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1. 发明授权

US5965135A HIV-1 virus isolates of a subtype and its differential diagnostics 失效
标题翻译：亚型的HIV-1病毒分离株及其鉴别诊断
公开(公告)号：US5965135A
公开(公告)日：1999-10-12
申请号：US392806
申请日：1995-04-20
申请人： Ursula Dietrich , Hagen Von Briesen , Manuel Grez , Helga Rubsamen-Waigmann
发明人： Ursula Dietrich , Hagen Von Briesen , Manuel Grez , Helga Rubsamen-Waigmann
IPC分类号： A61K39/00 , A61P31/18 , C07K14/16 , C12N7/00 , C12N15/48 , A61K39/21 , A61K39/38 , C07K1/00 , C07K14/00
CPC分类号： C07K14/005 , C12N7/00 , A61K39/00 , C12N2740/15022 , C12N2740/16021 , C12N2740/16122
摘要： Three new HIV-1 isolates HIV-1 D747(ECACC V92082718), HIV-1 D757(ECACC V92082719) and HIV-1 D760(ECACC V92082720) are disclosed, which represent a further independent subtype of the HIV-1 family and have been recovered from Indian patients which at the time when the virus was isolated showed no typical AIDS symptoms. Also disclosed are vaccines against HIV-1 infections by this subtype and a process for producing the same, as well as the use of the HIV-1 infection, as well as for differential diagnosis.
摘要翻译： PCT No.PCT / EP93 / 02275第 371日期1995年04月20日 102（e）1995年4月20日PCT PCT 1993年8月25日PCT公布。公开号WO94 / 05327 日期1994年3月17日公开了三种HIV-1分离物HIV-1 D747（ECACC V92082718），HIV-1 D757（ECACC V92082719）和HIV-1 D760（ECACC V92082720），其代表HIV- 1家族已经从印度病人那里得到回收，当病毒被分离时，没有典型的艾滋病症状。还公开了针对该亚型的HIV-1感染的疫苗及其制备方法，以及使用HIV-1感染以及鉴别诊断。

2. 发明授权

US06248328B1 HIV-1 virus isolates of a subtype and its differential diagnostics, a vaccine against HIV-1 virus infections of this subtype and method of producing same, use of the HIV-1 virus isolates 失效
标题翻译：亚型的HIV-1病毒分离物及其鉴别诊断，针对该亚型的HIV-1病毒感染的疫苗及其产生方法，使用HIV-1病毒分离物
公开(公告)号：US06248328B1
公开(公告)日：2001-06-19
申请号：US09257490
申请日：1999-02-25
申请人： Ursula Dietrich , Hagen Von Briesen , Manuel Grez , Helga Rubsamen-Waigmann
发明人： Ursula Dietrich , Hagen Von Briesen , Manuel Grez , Helga Rubsamen-Waigmann
IPC分类号： A61K3900
CPC分类号： C07K14/005 , A61K39/00 , C12N7/00 , C12N2740/15022 , C12N2740/16021 , C12N2740/16122
摘要： Three new HIV-1 isolates HIV-1 D747(ECACC V92082718), HIV-1 D757(ECACC V92082719) and HIV-1 D760(ECACC V92082720) are disclosed, which represent a further independent subtype of the HIV-1 family and have been recovered from Indian patients which at the time when the virus was isolated showed no typical AIDS symptoms. Also disclosed are vaccines against HIV-1 infections by this subtype and a process for producing the same, as well as the use of the HIV-1 infection, as well as for differential diagnosis.
摘要翻译：公开了三个新的HIV-1分离株HIV-1 D747（ECACC V92082718），HIV-1 D757（ECACC V92082719）和HIV-1 D760（ECACC V92082720），其代表HIV-1家族的另一独立亚型，从分离病毒时的印度患者中恢复，没有典型的艾滋病症状。还公开了针对该亚型的HIV-1感染的疫苗及其制备方法，以及使用HIV-1感染以及鉴别诊断。

3. 发明授权

US5637455A HIV-2 virus variants 失效
标题翻译： HIV-2病毒变体
公开(公告)号：US5637455A
公开(公告)日：1997-06-10
申请号：US358575
申请日：1994-12-14
申请人： Karsten Henco , Hagen von Briesen , Andreas Immelmann , Herbert Kuhnel , Ursula Dietrich , Helga Rubsamen-Waigmann , Michalina Adamski
发明人： Karsten Henco , Hagen von Briesen , Andreas Immelmann , Herbert Kuhnel , Ursula Dietrich , Helga Rubsamen-Waigmann , Michalina Adamski
IPC分类号： G01N33/569 , A61K38/00 , A61K39/21 , A61K39/395 , C07K14/005 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/195 , C07K14/705 , C07K16/00 , C07K16/10 , C07K19/00 , C12N5/00 , C12N5/10 , C12N7/00 , C12N15/48 , C12N15/49 , C12R1/92 , G01N33/577 , G01N33/53
CPC分类号： C12N7/00 , C07K14/005 , C07K16/1045 , A61K38/00 , C12N2740/16021 , C12N2740/16022 , C12N2740/16122 , Y10S435/974 , Y10S530/81 , Y10S530/815 , Y10S530/826
摘要： HIV-2 virus variants, namely virus HIV D194 and virus HIV D205, which can be cloned from the corresponding virus isolate HIV D194 (ECACC V 87122303) or from the infected cell line HUT 194 (ECACC V 87122306) or from the virus isolate HIV D205 (ECACC V 87122304), respectively, and their RNA or RNA-fragments and DNA and DNA-fragments derived therefrom and/or proteins and the use thereof for diagnostics and therapy.
摘要翻译：可以从相应的病毒分离物HIV D194（ECACC V 87122303）或感染的细胞系HUT 194（ECACC V 87122306）或来自病毒分离物HIV的HIV病毒变体，即病毒HIV D194和病毒HIV D205克隆 D205（ECACC V87122304）及其RNA或RNA片段以及从其衍生的DNA和DNA片段和/或蛋白质及其用于诊断和治疗的用途。

4. 发明授权

US5861243A Vaccine for protection against HIV infections, process for preparing same and their use as diagnostic and agent immunotherapeutic agent 失效
标题翻译：用于防止艾滋病毒感染的疫苗，其制备方法及其作为诊断和免疫治疗剂的用途
公开(公告)号：US5861243A
公开(公告)日：1999-01-19
申请号：US968689
申请日：1997-11-12
申请人： Ursula Dietrich , Michalina Adamski , Hagen Von Briesen , Herbert Kuhnel , Helga Rubsamen-Waigmann
发明人： Ursula Dietrich , Michalina Adamski , Hagen Von Briesen , Herbert Kuhnel , Helga Rubsamen-Waigmann
IPC分类号： A61K39/21 , A61K39/00 , A61P31/12 , A61P31/18 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/155 , C07K14/16 , C07K16/00 , G01N33/53 , G01N33/569 , C12Q1/70
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/16022 , C12N2740/16122 , C12N2740/16322 , Y10S435/974
摘要： Vaccine for protection against HIV infections, therapeutic agents for treatment subsequent to HIV infections, process for their preparation and their use; procedure for differentiation between HIV-2.sub.ALT type infections and HIV-2 infections defined by the prototype HIV-2.sub.ROD.Subject matter of the present invention are the virus HIV-2.sub.D205 as well as HIV-2 variants distinguishing from the HIV-2 prototypes of the type HIV-2.sub.ROD in that nucleotide sequence homology is less than 77%. Further, proteins and nucleic acids of HIV-2.sub.D205 and its variants for utilization as vaccines for protection against HIV infections, for geno- or immunotherapy, for establishing an animal model, and for differential diagnostics are part of this invention. Furthermore, the processes for preparing these vaccines, immunotherapeutic and diagnostic agents as well as their use are part of this invention.
摘要翻译：用于防止艾滋病毒感染的疫苗，艾滋病毒感染后的治疗剂，其制备及其使用过程; HIV-2ROD原型定义的HIV-2ALT型感染与HIV-2感染之间的分化程序。本发明的主题是病毒HIV-2D205以及与HIV-2ROD型HIV-2原型区别的HIV-2变体，因为核苷酸序列同源性小于77％。此外，本发明是HIV-2D205的蛋白质和核酸及其用于作为用于保护免受HIV感染的疫苗，用于基因或免疫治疗，用于建立动物模型和鉴别诊断的变体。此外，制备这些疫苗，免疫治疗剂和诊断剂及其用途的方法是本发明的一部分。

5. 发明授权

US5677147A HIV-2 virus variants 失效
公开(公告)号：US5677147A
公开(公告)日：1997-10-14
申请号：US684682
申请日：1996-07-22
申请人： Karsten Henco , Hagen von Briesen , Andreas Immelmann , Herbert Kuhnel , Ursula Dietrich , Helga Rubsamen-Waigmann , Michalina Adamski
发明人： Karsten Henco , Hagen von Briesen , Andreas Immelmann , Herbert Kuhnel , Ursula Dietrich , Helga Rubsamen-Waigmann , Michalina Adamski
IPC分类号： G01N33/569 , A61K38/00 , A61K39/21 , A61K39/395 , C07K14/005 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/195 , C07K14/705 , C07K16/00 , C07K16/10 , C07K19/00 , C12N5/00 , C12N5/10 , C12N7/00 , C12N15/48 , C12N15/49 , C12R1/92 , G01N33/577
CPC分类号： C12N7/00 , C07K14/005 , C07K16/1045 , A61K38/00 , C12N2740/16021 , C12N2740/16022 , C12N2740/16122 , Y10S435/974 , Y10S530/81 , Y10S530/815 , Y10S530/826
摘要： HIV-2 virus variants, namely virus HIV D194 and virus HIV D205, which can be cloned from the corresponding virus isolate HIV D194 (ECACC V 87122303) or from the infected cell line HUT 194 (ECACC V 87122306) or from the virus isolate HIV D205 (ECACC V 87122304), respectively, and their RNA or RNA-fragments and DNA and DNA-fragments derived therefrom and/or proteins and the use thereof for diagnostics and therapy.

6. 发明授权

US4031587A Toothbrush for canines 失效
标题翻译：犬齿牙刷
公开(公告)号：US4031587A
公开(公告)日：1977-06-28
申请号：US599579
申请日：1975-07-28
申请人： Ursula Dietrich
发明人： Ursula Dietrich
IPC分类号： A46B9/04
CPC分类号： A46B9/04 , A46B2200/1066
摘要： A toothbrush adapted to conform to the shape of the canine jaw and the teeth therein. The toothbrush includes a handle of suitable length to which are attached at least three rows of bristles, wherein a portion of the central row is shorter than the adjacent outer rows thereby defining an axial trough. The ends of the bristles for engaging the teeth define a contour having a peak adjacent to the end of the handle formed of at least one tuft of bristles from each row, a depression adjacent to the peak formed by at least the two outer rows of bristles, and a uniform slope increasing in height to the neck of the handle. The bristles are arranged in tightly clustered tufts which contribute to the stiffness and durability thereof. The shape of the brush promotes the simultaneous cleaning of the cuspid-type and molar-type teeth in the long narrow canine jaw.
摘要翻译：一种适合于符合犬颚形状和其中牙齿的牙刷。牙刷包括具有适当长度的手柄，至少连接三排刷毛，其中中心排的一部分比相邻的外排短，从而限定轴向槽。用于接合牙齿的刷毛的端部限定了一个轮廓，其轮廓具有与从每排形成的至少一个刷毛簇的手柄的端部相邻的尖端，与由至少两个外部刷毛刷形成的峰部相邻的凹陷，并且在手柄的颈部具有高度增加的均匀斜率。刷毛被布置成紧密聚簇的簇，其有助于其刚度和耐久性。刷子的形状促进同时清洁长狭窄的犬爪中的尖牙型和摩擦型牙齿。

7. 发明授权

US4022879A Oral hygiene product for animals 失效
标题翻译：动物口腔卫生用品
公开(公告)号：US4022879A
公开(公告)日：1977-05-10
申请号：US426151
申请日：1973-12-19
申请人： Ursula Dietrich
发明人： Ursula Dietrich
IPC分类号： A61K8/19 , A61K8/26 , A61Q11/00 , A61K7/16
CPC分类号： A61Q11/00 , A61K8/19 , A61K8/26
摘要： Method and composition are provided for the care of teeth and the reduction of dental treatment for carnivorous pets, particularly canines. A mildly abrasive, substantially neutral or mildly basic, meat flavored, particularly beef flavored, dentrifice is employed. The dentrifice is found to be acceptable to the animal, causes no harmful effects on ingestion, and greatly reduces the need of a veterinarian's scaling of the pet's teeth.
摘要翻译：提供了用于护理牙齿的方法和组合物，以及减少对食肉性宠物，特别是犬科动物的牙科治疗。使用温和磨碎的，基本上中性的或基本上温和的肉类风味，特别是牛肉风味的牙齿。发现这种牙齿是动物可以接受的，对摄入没有任何有害影响，并大大降低了兽医对宠物牙齿的缩放的需要。

8. 发明授权

US4944039A Protective mask 失效
标题翻译：保护面膜
公开(公告)号：US4944039A
公开(公告)日：1990-07-31
申请号：US357525
申请日：1989-05-26
申请人： Ursula Dietrich
发明人： Ursula Dietrich
IPC分类号： A41D13/11 , A61F9/02 , G02C11/00
CPC分类号： G02C11/00 , A41D13/11 , A41D13/1184 , A61F9/029
摘要： Described herein is a protective face mask attachable to glasses. The mask comprises a thin frame generally formed to cross transversely over the bridge of the nose, below the eyes and across the cheeks of the user; a protective cover attached to the frame and extending freely therefrom to hang in front of the nose and mouth of the user; and attachment hooks for attaching the frame to the glasses.
摘要翻译：这里描述的是可附着于眼镜的防护面罩。该面罩包括通常形成为跨越鼻梁，眼睛下方并横过使用者脸颊横穿的薄框架; 保护盖，其附接到框架并且自由地延伸以悬挂在使用者的鼻子和嘴部前面; 以及用于将框架附接到眼镜的附接钩。

9. 发明授权

US4109339A Toothbrush with curved handle 失效
标题翻译：具有弯曲手柄的牙刷
公开(公告)号：US4109339A
公开(公告)日：1978-08-29
申请号：US831579
申请日：1977-09-08
申请人： Ursula Dietrich
发明人： Ursula Dietrich
IPC分类号： A46B5/02 , A46B9/04
CPC分类号： A46B5/02 , A46B9/04 , A46B2200/1066 , Y10S16/12
摘要： A toothbrush adapted for brushing the teeth of a person or an animal. The handle is cross-sectionally flattened, is S-shaped in orthogonal lateral planes, and is longitudinally twisted to provide an improved grip. The curved handle positions the head at a twisted angle which enables the user to introduce the brush into the mouth of a person, such as a child, or an animal from the side of the mouth. The curved handle also makes it easier to brush the lingual surfaces of the teeth.
摘要翻译：用于刷牙人或动物牙齿的牙刷。手柄横截面扁平，在垂直的横向平面上是S形，并且被纵向扭曲以提供改进的抓地力。弯曲的手柄将头部以扭曲的角度定位，使得使用者能够将刷子从嘴侧引入诸如孩子或动物的人的口中。弯曲的手柄还使得更容易地刷牙齿的舌表面。

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