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1. 发明申请

WO2008075201A3 EPIGALLOCATECHIN-3-GALLATE COMPOSITIONS FOR CANCER THERAPY AND CHEMOPROTECTION 审中-公开
公开(公告)号：WO2008075201A3
公开(公告)日：2008-06-26
申请号：PCT/IB2007/004363
申请日：2007-12-17
申请人： UNIVERSIDAD DE MURCIA , RODRIGUEZ-LOPEZ, Jose Neptuno , CABEZAS-HERRERA, Juan , NAVARRO-PERAN, Encarnacion Maria , SANCHEZ DEL CAMPO, Luis
发明人： RODRIGUEZ-LOPEZ, Jose Neptuno , CABEZAS-HERRERA, Juan , NAVARRO-PERAN, Encarnacion Maria , SANCHEZ DEL CAMPO, Luis
IPC分类号： A61K31/353 , A61K31/4412 , A61K31/513 , A61K31/517 , A61K31/53 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K45/06 , A61P35/00
摘要： This invention relates to the treatment of cancer by administration of an effective amount of EGCG, or a derivative thereof, and an effective amount of either (a) an A3 adenosine receptor agonist or (b) a thymidylate synthase inhibitor, or (c) both an A3 adenosine receptor agonist and a thymidylate synthase inhibitor. Compositions, methods and uses relating to such treatment are provided.

2. 发明公开

EP2887937A1 COMBINATIONS (CATECHINS AND METHOTREXATE) FOR USE IN THE TREATMENT OF MELANOMAS 审中-公开
标题翻译：组合FOR USE IN黑色素瘤的治疗（儿茶素和甲氨蝶呤）
公开(公告)号：EP2887937A1
公开(公告)日：2015-07-01
申请号：EP13750682.0
申请日：2013-08-13
申请人： Universidad de Murcia
发明人： RODRIGUEZ-LOPEZ, Jose Neptuno
IPC分类号： A61K31/353 , A61K31/519 , A61P35/00 , A61K45/06
CPC分类号： A61K31/353 , A61K31/519 , A61K2300/00
摘要： The invention provides a method of treatment of melanoma comprising administering a tyrosinase expression enhancer, such as MTX, and a tyrosinase-activated prodrug, such as TMECG or TMCG, to an individual in need thereof. Also provided is a method of treating melanoma comprising administering a tyrosinase-activated prodrug and a compound for differentiating a stem-like tumor cell into a matured cell that is a tyrosinase producer to an individual in need thereof. Further provided is a method of treatment of melanoma comprising administering a tyrosinase expression enhancer and a tyrosinase-activated prodrug to an individual in need thereof, wherein the individual has a melanoma in which one or more of BRAF, NRAS, p53, GNAQ, EGFR, PDGFR, RAC or c-kit carries a mutation.

3. 发明申请

WO2014029669A1 COMBINATIONS (CATECHINS AND METHOTREXATE) FOR USE IN THE TREATMENT OF MELANOMAS 审中-公开
标题翻译：用于治疗梅毒的组合（卡培他滨和甲基）
公开(公告)号：WO2014029669A1
公开(公告)日：2014-02-27
申请号：PCT/EP2013/066934
申请日：2013-08-13
申请人： UNIVERSIDAD DE MURCIA
发明人： RODRIGUEZ-LOPEZ, Jose Neptuno
IPC分类号： A61K31/353 , A61K31/519 , A61P35/00 , A61K45/06
CPC分类号： A61K31/353 , A61K31/519 , A61K2300/00
摘要： The invention provides a method of treatment of melanoma comprising administering a tyrosinase expression enhancer, such as MTX, and a tyrosinase-activated prodrug, such as TMECG or TMCG, to an individual in need thereof. Also provided is a method of treating melanoma comprising administering a tyrosinase-activated prodrug and a compound for differentiating a stem-like tumor cell into a matured cell that is a tyrosinase producer to an individual in need thereof. Further provided is a method of treatment of melanoma comprising administering a tyrosinase expression enhancer and a tyrosinase-activated prodrug to an individual in need thereof, wherein the individual has a melanoma in which one or more of BRAF, NRAS, p53, GNAQ, EGFR, PDGFR, RAC or c-kit carries a mutation.
摘要翻译：本发明提供一种治疗黑素瘤的方法，其包括向有需要的个体施用酪氨酸酶表达增强剂，例如MTX和酪氨酸酶活化的前药如TMECG或TMCG。还提供了一种治疗黑素瘤的方法，包括施用酪氨酸酶活化的前药和将茎状肿瘤细胞分化成需要其的个体的酪氨酸酶生产者的成熟细胞的化合物。还提供了一种治疗黑素瘤的方法，其包括向有需要的个体施用酪氨酸酶表达增强剂和酪氨酸酶活化的前药，其中所述个体具有黑素瘤，其中BRAF，NRAS，p53，GNAQ，EGFR， PDGFR，RAC或c-kit携带突变。

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