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1. 发明申请

US20110009952A1 IMPLANT AND METHOD FOR MANUFACTURING SAME 有权
标题翻译：植入物及其制造方法
公开(公告)号：US20110009952A1
公开(公告)日：2011-01-13
申请号：US12792510
申请日：2010-06-02
申请人： Ullrich Bayer , Claus Harder , Elisabeta Burean
发明人： Ullrich Bayer , Claus Harder , Elisabeta Burean
IPC分类号： A61F2/82 , A61L27/04
CPC分类号： A61K9/0012 , A61K33/00 , A61L31/022 , A61L31/146 , A61L31/16
摘要： The present invention relates to a method for manufacturing an implant, in particular an intraluminal endoprosthesis, having a body containing metallic material, preferably iron. The following manufacturing method is provided for promotion of the anti-inflammatory effect of the implant: (i) providing the body of the implant; (ii) producing an at least partially closed pore structure in a portion of the structure of the implant body close to the surface; and (iii) incorporating NOX into the cavities of the pore structure. Also described is an implant manufactured in this manner.
摘要翻译：本发明涉及用于制造植入物的方法，特别是管腔内假体，其具有包含金属材料，优选铁的主体。提供以下制造方法用于促进植入物的抗炎作用：（i）提供植入物的主体; （ii）在所述植入体的结构的靠近所述表面的部分结构中产生至少部分闭合的孔结构; 和（iii）将NOX掺入到孔结构的空腔中。还描述了以这种方式制造的植入物。

2. 发明授权

US08574616B2 Implant and method for manufacturing same 有权
标题翻译：种植体及其制造方法
公开(公告)号：US08574616B2
公开(公告)日：2013-11-05
申请号：US12792510
申请日：2010-06-02
申请人： Ullrich Bayer , Claus Harder , Elisabeta Burean
发明人： Ullrich Bayer , Claus Harder , Elisabeta Burean
IPC分类号： A61F2/00 , A61F2/06 , A61L33/00
CPC分类号： A61K9/0012 , A61K33/00 , A61L31/022 , A61L31/146 , A61L31/16
摘要： The present invention relates to a method for manufacturing an implant, in particular an intraluminal endoprosthesis, having a body containing metallic material, preferably iron. The following manufacturing method is provided for promotion of the anti-inflammatory effect of the implant: (i) providing the body of the implant; (ii) producing an at least partially closed pore structure in a portion of the structure of the implant body close to the surface; and (iii) incorporating NOX into the cavities of the pore structure. Also described is an implant manufactured in this manner.
摘要翻译：本发明涉及用于制造植入物的方法，特别是管腔内假体，其具有包含金属材料，优选铁的主体。提供以下制造方法用于促进植入物的抗炎作用：（i）提供植入物的主体; （ii）在所述植入体的结构的靠近所述表面的部分结构中产生至少部分闭合的孔结构; 和（iii）将NOX掺入到孔结构的空腔中。还描述了以这种方式制造的植入物。

3. 发明授权

US10272183B2 Implant and method for manufacturing same 有权
公开(公告)号：US10272183B2
公开(公告)日：2019-04-30
申请号：US13164127
申请日：2011-06-20
申请人： Ullrich Bayer , Wolfgang Schultz , Nils Venohr , Johannes Riedmueller , Martina Schroeder
发明人： Ullrich Bayer , Wolfgang Schultz , Nils Venohr , Johannes Riedmueller , Martina Schroeder
IPC分类号： A61F2/82 , A61L31/02 , A61L31/08 , A61L31/14 , A61L31/18
摘要： The present invention relates to an implant, in particular an intraluminal endoprothesis, comprising a body containing a metallic material, and comprising at least one functional element that is fastened to the body and has a material composition in at least a portion of its volume that differs from the material of the body, the material composition preferably including radio-opaque and/or x-ray opaque material. To effectively prevent accelerated degradation due to the formation of a local cell of the material of the body and the functional element, the at least one functional element includes a first layer at least in the region of its surface where it is bonded to the body, the first layer primarily containing at least one metal oxide. Furthermore, the manufacture of an implant of this type is described.

4. 发明授权

US08992600B2 Marker composite and medical implant comprising an X-ray marker 有权
标题翻译：包括X射线标记的标记复合材料和医用植入物
公开(公告)号：US08992600B2
公开(公告)日：2015-03-31
申请号：US13288512
申请日：2011-11-03
申请人： Nils Goetzen , Anna Mirabelli , Andre Schoof , Ullrich Bayer , Dirk Sadler , Johannes Riedmueller
发明人： Nils Goetzen , Anna Mirabelli , Andre Schoof , Ullrich Bayer , Dirk Sadler , Johannes Riedmueller
IPC分类号： A61L31/18 , A61L31/02 , A61L31/12 , A61L31/14
CPC分类号： A61L31/18 , A61L31/022 , A61L31/128 , A61L31/148
摘要： A marker composite for medical implants composed of a biocorrodible metallic material and a medical implant comprising an X-ray marker which was made of the marker composite. The marker composite contains a large number of particles composed of a radio-opaque metal, which are embedded in an electrically non-conductive polymer. The particles have an additional electrically non-conductive coating.
摘要翻译：一种由生物可腐蚀的金属材料和医用植入物组成的医用植入物的标记复合物，其包含由标记复合材料制成的X射线标记物。标记复合物包含大量由不透射线的金属组成的颗粒，其嵌入在非导电聚合物中。颗粒具有额外的非导电涂层。

5. 发明申请

US20100324654A1 IMPLANT AND METHOD FOR MANUFACTURING SAME 有权
标题翻译：植入物及其制造方法
公开(公告)号：US20100324654A1
公开(公告)日：2010-12-23
申请号：US12786775
申请日：2010-05-25
申请人： Ullrich Bayer , Bjoern Klocke
发明人： Ullrich Bayer , Bjoern Klocke
IPC分类号： A61F2/82 , C23C14/34
CPC分类号： C23C24/04 , A61L31/022 , A61L31/148 , A61L2400/18 , C23C26/00
摘要： The present invention relates to a method for manufacturing an implant, in particular an intraluminal endoprosthesis, with a body containing metallic material, preferably iron. The method includes the following steps to control degradation of the implant: (i) providing the body of the implant; and (ii) tribochemically treating at least part of the body surface by means of beam particles. An implant produced in this way is also described.
摘要翻译：本发明涉及用于制造植入物，特别是管腔内假体的方法，其中身体含有金属材料，优选铁。该方法包括以下步骤来控制植入物的降解：（i）提供植入物的主体; 和（ii）通过光束颗粒摩擦化学处理身体表面的至少一部分。还描述了以这种方式产生的植入物。

6. 发明授权

US09480779B2 Implant and method for producing the same 有权
标题翻译：种植体及其生产方法
公开(公告)号：US09480779B2
公开(公告)日：2016-11-01
申请号：US13164179
申请日：2011-06-20
申请人： Ullrich Bayer
发明人： Ullrich Bayer
IPC分类号： C22C38/00 , C22C38/04 , A61L31/02 , A61L31/14
CPC分类号： A61L31/022 , A61L31/148 , B22D7/00 , B23K26/38 , C21D1/30 , C21D8/065 , C21D9/08 , C22C38/00 , C22C38/002 , C22C38/04 , C22C38/24 , C22C38/38 , C22C38/60
摘要： The present invention relates to an implant, in particular an intraluminal endoprosthesis, the body of which comprises at least predominantly a material with iron as the main constituent. For accelerating the degradation, the material comprises sulfur as first minor constituent with a concentration of more than 0.2% by weight and not more than 1% by weight, preferably not more than 0.5% by weight, and comprises as second minor constituent at least one element of the group which comprises calcium, manganese and magnesium. Furthermore, a method for producing such an implant is described.
摘要翻译：植入物，特别是腔内内用假体，其主体至少主要包含以铁为主要成分的材料。为了加速降解，该材料包含硫作为第一次要成分，其浓度大于0.2重量％且不超过1重量％，优选不超过0.5重量％，并且包含作为第二次要成分的至少一种包括钙，锰和镁的组元素。此外，描述了用于制造这种植入物的方法。

7. 发明申请

US20120053679A1 IMPLANT AND METHOD FOR PRODUCING THE SAME 有权
标题翻译：植入物及其制造方法
公开(公告)号：US20120053679A1
公开(公告)日：2012-03-01
申请号：US13219023
申请日：2011-08-26
申请人： Horst Fircho , Ullrich Bayer , Frank Endres
发明人： Horst Fircho , Ullrich Bayer , Frank Endres
IPC分类号： A61F2/82 , A61L27/28 , A61L27/56 , C25F3/02
CPC分类号： A61L31/022 , A61L31/088 , A61L2400/18
摘要： An implant and method for producing an implant, in particular an intraluminal endoprosthesis, with a body, wherein the body contains iron or an iron alloy, comprising the following steps: a) providing the implant body (1), b) applying a metallic coating comprising as main constituent at least one element of the group containing tantalum, niobium, zirconium, aluminum, magnesium, vanadium, molybdenum, hafnium, and wolfram onto at least a portion of the body surface, and c) plasmachemical treatment of the portion of the body surface provided with the coating in an aqueous solution for producing a plasmachemically generated layer (3, 5, 7) by means of applying a plasma-generating pulsating voltage to the body of the implant, wherein the pulsating voltage has sufficient energy that the metallic coating (3, 5, 7) is temporarily and sectionally ionized up to the underlying implant body (1) in such a manner that the generated layer has pores (5) which extend at least partially up to the implant body.
摘要翻译：一种用于制造植入物，特别是腔内内用假体的植入物和方法，其具有身体，其中所述主体包含铁或铁合金，包括以下步骤：a）提供植入体（1），b）施加金属涂层将至少一种含有钽，铌，锆，铝，镁，钒，钼，铪和钨的组分的至少一种元素作为主要成分包含在体表的至少一部分上，以及c）等离子体化学处理身体表面在水溶液中提供涂层，用于通过向植入体的主体施加等离子体产生的脉动电压来产生等离子体生成层（3,5,7），其中脉动电压具有足够的能量，金属涂层（3,5,7）以这样的方式临时地和截面地电离到下面的植入体（1），使得所产生的层具有至少部分地延伸到植入物的孔（5）身体。

8. 发明申请

US20110319986A1 IMPLANT AND METHOD FOR PRODUCING THE SAME 有权
标题翻译：植入物及其制造方法
公开(公告)号：US20110319986A1
公开(公告)日：2011-12-29
申请号：US13164082
申请日：2011-06-20
申请人： Ullrich Bayer , Alexander Rzany
发明人： Ullrich Bayer , Alexander Rzany
IPC分类号： A61F2/82 , C23C8/36
CPC分类号： A61L31/022 , A61L31/082 , A61L31/14 , A61L2400/18
摘要： A method for producing an implant, particularly an intralumimal endoprosthesis, having a body, wherein the body comprises magnesium or a magnesium alloy. In order to control the degradation in a desired time window, such as between four weeks and six months, the following production method is carried out: a) preparing the implant body, b) applying a metallic coating onto at least a portion of the body surface, the primary constituent of the coating being at least one element of the group containing titanium and aluminum, c) plasmachemical treatment of the portion of the body surface provided with the coating in an aqueous solution in order to produce a layer created by plasmachemical treatment by applying a mixed voltage generating the plasma to the body of the implant, wherein the mixed voltage has sufficient energy to temporarily ionize both the metallic coating and a subjacent region of the implant body. The invention further relates to an implant that can be obtained by such a method.
摘要翻译：一种用于制造具有身体的植入物，特别是内膜内假体的方法，其中所述主体包括镁或镁合金。为了控制在期望的时间窗口（例如四周至六个月）之间的降解，进行以下生产方法：a）制备植入体，b）将金属涂层施加到身体的至少一部分上表面，涂层的主要成分是含有钛和铝的组中的至少一种元素，c）在水溶液中提供涂层的体表部分的等离子体化学处理以产生由等离子体化学处理产生的层通过将产生等离子体的混合电压施加到植入物的主体，其中混合电压具有足够的能量来临时电离植入物体的金属涂层和下部区域。本发明还涉及可以通过这种方法获得的植入物。

9. 发明申请

US20110318219A1 IMPLANT AND METHOD FOR PRODUCING THE SAME 有权
标题翻译：植入物及其制造方法
公开(公告)号：US20110318219A1
公开(公告)日：2011-12-29
申请号：US13164179
申请日：2011-06-20
申请人： Ullrich Bayer
发明人： Ullrich Bayer
IPC分类号： B22D31/00 , C22C38/00
CPC分类号： A61L31/022 , A61L31/148 , B22D7/00 , B23K26/38 , C21D1/30 , C21D8/065 , C21D9/08 , C22C38/00 , C22C38/002 , C22C38/04 , C22C38/24 , C22C38/38 , C22C38/60
摘要： The present invention relates to an implant, in particular an intraluminal endoprosthesis, the body of which comprises at least predominantly a material with iron as the main constituent. For accelerating the degradation, the material comprises sulfur as first minor constituent with a concentration of more than 0.2% by weight and not more than 1% by weight, preferably not more than 0.5% by weight, and comprises as second minor constituent at least one element of the group which comprises calcium, manganese and magnesium. Furthermore, a method for producing such an implant is described.
摘要翻译：植入物，特别是腔内内用假体，其主体至少主要包含以铁为主要成分的材料。为了加速降解，该材料包含硫作为第一次要成分，其浓度大于0.2重量％且不超过1重量％，优选不超过0.5重量％，并且包含作为第二次要成分的至少一种包括钙，锰和镁的组元素。此外，描述了用于制造这种植入物的方法。

10. 发明申请

US20100324666A1 IMPLANT AND METHOD FOR PRODUCTION OF THE SAME 有权
标题翻译：植物及其生产方法
公开(公告)号：US20100324666A1
公开(公告)日：2010-12-23
申请号：US12820639
申请日：2010-06-22
申请人： Bjoern Klocke , Ullrich Bayer
发明人： Bjoern Klocke , Ullrich Bayer
IPC分类号： A61F2/82 , B05D7/00
CPC分类号： A61L31/022 , A61L31/082 , A61L31/148
摘要： One example embodiment of the present invention relates to an implant, particularly an intraluminal endoprosthesis, having a body that contains metallic material, preferably iron. The implant body has a first layer with at least one ionic compound that contains ions of at least one halogen, particularly chloride ions and/or bromide ions, on at least part of its surface. Furthermore, a method for the production of such an implant is described.
摘要翻译：本发明的一个示例性实施例涉及具有包含金属材料，优选铁的主体的植入物，特别是管腔内假体。植入体具有至少一种离子化合物的第一层，该离子化合物在其表面的至少一部分上含有至少一种卤素，特别是氯离子和/或溴离子的离子。此外，描述了用于生产这种植入物的方法。

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