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1. 发明申请

WO9947678A9 INTERFERON ALPHA PLASMIDS AND DELIVERY SYSTEMS, AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：干扰素PLASMIDS和传递系统及其制备和使用方法
公开(公告)号：WO9947678A9
公开(公告)日：2000-11-09
申请号：PCT/US9905394
申请日：1999-03-12
申请人： VALENTIS INC , NORDSTROM JEFF , PERICLE FEDERICA , ROLLAND ALLAIN , RALSTON ROBERT
发明人： NORDSTROM JEFF , PERICLE FEDERICA , ROLLAND ALLAIN , RALSTON ROBERT
IPC分类号： C12N15/09 , A61K9/127 , A61K38/00 , A61K38/21 , A61K48/00 , A61P35/00 , C07K14/54 , C07K14/56 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/21 , C12N15/85 , C12N15/24 , C12N15/88
CPC分类号： C07K14/5434 , A61K38/00 , A61K48/00 , C07K14/56 , C12N15/85 , C12N2830/42 , C12N2840/20
摘要： The present invention relates to gene delivery and gene therapy, and provides novel nucleic acid constructs for expression of interferon alpha in a mammal, formulations for delivery that incorporate a nucleic acid construct for expression, and methods for preparing and using such constructs and formulations. In particular, this invention relates to plasmid constructs for delivery of therapeutic interferon alpha encoding nucleic acids to cells in order to modulate tumor activity, methods of using those constructs (including combination therapy with other agents, such as cytokines, preferably IL-12), as well as methods for preparing such constructs.
摘要翻译：本发明涉及基因递送和基因治疗，并且提供用于在哺乳动物中表达干扰素α的新型核酸构建体，其用于递送用于表达的核酸构建体的递送制剂，以及用于制备和使用这些构建体和制剂的方法。特别地，本发明涉及用于将治疗性干扰素α编码核酸递送至细胞以调节肿瘤活性的质粒构建体，使用这些构建体的方法（包括与其它试剂例如细胞因子，优选IL-12的组合治疗），以及制备这种构建体的方法。

2. 发明申请

WO9947678A2 INTERFERON ALPHA PLASMIDS AND DELIVERY SYSTEMS, AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：干扰素PLASMIDS和传递系统及其制备和使用方法
公开(公告)号：WO9947678A2
公开(公告)日：1999-09-23
申请号：PCT/US9905394
申请日：1999-03-12
申请人： GENEMEDICINE INC , NORDSTROM JEFF , PERICLE FEDERICA , ROLLAND ALLAIN , RALSTON ROBERT
发明人： NORDSTROM JEFF , PERICLE FEDERICA , ROLLAND ALLAIN , RALSTON ROBERT
IPC分类号： C12N15/09 , A61K9/127 , A61K38/00 , A61K38/21 , A61K48/00 , A61P35/00 , C07K14/54 , C07K14/56 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/21 , C12N15/85 , C12N15/24 , C12N15/88
CPC分类号： C07K14/5434 , A61K38/00 , A61K48/00 , C07K14/56 , C12N15/85 , C12N2830/42 , C12N2840/20
摘要： The present invention relates to gene delivery and gene therapy, and provides novel nucleic acid constructs for expression of interferon alpha in a mammal, formulations for delivery that incorporate a nucleic acid construct for expression, and methods for preparing and using such constructs and formulations. In particular, this invention relates to plasmid constructs for delivery of therapeutic interferon alpha encoding nucleic acids to cells in order to modulate tumor activity, methods of using those constructs (including combination therapy with other agents, such as cytokines, preferably IL-12), as well as methods for preparing such constructs.
摘要翻译：本发明涉及基因递送和基因治疗，并且提供用于在哺乳动物中表达干扰素α的新型核酸构建体，其用于递送用于表达的核酸构建体的递送制剂，以及用于制备和使用这些构建体和制剂的方法。特别地，本发明涉及用于将治疗性干扰素α编码核酸递送至细胞以调节肿瘤活性的质粒构建体，使用这些构建体的方法（包括与其它试剂例如细胞因子，优选IL-12的组合治疗），以及制备这种构建体的方法。

3. 发明申请

WO0006759A2 ANTI-ANGIOGENESIS PLASMIDS AND DELIVERY SYSTEMS, AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：抗血管发生药物和递送系统及其制备和使用方法
公开(公告)号：WO0006759A2
公开(公告)日：2000-02-10
申请号：PCT/US9916388
申请日：1999-07-20
申请人： VALENTIS INC , MIN WANG , SZYMANSKI PAUL , MEHRENS DOROTHY , RALSTON ROBERT , SULLIVAN SEAN
发明人： MIN WANG , SZYMANSKI PAUL , MEHRENS DOROTHY , RALSTON ROBERT , SULLIVAN SEAN
IPC分类号： C12N15/09 , A61K38/00 , A61K47/18 , A61K47/32 , A61K47/44 , A61K48/00 , A61P35/00 , C07K14/78 , C12N5/10 , C12N9/68 , C12N15/55 , C12N15/85 , C12N15/88 , C12N15/12
CPC分类号： C12N9/6435 , A61K38/00 , A61K48/00 , C07K14/78 , C12N15/85 , C12N15/88 , C12N2830/007 , C12N2830/008 , C12N2830/15 , C12N2830/42 , C12N2830/85 , C12N2840/203 , C12Y304/21007
摘要： The present invention relates to gene delivery and gene therapy, and provides novel nucleic acid constructs for expression of anti-angiogenic agents in a mammal, formualtions for delivery that incorporate a nucleic acid construct for expression, and methods for preparing and using such constructs and formulations. In particular, this invention relates to plasmid constructs for delivery of therapeutic anti-angiogenic encoding nucleic acids to cells in order to modulate tumor activity, methods of using those constructs (including combination therapy with other agents, such as cytokines, preferably IL-12), as well as methods for preparing such constructs.
摘要翻译：本发明涉及基因递送和基因治疗，并且提供用于在哺乳动物中表达抗血管生成剂的新型核酸构建体，用于递送的用于表达的核酸构建体的递送形式，以及用于制备和使用这些构建体和制剂的方法。特别地，本发明涉及用于将治疗性抗血管生成编码核酸递送至细胞以调节肿瘤活性的质粒构建体，使用这些构建体的方法（包括与其它试剂例如细胞因子，优选IL-12的组合治疗），以及制备这种构建体的方法。

4. 发明专利

AU5318299A Anti-angiogenesis plasmids and delivery systems, and methods of making and usingthe same 未知
公开(公告)号：AU5318299A
公开(公告)日：2000-02-21
申请号：AU5318299
申请日：1999-07-20
申请人： VALENTIS INC
发明人： MIN WANG , SZYMANSKI PAUL , MEHRENS DOROTHY , RALSTON ROBERT , SULLIVAN SEAN
IPC分类号： C12N15/09 , A61K38/00 , A61K47/18 , A61K47/32 , A61K47/44 , A61K48/00 , A61P35/00 , C07K14/78 , C12N5/10 , C12N9/68 , C12N15/55 , C12N15/85 , C12N15/88 , C12N15/12

5. 发明专利

CA2323604A1 INTERFERON ALPHA PLASMIDS AND DELIVERY SYSTEMS, AND METHODS OF MAKING AND USING THE SAME 未知
公开(公告)号：CA2323604A1
公开(公告)日：1999-09-23
申请号：CA2323604
申请日：1999-03-12
申请人： VALENTIS INC
发明人： PERICLE FEDERICA , NORDSTROM JEFF , RALSTON ROBERT , ROLLAND ALLAIN
IPC分类号： C12N15/09 , A61K9/127 , A61K38/00 , A61K38/21 , A61K48/00 , A61P35/00 , C07K14/54 , C07K14/56 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/21 , C12N15/85 , C12N15/24 , C12N15/88
摘要： The present invention relates to gene delivery and gene therapy, and provides novel nucleic acid constructs for expression of interferon alpha in a mammal, formulations for delivery that incorporate a nucleic acid construct for expression, and methods for preparing and using such constructs and formulations. In particular, this invention relates to plasmid constructs for delivery of therapeutic interferon alpha encoding nucleic acids to cells in order to modulate tumor activity, methods of using those constructs (including combination therapy with other agents, such as cytokines, preferably IL-12), as well as methods for preparing such constructs.

6. 发明专利

CA234128A KEY TAG 未知
公开(公告)号：CA234128A
公开(公告)日：1923-09-11
申请号：CA234128D
申请人： RALSTON ROBERT
发明人： RALSTON ROBERT

7. 发明专利

AU1542802A IL-2 gene expression and delivery systems and uses 未知
公开(公告)号：AU1542802A
公开(公告)日：2002-03-21
申请号：AU1542802
申请日：2002-02-05
申请人： VALENTIS INC
发明人： RALSTON ROBERT , BRUNO MARIA , MUNGER WILLIAM , MUMPER RUSS , MULLER SUSANNE
IPC分类号： A61K48/00 , C07K14/55

8. 发明专利

CA2337496A1 ANTI-ANGIOGENESIS PLASMIDS AND DELIVERY SYSTEMS, AND METHODSOF MAKING AND USING THE SAME 未知
公开(公告)号：CA2337496A1
公开(公告)日：2000-02-10
申请号：CA2337496
申请日：1999-07-20
申请人： VALENTIS INC
发明人： MEHRENS DOROTHY , SZYMANSKI PAUL , MIN WANG , RALSTON ROBERT , SULLIVAN SEAN
IPC分类号： C12N15/09 , A61K38/00 , A61K47/18 , A61K47/32 , A61K47/44 , A61K48/00 , A61P35/00 , C07K14/78 , C12N5/10 , C12N9/68 , C12N15/55 , C12N15/85 , C12N15/88 , C12N15/12
摘要： The present invention relates to gene delivery and gene therapy, and provide s novel nucleic acid constructs for expression of anti-angiogenic agents in a mammal, formualtions for delivery that incorporate a nucleic acid construct for expression, and methods for preparing and using such constructs and formulations. In particular, this invention relates to plasmid constructs fo r delivery of therapeutic anti-angiogenic encoding nucleic acids to cells in order to modulate tumor activity, methods of using those constructs (includi ng combination therapy with other agents, such as cytokines, preferably IL-12), as well as methods for preparing such constructs.

9. 发明专利

CA1174211A LADDER STABILISING DEVICE 未知
公开(公告)号：CA1174211A
公开(公告)日：1984-09-11
申请号：CA415580
申请日：1982-11-15
申请人： RALSTON ROBERT
发明人： RALSTON ROBERT
IPC分类号： E06C7/42
摘要： An adjustable stablising device which is attached to an extension ladder without requiring modification of the ladder structure or affecting normal operation of the ladder is described. The device has two stabilising elements made of aluminum which are located at different side of the ladder. Each stabilising element has an upper and a lower bracket which are connected together by two rigid pivotably-linked longitudinal members. The stabilising elements are connected to each other by rods which extend through the rungs of the ladder and which connect the upper and the lower brackets. The lower bracket and the lower longitudinal member are pivotably connected, and the upper bracket has a number of apertures spaced lengthwise of the ladder. By choosing the aperture to which the upper longitudinal member is connected, the attitude of each of the lower members is varied via the pivotable connection so as to conform to the surface adjacent the ladder side. When not in use, the stabilising elements are retained flush against the sides of the ladder for storage.

10. 发明专利

CA258959A SHARPENER 未知
公开(公告)号：CA258959A
公开(公告)日：1926-03-16
申请号：CA258959D
申请人： RALSTON ROBERT
发明人： RALSTON ROBERT

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