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1. 发明申请

WO2008154632A2 SYSTEM AND METHOD FOR COMBINED ECG-ECHO FOR CARDIAC DIAGNOSIS 审中-公开
标题翻译：用于心脏诊断的组合ECG-ECHO的系统和方法
公开(公告)号：WO2008154632A2
公开(公告)日：2008-12-18
申请号：PCT/US2008/066711
申请日：2008-06-12
申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION , GARSON, Arthur, Jr. , WALKER, William, F. , HOSSACK, John, A. , BLALOCK, Travis, N.
发明人： GARSON, Arthur, Jr. , WALKER, William, F. , HOSSACK, John, A. , BLALOCK, Travis, N.
IPC分类号： A61B8/14
CPC分类号： A61B8/0858 , A61B8/0883 , A61B8/483
摘要： A system and related method for obtaining volumetric cardiac data of a subject. The data is generated by forming a plurality of focused ultrasound images corresponding to a series of ranges, generating myocardial boundary data for each of the plurality of ultrasound images, calculating the area of the region defined by said myocardial boundary data for each of the plurality of ultrasound images, multiplying the area for each of the plurality of ultrasound images by a slice depth corresponding to said ultrasound image to obtain the slice volume of each slice, and summing the slice volumes to obtain a total volume. In an alternative embodiment the system and related method combine an automated volumetric ultrasound system for finding chamber volumes and myocardial thicknesses, with a diagnostic electrocardiogram system to enable simultaneous diagnosis of mechanical and electrical cardiac problems.
摘要翻译：用于获得受试者体积心脏数据的系统和相关方法。通过形成对应于一系列范围的多个聚焦超声图像来生成数据，为多个超声图像中的每一个生成心肌边界数据，计算由多个超声图像中的每一个的所述心肌边界数据定义的区域的面积超声图像，将所述多个超声图像中的每一个的面积乘以对应于所述超声图像的切片深度，以获得每个切片的切片体积，并且对切片体积求和以获得总体积。在替代实施例中，系统和相关方法结合了用于发现腔室体积和心肌厚度的自动化体积超声系统，其具有诊断心电图系统，以能够同时诊断机械和电学心脏问题。

2. 发明申请

WO2011035162A1 ULTRASOUND-BASED METHOD AND RELATED SYSTEM TO EVALUATE HEMOSTATIC FUNCTION OF WHOLE BLOOD 审中-公开
标题翻译：基于超声波的方法和相关系统评估全血细胞的HEMOSTATIC功能
公开(公告)号：WO2011035162A1
公开(公告)日：2011-03-24
申请号：PCT/US2010/049342
申请日：2010-09-17
申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION , WALKER, William, F. , VIOLA, Francesco , MAULDIN, William, F., Jr.
发明人： WALKER, William, F. , VIOLA, Francesco , MAULDIN, William, F., Jr.
IPC分类号： G01N29/02
CPC分类号： G01N29/343 , G01N29/024 , G01N29/032 , G01N29/34 , G01N29/4472 , G01N33/4905 , G01N2291/02466 , G01N2291/025 , G01N2291/02827 , G01N2291/044
摘要： Method and systems for of evaluating a mechanical property of a material by applying force to the material sufficient to physically displace a portion of the material, measuring displacement of the material, adaptively adjusting the force when the displacement measured is not within a predetermined range of displacement values, wherein the force is increased or decreased depending upon whether the measured displacement is below or above the predetermined range, respectively, and computing a mechanical property value resultant from the displacement of the material
摘要翻译：用于通过对材料施加力来评估材料的机械性能的方法和系统，所述材料足以物理地移动材料的一部分，测量材料的位移，当所测量的位移不在预定的位移范围内时自适应地调节力值，其中所述力分别根据所测量的位移是否低于或高于所述预定范围而增加或减小，并且计算由所述材料的位移产生的机械性能值

3. 发明申请

WO2004065978A2 EFFICIENT ULTRASOUND SYSTEM FOR TWO-DIMENTIONAL C-SCAN IMAGING AND RELATED METHOD THEREOF 审中-公开
标题翻译：用于两次C扫描成像的有效超声系统及其相关方法
公开(公告)号：WO2004065978A2
公开(公告)日：2004-08-05
申请号：PCT/US2004/001002
申请日：2004-01-15
申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION , HOSSACK, John, A. , WALKER, William, F. , BLALOCK, Travis, N.
发明人： HOSSACK, John, A. , WALKER, William, F. , BLALOCK, Travis, N.
IPC分类号： G01S
CPC分类号： G01S15/8925 , A61B8/13 , A61B8/483 , G01S7/52085 , G01S7/52095 , G01S15/8993
摘要： An ultrasound system and related method for forming 2D C-scan images and/or collecting 3D image data from 2D transducer arrays. The system including in part a 2D transducer array of elements, transmit voltage generation means for each element, a memory buffer with or part of channels for each element, and a receive beamformer. On a time serial or sequential basis, several times for each line of firing, the contents of the per element memory buffer are read into the beamformer with different focusing values for each buffer reading cycle. In this way, the beamformer can calculate beamformed image values for multiple points per line firing cycle-or per each line of signals between the transducer array and receive beamformer.
摘要翻译：用于形成2D C扫描图像和/或从2D换能器阵列收集3D图像数据的超声系统和相关方法。该系统部分地包括2D换能器元件阵列，为每个元件传输电压产生装置，具有用于每个元件的通道的一部分的存储器缓冲器和接收波束形成器。在时间序列或顺序的基础上，对于每一次触发行，几次，每个缓冲区读取周期的每个元素存储器缓冲器的内容被读入具有不同聚焦值的波束形成器。以这种方式，波束形成器可以计算每行发射周期的多个点的波束形成图像值，或者计算换能器阵列和接收波束形成器之间的每一行信号。

4. 发明申请

WO2003075769A1 AN INTUITIVE ULTRASONIC IMAGING SYSTEM AND RELATED METHOD THEREOF 审中-公开
标题翻译：一种直观超声成像系统及其相关方法
公开(公告)号：WO2003075769A1
公开(公告)日：2003-09-18
申请号：PCT/US2003/006607
申请日：2003-03-06
申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION , WALKER, William, F. , HOSSACK, John, A. , BLALOCK, Travis, N.
发明人： WALKER, William, F. , HOSSACK, John, A. , BLALOCK, Travis, N.
IPC分类号： A61B8/00
CPC分类号： A61B8/5215 , A61B5/415 , A61B5/418 , A61B5/4818 , A61B8/06 , A61B8/08 , A61B8/0833 , A61B8/0841 , A61B8/13 , A61B8/14 , A61B8/4427 , A61B8/4455 , A61B8/462 , A61B8/466 , A61B8/483 , A61B8/488 , A61B2562/028 , G01S7/52038 , G01S7/52061 , G01S7/52071 , G01S7/5208 , G01S15/8925 , G01S15/8979 , G01S15/8993 , G01S15/8995
摘要： A hand held ultrasonic instrument (10) is provided in a portable unit that performs C-Mode imaging and collects 3D image data. In a preferred embodiment a transducer array (60), display unit (20), beamformer (40), power system, and image processor are integrated in one enclosure weighing less than three pounds. In operation, the portable unit is scanned across a target and the displayed image is conveniently presented to the operator whereby the displayed image corresponds exactly to the target, or a scaled fashion if desired.
摘要翻译：手持式超声波仪器（10）设置在执行C模式成像并收集3D图像数据的便携式单元中。在一个优选的实施例中，换能器阵列（60），显示单元（20），波束形成器（40），电力系统和图像处理器集成在重量小于3磅的一个外壳中。在操作中，便携式单元被扫描穿过目标，并且所显示的图像被方便地呈现给操作者，由此显示的图像精确地对准目标，或者如果需要，则按比例缩放。

5. 发明申请

WO2007035765A2 SYSTEM AND METHOD FOR ADAPTIVE BEAMFORMING FOR IMAGE RECONSTRUCTION AND/OR TARGET/SOURCE LOCALIZATION 审中-公开
标题翻译：用于图像重建和/或目标/源定位的自适应光束的系统和方法
公开(公告)号：WO2007035765A2
公开(公告)日：2007-03-29
申请号：PCT/US2006/036536
申请日：2006-09-19
申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION , WALKER, William, F. , VIOLA, Francesco
发明人： WALKER, William, F. , VIOLA, Francesco
IPC分类号： G06K9/00
CPC分类号： G01S7/52046 , G01S7/52026 , G01S7/5205 , G01S7/52052 , G01S15/8977
摘要： Methods, systems and computer readable media for reconstruction of target locations and amplitudes from signals received from one or more real targets in a space are provided, wherein the signals are at least one of signals received from the near-field and broadband signals. The space is modeled as a region of interest, and an array manifold matrix is calculated from signals received from hypothetical targets in the region of interest. One or more signal vectors received from the one or more real targets are reshaped into a data vector. A hypothetical target configuration is identified that, when applied to a signal model comprising the array manifold matrix, matches the data vector, a reconstruction vector is calculated. The reconstruction vector is reshaped into a reconstructed representation of the real targets in the space, and at least one of outputting the reconstructed representation for viewing by a user, and storing the reconstructed representation for later use are performed.
摘要翻译：提供了用于从从空间中的一个或多个实际目标接收的信号重建目标位置和幅度的方法，系统和计算机可读介质，其中所述信号是从近场和宽带信号接收的信号中的至少一个。该空间被建模为感兴趣的区域，并且根据从感兴趣区域中的假想目标接收的信号计算阵列歧管矩阵。从一个或多个实际目标接收到的一个或多个信号向量重新形成数据向量。识别出假设的目标配置，当应用于包括阵列歧管矩阵的信号模型时，匹配数据矢量，计算重构矢量。重建矢量被重构为空间中的真实目标的重建表示，并且执行输出用于观看的重建表示中的至少一个，并且存储用于稍后使用的重构表示。

6. 发明申请

WO2006042067A2 EFFICIENT ARCHITECTURE FOR 3D AND PLANAR ULTRASONIC IMAGING - SYNTHETIC AXIAL ACQUISITION AND METHOD THEREOF 审中-公开
标题翻译： 3D和平面超声波成像的有效建筑 - 合成轴向采集及其方法
公开(公告)号：WO2006042067A2
公开(公告)日：2006-04-20
申请号：PCT/US2005/036077
申请日：2005-10-05
申请人： THE UNIVERSITY OF VIRGINIA PATENT FOUNDATION , HOSSACK, John, A. , BLALOCK, Travis, N. , WALKER, William, F.
发明人： HOSSACK, John, A. , BLALOCK, Travis, N. , WALKER, William, F.
IPC分类号： A61B8/06
CPC分类号： A61B8/4483 , A61B8/00 , A61B8/483 , G01S7/52025 , G01S7/52088
摘要： An improved device and method for collecting data used for ultrasonic imaging. The data is gathered over numerous transmit and echo receive cycles, or iterations and combined into a synthetic acquisition representing a complete echo characteristic acquisition. At each iteration, only a portion, or subset, of the echo characteristic is sampled and stored. During the iterations, the portion of the echo characteristic that is measured and sampled is varied by changing the relative sampling instants. That is, the time offset from the transmission to the respective sampling instant is varied. The sample sets representative of the entire echo characteristic are then compiled from the multiple subsets of the ultrasonic transmissions.
摘要翻译：一种用于收集用于超声成像的数据的改进的装置和方法。数据在多个发送和回波接收周期或迭代中被收集，并被组合成代表完整回波特征采集的合成采集。在每次迭代中，仅对回波特性的一部分或子集进行采样和存储。在迭代期间，通过改变相对采样时刻来改变测量和采样的部分回波特性。也就是说，从发送到相应采样时刻的时间偏移是变化的。然后，从超声波传输的多个子集编译表示整个回波特性的样本集合。

7. 发明申请

WO2004064619A2 ULTRASOUND IMAGING BEAM-FORMER APPARATUS AND METHOD 审中-公开
标题翻译：超声波成像光束成像装置及方法
公开(公告)号：WO2004064619A2
公开(公告)日：2004-08-05
申请号：PCT/US2004/000887
申请日：2004-01-14
申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION , BLALOCK, Travis, N. , WALKER, William, F. , HOSSACK, John, A.
发明人： BLALOCK, Travis, N. , WALKER, William, F. , HOSSACK, John, A.
IPC分类号： A61B
CPC分类号： A61B8/4494 , A61B8/00 , A61B8/145 , A61B8/4483 , A61B8/4488 , A61B8/461 , A61B8/5207 , G01S7/52028 , G01S7/52034 , G01S7/5208 , G01S7/52085 , G01S15/8915 , G01S15/8959 , G01S15/8995 , G10K11/346
摘要： In some illustrative embodiments, an incoming signal from a transducer in an ultrasound imaging beam-former apparatus is applied to an in-phase sample-and-hold and a quadrature sample-and-hold. The quadrature sample-and-hold may be clocked a quarter period behind the in-phase sample-and-hold. The output of the sample-and-holds are applied to in-phase and quadrature analog-to-digital converters. A magnitude calculator receives the in-phase and quadrature digital values, and outputs a magnitude. A phase calculator receives the in-phase and quadrature digital values, and outputs a phase. An apodizer applies a difference between an amplitude of the outgoing signal and the magnitude and applies a first illumination to a image point in substantial proportion to the difference, and a phase rotator applies a second illumination to the image point in substantial proportion to the phase.
摘要翻译：在一些说明性实施例中，来自超声波成像束形成装置中的换能器的输入信号被施加到同相采样保持和正交采样保持。正交采样和保持可以在同相采样保持后四分之一时间钟。采样和保持的输出应用于同相和正交模数转换器。幅度计算器接收同相和正交数字值，并输出幅度。相位计算器接收同相和正交数字值，并输出相位。变迹器应用输出信号的振幅和幅度之间的差异，并且以与该差异相当大比例的方式对图像点施加第一照明，并且相位旋转器以与该相位相当比例的图像点施加第二照明。

8. 发明公开

EP1620015A2 EFFICIENT ULTRASOUND SYSTEM FOR TWO-DIMENTIONAL C-SCAN IMAGING AND RELATED METHOD THEREOF 有权
标题翻译：高效超声波系统二维C-SCAN演示和相关程序
公开(公告)号：EP1620015A2
公开(公告)日：2006-02-01
申请号：EP04702545.7
申请日：2004-01-15
申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION
发明人： HOSSACK, John, A. , WALKER, William, F. , BLALOCK, Travis, N.
IPC分类号： A61B8/02
CPC分类号： G01S15/8925 , A61B8/13 , A61B8/483 , G01S7/52085 , G01S7/52095 , G01S15/8993
摘要： An ultrasound system and related method for forming 2D C-scan images and/or collecting 3D image data from 2D transducer arrays. The system including in part a 2D transducer array of elements (50), transmit voltage generation means (51) for each element, a memory buffer (56) with or part of channels for each element, and a receive beamformer (58). On a time serial or sequential basis, several times for each line of firing, the contents of the per element memory buffer are read into the beamformer with different focusing values for each buffer reading cycle. In this way, the beamformer can calculate beamformed image values for multiple points per line firing cycle-or per each line of signals between the transducer array and receive beamformer.

9. 发明公开

EP2324337A1 FRONT END CIRCUITRY FOR IMAGING SYSTEMS AND METHODS OF USE 审中-公开
标题翻译： FRONT电路是否成像系统和使用方法
公开(公告)号：EP2324337A1
公开(公告)日：2011-05-25
申请号：EP09808508.7
申请日：2009-08-18
申请人： University Of Virginia Patent Foundation
发明人： WALKER, William, F. , FULLER, Michael, I. , RANGANATHAN, Karthik , HOSSACK, John, A. , BLALOCK, Travis, N.
IPC分类号： G01N9/24
CPC分类号： G01N29/0654 , A61B8/00 , A61B8/4483 , G01N2291/02475 , G01S7/52026 , G01S7/52046 , G01S7/52079 , G01S15/8959
摘要： Pulse-echo imaging systems and methods are provided, including a transmit code sequencer and a pulse generation circuit, The transmit code sequencer is configured to input a transmit code sequence to the pulse generation circuit. A transducer is configured to receive electrical signals provided as pulses using coded excitation according to the transmit code sequence, and to transduce the electrical signals to pulses of energy other than electrical signals. The transducer is further configured to receive echoes of the pulses of energy other than electrical signals and convert the echoes to received electrical signals generate using coded excitation. A receive circuit is configured to receive the received electrical signals generate using coded excitation, perform analog sampling of the received electrical signals generate using coded excitation, and provide a weighted, summed digital signal by processing the analog samples. At least one example of a pulse imaging system described is configured for ultrasonic pulse-echoes. At least one example of a pulse imaging system described is a medical diagnostic imaging system.

10. 发明公开

EP1949298A2 SYSTEM AND METHOD FOR ADAPTIVE BEAMFORMING FOR IMAGE RECONSTRUCTION AND/OR TARGET/SOURCE LOCALIZATION 审中-公开
标题翻译：系统和方法自适应波束成形图像重建和/或目的地/来源中分离
公开(公告)号：EP1949298A2
公开(公告)日：2008-07-30
申请号：EP06814967.3
申请日：2006-09-19
申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION
发明人： WALKER, William, F. , VIOLA, Francesco
IPC分类号： G06K9/00 , G06K9/40 , G06K9/36
CPC分类号： G01S7/52046 , G01S7/52026 , G01S7/5205 , G01S7/52052 , G01S15/8977
摘要： Methods, systems and computer readable media for reconstruction of target locations (2) and amplitudes from signals received from one or more real targets in a space are provided, wherein the signals are at least one of signals received from the near-field and broad band signals. The space is modeled as a region of interest, and an array manifold matrix is calculated from signals received from hypothetical targets in the region of interest. One or more signal vectors received from the one or more real targets are reshaped into a data vector. A hypothetical target configuration is identified (70) that, when applied to a signal model comprising the array manifold matrix, matches the data vector, a reconstruction vector is calculated. The reconstruction vector is reshaped into a reconstructed representation (74) of the real targets in the space, and at least one of outputting the reconstructed representation for viewing by a user, and storing the reconstructed representation for later use are performed.

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