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1. 发明授权

US09114162B2 Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same 有权
标题翻译：用于临床应用中增强成像的可装载聚合物颗粒及其制备和使用方法
公开(公告)号：US09114162B2
公开(公告)日：2015-08-25
申请号：US11877839
申请日：2007-10-24
申请人： Ulf Fritz , Olaf Fritz , Thomas A. Gordy , Jacques Blümmel , Alexander Küller , Gretchen B. Wojcik
发明人： Ulf Fritz , Olaf Fritz , Thomas A. Gordy , Ronald Wojcik , Jacques Blümmel , Alexander Küller
IPC分类号： A61K49/04
CPC分类号： A61K51/1244 , A61K49/0419 , A61K49/1824 , A61K49/225
摘要： Particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy)phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles can also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in specific selected sizes to allow for selective embolization of certain sized blood vessels or localized treatment with an active component agent in specific clinical uses. Microspheres of the present invention may further be provided with physical and/or chemical enhancements within the particles' cores to enhance visualization of the embolized tissue using a variety of medical imaging modalities, including conventional radiography, fluoroscopy, tomography, computerized tomography, ultrasound, scintillation, magnetic resonance, or other imaging technologies.
摘要翻译：颗粒被提供用于治疗和/或诊断过程。颗粒包括聚[双（三氟乙氧基）磷腈]和/或其衍生物，其可以存在于整个颗粒中或颗粒的外涂层内。颗粒还可以包括具有由丙烯酸类聚合物形成的水凝胶的芯。这样的颗粒可以以特定的选定尺寸提供给使用者，以允许特定大小的血管的选择性栓塞或在特定临床应用中用活性成分剂局部治疗。本发明的微球可以进一步提供颗粒内核内的物理和/或化学增强，以使用各种医学成像模式来增强栓塞组织的可视化，包括常规放射成像，荧光透视，层析成像，计算机断层扫描，超声，闪烁，磁共振或其他成像技术。

2. 发明授权

US09107850B2 Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same 有权
标题翻译：用于治疗和/或诊断应用的颜色编码和尺寸可加载的聚合物颗粒及其制备和使用方法
公开(公告)号：US09107850B2
公开(公告)日：2015-08-18
申请号：US11924674
申请日：2007-10-26
申请人： Ulf Fritz , Olaf Fritz , Thomas A. Gordy , Jacques Blümmel , Alexander Küller , Gretchen B. Wojcik
发明人： Ulf Fritz , Olaf Fritz , Thomas A. Gordy , Ronald Wojcik , Jacques Blümmel , Alexander Küller
IPC分类号： A61K9/50 , A61K47/32 , C08G79/02 , C08L85/02
CPC分类号： A61K9/5026 , A61K47/32 , C08G79/025 , C08L85/02 , C08L2666/02
摘要： Polymeric particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy)phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in specific selected sizes to allow for selective embolization of certain sized blood vessels or localized treatment with an active component agent in specific clinical uses. Particles of the present invention may further be provided as color-coded microspheres or nanospheres to allow ready identification of the sized particles in use. Such color-coded microspheres or nanospheres may further be provided in like color-coded delivery or containment devices to enhance user identification and provide visual confirmation of the use of a specifically desired size of microspheres or nanospheres.
摘要翻译：提供聚合物颗粒用于治疗和/或诊断过程。颗粒包括聚[双（三氟乙氧基）磷腈]和/或其衍生物，其可以存在于整个颗粒中或颗粒的外涂层内。颗粒还可以包括具有由丙烯酸类聚合物形成的水凝胶的芯。这样的颗粒可以以特定的选定尺寸提供给使用者，以允许特定大小的血管的选择性栓塞或在特定临床应用中用活性成分剂局部治疗。本发明的颗粒可进一步提供为彩色微球或纳米球，以便在使用中准确地鉴定尺寸的颗粒。这样的颜色编码的微球体或纳米球体可以进一步以类似颜色编码的输送或容纳装置提供，以增强用户识别，并提供对特定所需尺寸的微球体或纳米球体的使用的视觉确认。

3. 发明申请

US20210299056A9 Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods 有权
公开(公告)号：US20210299056A9
公开(公告)日：2021-09-30
申请号：US12467229
申请日：2009-05-15
申请人： Ulf Fritz , Olaf Fritz , Thomas A. Gordy , Ronald Wojcik , Jacques BLÜMMEL , Alexander KÜLLER
发明人： Ulf Fritz , Olaf Fritz , Thomas A. Gordy , Ronald Wojcik , Jacques BLÜMMEL , Alexander KÜLLER
IPC分类号： A61K9/50 , A61K47/32 , A61K47/34 , A61K49/04 , A61K49/18 , A61K49/22 , A61M5/00
摘要： Various embodiments are directed to color-coded and size-calibrated polymeric particles comprising an acrylate-based hydrogel core incorporating one or more chromophores of interest, and an outer shell comprising polyphosphazenes of formula I, useful for various therapeutic and/or diagnostic procedures. In various embodiments, the color-coded and size-calibrated polymeric particles can be employed in any particle-mediated procedure, including as embolic agents, dermal fillers, and various implantable devices for a broad range of clinical and cosmetic applications. The incorporation of a particular chromophore formulation that correlates with a pre-determined size specificity for implantable and loadable polymeric particles (“color-coded and size-calibrated”) enables the visual detection and identification of particles exhibiting a particular size of interest, and minimizes the probability of user-introduced or procedural errors.

4. 发明申请

US20100028260A1 Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods 审中-公开
标题翻译：用于治疗和/或诊断应用的预定尺寸的彩色编码聚合物颗粒及相关方法
公开(公告)号：US20100028260A1
公开(公告)日：2010-02-04
申请号：US12467229
申请日：2009-05-15
申请人： Ulf Fritz , Olaf Fritz , Thomas A. Gordy , Ronald Wojcik , Jacques BLÜMMEL , Alexander KÜLLER
发明人： Ulf Fritz , Olaf Fritz , Thomas A. Gordy , Ronald Wojcik , Jacques BLÜMMEL , Alexander KÜLLER
IPC分类号： A61K9/14 , A61K49/00 , A61K47/34 , A61K48/00
摘要： Various embodiments are directed to color-coded and size-calibrated polymeric particles comprising an acrylate-based hydrogel core incorporating one or more chromophores of interest, and an outer shell comprising polyphosphazenes of formula I, useful for various therapeutic and/or diagnostic procedures. In various embodiments, the color-coded and size-calibrated polymeric particles can be employed in any particle-mediated procedure, including as embolic agents, dermal fillers, and various implantable devices for a broad range of clinical and cosmetic applications. The incorporation of a particular chromophore formulation that correlates with a pre-determined size specificity for implantable and loadable polymeric particles (“color-coded and size-calibrated”) enables the visual detection and identification of particles exhibiting a particular size of interest, and minimizes the probability of user-introduced or procedural errors.
摘要翻译：各种实施方案涉及颜色编码和尺寸校准的聚合物颗粒，其包含掺入一种或多种感兴趣发色团的基于丙烯酸酯的水凝胶核心，以及包含式I聚磷腈的外壳，其可用于各种治疗和/或诊断程序。在各种实施方案中，颜色编码和尺寸校准的聚合物颗粒可以用于任何颗粒介导的过程，包括作为栓塞剂，皮肤填充剂和用于广泛临床和化妆品应用的各种可植入装置。结合与可植入和可加载的聚合物颗粒的预定尺寸特异性相关的特定发色团配方（“经颜色编码和尺寸校准”）使得能够目视检测和鉴定表现出特定感兴趣尺寸的颗粒，并且最小化用户引入或程序错误的概率。

5. 发明申请

US20090111763A1 LOADABLE POLYMERIC PARTICLES FOR BONE AUGMENTATION AND METHODS OF PREPARING AND USING THE SAME 审中-公开
标题翻译：用于骨骼补充的负载聚合物颗粒及其制备和使用方法
公开(公告)号：US20090111763A1
公开(公告)日：2009-04-30
申请号：US11924642
申请日：2007-10-26
申请人： Ulf Fritz , Olaf Fritz , Thomas A. Gordy , Ronald Wojcik
发明人： Ulf Fritz , Olaf Fritz , Thomas A. Gordy , Ronald Wojcik
IPC分类号： A61K31/7052 , A61P19/08 , C08L85/02
CPC分类号： C09D185/02 , A61K9/5031 , A61L27/34 , A61L2430/02 , C08F220/14 , C08F222/1006 , C08G79/025 , C08L33/04 , C08L33/14 , C08L2203/02 , C08L85/02
摘要： Particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy)phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided for placement within defects in bone within the body of a mammal to augment structural support and facilitate osteogenesis without causing adverse reactions therein. The hydrogel core may further be used as a delivery vehicle for therapeutic agents to treat or retard pathologic processes within the bone defect during healing.
摘要翻译：颗粒被提供用于治疗和/或诊断过程。颗粒包括聚[双（三氟乙氧基）磷腈]和/或其衍生物，其可以存在于整个颗粒中或颗粒的外涂层内。颗粒还可以包括具有由丙烯酸类聚合物形成的水凝胶的芯。可以提供这样的颗粒放置在哺乳动物身体内的骨缺损中，以增加结构支撑并促进成骨而不引起不良反应。水凝胶核心还可用作治疗剂的治疗或治疗期间骨缺损内的病理过程的递送载体。

6. 发明申请

US20090110730A1 Loadable Polymeric Particles for Marking or Masking Individuals and Methods of Preparing and Using the Same 审中-公开
标题翻译：用于标记或掩蔽个体的可负载聚合物颗粒及其制备和使用方法
公开(公告)号：US20090110730A1
公开(公告)日：2009-04-30
申请号：US11928772
申请日：2007-10-30
申请人： Ulf Fritz , Olaf Fritz , Thomas A. Gordy , Ronald Wojcik
发明人： Ulf Fritz , Olaf Fritz , Thomas A. Gordy , Ronald Wojcik
IPC分类号： A61K9/14 , A61K47/30 , A61P17/00 , G06K9/00 , A61K9/00
CPC分类号： A61B5/411 , A01K11/00 , A61K9/1641 , A61K49/0089
摘要： The present invention relates to the use of certain microspheres, nanospheres, and other structures to provide a method of marking or masking identifying marks in individual biological hosts. Biological hosts for the present invention may include humans, other animals, or plants. Such methods may be used to sense, signal, track, mark, or identify individual biological hosts. Microspheres, nanospheres, and other structures of the present invention may be implanted, injected, ingested, or attached to individual biological hosts. Microspheres, nanospheres, and other structures of the present invention comprise poly[bis(trifluoroethoxy)phosphazene] and/or a derivative thereof which may be present throughout the particles or within an outer coating of the particles. The microspheres, nanospheres, and other structures may also comprise a core having a hydrogel which may further comprise one or more dyes or other chromophoric agents covalently bound permanently to the hydrogel core material. The microspheres, nanospheres, and other structures and/or the hydrogel core may further comprise radio frequency or other electronic chips or nanochips, capable of transmitting and/or receiving electronic signals from external transmitters and/or receivers.
摘要翻译：本发明涉及使用某些微球，纳米球和其他结构来提供标记或掩蔽各个生物宿主中的识别标记的方法。本发明的生物宿主可以包括人，其他动物或植物。这样的方法可用于感测，信号，跟踪，标记或识别各个生物宿主。本发明的微球，纳米球和其他结构可以植入，注射，摄取或附着于各个生物宿主。本发明的微球，纳米球和其它结构包括聚[双（三氟乙氧基）磷腈]和/或其衍生物，其可以存在于整个颗粒中或在颗粒的外涂层内。微球，纳米球和其它结构还可以包含具有水凝胶的芯，其可以进一步包含与水凝胶芯材料永久结合共价结合的一种或多种染料或其它发色剂。微球，纳米球和其他结构和/或水凝胶芯还可以包括能够从外部发射器和/或接收器发射和/或接收电子信号的射频或其他电子芯片或纳米芯片。

7. 发明申请

US20080228284A1 Specific Polyphosphazene-Containing Three-Dimensional Bone Support Implants and Methods for Their Use 审中-公开
标题翻译：具体的含聚磷腈的三维骨支持植入物及其使用方法
公开(公告)号：US20080228284A1
公开(公告)日：2008-09-18
申请号：US11923263
申请日：2007-10-24
申请人： Ulf Fritz , Olaf Fritz , Thomas A. Gordy , Goetz Martin Richter
发明人： Ulf Fritz , Olaf Fritz , Thomas A. Gordy , Goetz Martin Richter
IPC分类号： A61F2/28 , A61K51/06 , A61B17/56
CPC分类号： A61B17/7097 , A61L27/18 , A61L2430/02 , C08L85/02
摘要： The present invention relates to expandable semi-compliant devices that may be used for the treatment of diseased or injured bone tissues, and methods of using the same. The semi-compliant device of the present invention is inserted into an interior space of a cancellous bone tissue, and is filled with a suitable material to provide internal structural support to the bone. The semi-compliant device may further comprise a polymer or a polymer surface coating of a biocompatible polyphosphazene polymer such as poly[bis-(trifluoroethoxy)phosphazene] or derivatives thereof. Such semi-compliant devices or surface coatings may also act as carriers for medicinal, radiological, or thermal treatments of diseased bone.
摘要翻译：本发明涉及可用于治疗患病或受伤的骨组织的可扩张的半顺应性装置及其使用方法。将本发明的半顺应性装置插入松质骨组织的内部空间中，并且填充有合适的材料以向骨提供内部结构支撑。半顺应性装置还可以包括生物相容性聚磷腈聚合物如聚[双 - （三氟乙氧基）磷腈]或其衍生物的聚合物或聚合物表面涂层。这种半顺应性装置或表面涂层还可以用作患病骨的药物，放射或热处理的载体。

8. 发明申请

US20090110738A1 Loadable Polymeric Particles for Cosmetic and Reconstructive Tissue Augmentation Applications and Methods of Preparing and Using the Same 审中-公开
标题翻译：用于化妆和重建组织增强的可负载聚合物颗粒应用及其制备和使用方法
公开(公告)号：US20090110738A1
公开(公告)日：2009-04-30
申请号：US11924728
申请日：2007-10-26
申请人： Thomas A. Gordy , Olaf Fritz , Ulf Fritz , Ronald Wojcik , Teresa Wilson , Harry R. Jacobson
发明人： Thomas A. Gordy , Olaf Fritz , Ulf Fritz , Ronald Wojcik , Teresa Wilson , Harry R. Jacobson
IPC分类号： A61K9/00 , A61K47/30 , A61K9/14 , A61P17/00
CPC分类号： A61Q11/00 , A61K8/37 , A61K8/42 , A61K8/4926 , A61K9/0024 , A61K9/5031 , A61K2800/244 , A61L27/34 , A61L27/50 , C08L85/02
摘要： Particles are provided for use in therapeutic cosmetic and/or reconstructive procedures to augment defects in tissue to restore contours and/or function. The particles include poly[bis(trifluoroethoxy)phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in various colors or with customized coloration to match desired tissues. Moreover, such particles may be loaded to provide localized treatment with an active component agent in specific clinical uses. Particles of the present invention may further be provided or used in conjunction with tissue adhesives or photoinitiator agents that may be activated by electromagnetic radiation or other energy sources to allow post-implantation cross-linking of the polymeric particles to cause their amalgamation to maintain their shape and location following implantation.
摘要翻译：颗粒被提供用于治疗化妆品和/或重建程序以增加组织中的缺陷以恢复轮廓和/或功能。颗粒包括聚[双（三氟乙氧基）磷腈]和/或其衍生物，其可以存在于整个颗粒中或颗粒的外涂层内。颗粒还可以包括具有由丙烯酸类聚合物形成的水凝胶的芯。这样的颗粒可以以各种颜色提供给使用者，或者通过定制着色来提供以匹配期望的组织。此外，可以加载这样的颗粒以在特定临床用途中用活性成分剂进行局部治疗。本发明的颗粒可以进一步提供或与组织粘合剂或光引发剂一起使用，所述组织粘合剂或光引发剂可以被电磁辐射或其他能源激活，以允许聚合物颗粒的植入后交联使其合并保持其形状和植入后的位置。

9. 发明申请

US20080113029A1 Color-Coded and Sized Loadable Polymeric Particles for Therapeutic and/or Diagnostic Applications and Methods of Preparing and Using the Same 有权
标题翻译：用于治疗和/或诊断应用的彩色编码和尺寸可加载的聚合物颗粒及其制备和使用方法
公开(公告)号：US20080113029A1
公开(公告)日：2008-05-15
申请号：US11924674
申请日：2007-10-26
申请人： Ulf Fritz , Olaf Fritz , Thomas A. Gordy , Ronald Wojcik
发明人： Ulf Fritz , Olaf Fritz , Thomas A. Gordy , Ronald Wojcik
IPC分类号： A61K9/14 , A61K9/50 , C08G79/02
CPC分类号： A61K9/5026 , A61K47/32 , C08G79/025 , C08L85/02 , C08L2666/02
摘要： Polymeric particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy) phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in specific selected sizes to allow for selective embolization of certain sized blood vessels or localized treatment with an active component agent in specific clinical uses. Particles of the present invention may further be provided as color-coded microspheres or nanospheres to allow ready identification of the sized particles in use. Such color-coded microspheres or nanospheres may further be provided in like color-coded delivery or containment devices to enhance user identification and provide visual confirmation of the use of a specifically desired size of microspheres or nanospheres.
摘要翻译：提供聚合物颗粒用于治疗和/或诊断过程。颗粒包括聚[双（三氟乙氧基）磷腈]和/或其衍生物，其可以存在于整个颗粒中或颗粒的外涂层内。颗粒还可以包括具有由丙烯酸类聚合物形成的水凝胶的芯。这样的颗粒可以以特定的选定尺寸提供给使用者，以允许特定大小的血管的选择性栓塞或在特定临床应用中用活性成分剂局部治疗。本发明的颗粒可进一步提供为彩色微球或纳米球，以便在使用中准确地鉴定尺寸的颗粒。这样的颜色编码的微球体或纳米球体可以进一步以类似颜色编码的输送或容纳装置提供，以增强用户识别，并提供对特定所需尺寸的微球体或纳米球体的使用的视觉确认。

10. 发明申请

US20100047324A1 Multi-Functional Wound Dressing Matrices and Related Methods 审中-公开
标题翻译：多功能伤口敷料矩阵及相关方法
公开(公告)号：US20100047324A1
公开(公告)日：2010-02-25
申请号：US12391040
申请日：2009-02-23
申请人： Ulf Fritz , Olaf Fritz , Thomas A. Gordy
发明人： Ulf Fritz , Olaf Fritz , Thomas A. Gordy
IPC分类号： A61L15/16 , A61P17/02
CPC分类号： A61F13/00063 , A61F13/0206 , A61L15/26 , C08L85/02
摘要： Various embodiments are directed to multi-functional wound-care dressing matrices that can protect and promote new tissue growth at a wound site. The multi-functional wound care matrix can incorporate polyphosphazenes of formula I, as a component that can be configured into various forms, including as fibrous mats, porous membranes, nonporous films, particulate formulations, and equivalents. The multi-functional wound-care dressing matrix of the present disclosure exhibit high-performance properties conferred by polyphosphazenes of formula I. Exceptional biocompatible properties of polyphosphazenes of formula I provide an ideal tissue-contacting surface for the multi-functional wound-care dressing matrix of interest.
摘要翻译：各种实施方案涉及可以在伤口部位保护和促进新组织生长的多功能伤口敷料基质。多功能伤口护理基质可以引入式I的聚磷腈作为可以配置成各种形式的组分，包括作为纤维垫，多孔膜，无孔膜，颗粒制剂和等同物。本公开的多功能伤口护理敷料基质表现出由式I的聚磷腈赋予的高性能特征。式I的聚磷腈的特殊的生物相容性质为多功能伤口敷料基质提供了理想的组织接触表面出于兴趣。

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