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1. 发明申请

US20130023817A1 COATING FORMULATIONS FOR SCORING OR CUTTING BALLOON CATHETERS 有权
标题翻译：用于分选或切割气泡导管的涂层配方
公开(公告)号：US20130023817A1
公开(公告)日：2013-01-24
申请号：US13628627
申请日：2012-09-27
申请人： Ulrich Speck , Madeleine Caroline Berg
发明人： Ulrich Speck , Madeleine Caroline Berg
IPC分类号： A61M37/00
CPC分类号： A61L29/08 , A61B17/320725 , A61B2017/320733 , A61L29/143 , A61L29/16 , A61L31/16 , A61L2300/216 , A61L2300/416 , A61L2300/606 , A61L2300/802 , A61M25/10 , A61M25/104 , A61M2025/105 , A61M2025/109
摘要： The present invention is related to scoring or cutting balloon catheters carrying at least on a portion of their surface at least one drug or drug preparation and at least one lipophilic antioxidant at a ratio of 3-100% by weight of the at least one lipophilic antioxidant in relation to 100% by weight of the drug, wherein a combination of the at least one drug being a limus drug and the at least one lipophilic antioxidant being butylated hydroxytoluene is excluded.
摘要翻译：本发明涉及评估或切割气球导管，其至少在其表面的一部分上携带至少一种药物或药物制剂和至少一种亲脂性抗氧化剂，其比例为至少一种亲脂性抗氧化剂的3-100重量％相对于100重量％的药物，其中排除了至少一种药物和至少一种亲脂性抗氧化剂作为药物的组合，其中所述至少一种亲脂性抗氧化剂是丁基化羟基甲苯。

2. 发明申请

US20130046231A1 COATING FORMULATIONS FOR SCORING OR CUTTING BALLOON CATHETERS 有权
公开(公告)号：US20130046231A1
公开(公告)日：2013-02-21
申请号：US13628608
申请日：2012-09-27
申请人： Ulrich Speck , Madeleine Caroline Berg
发明人： Ulrich Speck , Madeleine Caroline Berg
IPC分类号： A61M25/10
CPC分类号： A61L29/08 , A61B17/320725 , A61B2017/320733 , A61L29/143 , A61L29/16 , A61L31/16 , A61L2300/216 , A61L2300/416 , A61L2300/606 , A61L2300/802 , A61M25/10 , A61M25/104 , A61M2025/105 , A61M2025/109
摘要： The present invention is related to scoring or cutting balloon catheters carrying at least on a portion of their surface at least one oxidation-insensitive drug or oxidation-insensitive polymer-free drug preparation and at least one lipophilic antioxidant at a ratio of 3-100% by weight of the at least one lipophilic antioxidant in relation to 100% by weight of the drug, wherein the at least one oxidation-insensitive drug is selected of taxanes, thalidomide, statins, corticoids and lipophilic derivatives of corticoids, and the at least one lipophilic antioxidant is selected of nordihydroguaiaretic acid, resveratrol and propyl gallate.

3. 发明申请

US20140188036A1 COATING FORMULATIONS FOR SCORING OR CUTTING BALLOON CATHETERS 有权
公开(公告)号：US20140188036A1
公开(公告)日：2014-07-03
申请号：US13975220
申请日：2013-08-23
申请人： Ulrich Speck , Madeleine Caroline Berg
发明人： Ulrich Speck , Madeleine Caroline Berg
IPC分类号： A61L29/08 , A61L29/16
CPC分类号： A61L29/08 , A61B17/320725 , A61B2017/320733 , A61L29/143 , A61L29/16 , A61L31/16 , A61L2300/216 , A61L2300/416 , A61L2300/606 , A61L2300/802 , A61M25/10 , A61M25/104 , A61M2025/105 , A61M2025/109
摘要： The present invention is related to scoring or cutting balloon catheters carrying at least on a portion of their surface at least one oxidation-insensitive drug or oxidation-insensitive polymer-free drug preparation and at least one lipophilic antioxidant at a ratio of 3-100% by weight of the at least one lipophilic antioxidant in relation to 100% by weight of the drug, wherein the at least one oxidation-insensitive drug is selected of taxanes, thalidomide, statins, corticoids and lipophilic derivatives of corticoids, and the at least one lipophilic antioxidant is selected of nordihydroguaiaretic acid, resveratrol and propyl gallate.

4. 发明申请

US20130046237A1 IMPROVED FORMULATIONS FOR DRUG-COATED MEDICAL DEVICES 有权
标题翻译：用于药物包衣医疗器械的改进配方
公开(公告)号：US20130046237A1
公开(公告)日：2013-02-21
申请号：US13641941
申请日：2010-11-03
申请人： Ulrich Speck , Madeleine Caroline Berg
发明人： Ulrich Speck , Madeleine Caroline Berg
IPC分类号： A61M25/10
CPC分类号： A61L29/16 , A61L31/16 , A61L2300/416
摘要： The present invention is related to a medical device carrying at least on a portion of its surface at least one oxidation-insensitive drug or oxidation-insensitive polymer-free drug preparation and at least one lipophilic antioxidant at a ratio of 3-100% by weight of the at least one antioxidant in relation to 100% by weight of the drug, wherein the at least one oxidation-insensitive drug is selected of taxanes, thalidomide, statins, corticoids and lipophilic derivatives of corticoids, and the at least one lipophilic antioxidant is selected of nordihydroguaiarectic acid, resveratrol and propyl gallate, and wherein scoring or cutting balloons as medical devices are excluded.
摘要翻译：本发明涉及至少在其一部分表面上携带至少一种氧化不敏感药物或不含氧化物的无氧化物的药物制剂和至少一种亲脂性抗氧化剂，其比例为3-100重量％所述至少一种抗氧化剂相对于所述药物的100重量％，其中所述至少一种氧化不敏感药物选自紫杉烷类，沙利度胺，他汀类，皮质激素和皮质激素的亲脂性衍生物，并且所述至少一种亲脂性抗氧化剂是选择去甲二氢越南酸，白藜芦醇和没食子酸丙酯，并且其中排除作为医疗装置的评分或切割气球。

5. 发明授权

US09974888B2 Formulations for drug-coated medical devices 有权
公开(公告)号：US09974888B2
公开(公告)日：2018-05-22
申请号：US13641941
申请日：2010-11-03
申请人： Ulrich Speck , Madeleine Caroline Berg
发明人： Ulrich Speck , Madeleine Caroline Berg
IPC分类号： A61F2/00 , A61L29/16 , A61L31/16
CPC分类号： A61L29/16 , A61L31/16 , A61L2300/416
摘要： The present invention is related to a medical device carrying at least on a portion of its surface at least one oxidation-insensitive drug or oxidation-insensitive polymer-free drug preparation and at least one lipophilic antioxidant at a ratio of 3-100% by weight of the at least one antioxidant in relation to 100% by weight of the drug, wherein the at least one oxidation-insensitive drug is selected of taxanes, thalidomide, statins, corticoids and lipophilic derivatives of corticoids, and the at least one lipophilic antioxidant is selected of nordihydroguaiarectic acid, resveratrol and propyl gallate, and wherein scoring or cutting balloons as medical devices are excluded.

6. 发明申请

US20130338572A1 COATING FORMULATIONS FOR SCORING OR CUTTING BALLOON CATHETERS 有权
标题翻译：用于分选或切割气泡导管的涂层配方
公开(公告)号：US20130338572A1
公开(公告)日：2013-12-19
申请号：US13975209
申请日：2013-08-23
申请人： Ulrich Speck , Madeleine Caroline Berg
发明人： Ulrich Speck , Madeleine Caroline Berg
IPC分类号： A61M25/10
CPC分类号： A61L29/08 , A61B17/320725 , A61B2017/320733 , A61L29/143 , A61L29/16 , A61L31/16 , A61L2300/216 , A61L2300/416 , A61L2300/606 , A61L2300/802 , A61M25/10 , A61M25/104 , A61M2025/105 , A61M2025/109
摘要： The present invention is related to scoring or cutting balloon catheters carrying at least on a portion of their surface at least one oxidation-insensitive drug or oxidation-insensitive polymer-free drug preparation and at least one lipophilic antioxidant at a ratio of 3-100% by weight of the at least one lipophilic antioxidant in relation to 100% by weight of the drug, wherein the at least one oxidation-insensitive drug is selected of taxanes, thalidomide, statins, corticoids and lipophilic derivatives of corticoids, and the at least one lipophilic antioxidant is selected of nordihydroguaiaretic acid, resveratrol and propyl gallate.
摘要翻译：本发明涉及评估或切割气球导管，其至少在其表面的一部分上携带至少一种氧化不敏感药物或不含氧化物的无氧化物的药物制剂和至少一种亲脂性抗氧化剂，其比例为3-100％的至少一种亲脂性抗氧化剂相对于100重量％的药物，其中所述至少一种氧化不敏感药物选自紫杉烷类，沙利度胺，他汀类，皮质激素和皮质激素的亲脂性衍生物，并且所述至少一种亲脂性抗氧化剂选自去甲二氢愈创木酸，白藜芦醇和没食子酸丙酯。

7. 发明授权

US08608689B2 Pharmaceutical-coated medical products, the production thereof and the use thereof 有权
公开(公告)号：US08608689B2
公开(公告)日：2013-12-17
申请号：US12671910
申请日：2008-08-01
申请人： Bruno Scheller , Ulrich Speck
发明人： Bruno Scheller , Ulrich Speck
IPC分类号： A61M25/12
CPC分类号： A61M25/1029 , A61L29/08 , A61L29/145 , A61L29/16 , A61L2300/204 , A61L2300/21 , A61L2300/22 , A61L2300/602 , A61L2420/02 , A61L2420/06 , A61M25/0045 , A61M25/10 , A61M2025/0057 , A61M2025/1031 , A61M2025/105 , B05D1/26
摘要： This present invention concerns a new combination of balloon catheters and formulations containing active substances that adhere to the surface of the balloon membrane. Furthermore the present invention concerns coating processes for the manufacture of these balloon catheters as well as their use in the treatment and prophylaxis of vascular diseases.

8. 发明申请

US20110295200A1 DRUG-ELUTING MEDICAL DEVICE 审中-公开
标题翻译：药物治疗设备
公开(公告)号：US20110295200A1
公开(公告)日：2011-12-01
申请号：US13143703
申请日：2010-01-08
申请人： Ulrich Speck , Silvio Schaffner , Magdalena Renke-gluszko
发明人： Ulrich Speck , Silvio Schaffner , Magdalena Renke-gluszko
IPC分类号： A61M25/10 , B65B1/04 , B05C13/02 , A61M29/00 , B05C11/00
CPC分类号： A61L29/16 , A61L29/06 , A61L2300/216 , A61L2300/416 , A61L2300/602 , A61L2300/63 , A61M25/1002 , A61M25/1029 , A61M2025/1004 , A61M2025/1031 , A61M2025/105 , C08L77/00
摘要： The present invention relates to a drug-eluting medical device, in particular a balloon for angioplasty catheters with drug elution to prevent the restenosis of the vessel subjected to angioplasty. More particularly, the present invention relates to a catheter balloon completely or partially coated with paclitaxel in hydrated crystalline form or in hydrated solvated crystalline form, having an immediate release and bioavailability of a therapeutically effective amount of paclitaxel at the site of intervention. The balloon can be made of a polyether-polyamide block copolymer, or a polyester amide, or polyamide-12.
摘要翻译：本发明涉及一种药物洗脱医学装置，特别是用于血管成形术导管的气囊，其具有药物洗脱以防止经血管成形术的血管的再狭窄。更具体地说，本发明涉及完全或部分地涂覆有水合结晶形式的紫杉醇或水合溶剂化晶体形式的导管球囊，其在干预部位具有治疗有效量的紫杉醇的即时释放和生物利用度。气球可以由聚醚 - 聚酰胺嵌段共聚物或聚酯酰胺或聚酰胺-12制成。

9. 发明授权

US07655217B2 Near infrared imaging agent 失效
标题翻译：近红外成像剂
公开(公告)号：US07655217B2
公开(公告)日：2010-02-02
申请号：US11387367
申请日：2006-03-22
申请人： Kai Licha , Björn Riefke , Wolfhard Semmler , Ulrich Speck , Christoph-Stephan Hilger
发明人： Kai Licha , Björn Riefke , Wolfhard Semmler , Ulrich Speck , Christoph-Stephan Hilger
IPC分类号： A61B10/00 , A61B5/00 , A61B8/00
CPC分类号： A61K49/0032 , A61K49/0017 , A61K49/0021 , A61K49/005 , C09B23/086 , C09B69/105
摘要： This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
摘要翻译：本发明涉及一种基于近红外辐射（NIR辐射）的体内诊断方法，其使用水溶性染料及其生物分子加合物，其具有特定的光物理和药物化学性质，作为用于荧光和透照诊断的造影剂 NIR范围，新染料和含有这些染料的药物。

10. 发明申请

US20050008574A1 Use of intravenous contrast media for projection mammography 审中-公开
标题翻译：使用静脉造影剂进行投影乳房X线摄影
公开(公告)号：US20050008574A1
公开(公告)日：2005-01-13
申请号：US10851213
申请日：2004-05-24
申请人： Ulrich Speck , Irtel Von Brenndorff
发明人： Ulrich Speck , Irtel Von Brenndorff
IPC分类号： A61B6/00 , A61K49/00 , A61K49/04 , A61K49/06 , A61P35/04 , G06T5/00 , G06T5/50
CPC分类号： A61K49/0409 , A61K49/0457
摘要： The invention relates to the use of intravenous contrast media for projection mammography as well as new devices for projection mammography. The invention therefore relates to the use of intravenous contrast media for the production of a diagnostic agent for projection mammography. Through the additional intravenous administration of contrast media, projection mammography achieves a sensitivity that is comparable to that of the most modern processes such as magnetic resonance tomography (MRT) while being considerably more versatile and avoiding the costs of MRT. The new process can be implemented simply and without special stress on the patients and provides a significant improvement in a) sensitivity to the detection of focal lesions in the breast, and b) additional information on the nature of lesions detected previously.
摘要翻译：本发明涉及用于投影乳房X线照相术的静脉造影剂的使用以及用于投影乳房X线照相术的新装置。因此，本发明涉及静脉造影剂用于生产用于投影乳房X线照相术的诊断剂的用途。通过额外静脉注射造影剂，投影乳房X线照相术的灵敏度可以达到最现代的方法，如磁共振断层扫描（MRT）的灵敏度，同时具有更大的灵活性，避免了MRT的成本。新过程可以简单实现，对患者没有特别的压力，并且对a）对乳房局灶性病变检测的敏感度以及b）关于先前检测到的病变性质的额外信息提供了显着的改善。

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