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1. 发明申请

US20130195848A1 IMIDAZOPYRAZINES 有权
标题翻译：咪唑并吡嗪
公开(公告)号：US20130195848A1
公开(公告)日：2013-08-01
申请号：US13635734
申请日：2011-03-16
申请人： Ulrich Klar , Marcus Koppitz , Dirk Kosemund , Rolf Bohlmann , Benjamin Bader , Philip Lienau , Gerhard Siemeister , Stefan Prechtl , Duy Nguyen , William Scott
发明人： Ulrich Klar , Marcus Koppitz , Dirk Kosemund , Rolf Bohlmann , Benjamin Bader , Philip Lienau , Gerhard Siemeister , Stefan Prechtl , Duy Nguyen , William Scott
IPC分类号： A61K31/519 , A61K45/06 , C07D487/04
CPC分类号： A61K31/519 , A61K45/06 , C07D487/04 , C07D487/14
摘要： The present invention relates to imidazopyrazine compounds of general Formula (I): in which X, R1, R2, R3a, R3b, R4a, R4b, R4C, and R4D are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.
摘要翻译：本发明涉及通式（I）的咪唑并吡嗪化合物：其中X，R1，R2，R3a，R3b，R4a，R4b，R4C和R4D如说明书和权利要求书中所给出的，涉及制备所述化合物，包含所述化合物的药物组合物和组合，用于制备用于治疗或预防疾病的药物组合物的所述化合物的用途，以及可用于制备所述化合物的中间体化合物。

2. 发明授权

US09468642B2 Imidazopyrazines 有权
标题翻译：咪唑吡嗪
公开(公告)号：US09468642B2
公开(公告)日：2016-10-18
申请号：US13635734
申请日：2011-03-16
申请人： Ulrich Klar , Marcus Koppitz , Dirk Kosemund , Rolf Bohlmann , Benjamin Bader , Philip Lienau , Gerhard Siemeister , Stefan Prechtl , Duy Nguyen , William Scott
发明人： Ulrich Klar , Marcus Koppitz , Dirk Kosemund , Rolf Bohlmann , Benjamin Bader , Philip Lienau , Gerhard Siemeister , Stefan Prechtl , Duy Nguyen , William Scott
IPC分类号： C07D487/14 , A61K31/519 , C07D487/04 , A61K45/06
CPC分类号： A61K31/519 , A61K45/06 , C07D487/04 , C07D487/14
摘要： The present invention relates to imidazopyrazine compounds of general Formula (I): in which X, R1, R2, R3a, R3b, R4a, R4b, R4C, and R4D are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.

3. 发明授权

US09199999B2 Substituted imidazopyrazines 有权
标题翻译：取代的咪唑并吡嗪
公开(公告)号：US09199999B2
公开(公告)日：2015-12-01
申请号：US13700956
申请日：2011-05-27
申请人： Ulrich Klar , Marcus Koppitz , Rolf Jautelat , Dirk Kosemund , Rolf Bohlmann , Benjamin Bader , Philip Lienau , Gerhard Siemeister , William Scott
发明人： Ulrich Klar , Marcus Koppitz , Rolf Jautelat , Dirk Kosemund , Rolf Bohlmann , Benjamin Bader , Philip Lienau , Gerhard Siemeister , William Scott
IPC分类号： A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495 , C07D491/00 , C07D495/00 , C07D497/00 , C07D487/04 , A61K31/4985
CPC分类号： C07D487/04 , A61K31/4985
摘要： The present invention relates to substituted imidazopyrazine compounds of general formula (I) in which A, R1, R3 and R5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.
摘要翻译：本发明涉及通式（I）的取代咪唑并吡嗪化合物，其中A，R 1，R 3和R 5如在说明书和权利要求书中所述，涉及制备所述化合物的方法，药物组合物和包含所述化合物的组合，涉及用于制备用于治疗或预防疾病的药物组合物的所述化合物的使用，以及可用于制备所述化合物的中间体化合物。

4. 发明申请

US20130210815A1 SUBSTITUTED IMIDAZOPYRAZINES 有权
标题翻译：取代的咪唑并吡嗪
公开(公告)号：US20130210815A1
公开(公告)日：2013-08-15
申请号：US13700956
申请日：2011-05-27
申请人： Ulrich Klar , Marcus Koppitz , Rolf Jautelat , Dirk Kosemund , Rolf Bohlmann , Benjamin Bader , Philip Lienau , Gerhard Siemeister , William Scott
发明人： Ulrich Klar , Marcus Koppitz , Rolf Jautelat , Dirk Kosemund , Rolf Bohlmann , Benjamin Bader , Philip Lienau , Gerhard Siemeister , William Scott
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , A61K31/4985
摘要： The present invention relates to substituted imidazopyrazine compounds of general formula (I) in which A, R1, R3 and R5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.
摘要翻译：本发明涉及通式（I）的取代咪唑并吡嗪化合物，其中A，R 1，R 3和R 5如在说明书和权利要求书中所述，涉及制备所述化合物的方法，药物组合物和包含所述化合物的组合，涉及用于制备用于治疗或预防疾病的药物组合物的所述化合物的使用，以及可用于制备所述化合物的中间体化合物。

5. 发明申请

US20140213575A1 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepines 审中-公开
标题翻译： 6H-Thieno [3,2-f] [1,2,4]三唑并[4,3-a] [1,4]二氮杂
公开(公告)号：US20140213575A1
公开(公告)日：2014-07-31
申请号：US14342519
申请日：2012-08-27
申请人： Norbert Schmees , Joachim Kuhnke , Bernard Haendler , Philip Lienau , Amaury Ernesto Fernandez-Montalvan , Pascale Lejeune , Stephan Siegel , William Scott
发明人： Norbert Schmees , Joachim Kuhnke , Bernard Haendler , Philip Lienau , Amaury Ernesto Fernandez-Montalvan , Pascale Lejeune , Stephan Siegel , William Scott
IPC分类号： C07D519/00
CPC分类号： C07D519/00 , A61K31/551 , A61K45/06 , C07D495/14 , A61K2300/00
摘要： The invention relates to 6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepines, in particular for therapeutic purposes, pharmaceutical agents and use thereof in therapy, in particular for the prevention and treatment of tumour diseases.
摘要翻译：本发明涉及6H-噻吩并[3,2-f] [1,2,4]三唑并[4,3-a] [1,4]二氮杂，特别是用于治疗目的，药物及其在治疗中的用途，特别是用于预防和治疗肿瘤疾病。

6. 外观设计

USD832748S1 Trailer hitch guide 有权
公开(公告)号：USD832748S1
公开(公告)日：2018-11-06
申请号：US29609372
申请日：2017-06-29
申请人： William Scott
设计人： William Scott

7. 发明申请

US20150075343A1 SAFETY MECHANISMS FOR POWER TOOLS, INCLUDING MAGNETORHELOGICAL BRAKE FOR BLADE 审中-公开
标题翻译：用于电动工具的安全机构，包括用于刀片的磁力制动器
公开(公告)号：US20150075343A1
公开(公告)日：2015-03-19
申请号：US14495311
申请日：2014-09-24
申请人： Andy Butler , Brian Lamb , Chris Tacklind , Clinton Lazzari , Edward Cooper , Eric Edward Schultz , Frank Buhrmann , John Gilbert , David Titzler , William Scott , Peter Domeny
发明人： Andy Butler , Brian Lamb , Chris Tacklind , Clinton Lazzari , Edward Cooper , Eric Edward Schultz , Frank Buhrmann , John Gilbert , David Titzler , William Scott , Peter Domeny
IPC分类号： B27B5/38 , B27B5/22
CPC分类号： B27B5/38 , B23D45/067 , B23D47/10 , B27B5/222 , B27B5/243 , Y10T83/081 , Y10T83/088 , Y10T83/089 , Y10T83/141 , Y10T83/613 , Y10T83/7697 , Y10T83/773 , Y10T83/7788 , Y10T83/8773
摘要： Various safety systems for power tools, and in particular table saws include detection systems for detecting a dangerous condition relative to a blade of the power tool, reaction systems for taking mitigation action in response to detection of a dangerous condition. The safety system may detect, prevent, and/or mitigate a dangerous condition associated with the power tool.
摘要翻译：用于电动工具，特别是台锯的各种安全系统包括用于检测相对于电动工具的叶片的危险状况的检测系统，用于响应于危险状况的检测而采取缓解作用的反应系统。安全系统可以检测，防止和/或减轻与电动工具相关联的危险状况。

8. 发明授权

US08919231B2 Safety mechanisms for power tools 有权
标题翻译：电动工具的安全机制
公开(公告)号：US08919231B2
公开(公告)日：2014-12-30
申请号：US13129948
申请日：2009-11-19
申请人： Andy Butler , Brian Lamb , Chris Tacklind , Clinton Lazzari , Edward Cooper , Eric Edward Schultz , Frank Buhrmann , John Gilbert , David Titzler , William Scott , Peter L. Domeny
发明人： Andy Butler , Brian Lamb , Chris Tacklind , Clinton Lazzari , Edward Cooper , Eric Edward Schultz , Frank Buhrmann , John Gilbert , David Titzler , William Scott , Peter L. Domeny
IPC分类号： B27B5/29 , B27B3/28 , B23D45/04 , B23D45/06 , B27B5/22 , B27B5/38
CPC分类号： B27B5/38 , B27B5/222 , Y10T83/081 , Y10T83/088 , Y10T83/089 , Y10T83/141 , Y10T83/613 , Y10T83/7697 , Y10T83/773 , Y10T83/7788 , Y10T83/8773
摘要： Various safety systems for power tools, and in particular table saws, include detection systems for detecting a dangerous condition relative to a blade of the power tool, and reaction systems for taking mitigation action in response to detection of a dangerous condition. The safety system may detect, prevent, and/or mitigate a dangerous condition associated with the power tool.
摘要翻译：用于电动工具，特别是台锯的各种安全系统包括用于检测相对于电动工具的叶片的危险状况的检测系统和用于响应于危险状况的检测而采取缓解作用的反应系统。安全系统可以检测，防止和/或减轻与电动工具相关联的危险状况。

9. 发明授权

US08859572B2 Sulfone substituted 2,3-dihydroimidazo [1,2-C] quinazoline derivatives useful for treating hyper-proliferative disorders and diseases with angiogenesis 有权
标题翻译：用于治疗高增殖性疾病和血管生成疾病的砜取代的2,3-二氢咪唑并[1,2-C]喹唑啉衍生物
公开(公告)号：US08859572B2
公开(公告)日：2014-10-14
申请号：US12812911
申请日：2009-01-13
申请人： Martin F. Hentemann , William Scott , Jill Wood , Jeffrey Johnson , Aniko Redman , Ann-Marie Bullion , Leatte Guernon
发明人： Martin F. Hentemann , William Scott , Jill Wood , Jeffrey Johnson , Aniko Redman , Ann-Marie Bullion , Leatte Guernon
IPC分类号： A61K31/519 , A61K45/06 , A61K31/541 , C07D487/04
CPC分类号： A61K45/06 , A61K31/519 , A61K31/541 , A61K2300/00 , C07D487/04
摘要： This invention relates to novel sulfone 2I3-dihydroimidazo[1 l2-c]quinazoline compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for phosphotidylinositol-3-kinase (PI3K) inhibition and treating diseases associated with phosphotidylinositol-3-kinase (PI3K) activity, in particular treating hyper-proliferative and/or angiogenesis mediated disorders, as a sole agent or in combination with other active ingredients.
摘要翻译：本发明涉及新的砜2I3-二氢咪唑并[11l-c]喹唑啉化合物，含有这些化合物的药物组合物以及这些化合物或组合物用于磷脂酰肌醇-3-激酶（PI3K）的用途，其用于抑制和治疗与磷脂酰肌醇-3- 激酶（PI3K）活性，特别是治疗高增殖和/或血管发生介导的病症，作为唯一的药剂或与其它活性成分组合。

10. 发明申请

US20140228138A1 SELF-CONTAINED TRIATHLON COMPLEX 有权
标题翻译：自包含三元复合物
公开(公告)号：US20140228138A1
公开(公告)日：2014-08-14
申请号：US14055026
申请日：2013-10-16
申请人： William Scott
发明人： William Scott
IPC分类号： E01C1/00
CPC分类号： E01C1/002 , A63C19/00 , E04H3/14
摘要： A self-contained, controlled access, triathlon complex is described that includes a dedicated artificial body of water having a swimming starting point and a swimming finish point; dedicated biking roadway having a biking starting point adjacent the swimming finish point, and a biking finish point; a dedicated running path having a running starting point adjacent the biking finish point, and a running finish point; and an access limiting boundary surrounding the body of water, biking roadway and running path, the boundary including at least one gate for allowing controlled access to the complex.
摘要翻译：描述了一个独立的，受控的进入，铁人三项综合体，其包括具有游泳起点和游泳完成点的专用人造水体; 专用的自行车道具有靠近游泳终点的自行车起点，以及骑自行车的终点; 具有与自行车完成点相邻的运行起点的专用行进路径和运行终点; 以及围绕水体，自行车道和行驶路径的入口限制边界，边界包括至少一个用于允许受控进入复合体的门。

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