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1. 发明申请

WO02064797A9 MITOCHONDRIAL TOPOISOMERASE I 审中-公开
公开(公告)号：WO02064797A9
公开(公告)日：2002-12-05
申请号：PCT/US0204607
申请日：2002-02-15
申请人： US HEALTH , POMMIER YVES , ZHANG HONG-LIANG
发明人： POMMIER YVES , ZHANG HONG-LIANG
IPC分类号： A61K38/00 , C12N9/90 , C12N15/61 , C12Q1/533 , G01N33/573 , C07K16/40 , C12N5/10
CPC分类号： G01N33/573 , A61K38/00 , C12N9/90 , C12Q1/533 , G01N2500/00
摘要： An isolated or purified nucleic acid molecule consisting essentially of a nucleotide sequence encoding mitochondrial topoisomerase I (mt topo I), a 5' fragment thereof, or a variant mt topo I, an isolated or purified nucleic acid molecule consisting essentially of a nucleotide sequence that is complementary to a nucleotide sequence encoding mt topo I, a 5' fragment thereof, or a variant mt topo I, a vector comprising such an isolated or purified nucleic acid molecule, a cell comprising such a vector, an isolated or purified polypeptide molecule consisting essentially of an amino acid sequence encoding mt topo I or a variant mt topo I, a conjugate comprising such an isolated or purified polypeptide molecule and a cell-surface targeting moiety, a hybridoma cell line that produces a monoclonal antibody that is specific for an aforementioned isolated or purified polypeptide molecule, the monoclonal antibody produced by the hybridoma cell line, a polyclonal antiserum raised against an aforementioned isolated or purified polypeptide molecule, a method of altering the level of mt topo I in a cell, and a method of identifying an inhibitor or an activator of mt topo I.
摘要翻译：分离的或纯化的核酸分子基本上由编码线粒体拓扑异构酶I（mt topo I）的核苷酸序列，其5'片段或变体mt topo I组成，分离的或纯化的核酸分子基本上由核苷酸序列组成，与编码mt topo I，其5'片段或变体mt topo I的核苷酸序列互补，包含此类分离或纯化的核酸分子的载体，包含此类载体的细胞，分离或纯化的多肽分子，基本上编码mt topo I或变体mt topo I的氨基酸序列，包含此类分离或纯化的多肽分子和细胞表面靶向部分的缀合物，产生对上述特异性的单克隆抗体的杂交瘤细胞系分离的或纯化的多肽分子，由杂交瘤细胞系产生的单克隆抗体，针对前述的多克隆抗血清提及的分离或纯化的多肽分子，改变细胞中mt topo I水平的方法，以及鉴定mt topo I的抑制剂或激活剂的方法。

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