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1. 发明申请

WO2009109156A3 NOVEL ANTIMICROBIAL PEPTIDES AND THEIR APPLICATION 审中-公开
标题翻译：新型抗微生物肽及其应用
公开(公告)号：WO2009109156A3
公开(公告)日：2010-04-29
申请号：PCT/CZ2009000034
申请日：2009-03-03
申请人： USTAV ORGANICKE CHEMIE A BIOCH , CEROVSKY VACLAV , SLANINOVA JIRINA , HOVORKA OLDRICH , CVACKA JOSEF , VOBURKA ZDENEK , FUCIK VLADIMIR , BEDNAROVA LUCIE , VOTRUBA IVAN , BOROVICKOVA LENKA , TURANEK JAROSLAV
发明人： CEROVSKY VACLAV , SLANINOVA JIRINA , HOVORKA OLDRICH , CVACKA JOSEF , VOBURKA ZDENEK , FUCIK VLADIMIR , BEDNAROVA LUCIE , VOTRUBA IVAN , BOROVICKOVA LENKA , TURANEK JAROSLAV
IPC分类号： C07K7/08 , A61K38/10
CPC分类号： C07K14/43572 , A61K38/00 , C07K7/08
摘要： This invention involves four novel peptides of the formulas I, II, III a IV isolated from natural sources and their synthetic analogs of general formula V and VI, where R 1 represents acyl, alkyl or unprotected amino group, R 2 represents amid, substituted amid, unprotected carboxylic group or ester, Xaa represents, independently from each other, proteinogenic amino acid, D-amino acid, non-standard amino acid or amino acid with the side chain modification, n means position of the amino acid replacement and m means the number of the replacements in the peptide chain, and their applications as antimicrobial, antiviral, antifungal, antiparasitic and anticancer compounds. Therefore, they are practical for the production of medication for the treatment of microbial, parasitic and fungal diseases and for the cancer treatment. Formulas for summary: H-Gly-Phe-Leu-Ser-Ile-Leu-Lys-Lys-Val-Leu-Pro-Lys-Val-Met-Ala-His-Met-Lys-NH2 (I) H-VaI-Asn-Trp-Lys-Lys-VaI-Leu-GIy-Lys-IIe-IIe-Lys-VaI-AIa-Lys-NH2 (II) H-VaI-Asn-Trp-Lys-Lys-IIe-Leu-GIy-Lys-IIe-IIe-Lys-VaI-AIa-Lys-NH2 (III) H-Val-Asn-Trp-Lys-Lys-Ile-Leu-Gly-Lys-Ile-Ile-Lys-Val-Val-Lys-NH2 (IV) R1-[Xaan]m -Gly-Phe-Leu-Ser-Ile-Leu-Lys-Lys-Val-Leu-Pro-Lys-Val-Met-Ala-His-Met-Lys-R2 (V) R1-[Xaan]m-Val-Asn-Trp-Lys-Lys-Ile-Leu-Gly-Lys-Ile-Ile-Lys-Val-Val-Lys-R2 (VI)
摘要翻译：本发明涉及从天然来源分离的四种分子式I，II，III和IV的新型肽及其通式V和VI的合成类似物，其中R 1表示酰基，烷基或未被保护的氨基，R 2表示氨基，取代的氨基，未被保护的羧基或酯，Xaa彼此独立地表示蛋白质氨基酸，D-氨基酸，非标准氨基酸或具有侧链修饰的氨基酸，n表示氨基酸置换的位置，m表示肽链中的替代物的数量，以及它们作为抗微生物剂，抗病毒剂，抗真菌剂，抗寄生虫和抗癌化合物的应用。因此，它们可用于生产用于治疗微生物，寄生虫和真菌疾病和癌症治疗的药物。总结公式：H-Gly-Phe-Leu-Ser-Ile-Leu-Lys-Lys-Val-Leu-Pro-Lys-Val-Met-Ala-His-Met-Lys-NH2（I） Asn-Trp-Lys-Lys-Val-Leu-Gly-Lys-IIe-IIe-Lys-Val-Ala-Lys-NH2（II）H-Val-Asn-Trp-Lys-Lys-IIe-Leu- Lys-IIe-IIe-Lys-Val-Ala-Lys-NH 2（III）H-Val-Asn-Trp-Lys-Lys-Ile-Leu-Gly-Lys-Ile-Ile-Lys-Val-Val- NH 2（IV）R 1 - [Xanan] m -Gly-Phe-Leu-Ser-Ile-Leu-Lys-Lys-Val-Leu-Pro-Lys-Val-Met-Ala-His-Met-Lys-R2 ）R1- [Xanan] m-Val-Asn-Trp-Lys-Lys-Ile-Leu-Gly-Lys-Ile-Ile-Lys-Val-Val-Lys-R2（VI）

2. 发明申请

WO2010091651A3 NOVEL ANTIMICROBIAL PEPTIDES 审中-公开
标题翻译：新型抗微生物肽
公开(公告)号：WO2010091651A3
公开(公告)日：2010-11-11
申请号：PCT/CZ2010000016
申请日：2010-02-10
申请人： ACAD OF SCIENCE CZECH REPUBLIC , MONINCOVA LENKA , CEROVSKY VACLAV , SLANINOVA JIRINA , HOVORKA OLDRICH , CVACKA JOSEF , VOBURKA ZDENEK , FUCIK VLADIMIR , BOROVICKOVA LENKA
发明人： MONINCOVA LENKA , CEROVSKY VACLAV , SLANINOVA JIRINA , HOVORKA OLDRICH , CVACKA JOSEF , VOBURKA ZDENEK , FUCIK VLADIMIR , BOROVICKOVA LENKA
IPC分类号： A61K38/10 , C07K7/08 , C07K14/435
CPC分类号： C07K14/43572
摘要： This invention involves two novel peptides of the formulas (1) H-Gly -Met-Trp -Ser-Lys- -Ile-Leu-Gly -His-Leu-Ile-Arg -NH2 and (2), H-Gly -Lys-Trp -Met-Ser-Leu-Leu-Lys -His-Ile-Leu-Lys-NH2 isolated from natural sources and their synthetic analogs of general formula (1-A) [Xaan]m -Gly-Met-Trp-Ser-Lys-Ile-Leu-Gly-His-Leu-Ile-Arg-NH2 and (2-A), [Xaan]m -Gly-Lys-Trp-Met-Ser-Leu-Leu-Lys-His-Ile-Leu-Lys-NH2 where Xaa represents, independently from each other, proteinogenic amino acid, D-amino acid, non- standard amino acid or amino acid with the side chain modification, n means position of the amino acid replacement and m means the number of the replacements in the peptide chain. Described is also their use for the preparation of medicaments for the treatment of microbial, parasitic and fungal diseases and for the cancer treatment.
摘要翻译：本发明涉及式（1）H-Gly-Met-Trp-Ser-Lys-Ile-Leu-Gly -His-Leu-Ile-Arg -NH 2的新型肽和（2）H-Gly -Lys -Trp -Met-Ser-Leu-Leu-Lys-His-Ile-Leu-Lys-NH2，其自然来源及其通式（1-A）[Xaan] m -Gly-Met-Trp-Ser -Lys-Ile-Leu-Gly-His-Leu-Ile-Arg-NH 2和（2-A），[Xanan] m -Gly-Lys-Trp-Met-Ser-Leu-Leu-Lys-His- Leu-Lys-NH 2，其中Xaa彼此独立地表示蛋白质氨基酸，D-氨基酸，非标准氨基酸或具有侧链修饰的氨基酸，n表示氨基酸置换的位置，m表示数的肽链中的替代物。还描述了其用于制备用于治疗微生物，寄生虫和真菌疾病和癌症治疗的药物的用途。

3. 发明申请

WO2010091651A4 NOVEL ANTIMICROBIAL PEPTIDES 审中-公开
标题翻译：新型抗微生物肽
公开(公告)号：WO2010091651A4
公开(公告)日：2011-01-06
申请号：PCT/CZ2010000016
申请日：2010-02-10
申请人： ACAD OF SCIENCE CZECH REPUBLIC , MONINCOVA LENKA , CEROVSKY VACLAV , SLANINOVA JIRINA , HOVORKA OLDRICH , CVACKA JOSEF , VOBURKA ZDENEK , FUCIK VLADIMIR , BOROVICKOVA LENKA
发明人： MONINCOVA LENKA , CEROVSKY VACLAV , SLANINOVA JIRINA , HOVORKA OLDRICH , CVACKA JOSEF , VOBURKA ZDENEK , FUCIK VLADIMIR , BOROVICKOVA LENKA
IPC分类号： A61K38/10 , C07K7/08 , C07K14/435
CPC分类号： C07K14/43572
摘要： This invention involves two novel peptides of the formulas (1) H-Gly -Met-Trp -Ser-Lys- -Ile-Leu-Gly -His-Leu-Ile-Arg -NH2 and (2), H-Gly -Lys-Trp -Met-Ser-Leu-Leu-Lys -His-Ile-Leu-Lys-NH2 isolated from natural sources and their synthetic analogs of general formula (1-A) [Xaan]m -Gly-Met-Trp-Ser-Lys-Ile-Leu-Gly-His-Leu-Ile-Arg-NH2 and (2-A), [Xaan]m -Gly-Lys-Trp-Met-Ser-Leu-Leu-Lys-His-Ile-Leu-Lys-NH2 where Xaa represents, independently from each other, proteinogenic amino acid, D-amino acid, non- standard amino acid or amino acid with the side chain modification, n means position of the amino acid replacement and m means the number of the replacements in the peptide chain. Described is also their use for the preparation of medicaments for the treatment of microbial, parasitic and fungal diseases and for the cancer treatment.
摘要翻译：本发明涉及式（1）H-Gly-Met-Trp-Ser-Lys-Ile-Leu-Gly -His-Leu-Ile-Arg -NH 2的新型肽和（2）H-Gly -Lys -Trp-Met-Ser-Leu-Leu-Lys-His-Ile-Leu-Lys-NH2，其自然来源及其通式（1-A）[Xaan] m -Gly-Met-Trp-Ser -Lys-Ile-Leu-Gly-His-Leu-Ile-Arg-NH 2和（2-A），[Xanan] m -Gly-Lys-Trp-Met-Ser-Leu-Leu-Lys-His- Leu-Lys-NH 2，其中Xaa彼此独立地表示蛋白质氨基酸，D-氨基酸，非标准氨基酸或具有侧链修饰的氨基酸，n表示氨基酸置换的位置，m表示数的肽链中的替代物。还描述了其用于制备用于治疗微生物，寄生虫和真菌疾病和癌症治疗的药物的用途。

4. 发明专利

CS229896B1 未知
公开(公告)号：CS229896B1
公开(公告)日：1984-07-16
申请号：CS620682
申请日：1982-08-26
申请人： SIMEK PETR , BRTNIK FRANTISEK , SLANINOVA JIRINA , BARTH TOMISLAV , MACHOVA ALENA , JOST KAREL , SERVITOVA LINDA
发明人： SIMEK PETR , BRTNIK FRANTISEK , SLANINOVA JIRINA , BARTH TOMISLAV , MACHOVA ALENA , JOST KAREL , SERVITOVA LINDA
IPC分类号： C07G15/00

5. 发明专利

CS229894B1 ANALOGY OF VASOPRESINE AND METHOD OF ITS PRODUCTION 未知
公开(公告)号：CS229894B1
公开(公告)日：1984-07-16
申请号：CS620482
申请日：1982-08-26
申请人： LEBL MICHAL , BARTH TOMISLAV , MACHOVA ALENA , JOST KAREL , SERVITOVA LINDA , SLANINOVA JIRINA
发明人： LEBL MICHAL , BARTH TOMISLAV , MACHOVA ALENA , JOST KAREL , SERVITOVA LINDA , SLANINOVA JIRINA
IPC分类号： C07G15/00

7. 发明专利

CS229895B1 ANALOGY OF OXYTOCINE AND METHOD OF ITS PRODUCTION 未知
公开(公告)号：CS229895B1
公开(公告)日：1984-07-16
申请号：CS620582
申请日：1982-08-26
申请人： LEBL MICHAL , MACHOVA ALENA , BARTH TOMISLAV , JOST KAREL , SERVITOVA LINDA , SLANINOVA JIRINA
发明人： LEBL MICHAL , MACHOVA ALENA , BARTH TOMISLAV , JOST KAREL , SERVITOVA LINDA , SLANINOVA JIRINA
IPC分类号： C07G15/00

8. 发明专利

CS187829B1 LYSIN-VASOPRESSIN ANALOG AND METHOD OF PREPARING THE SAME 未知
公开(公告)号：CS187829B1
公开(公告)日：1979-02-28
申请号：CS809176
申请日：1976-12-10
申请人： BARTH TOMISLAV , KREJCI IVAN , JOST KAREL , PRUSIK ZDENEK , SLANINOVA JIRINA , PROCHAZKA ZDENKO , BOJANOVSKA VERA
发明人： BARTH TOMISLAV , KREJCI IVAN , JOST KAREL , PRUSIK ZDENEK , SLANINOVA JIRINA , PROCHAZKA ZDENKO , BOJANOVSKA VERA
IPC分类号： C07K7/16 , C07C103/52

9. 发明专利

CS237718B1 ANALOGOUS OF OXYTOCINE WITH MODIFIED BIOLOGICAL CHARACTERISTICS 未知
公开(公告)号：CS237718B1
公开(公告)日：1985-10-16
申请号：CS328183
申请日：1983-05-10
申请人： LEBL MICHAL , SLANINOVA JIRINA , HRBAS PAVEL , SERVITOVA LINDA , BARTH TOMISLAV
发明人： LEBL MICHAL , SLANINOVA JIRINA , HRBAS PAVEL , SERVITOVA LINDA , BARTH TOMISLAV
IPC分类号： C07K7/16 , A61K37/34

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