专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

AU778735B2 Fused azepinone cyclin dependent kinase inhibitors 未知
公开(公告)号：AU778735B2
公开(公告)日：2004-12-16
申请号：AU4571499
申请日：1999-06-16
申请人： US GOV HEALTH & HUMAN SERV , KUNICK CONRAD , CENTRE NAT RECH SCIENT
发明人： KUNICK CONRAD , MEIJER LAURENT , ZAHAREVITZ DANIEL W , GUSSIO RICK , JALLURI RAVI K , SAUSVILLE EDWARD A
IPC分类号： A61K31/55 , A61P35/00 , A61P43/00 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D495/14
摘要： A new class of cyclin dependent kinase inhibitors that also have antiproliferative activity in human tumor cell line assays are described. Most of these compounds satisfy the formulawherein A is oxygen or sulfur coupled to the right by a single or double bond; R2 is selected from the group consisting of hydrogen, aryl, lower aliphatic substituents, particularly alkyl and lower alkyl ester; R4-R7 are independently selected from the group consisting of alkoxy, amino, acyl, aliphatic substituents, particularly alkyl, alkenyl and alkinyl substituents, aliphatic alcohols, particularly alkyl alcohols, aliphatic nitriles, particularly alkyl nitriles, cyano, nitro, carboxyl, halogen, hydrogen, hydroxyl, imino, and alpha, beta, unsaturated ketones; R8-R11 are independently selected from the group consisting of aliphatic substituents, particularly alkyl, alkenyl and alkinyl substituents, particularly lower aliphatic substituents, alipahatic alcohols, particularly alkyl alcohols, alkoxy, acyl, cyano, nitro, epoxy, haloalkyl groups, halogen, hydrogen and hydroxyl; R12 is selected from the group consisting of aliphatic groups, particularly lower alkyl groups, aliphatic alcohols, particularly alkyl alcohols, carboxylic acids and hydrogen. Compositions comprising effective amounts of such compounds also are described. These compounds and compositions can be used in a method for inhibiting the proliferation of living cells in a subject comprising administering an effective amount of the compound(s), or composition(s) comprising the compound(s), to a subject to inhibit the proliferation of living cells, such as neoplastic cells.

2. 发明专利

CA2335115C FUSED AZEPINONE CYCLIN DEPENDENT KINASE INHIBITORS 未知
公开(公告)号：CA2335115C
公开(公告)日：2009-01-27
申请号：CA2335115
申请日：1999-06-16
申请人： US GOV HEALTH & HUMAN SERV , KUNICK CONRAD , CENTRE NAT RECH SCIENT
发明人： SAUSVILLE EDWARD A , KUNICK CONRAD , GUSSIO RICK , JALLURI RAVI K , MEIJER LAURENT , ZAHAREVITZ DANIEL W
IPC分类号： C07D487/04 , A61K31/55 , A61P35/00 , A61P43/00 , C07D471/04 , C07D471/14 , C07D487/14 , C07D495/14
摘要： A new class of cyclin dependent kinase inhibitors that also have antiproliferative activity in human tumor cell line assays are described. Most of these compounds satisfy formula (1); wherein A is oxygen or sulfur coupled to the right by a single or double bond; R2 is selected from the group consisting of hydrogen, aryl, lower aliphatic substituents, particularly alkyl and lower alkyl ester, R4-R7 are independently selected from the group consisting of alkoxy, amino, acyl, aliphatic substituents, particularly alkyl, alkenyl and alkinyl substituents, aliphati c alcohols, particularly alkyl alcohols, aliphatic nitriles, particularly alky l nitriles, cyano, nitro, carboxyl, halogen, hydrogen, hydroxyl, imino, and .alpha., .beta. unsaturated ketones; R8-R11 are independently selected from the group consisting of aliphatic substituents, particularly alkyl, alkenyl and alkinyl substituents, particularly lower aliphatic substituents, aliphatic alcohols, particularly alkyl alcohols, alkoxy, acyl, cyano, nitro, epoxy, haloalkyl groups, halogen, hydrogen and hydroxyl; R12 is selected from the group consisting of aliphatic groups, particularly lower alkyl groups, aliphatic alcohols, particularly alkyl alcohols, carboxylic acids and hydrogen. Compositions comprising effective amounts of such compoundsalso are described. These compounds and composition s can be used in a method for inhibiting the proliferation of living cells in a subject comprising administering an effective amount of the compound(s), or composition(s) comprising the compound(s), to a subject to inhibit the proliferation of living cells, such as neoplasti c cells.

3. 发明专利

AU1500901A Fused azepinone cyclin dependent kinase inhibitors 未知
公开(公告)号：AU1500901A
公开(公告)日：2002-07-18
申请号：AU1500901
申请日：2001-01-16
申请人： CENTRE NAT RECH SCIENT , US GOV HEALTH & HUMAN SERV , KUNICK CONRAD
发明人： KUNICK CONRAD , MEIJER LAURENT , ZAHAREVITZ DANIEL W , GUSSIO RICK , JALLURI RAVI K , SAUSVILLE EDWARD A
IPC分类号： C07D487/04 , C07D495/14

4. 发明专利

AU4571499A Fused azepinone cyclin dependent kinase inhibitors 未知
公开(公告)号：AU4571499A
公开(公告)日：2000-01-05
申请号：AU4571499
申请日：1999-06-16
申请人： CENTRE NAT RECH SCIENT , US GOV HEALTH & HUMAN SERV , KUNICK CONRAD
发明人： KUNICK CONRAD , MEIJER LAURENT , ZAHAREVITZ DANIEL W , GUSSIO RICK , JALLURI RAVI K , SAUSVILLE EDWARD A
IPC分类号： A61K31/55 , A61P35/00 , A61P43/00 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D495/14
摘要： A new class of cyclin dependent kinase inhibitors that also have antiproliferative activity in human tumor cell line assays are described. Most of these compounds satisfy the formulawherein A is oxygen or sulfur coupled to the right by a single or double bond; R2 is selected from the group consisting of hydrogen, aryl, lower aliphatic substituents, particularly alkyl and lower alkyl ester; R4-R7 are independently selected from the group consisting of alkoxy, amino, acyl, aliphatic substituents, particularly alkyl, alkenyl and alkinyl substituents, aliphatic alcohols, particularly alkyl alcohols, aliphatic nitriles, particularly alkyl nitriles, cyano, nitro, carboxyl, halogen, hydrogen, hydroxyl, imino, and alpha, beta, unsaturated ketones; R8-R11 are independently selected from the group consisting of aliphatic substituents, particularly alkyl, alkenyl and alkinyl substituents, particularly lower aliphatic substituents, alipahatic alcohols, particularly alkyl alcohols, alkoxy, acyl, cyano, nitro, epoxy, haloalkyl groups, halogen, hydrogen and hydroxyl; R12 is selected from the group consisting of aliphatic groups, particularly lower alkyl groups, aliphatic alcohols, particularly alkyl alcohols, carboxylic acids and hydrogen. Compositions comprising effective amounts of such compounds also are described. These compounds and compositions can be used in a method for inhibiting the proliferation of living cells in a subject comprising administering an effective amount of the compound(s), or composition(s) comprising the compound(s), to a subject to inhibit the proliferation of living cells, such as neoplastic cells.

5. 发明专利

AT318818T 未知
公开(公告)号：AT318818T
公开(公告)日：2006-03-15
申请号：AT99928715
申请日：1999-06-16
申请人： US GOV HEALTH & HUMAN SERV , KUNICK CONRAD , MEIJER LAURENT
发明人： KUNICK CONRAD , MEIJER LAURENT , ZAHAREVITZ DANIEL W , GUSSIO RICK , JALLURI RAVI K , SAUSVILLE EDWARD A
IPC分类号： A61K31/55 , A61P35/00 , A61P43/00 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D495/14
摘要： A new class of cyclin dependent kinase inhibitors that also have antiproliferative activity in human tumor cell line assays are described. Most of these compounds satisfy the formulawherein A is oxygen or sulfur coupled to the right by a single or double bond; R2 is selected from the group consisting of hydrogen, aryl, lower aliphatic substituents, particularly alkyl and lower alkyl ester; R4-R7 are independently selected from the group consisting of alkoxy, amino, acyl, aliphatic substituents, particularly alkyl, alkenyl and alkinyl substituents, aliphatic alcohols, particularly alkyl alcohols, aliphatic nitriles, particularly alkyl nitriles, cyano, nitro, carboxyl, halogen, hydrogen, hydroxyl, imino, and alpha, beta, unsaturated ketones; R8-R11 are independently selected from the group consisting of aliphatic substituents, particularly alkyl, alkenyl and alkinyl substituents, particularly lower aliphatic substituents, alipahatic alcohols, particularly alkyl alcohols, alkoxy, acyl, cyano, nitro, epoxy, haloalkyl groups, halogen, hydrogen and hydroxyl; R12 is selected from the group consisting of aliphatic groups, particularly lower alkyl groups, aliphatic alcohols, particularly alkyl alcohols, carboxylic acids and hydrogen. Compositions comprising effective amounts of such compounds also are described. These compounds and compositions can be used in a method for inhibiting the proliferation of living cells in a subject comprising administering an effective amount of the compound(s), or composition(s) comprising the compound(s), to a subject to inhibit the proliferation of living cells, such as neoplastic cells.

6. 发明专利

CA2335115A1 FUSED AZEPINONE CYCLIN DEPENDENT KINASE INHIBITORS 未知
公开(公告)号：CA2335115A1
公开(公告)日：1999-12-23
申请号：CA2335115
申请日：1999-06-16
申请人： KUNICK CONRAD , US GOV HEALTH & HUMAN SERV , MEIJER LAURENT
发明人： GUSSIO RICK , ZAHAREVITZ DANIEL W , KUNICK CONRAD , SAUSVILLE EDWARD A , JALLURI RAVI K , MEIJER LAURENT
IPC分类号： A61K31/55 , A61P35/00 , A61P43/00 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D495/14 , C07D209/00 , C07D223/00 , C07D333/00
摘要： A new class of cyclin dependent kinase inhibitors that also have antiproliferative activity in human tumor cell line assays are described. Mo st of these compounds satisfy formula (I); wherein A is oxygen or sulfur couple d to the right by a single or double bond; R2 is selected from the group consisting of hydrogen, aryl, lower aliphatic substituents, particularly alk yl and lower alkyl ester; R4-R7 are independently selected from the group consisting of alkoxy, amino, acyl, aliphatic substituents, particularly alky l, alkenyl and alkinyl substituents, aliphatic alcohols, particularly alkyl alcohols, aliphatic nitriles, particularly alkyl nitriles, cyano, nitro, carboxyl, halogen, hydrogen, hydroxyl, imino, and .alpha., .beta. unsaturate d ketones; R8-R11 are independently selected from the group consisting of aliphatic substituents, particularly alkyl, alkenyl and alkinyl substituents , particularly lower aliphatic substituents, aliphatic alcohols, particularly alkyl alcohols, alkoxy, acyl, cyano, nitro, epoxy, haloalkyl groups, halogen , hydrogen and hydroxyl; R12 is selected from the group consisting of aliphati c groups, particularly lower alkyl groups, aliphatic alcohols, particularly alkyl alcohols, carboxylic acids and hydrogen. Compositions comprising effective amounts of such compounds also are described. These compounds and compositions can be used in a method for inhibiting the proliferation of living cells in a subject comprising administering an effective amount of th e compound(s), or composition(s) comprising the compound(s), to a subject to inhibit the proliferation of living cells, such as neoplastic cells.

7. 发明专利

AU780528B2 Fused azepinone cyclin dependent kinase inhibitors 未知
公开(公告)号：AU780528B2
公开(公告)日：2005-03-24
申请号：AU1500901
申请日：2001-01-16
申请人： US HEALTH , KUNICK CONRAD , CENTRE NAT RECH SCIENT
发明人： KUNICK CONRAD , MEIJER LAURENT , ZAHAREVITZ DANIEL W , GUSSIO RICK , JALLURI RAVI K , SAUSVILLE EDWARD A
IPC分类号： C07D487/04 , C07D495/14

8. 发明专利

AU1786602A Geldanamycin derivatives useful for the treatment of cancer 未知
公开(公告)号：AU1786602A
公开(公告)日：2002-05-15
申请号：AU1786602
申请日：2001-11-06
申请人： US GOV HEALTH & HUMAN SERV
发明人： SNADER KENNETH M , NECKERS LEONARD M , VISHNUVAJJALA B ROA , SAUSVILLE EDWARD A , XU WANPING , ROSSER MEREDITH F , NICCHITTA CHRISTOPHER , ISAACS JENNIFER A
IPC分类号： A61P35/00 , C07D225/06 , A61K31/395

9. 发明专利

AU1711499A Ureido derivatives of poly-4-amino-2-carboxy-1-methyl pyrrole compounds for inhibition of inflammation 未知
公开(公告)号：AU1711499A
公开(公告)日：1999-06-16
申请号：AU1711499
申请日：1998-12-04
申请人： US GOV HEALTH & HUMAN SERV
发明人： HOWARD O M ZACK , OPPENHEIM JOOST J , MURPHY WILLIAM J , SAUSVILLE EDWARD A
IPC分类号： A61K31/00 , A61K31/40 , A61K31/4025 , A61K31/675 , A61K31/415
摘要： A method of using a ureido derivative of a poly-4-amino-2-carboxy-1-methyl pyrrole or a pharmaceutically acceptable salt thereof to inhibit inflammation, particularly non-TNF-alpha dependent inflammation, in a mammal.

10. 发明申请

WO9965910A9 FUSED AZEPINONE CYCLIN DEPENDENT KINASE INHIBITORS 审中-公开
标题翻译：融合AZEPINONE CYCLIN依赖性激酶抑制剂
公开(公告)号：WO9965910A9
公开(公告)日：2000-03-16
申请号：PCT/US9913579
申请日：1999-06-16
申请人： US HEALTH , KUNICK CONRAD , MEIJER LAURENT , ZAHAREVITZ DANIEL W , GUSSIO RICK , JALLURI RAVI K , SAUSVILLE EDWARD A
发明人： KUNICK CONRAD , MEIJER LAURENT , ZAHAREVITZ DANIEL W , GUSSIO RICK , JALLURI RAVI K , SAUSVILLE EDWARD A
IPC分类号： A61K31/55 , A61P35/00 , A61P43/00 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D495/14
CPC分类号： C07D487/04 , C07D495/14
摘要： A new class of cyclin dependent kinase inhibitors that also have antiproliferative activity in human tumor cell line assays are described. Most of these compounds satisfy formula (I); wherein A is oxygen or sulfur coupled to the right by a single or double bond; R>2 4 7 8 11 12
摘要翻译：描述了一类在人肿瘤细胞系测定中也具有抗增殖活性的细胞周期蛋白依赖性激酶抑制剂。这些化合物中的大多数满足式（I）; 其中A是通过单键或双键偶联到右侧的氧或硫; R 2选自氢，芳基，低级脂族取代基，特别是烷基和低级烷基酯; R 4 <-R 7独立地选自烷氧基，氨基，酰基，脂族取代基，特别是烷基，烯基和炔基取代基，脂族醇，特别是烷基醇，脂族腈，特别是烷基腈，氰基，硝基，羧基，卤素，氢，羟基，亚氨基和α，β不饱和酮; 特别是低级脂族取代基，脂族醇，特别是烷基醇，烷氧基，酰基，氰基，硝基，环氧基，环烷基，环烷基，卤代烷基，卤素，氢和羟基; R 12选自脂族基团，特别是低级烷基，脂族醇，特别是烷基醇，羧酸和氢。还描述了包含有效量的这种化合物的组合物。这些化合物和组合物可用于抑制受试者中活细胞增殖的方法，包括向受试者施用有效量的化合物或包含该化合物的组合物以抑制受试者的抑制活细胞增殖，如肿瘤细胞。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式