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1. 发明申请

WO2011101373A1 A PHARMACEUTICAL COMPOSITION FOR TREATMENT OF THROMBOSIS-RELATED DISEASES COMPRISING A FRAGMENT OF PROLACTIN (PRL)-GROWTH HORMONE (GH)-PLACENTAL LACTOGEN (PL)-FAMILY PROTEIN 审中-公开
标题翻译：用于治疗包含丙泊酚（PRL） - 生长激素（GH） - 原位乳酸（PL） - 蛋白质蛋白的片段的相关性疾病的药物组合物
公开(公告)号：WO2011101373A1
公开(公告)日：2011-08-25
申请号：PCT/EP2011/052293
申请日：2011-02-16
申请人： UNIVERSITÉ DE LIÈGE , STRUMAN, Ingrid , MARTIAL, Joseph , BAJOU, Khalid , D'AMICO, Salvino
发明人： STRUMAN, Ingrid , MARTIAL, Joseph , BAJOU, Khalid , D'AMICO, Salvino
IPC分类号： A61K38/22 , A61K38/27 , A61P9/10
CPC分类号： A61K38/2257 , A61K38/22 , A61K38/27
摘要： The present invention refers to a pharmaceutical composition for use in the preventive and/or therapeutic treatment of thrombosis-related diseases or conditions relating to high level of PAI-1 expression, which composition is comprising A) a fragment of a polypeptide or protein of prolactin (PRL)-growth hormone (GH) - placental lactogen (PL)-family and homologous derivatives thereof, which fragment comprises from 6 to 14 consecutive amino acid residues of the amino acid sequence having the following general formula (I): X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11 -X12-X13-X14 (SEQ ID NO: 11), wherein X1 is an amino acid residue of : Leu, Phe; X2 is an amino acid residue of : Leu; X3 is an amino acid residue of : Arg, Ser; X4 is an amino acid residue of : Ile, Leu; X5 is an amino acid residue of : Ser, Ile; X6 is an amino acid residue of : Leu, VaI; X7 is an amino acid residue of : Leu, Ser, X8 is an amino acid residue of : Leu, lIe X9 is an amino acid residue of : Ile, Leu; X10 is an amino acid residue of : GIn, GIu, Arg; II 1 is an amino acid residue of : Ser; X12 is an amino acid residue of : Trp; X13 is an amino acid residue of : Leu, Asn; X14 is an amino acid residue of : GIu; or B) a peptide or a recombinant protein comprising said peptide, wherein the peptide is from 6 to 50 amino acids in length and has the activity to inhibit plasminogen activator inhibitor I (PAI-1 ), said peptide comprising from 6 to 14 consecutive amino acid residues of the amino acid sequence of said general formula (I); or C) a polynucleotide encoding said fragment of a polypeptide or protein of A) or said peptide or recombinant protein of B).
摘要翻译：本发明涉及用于预防和/或治疗血栓形成相关疾病或与高水平PAI-1表达有关的病症的药物组合物，该组合物包含A）多肽或催乳素蛋白的片段（PRL）生长激素（GH） - 胎盘催乳素（PL）家族及其同源衍生物，该片段包含具有以下通式（I）的氨基酸序列的6至14个连续氨基酸残基：X1-X2 -X3-X4-X5-X6-X7-X8-X9-X10-X11 -X12-X13-X14（SEQ ID NO：11），其中X1是氨基酸残基：Leu，Phe; X2是氨基酸残基：Leu; X3是氨基酸残基：Arg，Ser; X4是以下氨基酸残基：Ile，Leu; X5是以下氨基酸残基：Ser，Ile; X6是以下氨基酸残基：Leu，Val; X7是以下氨基酸残基：Leu，Ser，X8是Leu的氨基酸残基，I X9是Ile，Leu的氨基酸残基; X10是以下氨基酸残基：Gln，Glu，Arg; II 1是以下氨基酸残基：Ser; X12是以下氨基酸残基：Trp; X13是以下氨基酸残基：Leu，Asn; X14是以下氨基酸残基：Glu; 或B）包含所述肽的肽或重组蛋白，其中所述肽的长度为6至50个氨基酸并且具有抑制纤溶酶原激活物抑制剂I（PAI-1）的活性，所述肽包含6至14个连续氨基所述通式（I）的氨基酸序列的酸残基; 或C）编码A）或B）的多肽或蛋白质的所述肽或重组蛋白的所述片段的多核苷酸。

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