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1. 发明公开

EP0299010A4 CHIMERIC NEOMORPHOGENESIS OF ORGANS BY CONTROLLED CELLULAR IMPLANTATION USING ARTIFICIAL MATRICES. 有权转让
标题翻译： PRODUCTION身体器官BY KONTROLIERTES细胞生长的人工基质。
公开(公告)号：EP0299010A4
公开(公告)日：1990-01-26
申请号：EP88900726
申请日：1987-11-20
申请人： VACANTI JOSEPH P , LANGER ROBERT S
发明人： VACANTI JOSEPH P
IPC分类号： C12N5/06 , A61F2/06 , A61L26/00 , A61L27/00 , A61L27/38 , C12N5/00
CPC分类号： A61L27/3839 , A61F2/062 , A61L27/36 , A61L27/38 , A61L2430/06 , A61L2430/28 , C12N5/0068 , C12N2501/18 , C12N2533/30 , C12N2533/40
摘要： Fibers of a biocompatible, biodegradable or non-biodegradable, synthetic polymer are provided, and are formed into a three-dimensional scaffold. The fibers of the scaffold may have a branched configuration extending outwardly from a central stem. The fibers provide sufficient surface area to permit attachment to the scaffold in vitro of an amount of cells effective to produce functional vascularized organ tissue in vivo. Fibers of the scaffold are spaced apart such that the maximum distance over which diffusion of nutrients and gases must occur through a mass of cells attached to the fibers is between 200 and 300 microns. The diffusion provides free exchange of nutrients, gases and waste to and from cells proliferating throughout the scaffold in an amount effective to maintain cell viability throughout the scaffold in the absence of vascularization. Cells derived from vascularized organ tissue are attached in vitro to the surface of the fibers uniformly throughout the scaffold and the cells are grown on the scaffold in a nutrient solution in vitro to form a cell-scaffold composition. Growth factors, compounds stimulating angiogenesis and immunomodulators may be provided in the cell-scaffold composition and the fibers may have a coating to enhance cell attachment. The cell-scaffold composition is implanted in a host at a location having adequate vascularization to allow growth of blood vessels into the cell-scaffold composition. Combinations of cell-scaffold compositions containing different cell populations may be implanted.

2. 发明专利

CA2051663A1 NEOMORPHOGENSIS OF CARTILAGE IN VIVO FROM CELL CULTURE 未知
公开(公告)号：CA2051663A1
公开(公告)日：1990-10-18
申请号：CA2051663
申请日：1990-04-16
申请人： VACANTI JOSEPH P , VACANTI CHARLES A , LANGER ROBERT S
发明人： VACANTI JOSEPH P , VACANTI CHARLES A , LANGER ROBERT S
IPC分类号： A61F2/30 , A61F2/02 , A61F2/06 , A61K35/12 , A61L27/00 , A61L27/38 , A61L27/60 , C12N5/00 , C12N5/02 , C12N5/077

3. 发明专利

AU5556890A NEOMORPHOGENESIS OF CARTILAGE (IN VIVO) FROM CELL CULTURE 未知
公开(公告)号：AU5556890A
公开(公告)日：1990-11-16
申请号：AU5556890
申请日：1990-04-16
申请人： LANGER ROBERT S , NEOMORPHICS INC , VACANTI JOSEPH P
发明人： VACANTI JOSEPH P , VACANTI CHARLES A , LANGER ROBERT S
IPC分类号： A61F2/30 , A61F2/02 , A61F2/06 , A61K35/12 , A61L27/00 , A61L27/38 , A61L27/60 , C12N5/00 , C12N5/02 , C12N5/077

4. 发明专利

CA1340581C CHIMERIC NEOMORPHOGENESIS OF ORGANS BY CONTROLLED CELLULAR IMPLANTATION USING ARTIFICIAL MATRICES 未知
公开(公告)号：CA1340581C
公开(公告)日：1999-06-08
申请号：CA552171
申请日：1987-11-18
申请人： VACANTI JOSEPH P , LANGER ROBERT S
发明人： VACANTI JOSEPH P , LANGER ROBERT S
IPC分类号： C12N5/06 , A61F2/06 , A61L26/00 , A61L27/00 , A61L27/38 , C12N5/00 , C12N5/08 , A61K35/12
摘要： A method and means for providing functional equivalents to organs wherein cells are grown on polymer scaffolding using cell culture techniques followed by transfer of the polymer-cell scaffold into a patient at a site appropriate for attachment, growth and function, after growth and vascularization. Once the structure is implanted and vascularization takes place, the resulting organ is a true blend of the parenchymal elements of the donated tissue and vascular and matrix elements of the host. A key element of the method is to design and construct the polymer scaffold using a material and shape that provides for attachment and growth of the cells such that adequate nutrients and oxygen are supplied to the inner layers of the cells by diffusion, until such time as implantation and vascularization occur.

5. 发明申请

WO2008127732A3 BIOMIMETIC VASCULAR NETWORK AND DEVICES USING THE SAME 审中-公开
标题翻译：生物体血管网络及使用该装置的装置
公开(公告)号：WO2008127732A3
公开(公告)日：2008-12-24
申请号：PCT/US2008004872
申请日：2008-04-14
申请人： GEN HOSPITAL CORP , HOGANSON DAVID M , VACANTI JOSEPH P , PRYOR HOWARD , SPOOL IRA
发明人： HOGANSON DAVID M , VACANTI JOSEPH P , PRYOR HOWARD , SPOOL IRA
IPC分类号： A01N1/00 , A61F2/06
CPC分类号： A61F2/06 , A61F2/022 , A61F2/04 , A61F2/062 , A61F2002/068 , G01N33/5008
摘要： The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of. (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a charactepstic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity withm the network of channels; (d) measuring the sheer stress and the velocity and compapng the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b) - (e). The invention also provides compositions comprising a vascular layer for use in tissue lamina as well as a medical devices having a vascular layer and kits.
摘要翻译：本发明提供制造包括流体网络的支架的方法，包括以下步骤。（a）产生用于封闭所述腔室并向细胞提供流体的初始血管层，所述初始血管层具有用于流体的通道网络; （b）将初始血管层转化为用于流体动力学分析的模型; （c）基于选自特定流体的特征，输入压力，输出压力，总体流量及其组合的所需参数来分析初始血管层，以确定网络的简单应力和速度渠道; （d）测量纯粹的应力和速度，并将所获得的值与预定值进行比较; （e）确定剪切应力或速度是否大于或小于预定值，和（f）任选地修饰初始血管层并重复步骤（b） - （e）。本发明还提供包含用于组织层的血管层的组合物以及具有血管层和试剂盒的医疗装置。

6. 发明申请

WO2009102751A3 SYSTEM AND METHOD FOR IN VITRO BLOOD VESSEL MODELING 审中-公开
标题翻译：血管内血管造影的系统与方法
公开(公告)号：WO2009102751A3
公开(公告)日：2009-11-12
申请号：PCT/US2009033736
申请日：2009-02-11
申请人： GEN HOSPITAL CORP , HOGANSON DAVID M , VACANTI JOSEPH P
发明人： HOGANSON DAVID M , VACANTI JOSEPH P
IPC分类号： G09B23/28 , A61F2/06 , A61L27/14 , A61L27/24
CPC分类号： G01N33/5088 , A61L27/18 , A61L27/38 , A61L27/507 , A61L27/56 , B01L3/5027 , B01L3/502707 , B01L2200/027 , B01L2300/0681 , C12M21/08 , C12M23/34 , C12M25/02 , C12M35/08 , G09B23/28 , C08L69/00
摘要： The present invention provides an in vitro blood vessel model for investigation of drug induced vascular injury and other vascular pathologies. The in vitro blood vessel model provides two channels separated by a porous membrane that is coated on one side by an endothelial cell layer and is coated on the other side by a smooth muscle cell layer, wherein said model is susceptible to the extravasation of red blood cells across said porous membrane due to drug induced vascular injury.
摘要翻译：本发明提供了用于研究药物诱导的血管损伤和其它血管病变的体外血管模型。体外血管模型提供了由多孔膜分离的两个通道，其通过内皮细胞层在一侧被涂覆并且被另一侧涂覆在平滑肌细胞层上，其中所述模型易于血液外渗由于药物引起的血管损伤，穿过所述多孔膜的细胞。

7. 发明专利

IL257528D0 Systems for and methods for using biomimetic structures providing communication in living tissue 未知
公开(公告)号：IL257528D0
公开(公告)日：2018-04-30
申请号：IL25752818
申请日：2018-02-14
申请人： MASSACHUSETTS GEN HOSPITAL , VACANTI JOSEPH P
发明人： VACANTI JOSEPH P
IPC分类号： C12N20060101

8. 发明专利

DE69935786D1 未知
公开(公告)号：DE69935786D1
公开(公告)日：2007-05-24
申请号：DE69935786
申请日：1999-04-22
申请人： VACANTI CHARLES A , VACANTI MARTIN , VACANTI JOSEPH P
发明人： VACANTI CHARLES A , VACANTI MARTIN , VACANTI JOSEPH P
IPC分类号： A61F2/02 , A61F2/00 , A61F2/04 , A61F2/28 , A61F2/30 , A61L27/12 , A61L27/18 , A61L27/38 , A61L27/52 , A61L27/54 , A61L27/56
摘要： The invention features a method for generating new tissue by obtaining a liquid hydrogel-cell composition including a hydrogel and tissue precursor cells; delivering the liquid hydrogel-cell composition into a permeable, biocompatible support structure; and allowing the liquid hydrogel-cell composition to solidify within the support structure and the tissue precursor cells to grow and generate new tissue. The invention also features a tissue forming structure including a permeable, biocompatible support structure having a predetermined shape that corresponds to the shape of desired tissue; and a hydrogel-cell composition at least partially filling the support structure, wherein the hydrogel-cell composition includes a hydrogel and tissue precursor cells. The new tissue forming structure can be used in new methods to generate various tissues (e.g., to treat defective tissue) including new bone, cartilage, and nervous tissue such as spinal cord tissue. The invention also features new isolated nervous system stem cells.

9. 发明专利

AU2002367580A1 TISSUE-ENGINEERED ORGANS 未知
公开(公告)号：AU2002367580A1
公开(公告)日：2003-09-22
申请号：AU2002367580
申请日：2002-05-16
申请人： OGILIVIE JENNIFER , GEN HOSPITAL CORP , GRIKSCHEIT TRACY C , VACANTI JOSEPH P
发明人： OGILIVIE JENNIFER , GRIKSCHEIT TRACY C , VACANTI JOSEPH P
IPC分类号： A61K35/12 , A61L27/36 , C12N5/00 , C12N5/071 , C12N5/077

10. 发明专利

AU5569190A METHOD FOR IMPLANTING LARGE VOLUMES OF CELLS ON POLYMERIC MATRICES 未知
公开(公告)号：AU5569190A
公开(公告)日：1990-11-16
申请号：AU5569190
申请日：1990-04-25
申请人： VACANTI JOSEPH P
发明人： VACANTI JOSEPH P , LANGER ROBERT S , JOHNSON LYNT , GRIFFITH-CIMA LINDA
IPC分类号： C12N11/08 , A61F2/02 , A61L27/00 , A61L27/38 , C12N5/00 , C12N5/071

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