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1. 发明申请

US20070159624A1 Multi-functional calibration system and kit, and their uses for characterizing luminescence measurement systems 有权
标题翻译：多功能校准系统和套件，以及其用于表征发光测量系统的用途
公开(公告)号：US20070159624A1
公开(公告)日：2007-07-12
申请号：US11377593
申请日：2006-03-15
申请人： Ute Resch-Genger , Katrin Hoffman , Roland Nitschke , Axel Engel
发明人： Ute Resch-Genger , Katrin Hoffman , Roland Nitschke , Axel Engel
IPC分类号： G01J1/10
CPC分类号： G01N21/6458 , G01N21/278 , G02B21/0076
摘要： The invention relates to a multi-functional calibration system (10) for characterizing luminescence measurement systems, in particular spectrally resolving, wide-field and/or confocal imaging systems, with (a) a baseplate (12), (b) at least one calibration module (24) arranged on the baseplate (12) and including at least one calibration and/or characterization function, and (c) at least one focusing device (20) integrated in the baseplate (12) with a focusing surface (22) for setting a defined measurement beam focus of the luminescence measurement systems to be calibrated, the focusing surface (22) arranged in a common plane with the at least one calibration module (24).
摘要翻译：本发明涉及用于表征发光测量系统，特别是光谱分辨，宽场和/或共焦成像系统的多功能校准系统（10），其中（a）底板（12），（b）至少一个校准模块（24），其布置在所述基板（12）上并且包括至少一个校准和/或表征功能，以及（c）集成在所述基板（12）中的至少一个聚焦装置（20）用于设置待校准的发光测量系统的定义的测量束聚焦，所述聚焦表面（22）与所述至少一个校准模块（24）布置在公共平面中。

2. 发明申请

US20120065134A1 CD40-L INHIBITORY PHYLOMER PEPTIDES 有权
标题翻译： CD40-L抑制物质蛋白酶
公开(公告)号：US20120065134A1
公开(公告)日：2012-03-15
申请号：US13003726
申请日：2009-07-13
申请人： Paul Michael Watt , Richard Hopkins , Katrin Hoffman
发明人： Paul Michael Watt , Richard Hopkins , Katrin Hoffman
IPC分类号： A61K38/02 , A61P37/06 , C07K19/00 , A61P7/04 , A61P31/12 , C07K2/00 , A61P29/00 , A61P35/00
CPC分类号： C07K14/195 , A61K38/00 , C07K7/08
摘要： The present invention provides compositions comprising peptidyl inhibitors of CD40L-dependent signalling that are not derived from a natural binding partner of CD40L such as CD40, or from a native CD40-CD40L interface. More particularly, the peptidyl inhibitors of the present invention are derived from natural sources that do not express CD40-CD40L costimulatory pathways. The invention also provides synthetic derivatives and analogs of the peptidyl inhibitors having enhanced binding affinity for CD40L or enhanced inhibitory activity relative to their parent molecules.
摘要翻译：本发明提供组合物，其包含不衍生自CD40L的天然结合配偶体如CD40或来自天然CD40-CD40L界面的CD40L依赖性信号传导肽基抑制剂。更具体地，本发明的肽基抑制剂衍生自不表达CD40-CD40L共刺激途径的天然来源。本发明还提供具有增强的CD40L结合亲和力的肽基抑制剂的合成衍生物和类似物或相对于其母体分子增强的抑制活性。

3. 发明授权

US08802634B2 CD40-L Inhibitory Peptides 有权
标题翻译： CD40-L抑制肽
公开(公告)号：US08802634B2
公开(公告)日：2014-08-12
申请号：US13003726
申请日：2009-07-13
申请人： Paul Michael Watt , Richard Hopkins , Katrin Hoffman
发明人： Paul Michael Watt , Richard Hopkins , Katrin Hoffman
IPC分类号： A61K38/16 , A61K38/10 , A61K38/00 , A61K39/385
CPC分类号： C07K14/195 , A61K38/00 , C07K7/08
摘要： The present invention provides compositions comprising peptidyl inhibitors of CD40L-dependent signalling that are not derived from a natural binding partner of CD40L such as CD40, or from a native CD40-CD40L interface. More particularly, the peptidyl inhibitors of the present invention are derived from natural sources that do not express CD40-CD40L costimulatory pathways. The invention also provides synthetic derivatives and analogs of the peptidyl inhibitors having enhanced binding affinity for CD40L or enhanced inhibitory activity relative to their parent molecules.
摘要翻译：本发明提供组合物，其包含不衍生自CD40L的天然结合配偶体如CD40或来自天然CD40-CD40L界面的CD40L依赖性信号传导肽基抑制剂。更具体地，本发明的肽基抑制剂衍生自不表达CD40-CD40L共刺激途径的天然来源。本发明还提供具有增强的CD40L结合亲和力的肽基抑制剂的合成衍生物和类似物或相对于其母体分子增强的抑制活性。

4. 发明授权

US09880151B2 Method of determining, identifying or isolating cell-penetrating peptides 有权
公开(公告)号：US09880151B2
公开(公告)日：2018-01-30
申请号：US14112512
申请日：2012-05-23
申请人： Paul Michael Watt , Richard Hopkins , Katrin Hoffman
发明人： Paul Michael Watt , Richard Hopkins , Katrin Hoffman
IPC分类号： G01N33/50 , C07K14/47 , C40B60/12
CPC分类号： G01N33/5014 , C07K14/4723 , C07K2319/00 , C07K2319/74 , C12N2503/02 , C40B60/12
摘要： The present invention provides a method of determining or identifying or isolating a cell-penetrating peptide (CPP) or analog or derivative thereof having cell-type selectivity and/or at least capable of passing through a Blood Brain Barrier of an animal subject. This invention also provides CPPs and analogs and derivatives thereof, such as those set forth in SEQ ID NOs: 1-27 of the Sequence Listing, and compositions comprising one or more of the CPPs, including conjugates in which a CPP or analog or derivative thereof is linked to a cargo molecule. The invention also provides methods for transporting cargo molecules across cell membranes to specific locations within cells, and for treating, preventing and/or diagnosing diseases that are treatable by a cargo molecule to which a CPP or analog or derivative of the invention is attached. The invention also provides tailored peptide libraries for use in identifying or isolating CPPs.

5. 发明申请

US20140141452A1 Method of Determining, Identifying or Isolating Cell-Penetrating Peptides 有权
标题翻译：确定，鉴定或分离细胞穿透肽的方法
公开(公告)号：US20140141452A1
公开(公告)日：2014-05-22
申请号：US14112512
申请日：2012-05-23
申请人： Paul Michael Watt , Richard Hopkins , Katrin Hoffman
发明人： Paul Michael Watt , Richard Hopkins , Katrin Hoffman
IPC分类号： G01N33/50
CPC分类号： G01N33/5014 , C07K14/4723 , C07K2319/00 , C07K2319/74 , C12N2503/02 , C40B60/12
摘要： The present invention provides a method of determining or identifying or isolating a cell-penetrating peptide (CPP) or analog or derivative thereof having cell-type selectivity and/or at least capable of passing through a Blood Brain Barrier of an animal subject. This invention also provides CPPs and analogs and derivatives thereof, such as those set forth in SEQ ID NOs: 1-27 of the Sequence Listing, and compositions comprising one or more of the CPPs, including conjugates in which a CPP or analog or derivative thereof is linked to a cargo molecule. The invention also provides methods for transporting cargo molecules across cell membranes to specific locations within cells, and for treating, preventing and/or diagnosing diseases that are treatable by a cargo molecule to which a CPP or analog or derivative of the invention is attached. The invention also provides tailored peptide libraries for use in identifying or isolating CPPs.
摘要翻译：本发明提供了确定或鉴定或分离具有细胞类型选择性和/或至少能够通过动物受试者的血液脑屏障的细胞穿透肽（CPP）或其类似物或衍生物的方法。本发明还提供CPP及其类似物及其衍生物，例如序列表SEQ ID NO：1-27所列的那些，以及包含一种或多种CPP的组合物，包括其中CPP或其类似物或衍生物的缀合物与货物分子有关。本发明还提供了将货物分子跨细胞膜运送到细胞内的特定位置，以及用于治疗，预防和/或诊断本发明的CPP或类似物或衍生物所连接的货物分子可治疗的疾病的方法。本发明还提供用于鉴定或分离CPP的定制肽文库。

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