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1. 发明申请

WO2011057254A3 SIMIAN ADENOVIRAL VECTOR-BASED VACCINES 审中-公开
标题翻译：基于SIMIAN腺病毒的基于矢量的疫苗
公开(公告)号：WO2011057254A3
公开(公告)日：2011-08-18
申请号：PCT/US2010056004
申请日：2010-11-09
申请人： US HEALTH , GENVEC INC , NABEL GARY J , CHENG CHENG , KO SUNG-YOUL , GALL JASON G D , KONG WING-PUI , BROUGH DOUGLAS E , MCVEY DUNCAN L , KAHL CHRISTOPH , WEI CHIH-JEN
发明人： NABEL GARY J , CHENG CHENG , KO SUNG-YOUL , GALL JASON G D , KONG WING-PUI , BROUGH DOUGLAS E , MCVEY DUNCAN L , KAHL CHRISTOPH , WEI CHIH-JEN
IPC分类号： A61K35/76 , C07K14/11 , C07K14/16 , C07K14/35 , C12N15/861
CPC分类号： C12N15/86 , A61K39/12 , A61K39/145 , A61K39/21 , A61K2039/5256 , A61K2039/5258 , A61K2039/54 , A61K2039/545 , C12N2710/10332 , C12N2710/10343 , C12N2740/16134 , C12N2760/16134
摘要： The invention relates to a replication-deficient simian adenoviral vector construct comprising a nucleic acid sequence which encodes an antigen of a pathogen, such as an HIV antigen or an influenza virus antigen. The invention also provides a method of inducing an immune response against a pathogen, such as HIV or influenza, in a mammal using a composition comprising the simian adenoviral vector construct. The invention also provides a monkey adenovirus which is capable of propagation in a human cell.
摘要翻译：本发明涉及复制缺陷型猿猴腺病毒载体构建体，其包含编码病原体如HIV抗原或流感病毒抗原的抗原的核酸序列。本发明还提供了使用包含猿猴腺病毒载体构建体的组合物在哺乳动物中诱导抗病原体如HIV或流感病毒的免疫应答的方法。本发明还提供了能够在人类细胞中增殖的猴腺病毒。

2. 发明申请

WO0158494A3 GENE THERAPY FOR TREATING OCULAR-RELATED DISORDERS 审中-公开
标题翻译：用于治疗与眼睛有关的疾病的基因治疗
公开(公告)号：WO0158494A3
公开(公告)日：2002-04-04
申请号：PCT/US0104203
申请日：2001-02-09
申请人： GENVEC INC , KOVESDI IMRE , BROUGH DOUGLAS E , MCVEY DUNCAN L , WEI LISA
发明人： KOVESDI IMRE , BROUGH DOUGLAS E , MCVEY DUNCAN L , WEI LISA
IPC分类号： C12N15/09 , A61K35/76 , A61K48/00 , A61P27/02 , C07K14/71 , C07K14/81 , C12N15/861 , C07K14/515
CPC分类号： A61K48/0075 , A61K48/005 , C07K14/71 , C07K14/811 , C12N15/86 , C12N2710/10343
摘要： The present invention is directed to a method of prophylactically or therapeutically treating an animal for at least one ocular-related disorder, e.g., ocular neovascularization or age-related macular degeneration. The method comprises contacting an ocular cell with an expression vector comprising a nucleic acid sequence encoding an inhibitor of angiogenesis and the same or different nucleic acid sequence encoding a neurotrophic agent. The method also can comprise contacting an ocular cell with different expression vectors, each comprising a nucleic acid sequence encoding an inhibitor of angiogenesis and/or a nucleic acid sequence encoding a neurotrophic agent. In addition, the present invention provides a viral vector comprising a nucleic acid sequence encoding pigment epithelium-derived factor (PEDF) or a therapeutic fragment thereof.
摘要翻译：本发明涉及一种预防性或治疗性地治疗动物至少一种与眼部相关的疾病，例如眼睛新生血管形成或年龄相关性黄斑变性的方法。该方法包括使眼细胞与包含编码血管生成抑制剂的核酸序列和编码神经营养剂的相同或不同核酸序列的表达载体接触。该方法还可以包括使眼细胞与不同的表达载体接触，每种表达载体包含编码血管生成抑制剂的核酸序列和/或编码神经营养剂的核酸序列。此外，本发明提供了包含编码色素上皮衍生因子（PEDF）的核酸序列或其治疗片段的病毒载体。

3. 发明申请

WO2004050027A3 MATERIALS AND METHODS FOR TREATING OCULAR-RELATED DISORDERS 审中-公开
标题翻译：用于治疗眼睛相关疾病的材料和方法
公开(公告)号：WO2004050027A3
公开(公告)日：2004-12-02
申请号：PCT/US0338169
申请日：2003-12-01
申请人： GENVEC INC , MCVEY DUNCAN L , BROUGH DOUGLAS E , KOVESDI IMRE , WEI LISA
发明人： MCVEY DUNCAN L , BROUGH DOUGLAS E , KOVESDI IMRE , WEI LISA
IPC分类号： A61K20060101 , A61K9/00 , A61K31/203 , A61K31/7088 , A61K38/55 , A61K45/06 , A61K48/00 , C12N15/85 , C12N15/86 , C12N15/861
CPC分类号： A61K48/005 , A61K9/0048 , A61K31/203 , A61K31/7088 , A61K38/57 , A61K45/06 , A61K48/00 , A61K48/0058 , A61K48/0075 , A61K48/0083 , C12N15/86 , C12N2710/10343 , C12N2799/022 , A61K2300/00
摘要： The invention is directed to a method of delivering a gene product to an animal. The method comprises administering an expression vector comprising a nucleic acid sequence operably linked to a promoter and encoding a gene product, and upregulating transcription of the nucleic acid sequence in the ocular cell. The expression vector can be an adenoviral vector. The invention further provides a method of prophylactically or therapeutically treating an animal for at least one ocular-related disorder. The method comprises contacting an ocular cell with an expression vector comprising a nucleic acid sequence encoding an inhibitor of angiogenesis and/or a neurotrophic agent. In one aspect, the method further comprises upregulating transcription of the nucleic acid sequence. Preferably, if 2x10 adenoviral particles of the inventive method are administered to a mouse, the level of expression of the nucleic acid sequence is not diminished more than tenfold at 28 days post-administration.
摘要翻译：本发明涉及将基因产物递送至动物的方法。该方法包括施用表达载体，所述表达载体包含与启动子可操作连接并编码基因产物的核酸序列，并且上调核酸序列在眼细胞中的转录。表达载体可以是腺病毒载体。本发明进一步提供了预防性或治疗性治疗动物以治疗至少一种眼部相关病症的方法。该方法包括使眼细胞与包含编码血管生成抑制剂和/或神经营养剂的核酸序列的表达载体接触。一方面，该方法还包括上调核酸序列的转录。优选地，如果将本发明方法的2×10 8个腺病毒颗粒给予小鼠，则核酸序列的表达水平在给药后28天不会减少超过10倍。

4. 发明申请

WO9856937A2 CHIMERIC VECTORS COMPRISING A PHAGE PACKAGING SITE AND A PORTION DERIVED FROM A GENOME OF A EUKARYOTIC VIRUS 审中-公开
标题翻译：包含噬菌体包装场所的重要载体和从原始病毒的基因衍生的部分
公开(公告)号：WO9856937A2
公开(公告)日：1998-12-17
申请号：PCT/US9812158
申请日：1998-06-09
申请人： GENVEC INC , MCVEY DUNCAN L , BROUGH DOUGLAS E , ZUBER MOHAMMED , KOVESDI IMRE
发明人： MCVEY DUNCAN L , BROUGH DOUGLAS E , ZUBER MOHAMMED , KOVESDI IMRE
IPC分类号： C12N1/21 , C12N7/00 , C12N7/01 , C12N15/86 , C12N15/861
CPC分类号： C12N15/86 , C12N2710/10343 , C12N2710/10344 , C12N2795/10344 , C12N2810/405 , C12N2830/002 , C12N2830/005 , C12N2830/15 , C12N2830/55
摘要： The present invention provides an improved method of making eukaryotic gene transfer vectors comprising homologous recombining lambdid vectors with a second DNA in a bacterium to generate novel recombinant eukaryotic viral gene transfer vectors as well as a novel lambdid vector used in the inventive method and an inventive system comprising the novel lambdid vector.
摘要翻译：本发明提供了一种制备包含同源重组羊羔载体的真核基因转移载体与细菌中的第二DNA以产生新的重组真核病毒基因转移载体以及用于本发明方法和本发明系统的新型羔羊载体的改进方法包括新的小鼠载体。

5. 发明申请

WO2007027860A2 ADENOVIRAL VECTOR-BASED MALARIA VACCINES 审中-公开
标题翻译：基于腺病毒载体的疟疾疫苗
公开(公告)号：WO2007027860A2
公开(公告)日：2007-03-08
申请号：PCT/US2006033982
申请日：2006-08-31
申请人： GENVEC INC , US NAVY NAVAL RES LAB , BRUDER JOSEPH T , KOVESDI IMRE , KING C RICHTER , MCVEY DUNCAN L , ETTYREDDY DAMODAR R , DOOLAN DENISE LOUISE , CARUCCI DANIEL JOHN , LIMBACH KEITH
发明人： BRUDER JOSEPH T , KOVESDI IMRE , KING C RICHTER , MCVEY DUNCAN L , ETTYREDDY DAMODAR R , DOOLAN DENISE LOUISE , CARUCCI DANIEL JOHN , LIMBACH KEITH
IPC分类号： C12N15/09
CPC分类号： C07K14/445 , A61K39/015 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2830/00 , C12N2830/002 , C12N2830/008
摘要： The invention provides adenoviral vectors comprising an adenoviral genome comprising heterologous antigen-encoding nucleic acid sequences, such as Plasmodium nucleic acid sequences, operably linked to promoters. The invention further provides a method of inducing an immune response against malaria in a mammal comprising administering the adenoviral vectors to the mammal.
摘要翻译：本发明提供包含腺病毒基因组的腺病毒载体，所述腺病毒基因组包含可操作地连接至启动子的编码异源抗原的核酸序列，例如疟原虫核酸序列。本发明进一步提供了在哺乳动物中诱导针对疟疾的免疫应答的方法，其包括将腺病毒载体给予哺乳动物。

6. 发明申请

WO0111087A3 METHOD OF EVALUATING A GENE TRANSFER VECTOR AND GENE TRANSFER VECTOR PRODUCT INTERACTIONS 审中-公开
标题翻译：评估基因转移载体和基因转移载体产品交互的方法
公开(公告)号：WO0111087A3
公开(公告)日：2002-07-11
申请号：PCT/US0022234
申请日：2000-08-10
申请人： GENVEC INC , CARRION MIGUEL , MCVEY DUNCAN L , KOVESDI IMRE
发明人： CARRION MIGUEL , MCVEY DUNCAN L , KOVESDI IMRE
IPC分类号： C12N15/10 , G01N33/569 , G01N33/68 , G01N33/53
CPC分类号： C12N15/1086 , G01N33/56983 , G01N33/6848 , G01N33/6851 , G01N2333/075
摘要： The present invention provides a method of evaluating a gene transfer vector as well as gene transfer vector interactions. The method comprises providing a gene transfer vector including an exogenous gene encoding a gene transfer vector product, inserting the gene transfer vector into a cell, permissive for expression of the exogenous gene and production of the gene transfer vector product, to form a transduced cell, and expressing the exogenous gene to produce the gene transfer vector product. Charged fragments are produced from the gene transfer vector product, and a detector detects the charged fragments and produces a sample signal corresponding to the mass-to-charge ratio of the charged fragments and includes information characteristic of the gene transfer vector product. The gene transfer vector is evaluated by evaluating the sample signal. The present invention also provides a method of evaluating a vector for interactions with interacting molecules. The vector is permitted to associate with one or more potentially interacting molecules, such that a vector-interacting molecule complex will form if a potentially interacting molecule associates with the vector. The method further calls for producing charged fragments from the vector, and, if a complex is formed, the interacting molecule, detecting the charged fragments with a detector that produces a sample signal corresponding to the mass-to-charge ratio of the charged fragments and comprising information characteristic of the vector, and, if a complex is formed, optionally characteristic of the interacting molecule. The vector's interactions with interacting molecules then are evaluated by evaluation of the sample signal.
摘要翻译：本发明提供了评估基因转移载体以及基因转移载体相互作用的方法。该方法包括提供包含编码基因转移载体产物的外源基因的基因转移载体，将基因转移载体插入细胞，允许表达外源基因并产生基因转移载体产物，形成转导的细胞，并表达外源基因以产生基因转移载体产物。从基因转移载体产物产生带电片段，检测器检测带电片段并产生与带电片段的质荷比相对应的样品信号，并包括基因转移载体产物的特征信息。通过评估样品信号来评估基因转移载体。本发明还提供了评价载体与相互作用分子的相互作用的方法。允许载体与一个或多个潜在相互作用的分子缔合，使得如果潜在相互作用的分子与载体相关联，将形成载体相互作用的分子复合物。该方法还要求从载体产生带电片段，并且如果形成复合体，则相互作用的分子用检测器检测带电片段，该检测器产生对应于带电片段的质荷比的样品信号，以及包括载体的信息特征，并且如果形成复合物，则任选地具有相互作用分子的特征。然后通过评估样品信号来评估载体与相互作用分子的相互作用。

7. 发明专利

JPH11502421A 失效
公开(公告)号：JPH11502421A
公开(公告)日：1999-03-02
申请号：JP52221897
申请日：1996-12-12
申请人： GENVEC INC
发明人： KOVESDI IMRE , BROUGH DOUGLAS E , MCVEY DUNCAN L , BRUDER JOSEPH T , LIZONOVA ALENA
IPC分类号： C12N15/09 , A61K31/70 , A61K35/76 , A61K38/00 , A61K39/00 , A61K48/00 , A61P37/04 , A61P43/00 , C07K14/075 , C07K14/47 , C12N5/10 , C12N7/00 , C12N15/00 , C12N15/12 , C12N15/34 , C12N15/86 , C12N15/861 , C12Q1/02 , C12Q1/68 , C12R1/92 , G01N33/15

8. 发明申请

WO0159071A3 METHODS OF PREPARING AND USING A VIRAL VECTOR LIBRARY 审中-公开
标题翻译：制作和使用虚拟矢量图书馆的方法
公开(公告)号：WO0159071A3
公开(公告)日：2002-01-10
申请号：PCT/US0104232
申请日：2001-02-09
申请人： GENVEC INC
发明人： KOVESDI IMRE , MCVEY DUNCAN L , WICKHAM THOMAS J , BRUDER JOSEPH T , BROUGH DOUGLAS E
IPC分类号： C12N15/09 , A61K31/711 , A61K35/76 , A61K38/00 , A61K48/00 , A61P1/04 , A61P1/16 , A61P3/04 , A61P3/10 , A61P7/04 , A61P9/04 , A61P9/06 , A61P9/10 , A61P11/00 , A61P13/02 , A61P13/08 , A61P13/10 , A61P13/12 , A61P15/00 , A61P15/10 , A61P17/02 , A61P17/14 , A61P19/02 , A61P19/08 , A61P19/10 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/06 , A61P27/16 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P33/00 , A61P33/06 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C12N15/10 , C12N15/861 , C12Q1/68 , C12N7/01
CPC分类号： C12N15/1093 , A61K48/00 , C12N15/86 , C12N2710/10343 , C12N2710/10345 , C12N2810/40
摘要： The present invention provides a library of viral vectors, wherein each member comprises a first heterologous DNA encoding a first gene product and a second heterologous DNA encoding a second gene product. The first heterologous DNA is common to each member of the library, while the second heterologous DNA varies between members of the library. The present invention additionally provides a method of constructing a library of viral vectors. The method comprises carrying out homologous recombination between a first DNA molecule and a second DNA molecule to form a pool of intermediate viral vector genomes. One or more linear third DNA molecules are ligated into the pool of intermediate viral geneomes to produce a library of viral vector genomes. Alternatively, homologous recombination between linear DNA molecules and recipient DNA molecules produces a library of viral vector genomes. The library of viral vector genomes is converted into a library of viral vectors.
摘要翻译：本发明提供病毒载体文库，其中每个成员包含编码第一基因产物的第一异源DNA和编码第二基因产物的第二异源DNA。第一个异源DNA对于文库的每个成员是共同的，而第二异源DNA在文库的成员之间是不同的。本发明另外提供构建病毒载体文库的方法。该方法包括在第一DNA分子和第二DNA分子之间进行同源重组以形成中间病毒载体基因组池。将一个或多个线性第三DNA分子连接到中间病毒基因组的池中以产生病毒载体基因组文库。或者，线性DNA分子和受体DNA分子之间的同源重组产生病毒载体基因组文库。将病毒载体基因组文库转化为病毒载体文库。

9. 发明公开

EP1567198A4 MATERIALS AND METHODS FOR TREATING OCULAR-RELATED DISORDERS 审中-公开
标题翻译：材料和方法治疗眼病
公开(公告)号：EP1567198A4
公开(公告)日：2006-05-31
申请号：EP03812479
申请日：2003-12-01
申请人： GENVEC INC
发明人： MCVEY DUNCAN L , BROUGH DOUGLAS E , KOVESDI IMRE , WEI LISA
IPC分类号： A61K20060101 , A61K9/00 , A61K31/203 , A61K31/7088 , A61K38/55 , A61K45/06 , A61K48/00 , C12N15/85 , C12N15/86 , C12N15/861 , A61K33/00
CPC分类号： A61K48/005 , A61K9/0048 , A61K31/203 , A61K31/7088 , A61K38/57 , A61K45/06 , A61K48/00 , A61K48/0058 , A61K48/0075 , A61K48/0083 , C12N15/86 , C12N2710/10343 , C12N2799/022 , A61K2300/00

10. 发明申请

WO9721826A2 COMPLEMENTARY ADENOVIRAL VECTOR SYSTEMS AND CELL LINES 审中-公开
标题翻译：补充腺病毒载体系统和细胞系
公开(公告)号：WO9721826A2
公开(公告)日：1997-06-19
申请号：PCT/US9619839
申请日：1996-12-12
申请人： GENVEC INC
发明人： KOVESDI IMRE , BROUGH DOUGLAS E , MCVEY DUNCAN L , BRUDER JOSEPH T , LIZONOVA ALENA
IPC分类号： C12N15/09 , A61K31/70 , A61K35/76 , A61K38/00 , A61K48/00 , A61P37/04 , A61P43/00 , C07K14/075 , C07K14/47 , C12N5/10 , C12N7/00 , C12N15/00 , C12N15/12 , C12N15/34 , C12N15/86 , C12N15/861 , C12Q1/02 , C12Q1/68 , C12R1/92 , G01N33/15 , G01N33/50
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , A61K2039/5256 , C07K14/005 , C07K14/4712 , C12N7/00 , C12N2710/10322 , C12N2710/10343 , C12N2710/10352 , C12N2800/108 , C12N2810/60 , C12N2810/6081 , C12N2830/002 , C12N2830/85 , C12N2840/20 , C12N2840/203 , C12N2840/44
摘要： The present invention provides multiply replication deficient adenoviral vectors having a spacer in at least one replication deficient adenoviral region, as well as complementing cell lines therefor. Also provided are means of constructing the multiply replication deficient adenoviral vectors and methods of use thereof, e.g., in gene therapy.
摘要翻译：本发明提供在至少一个复制缺陷型腺病毒区域中具有间隔基的多重复制缺陷型腺病毒载体，以及补体细胞系。还提供构建多重复制缺陷型腺病毒载体的方法及其使用方法，例如在基因治疗中。

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