

2. 发明申请

WO2007016065A2 METHOD OF OBTAINING ADVERTISING LOCATIONS 审中-公开
标题翻译：获取广告位置的方法
公开(公告)号：WO2007016065A2
公开(公告)日：2007-02-08
申请号：PCT/US2006/028762
申请日：2006-07-25
申请人： JOHNSON, James, H.
发明人： JOHNSON, James, H.
IPC分类号： G09F9/37
CPC分类号： G09F19/22 , E04H1/1222 , G06Q30/0247 , G06Q30/0249
摘要： A method includes the steps of working with a beer or soft drink company to obtain site placement rights adjacent a beer or soft drink retailer, placing a beer or soft drink staging structure at the site, storing beer or soft drinks in the structure and marketing beer or soft drinks on the structure.
摘要翻译：一种方法包括以下步骤：与啤酒或软饮料公司合作，获得邻近啤酒或软饮料零售商的现场安置权利，在场地放置啤酒或软饮料分级结构，将啤酒或软饮料储存在结构中并销售啤酒或结构上的软饮料。

3. 发明申请

WO2004013096A2 METHODS AND COMPOSITIONS FOR CONVERTING TAXANE AMIDES TO PACLITAXEL OR OTHER TAXANES 审中-公开
标题翻译：将紫杉醇转化为紫杉醇或其他紫杉醇的方法和组合物
公开(公告)号：WO2004013096A2
公开(公告)日：2004-02-12
申请号：PCT/US2003/024666
申请日：2003-08-04
申请人： NATURAL PHARMACEUTICALS INC. , JOHNSON, James, H. , GALLEGHER, Rex, T. , WANG, Dasheng , JUCHUM, John, S.
发明人： JOHNSON, James, H. , GALLEGHER, Rex, T. , WANG, Dasheng , JUCHUM, John, S.
IPC分类号： C07D
CPC分类号： C07F7/1856 , C07D305/14 , Y02P20/55
摘要： The invention relates to methods and compositions for converting taxane amides to paclitaxel or other taxanes. In one alternative embodiment, the present invention comprises; (i) selectively protecting at least one OH group of a taxane amide; (ii) contacting the taxane amide with a transition metal compound to reduce the amide; (iii) contacting the reduced amide with an agent capable of substantially removing the transition metal; (iv) contacting the reduced amide with a hydrolyzing amount of acid to form a taxane amine salt in solution; (v) adding a sufficient amount of solvent to solidify the amine salt; and (vi) converting the taxane amine salt into paclitaxel or other taxanes.
摘要翻译：本发明涉及将紫杉烷酰胺转化为紫杉醇或其他紫杉烷的方法和组合物。在一个替代实施例中，本发明包括：（i）选择性保护紫杉烷酰胺的至少一个OH基团; （ii）使紫杉烷酰胺与过渡金属化合物接触以还原酰胺; （iii）使还原酰胺与能够基本除去过渡金属的试剂接触; （iv）使还原酰胺与水解量的酸接触以在溶液中形成紫杉烷胺盐; （v）加入足够量的溶剂以固化胺盐; 和（vi）将紫杉烷胺盐转化成紫杉醇或其他紫杉烷。

4. 发明申请

WO2003087079A1 CONVERSION OF TAXANE MOLECULES 审中-公开
标题翻译： TAXANE分子转化
公开(公告)号：WO2003087079A1
公开(公告)日：2003-10-23
申请号：PCT/US2003/010557
申请日：2003-04-05
申请人： NATURAL PHARMACEUTICALS, INC. , JOHNSON, James, H. , GALLAGHER, Rex, T. , FRANKE, Roland, R.
发明人： JOHNSON, James, H. , GALLAGHER, Rex, T. , FRANKE, Roland, R.
IPC分类号： C07D305/14
CPC分类号： C07D305/14
摘要： The invention provides methods and compositions for reductively deoxygenating an amide group at a C-3’ position of a taxane molecule followed by subsequent intra-molecular acyl migration of an acyl group to the C-3’ position.
摘要翻译：本发明提供了用于在紫杉烷分子的C-3'位置还原性脱氧酰胺基团的方法和组合物，随后将酰基分子内酰基迁移至C-3'位置。

5. 发明申请

WO2004083176A3 PURIFICATION OF TAXANES AND TAXANE MIXTURES USING POLYETHYLENEIMINE-BONDED RESINS 审中-公开
公开(公告)号：WO2004083176A3
公开(公告)日：2004-09-30
申请号：PCT/US2004/008055
申请日：2004-03-17
申请人： NATURAL PHARMACEUTICALS, INC. , JOHNSON, James, H. , SAMBANDAM, T., G. , HAND, Barry, J. , HOWE, Christopher, D. , FRANKE, Roland, R. , BUCHER, Brian, A. , JUCHUM, John, S. , GALLAGHER, Rex, T. , PLANTE, Marc, A. , DESIMONE, Edward, M., III. , YANG, Dong, S.
发明人： JOHNSON, James, H. , SAMBANDAM, T., G. , HAND, Barry, J. , HOWE, Christopher, D. , FRANKE, Roland, R. , BUCHER, Brian, A. , JUCHUM, John, S. , GALLAGHER, Rex, T. , PLANTE, Marc, A. , DESIMONE, Edward, M., III. , YANG, Dong, S.
IPC分类号： C07D305/14
摘要： This invention is directed to a method for isolating and /or purifying one or more taxanes from materials comprising taxanes. In one embodiment, the method comprises the steps of: (a) treating a taxane containing material with an amino containing material attached to a solid matrix, such as a polyethyleneimine-bonded silica chromatographic resin; (b) eluting the desired taxane compound from the resin; and (c) recovering the eluted taxane compound.

6. 发明申请

WO2004068930A2 METHOD AND COMPOSITION FOR PREPARING A COMPOUND USING A BENZOLATING AGENT ESSENTIALLY FREE OF RING CHLORINATION 审中-公开
标题翻译：使用基本不含环氯化剂的苯甲酸酯化合物制备化合物的方法和组合物
公开(公告)号：WO2004068930A2
公开(公告)日：2004-08-19
申请号：PCT/US2004/003259
申请日：2004-02-03
申请人： NATURAL PHARMACEUTICALS INC. , JOHNSON, James, H. , HAND, Barry, J. , GALLAGHER, Rex, T.
发明人： JOHNSON, James, H. , HAND, Barry, J. , GALLAGHER, Rex, T.
IPC分类号： C07D305/14
CPC分类号： C07D305/14
摘要： This invention relates to methods and compositions for preparing compounds using a benzoylating agent essentially free of ring chlorination. In one alternative embodiment, the present invention relates to methods and compositions for preparing taxanes essentially free of ring chlorinated impurities. In another alternative embodiment, the present invention comprises methods for converting taxane amine to paclitaxel by contacting the taxane amine with a benzoylating agent essentially free of ring chlorination.
摘要翻译：本发明涉及使用基本不含环氯化的苯甲酰化剂制备化合物的方法和组合物。在一个替代实施方案中，本发明涉及用于制备基本上不含环状氯化杂质的紫杉烷的方法和组合物。在另一个可供选择的实施方案中，本发明包括通过使紫杉烷胺与基本上不含环氯化的苯甲酰化试剂接触将紫杉烷胺转化为紫杉醇的方法。

7. 发明申请

WO2007016063A3 STORAGE FACILITIES FOR EMERGENCY RELIEF SUPPLIES 审中-公开
公开(公告)号：WO2007016063A3
公开(公告)日：2007-02-08
申请号：PCT/US2006/028760
申请日：2006-07-25
申请人： JOHNSON, James, H.
发明人： JOHNSON, James, H.
IPC分类号： F25D23/00
摘要： A method of community service including placing a storage structure at a strategic location for direct distribution of emergency relief supplies from the storage structure to a populace in the event of an actual disaster. In addition the method includes marketing advertising on the storage structure.

8. 发明申请

WO2007015984A3 METHOD OF STAGING PRODUCT 审中-公开
公开(公告)号：WO2007015984A3
公开(公告)日：2007-02-08
申请号：PCT/US2006/028499
申请日：2006-07-24
申请人： JOHNSON, James, H.
发明人： JOHNSON, James, H.
IPC分类号： G06Q30/00
摘要： A method of promoting a product includes steps of placing a storage structure adjacent a retailer of the product, staging the product in the storage structure and advertising the product on the storage structure.

9. 发明申请

WO2003087078A1 SELECTIVE ACYLATION OF SECONDARY HYDROXYL GROUPS 审中-公开
标题翻译：二级羟基组合的选择性研究
公开(公告)号：WO2003087078A1
公开(公告)日：2003-10-23
申请号：PCT/US2003/010556
申请日：2003-04-05
申请人： NATURAL PHARMACEUTICALS, INC. , JOHNSON, James, H. , PARIZA, Richard, J. , GALLAGHER, Rex, T.
发明人： JOHNSON, James, H. , PARIZA, Richard, J. , GALLAGHER, Rex, T.
IPC分类号： C07D305/14
CPC分类号： C07D305/14
摘要： The invention provides methods and compositions for selectively acylating a specific hydroxyl group in a molecule of interest containing at least two unprotected secondary hydroxyl groups. Although the methods and compositions of the invention have general applicability, they are particularly useful in the selective acylation of the taxane molecules.
摘要翻译：本发明提供用于选择性酰化目标分子中特定羟基的方法和组合物，其含有至少两个未被保护的仲羟基。尽管本发明的方法和组合物具有一般适用性，但它们在紫杉烷分子的选择性酰化中特别有用。

10. 发明申请

WO2007016102A3 METHOD OF MARKETING A PRODUCT 审中-公开
公开(公告)号：WO2007016102A3
公开(公告)日：2007-02-08
申请号：PCT/US2006/028865
申请日：2006-07-25
申请人： JOHNSON, James, H.
发明人： JOHNSON, James, H.
IPC分类号： A47F3/00 , B65G1/06
摘要： A marketing method includes the steps of acquiring site placement rights from retailers of a product at different locations, providing staging structures for the product at those different locations and promoting sales of the product by transmitting promotional information about the product over a radio frequency at the different locations.

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