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1. 发明申请

US20050280817A1 Polychromic laser scanning system and method of use 失效
标题翻译：多色激光扫描系统及其使用方法
公开(公告)号：US20050280817A1
公开(公告)日：2005-12-22
申请号：US11090673
申请日：2005-03-25
申请人： Uwe Horchner , Aaron Kantor
发明人： Uwe Horchner , Aaron Kantor
IPC分类号： G01J3/28 , G01J3/30 , G01J3/44 , G01N15/14 , G01N21/65
CPC分类号： G01J3/2803 , G01J3/44 , G01N15/1434 , G01N21/6428 , G01N21/658 , G01N2015/008 , G01N2015/144 , G01N2021/6482
摘要： A system for laser scanning provides spectral flexibility needed for the spectroscopic monitoring of highly multiplexed samples, such as cellular and particle assays in whole blood or other suspensions. In accordance with embodiments of the present invention, the system comprises a scanner to direct an excitation laser through a sample, an objective to collect light emitted by the sample in response to the excitation laser, a spectrograph to disperse the emitted light over a plurality of wavelengths as a spectrum, and a charge coupled device for detecting the spectrum. The system can be used with samples having a variety of reporter tags, including one or more SERS tags, fluorescent organic and protein tags, and quantum dot tags. A laser scanning apparatus and method of using the same is also provided.
摘要翻译：用于激光扫描的系统提供了高分辨率样品的光谱监测所需的光谱灵活性，例如全血或其它悬浮液中的细胞和颗粒测定。根据本发明的实施例，该系统包括扫描器，用于将激发激光引导通过样本，用于响应于激发激光收集由样本发射的光的目标，将发射的光分散在多个波长作为光谱，以及用于检测光谱的电荷耦合器件。该系统可以与具有各种报告标签的样品一起使用，包括一个或多个SERS标签，荧光有机和蛋白质标签以及量子点标签。还提供一种激光扫描装置及其使用方法。

2. 发明申请

US20050214877A1 Method for monitoring resting and activated platelets in unfixed blood samples 失效
公开(公告)号：US20050214877A1
公开(公告)日：2005-09-29
申请号：US11075024
申请日：2005-03-07
申请人： Timothy Wyant , Paul Raju , Aaron Kantor
发明人： Timothy Wyant , Paul Raju , Aaron Kantor
IPC分类号： G01N15/00 , G01N15/14 , G01N33/86 , G01N33/567 , A61K31/522
CPC分类号： G01N33/86 , G01N15/1468 , G01N15/1484 , G01N2015/0084 , G01N2015/1465 , G01N2015/1472 , G01N2015/1486 , Y10T436/108331 , Y10T436/24 , Y10T436/2525
摘要： The amount of platelet surface proteins in a sample may be measured by collecting a sample containing platelets into a collection tube containing a platelet stabilizing composition, labeling the platelet surface protein and detecting by cytometry.

3. 发明授权

US06190870B1 Efficient enrichment and detection of disseminated tumor cells 失效
公开(公告)号：US06190870B1
公开(公告)日：2001-02-20
申请号：US08667464
申请日：1996-06-21
申请人： Jürgen Schmitz , Stefan Miltenyi , Fawn Qian , Aaron Kantor
发明人： Jürgen Schmitz , Stefan Miltenyi , Fawn Qian , Aaron Kantor
IPC分类号： G01N33553
CPC分类号： G01N33/54326 , G01N33/574 , Y10S435/962 , Y10S436/813 , Y10S436/824 , Y10S436/825
摘要： Tumor cells, particularly carcinoma cells, are separated from peripheral blood by magnetic sorting. The tumor cells are magnetically labeled with antibodies directed to tissue specific antigens, preferably cytoplasmic proteins. Labeling for cytoplasmic antigens is accomplished first permeabilizing, then fixing the cells. The cells are separated on a magnetic matrix. The number of tumor cells in the enriched fraction is used to calculate the number of tumor cells present in a patient hematopoietic sample.

4. 发明申请

US20050002862A1 Biological markers for evaluating therapeutic treatment of inflammatory and autoimmune disorders 审中-公开
标题翻译：用于评估炎性和自身免疫性疾病的治疗性治疗的生物标志物
公开(公告)号：US20050002862A1
公开(公告)日：2005-01-06
申请号：US10845473
申请日：2004-05-12
申请人： Susan Alters , Karen Cheal , Aaron Kantor
发明人： Susan Alters , Karen Cheal , Aaron Kantor
IPC分类号： G01N33/50 , A61K49/00 , G01N33/53
CPC分类号： G01N33/5094 , G01N33/5008 , G01N33/5023 , G01N33/5047 , G01N33/505 , G01N33/5052 , G01N33/5082 , G01N33/5088 , G01N2333/70535 , G01N2800/52
摘要： Novel biological markers indicative of the action of an anti-inflammatory or immunosuppressive drug can be used to evaluate drug efficacy and compare local and systemic drug effects. They can also aid in comparison of different drugs, doses, and delivery routes. The biological markers include cell populations, cell surface antigen expression levels, and soluble factor concentrations. Measurement values of the novel biomarkers were shown to change significantly in allergic, atopic asthmatic, and healthy subjects after administration of prednisone.
摘要翻译：可以使用指示抗炎或免疫抑制药物作用的新型生物标志物来评估药物功效并比较局部和全身药物作用。他们也可以帮助比较不同的药物，剂量和分娩途径。生物标志物包括细胞群，细胞表面抗原表达水平和可溶性因子浓度。在施用泼尼松后，新生物标志物的测量值显示在过敏性，特应性哮喘和健康受试者中显着变化。

5. 发明申请

US20050064516A1 Biological markers for diagnosing multiple sclerosis 审中-公开
标题翻译：用于诊断多发性硬化症的生物标志物
公开(公告)号：US20050064516A1
公开(公告)日：2005-03-24
申请号：US10946359
申请日：2004-09-20
申请人： Aaron Kantor , Christopher Becker
发明人： Aaron Kantor , Christopher Becker
IPC分类号： G01N33/564 , G01N33/53
CPC分类号： G01N33/564 , G01N2800/285
摘要： Biological markers for multiple sclerosis, and their use in the diagnosis and clinical applications of the disease, are described.
摘要翻译：描述了用于多发性硬化的生物标志物及其在该疾病的诊断和临床应用中的用途。

6. 发明申请

US20050048574A1 Biomarkers for diagnosing rheumatoid arthritis 审中-公开
标题翻译：用于诊断类风湿关节炎的生物标志物
公开(公告)号：US20050048574A1
公开(公告)日：2005-03-03
申请号：US10801990
申请日：2004-03-15
申请人： Aaron Kantor , Christopher Becker , Howard Schulman
发明人： Aaron Kantor , Christopher Becker , Howard Schulman
IPC分类号： A61K20060101 , C12Q1/68 , G01N33/53 , G01N33/564
CPC分类号： G01N33/564 , C12Q1/6883
摘要： Biological markers for rheumatoid arthritis (RA) are disclosed. Also disclosed are the uses of such markers to diagnose and treat RA, monitor progression of the disease, evaluate therapeutic interventions, and screen candidate drugs in a clinical or preclinical trial.
摘要翻译：公开了类风湿性关节炎（RA）的生物标志物。还公开了这种标记物用于诊断和治疗RA，监测疾病进展，评估治疗干预和在临床或临床前试验中筛选候选药物的用途。

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