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1. 发明申请

WO2013049845A3 SEMANTIC RADIATION TREATMENT PLAN OPTIMIZATION GUIDANCE 审中-公开
标题翻译：语义辐射治疗计划优化指导
公开(公告)号：WO2013049845A3
公开(公告)日：2013-05-23
申请号：PCT/US2012058355
申请日：2012-10-01
申请人： VARIAN MEDICAL SYSTEMS INT AG , TOIMELA LASSE , NORD JANNE , ZANKOWSKI COREY
发明人： TOIMELA LASSE , NORD JANNE , ZANKOWSKI COREY
IPC分类号： A61N5/00 , G06Q50/22
CPC分类号： A61N5/1031 , A61N2005/1041
摘要： A method for radiation therapy treatment plan optimization, comprising generating a first radiation therapy treatment plan for a patient using a selected treatment type from a database and optimizing the first radiation therapy treatment plan. A selection of metrics from the first radiation therapy treatment plan are identified and compared to metrics from aggregated prior patient records selected from the database. At least one parameter is identified that affects the ability of the first radiation therapy treatment plan to meet an identified metric. The at least one parameter is defined with a single, clinically meaningful, human understandable language statement. The at least one parameter for the identified metric is compared to at least one parameter for a competing metric and at least one alternative treatment step for the treatment plan is determined that will change the identified at least one parameter to improve the identified metric. The at least one alternative treatment step is expressed in clinically meaningful, human understandable language.
摘要翻译：一种用于放射疗法治疗计划优化的方法，包括使用来自数据库的选择的治疗类型为患者生成第一放射疗法治疗计划并优化第一放射疗法治疗计划。识别来自第一放射疗法治疗计划的一系列指标并将其与来自数据库中选择的聚集的先前患者记录的指标进行比较。识别至少一个参数，其影响第一放射疗法治疗计划满足所识别的度量的能力。至少一个参数用单一的临床上有意义的，人类可理解的语言陈述来定义。将针对所识别的度量的所述至少一个参数与针对竞争性度量的至少一个参数进行比较，并且确定将改变所识别的至少一个参数以改善所识别的度量的治疗计划的至少一个替代治疗步骤。至少一个替代治疗步骤以临床上有意义的，人类可理解的语言表达。

2. 发明申请

WO2014139040A3 RADIATION THERAPY PLANNING USING INTEGRATED MODEL 审中-公开
标题翻译：使用综合模型进行辐射治疗计划
公开(公告)号：WO2014139040A3
公开(公告)日：2014-10-30
申请号：PCT/CH2014000029
申请日：2014-03-14
申请人： VARIAN MEDICAL SYSTEMS INT AG
发明人： KUUSELA ESA , MARIA CORDERO MARCOS , HARTMAN JOONA , PELTOLA JARKKO , NORD JANNE
IPC分类号： A61N5/10
CPC分类号： G06F19/3437 , A61N5/103 , A61N2005/1041 , G06N5/00 , G06N5/022 , G16H50/50
摘要： System and method for automatically generate therapy plan parameters by use of an integrate model with extended applicable regions. The integrated model integrates multiple predictive models from which a suitable predictive model can be selected automatically to perform prediction for a new patient case. The integrated model may operate to evaluate prediction results generated by each predictive model and the associated prediction reliabilities and selectively output a satisfactory prediction. Alternatively, the integrated model may select a suitable predictive model by a decision hierarchy in which each level corresponds to divisions of a patient data feature set and divisions on a subordinate level are nested with divisions on a superordinate level.
摘要翻译：通过使用具有扩展适用区域的集成模型自动生成治疗计划参数的系统和方法。综合模型集成了多个预测模型，从中可以自动选择合适的预测模型，以对新的患者病例进行预测。集成模型可以用于评估由每个预测模型和相关联的预测可靠性产生的预测结果，并且选择性地输出令人满意的预测。或者，集成模型可以通过决策层级来选择合适的预测模型，其中每个级别对应于患者数据特征集合的分割，并且下级的分组与上级的分组嵌套。

3. 发明公开

EP2758128A4 METHOD AND APPARATUS PERTAINING TO MULTI-STAGE RADIATION-TREATMENT PLAN OPTIMIZATION 有权转让
标题翻译： VERFAHREN UND VORRICHTUNG ZUR OPTIMIERUNG EINES MEHRSTUFIGEN STRAHLUNGSBEHANDLUNGSPLANS
公开(公告)号：EP2758128A4
公开(公告)日：2015-06-03
申请号：EP12834356
申请日：2012-09-20
申请人： VARIAN MEDICAL SYSTEMS INT AG , VARIAN MEDICAL SYSTEMS CANADA INC
发明人： NORD JANNE , ARCHAMBAULT YVES
IPC分类号： A61N5/00 , A61N5/10 , G06Q50/22
CPC分类号： A61N5/1031
摘要： A control circuit employs at least two optimization stages while developing a radiation-treatment plan. During a first optimization stage the control circuit uses a first radiation-treatment plan optimization process that employs user-selected constraints to provide general plan results. During this first optimization stage the control circuit then provides one or more opportunities for a user to modify those user-selected constraints to thereby influence the general plan results. Eventually, this first optimization stage identifies a set of resultant user-selected constraints. During the second optimization stage the control circuit then uses a second radiation-treatment plan optimization process that employs the aforementioned resultant user-selected constraints to provide an optimized radiation-treatment plan.
摘要翻译：控制电路在开发放射治疗计划时采用至少两个优化阶段。在第一优化阶段期间，控制电路使用采用用户选择的约束来提供总体计划结果的第一辐射处理计划优化过程。在该第一优化阶段期间，控制电路为用户提供一个或多个机会来修改这些用户选择的约束从而影响总体计划结果。最终，该第一优化阶段标识一组由此产生的用户选择的约束。在第二优化阶段期间，控制电路然后使用第二辐射处理计划优化过程，其采用前述的所得到的用户选择的约束来提供优化的辐射处理计划。

4. 发明公开

EP2323732A4 TRAJECTORY OPTIMIZATION METHOD 有权转让
标题翻译：移动的列车优化过程
公开(公告)号：EP2323732A4
公开(公告)日：2011-12-28
申请号：EP09810493
申请日：2009-08-24
申请人： VARIAN MEDICAL SYSTEMS INT AG
发明人： NORD JANNE , PELTOLA JARKKO
IPC分类号： A61N5/10 , H05G1/42
CPC分类号： A61N5/1031 , A61N5/1047 , G06Q50/22
摘要： A method for determining a radiation treatment plan includes defining a part of a treatment using control points, defining dose calculation points, calculating dose in the dose calculation points, and changing a number of the dose calculation points. A method for determining a radiation treatment plan includes modeling a first part of a treatment plan using a fluence map, and modeling a second part of the treatment plan using a first machine parameter. A method for determining a radiation treatment plan includes determining a plurality of dose calculation points, determining a level of complexity of fluence for one of the plurality of dose calculation points, and converting a fluence map to one or more machine parameters for the one of the plurality of dose calculation points based on the determined level of complexity.

5. 发明公开

EP2856420A4 APPARATUS AND METHOD PERTAINING TO OPTIMIZING A RADIATION-TREATMENT PLAN USING HISTORICAL INFORMATION 有权转让
标题翻译：设备与优化的放射治疗方案方法使用历史信息
公开(公告)号：EP2856420A4
公开(公告)日：2016-03-02
申请号：EP13797463
申请日：2013-05-16
申请人： VARIAN MED SYS INC , VARIAN MEDICAL SYSTEMS INT AG
发明人： ZANKOWSKI COREY E , NORD JANNE , PELTOLA JARKKO , KUUSELA ESA
IPC分类号： G06Q50/22 , A61N5/00
CPC分类号： A61N5/1031 , A61N5/1038 , A61N2005/1041
摘要： A control circuit operably couples to a memory having historical information stored therein. This historical information comprises information regarding delivered radiation doses to non-targeted patient volumes for a plurality of different volume presentations. The control circuit iteratively optimizes a radiation-treatment plan for a specific plan using that historical information. The aforementioned historical information can comprise delivered-dose metrics as correspond to different relative distances within given patients. The control circuit can employ such information to determine, for example, an estimated dosage (including, if desired, a corresponding range of estimated dosages) for at least one volume within the specific patient at a specific distance from a specific point of reference. The control circuit can compare such historical information against radiation-treatment plan optimization results to qualitatively assess the radiation-treatment plan optimization results.

6. 发明公开

EP2773425A4 APPARATUS AND METHOD PERTAINING TO MOVEMENT COMPENSATION DURING RADIATION TREATMENT 审中-公开
标题翻译：设备和方法在运动补偿期间放射治疗
公开(公告)号：EP2773425A4
公开(公告)日：2015-06-24
申请号：EP12844830
申请日：2012-10-25
申请人： VARIAN MEDICAL SYSTEMS INT AG , VARIAN MED SYS INC
发明人： SILJAMAKI SAMI , NORD JANNE , SVATOS MICHELLE MARIE , ZANKOWSKI COREY E , MANSFIELD STANLEY
IPC分类号： A61N5/00 , A61B6/08 , A61N5/10
CPC分类号： A61N5/1045 , A61N5/1037 , A61N5/1067 , A61N5/107 , A61N2005/105
摘要： A control circuit controls real-time administration of a radiation-treatment plan that administers a therapeutic radiation dose to a patient. This includes compensating for a first movement as regards the application setting using a first treatment-administration modality and responding to detection of a second movement by using a second treatment-administration modality that is different from the first treatment-administration modality.
摘要翻译：控制电路控制辐射治疗计划进行实时管理做管理一个治疗辐射剂量给患者。这包括补偿的第一运动是关于使用第一治疗形式施用和通过使用第二治疗形式施用响应检测到第二运动并应用设置是从第一处理给药方式不同。

7. 发明公开

EP2760544A4 SEMANTIC RADIATION TREATMENT PLAN OPTIMIZATION GUIDANCE 有权转让
标题翻译：西班牙语十二指肠UR UNG S S S S S S S S S S S S S
公开(公告)号：EP2760544A4
公开(公告)日：2015-06-17
申请号：EP12837229
申请日：2012-10-01
申请人： VARIAN MEDICAL SYSTEMS INT AG
发明人： TOIMELA LASSE , NORD JANNE , ZANKOWSKI COREY
IPC分类号： G06Q50/22 , A61N5/10
CPC分类号： A61N5/1031 , A61N2005/1041

8. 发明申请

WO2010025115A8 TRAJECTORY OPTIMIZATION METHOD 审中-公开
标题翻译： TRAJECTORY优化方法
公开(公告)号：WO2010025115A8
公开(公告)日：2010-10-21
申请号：PCT/US2009054807
申请日：2009-08-24
申请人： VARIAN MED SYS TECH INC , NORD JANNE , PELTOLA JARKKO
发明人： NORD JANNE , PELTOLA JARKKO
IPC分类号： A61N5/10 , H05G1/42
CPC分类号： A61N5/1031 , A61N5/1047 , G06Q50/22
摘要： A method for determining a radiation treatment plan includes defining a part of a treatment using control points, defining dose calculation points, calculating dose in the dose calculation points, and changing a number of the dose calculation points. A method for determining a radiation treatment plan includes modeling a first part of a treatment plan using a fluence map, and modeling a second part of the treatment plan using a first machine parameter. A method for determining a radiation treatment plan includes determining a plurality of dose calculation points, determining a level of complexity of fluence for one of the plurality of dose calculation points, and converting a fluence map to one or more machine parameters for the one of the plurality of dose calculation points based on the determined level of complexity.
摘要翻译：用于确定放射治疗计划的方法包括使用控制点定义治疗的一部分，定义剂量计算点，计算剂量计算点中的剂量，以及改变剂量计算点的数量。用于确定放射治疗计划的方法包括使用注量图来建模治疗计划的第一部分，以及使用第一机器参数对治疗计划的第二部分建模。一种用于确定辐射治疗计划的方法包括：确定多个剂量计算点，确定所述多个剂量计算点中的一个剂量计算点的能量密度的复杂程度，以及将注量图转换为所述多个剂量计算点中的一个的一个或多个机器参数基于确定的复杂程度的多个剂量计算点。

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