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1. 发明申请

WO2018122251A1 INTERACTIVE DOSE MANIPULATION USING PRIORITIZED CONSTRAINTS 审中-公开
公开(公告)号：WO2018122251A1
公开(公告)日：2018-07-05
申请号：PCT/EP2017/084629
申请日：2017-12-27
申请人： VARIAN MEDICAL SYSTEMS INTERNATIONAL AG
发明人： KUUSELA, Esa , SIKET-SZASZ, Edit , LESSARD, Marco , HALKO, Lauri
IPC分类号： A61N5/10
摘要： In a method of interactive manipulation of the dose distribution of a radiation treatment plan, after an initial candidate treatment plan has been obtained, a set of clinical goals are transferred into a set of constraints. Each constraint may be expressed in terms of a threshold value for a respective quality index of the dose distribution. The dose distribution can then be modified interactively by modifying the threshold values for the set of constraints. Re-optimization may be performed based on the modified threshold values. A user may assign relative priorities among the set of constraints. When a certain constraint is modified, a re-optimized treatment plan may not violate those constraints that have priorities that are higher than that of the modified constraint, but may violate those constraints that have priorities that are lower than that of the modified constraint.

2. 发明公开

EP3741431A1 DETERMINING A RADIATION TREATMENT PLAN FOR DELIVERING RADIATION TO A PATIENT USING AN EXTERNAL-BEAM RADIATION TREATMENT SYSTEM 有权转让
公开(公告)号：EP3741431A1
公开(公告)日：2020-11-25
申请号：EP20185552.5
申请日：2017-12-27
申请人： Varian Medical Systems International AG
发明人： KUUSELA, Esa , SIKET-SZASZ, Edit , LESSARD, Marco , HALKO, Lauri
IPC分类号： A61N5/10
摘要： A method of determining a radiation treatment plan for delivering radiation to a patient using an external-beam radiation treatment system is described. A first clinical goal and a second clinical goal are received, wherein the first clinical goal includes a first threshold value for a first quality index relating to a first statistical quantity of a dose distribution, and the second clinical goal includes a second threshold value for a second quality index relating to a second statistical quantity of the dose distribution. A first clinically significant change and a first clinically insignificant change for the first quality index are specified by a user, and a second clinically significant change and a second clinically insignificant change for the second quality index are specified by the user. A cost function includes a first term, a second term, and a third term, wherein the first term is proportional to a value of the first quality index in excess of the first threshold value and proportional to a value of the second quality index in excess of the second threshold value, the second term relates to the first clinically insignificant change for the first quality index and to the second clinically significant change for the second quality index, and the third term relates to the first clinically significant change for the first quality index and to the second clinically insignificant change for the second quality index. Optimization is then performed using the cost function to obtain an optimal radiation treatment plan having an optimal value for the cost function.

3. 发明公开

EP3562549A1 INTERACTIVE DOSE MANIPULATION USING PRIORITIZED CONSTRAINTS 有权转让
公开(公告)号：EP3562549A1
公开(公告)日：2019-11-06
申请号：EP17832970.2
申请日：2017-12-27
申请人： Varian Medical Systems International AG
发明人： KUUSELA, Esa , SIKET-SZASZ, Edit , LESSARD, Marco , HALKO, Lauri
IPC分类号： A61N5/10

4. 发明公开

EP3744395A1 DETERMINING A RADIATION TREATMENT PLAN FOR DELIVERING RADIATION TO A PATIENT USING AN EXTERNAL-BEAM RADIATION TREATMENT SYSTEM 有权转让
公开(公告)号：EP3744395A1
公开(公告)日：2020-12-02
申请号：EP20185545.9
申请日：2017-12-27
申请人： Varian Medical Systems International AG
发明人： KUUSELA, Esa , SIKET-SZASZ, Edit , LESSARD, Marco , HALKO, Lauri
IPC分类号： A61N5/10
摘要： A method of determining a radiation treatment plan for delivering radiation to a patient using an external-beam radiation treatment system is described. A first clinical goal and a second clinical goal are received, wherein the first clinical goal includes a first acceptable threshold value and a first desired threshold value for a first quality index relating to a first statistical quantity of a dose distribution, and the second clinical goal includes a second acceptable threshold value and a second desired threshold value for a second quality index relating to a second statistical quantity of the dose distribution. A cost function is obtained which includes a first term with a first weight and a second term with a second weight, wherein the first term is proportional to a value of the first quality index in excess of the first acceptable threshold value, and the second term is proportional to a value of the second quality index in excess of the second acceptable threshold value, and wherein the first weight is inversely proportional to a difference between the first desired threshold value and the first acceptable threshold value, and the second weight is inversely proportional to a difference between the second desired threshold value and the second acceptable threshold value. Optimization then uses the cost function to obtain an optimal radiation treatment plan having an optimal value for the cost function.

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