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1. 发明专利

JPS5530784B2 失效
公开(公告)号：JPS5530784B2
公开(公告)日：1980-08-13
申请号：JP1554276
申请日：1976-02-17
申请人： UPJOHN CO
发明人： KELLY R C
IPC分类号： C07C43/162 , C07B31/00 , C07B57/00 , C07C41/00 , C07C45/00 , C07C47/44 , C07C47/445 , C07C49/517 , C07C67/00 , C07C401/00 , C07C405/00 , C07D263/04 , C07D307/93 , C07D307/935 , C07D317/12 , C07D317/26 , C07D319/06 , C07D413/04

2. 发明授权

USB315363I5 失效
公开(公告)号：USB315363I5
公开(公告)日：1975-01-28
申请号：US31536372
申请日：1972-12-15
申请人： UPJOHN CO
发明人： KELLY R C
IPC分类号： C07C405/00 , C07D263/04 , C07D307/93 , C07D307/935 , C07D317/12 , C07D317/14 , C07D317/26 , C07D319/06 , C07D319/16
CPC分类号： C07D263/04 , C07C405/00 , C07D307/93 , C07D307/935 , C07D317/12 , C07D317/14 , C07D317/26 , C07D319/06 , C07D319/16

3. 发明专利

DE2166797C2 未知
公开(公告)号：DE2166797C2
公开(公告)日：1985-08-29
申请号：DE2166797
申请日：1971-11-25
申请人： UPJOHN CO
发明人： KELLY R C
IPC分类号： C07C43/162 , C07B31/00 , C07B57/00 , C07C41/00 , C07C45/00 , C07C47/44 , C07C47/445 , C07C49/517 , C07C67/00 , C07C401/00 , C07C405/00 , C07D263/04 , C07D307/93 , C07D307/935 , C07D317/12 , C07D317/26 , C07D319/06 , C07D413/04

4. 发明专利

SE8304218L 未知
公开(公告)号：SE8304218L
公开(公告)日：1983-08-01
申请号：SE8304218
申请日：1983-08-01
申请人： UPJOHN CO
发明人： AXEN U F , JOHNSON R A , KELLY R C , LINCOLN F H , PIKE J E
IPC分类号： A61K31/16 , A61K31/19 , A61P43/00 , C07C67/00 , C07C231/00 , C07C233/09 , C07C235/06 , C07C235/16 , C07C235/74 , C07C235/76 , C07C235/78 , C07C401/00 , C07C405/00 , C07D307/935 , C07D307/937 , C07D311/94 , C07D313/06

6. 发明专利

AU508355B2 PROSTAGLANDIN DERIVATIVES 未知
公开(公告)号：AU508355B2
公开(公告)日：1980-03-20
申请号：AU2812377
申请日：1977-08-23
申请人： UPJOHN CO
发明人： KELLY R C
IPC分类号： C07C405/00 , C07D311/94 , C07D407/12 , C07D407/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D307/20 , C07F3/10 , C07F3/12 , C07F3/14 , C07F7/18 , C07C49/28 , C07C49/61 , C07C35/06 , C07C33/05 , C07C33/10 , C07C43/18 , C07C43/22 , C07C43/27
摘要： Processes for preparing prostacyclin analogs which are 9-deoxy-6,9-epoxymethano derivatives of prostaglandin F1 alpha -type compounds, illustrated, for example, by a compound of the formula wherein DIFFERENCE indicates alpha or beta configuration; including the products and intermediates produced therein, said products having pharmacological utility.

7. 发明专利

SE7808040L 未知
公开(公告)号：SE7808040L
公开(公告)日：1979-01-29
申请号：SE7808040
申请日：1978-07-21
申请人： UPJOHN CO
发明人： AXEN U F , JOHNSON R A , KELLY R C , LINCOLN F H , PIKE J E
IPC分类号： A61K31/16 , A61K31/19 , A61P43/00 , C07C67/00 , C07C231/00 , C07C233/09 , C07C235/06 , C07C235/16 , C07C235/74 , C07C235/76 , C07C235/78 , C07C401/00 , C07C405/00 , C07D307/935 , C07D307/937 , C07D311/94 , C07D313/06 , C07C177/00

8. 发明专利

SE7709623A 未知
公开(公告)号：SE7709623A
公开(公告)日：1978-10-20
申请号：SE7709623
申请日：1977-08-26
申请人： UPJOHN CO
发明人： KELLY R C
IPC分类号： C07C405/00 , C07D311/94
CPC分类号： C07C405/0041 , C07D311/94

9. 发明专利

NL7801046A Prostaglandins e3 and f3 alpha prepn - from a tricyclic lactone 未知
公开(公告)号：NL7801046A
公开(公告)日：1978-05-31
申请号：NL7801046
申请日：1978-01-30
申请人： UPJOHN CO
发明人： KELLY R C
IPC分类号： C07C405/00 , C07D263/04 , C07D307/93 , C07D307/935 , C07D317/26 , C07B19/00
摘要： Title cpds. are prepd. from cpds. (i):- by (a) blocking free OH by alkyl SO2-; (b) hydrolysing with water; (c) sepg. (S) and (R) forms; (d) forming the bis THP-ethers, (e) reducing lactone-OXO to -OH. (f) Witting alkylation with Hal(CH2)4COOH; (g) oxidn. of 9-OH to 9-OXO (h) liberation of etherified OH, provided that -C triple bond C- may be reduced to -CH=CH(cis) before or after any stage (a)-(h).

10. 发明专利

FR2115445B1 未知
公开(公告)号：FR2115445B1
公开(公告)日：1978-02-10
申请号：FR7142514
申请日：1971-11-26
申请人： UPJOHN CO
发明人： KELLY R C
IPC分类号： C07C405/00 , C07D263/04 , C07D307/93 , C07D307/935 , C07D317/12 , C07D317/14 , C07D317/26 , C07D319/06 , C07D319/16 , A61K27/00 , C07C61/00
摘要： 1369254 Bicyclohexane and tricyclooctane derivatives UPJOHN CO 1 Nov 1971 [27 Nov 1970] 58575/73 Divided out of 1369251 Heading C2C The invention comprises optically active compounds of the formulae or the mirror images thereof, or racemic compounds thereof, wherein R 1 and R 2 are C 1-4 alkyl or together form wherein R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are H, C 1-4 alkyl or phenyl; with the proviso that not more than one of the Rs is phenyl and the total number of carbon atoms is from 2 to 10, x is 0 or 1, # indicates the attachment of the radical to the cyclopropane ring in exo or endo configuration, and R 12 and R 13 each are H, Br or Cl, optically active bicyclo[3,1,0]hex-2-ene-6-carboxaldehyde and an oxazolidine thereof with an optically active ephedrine, and an oxazolidine of an optically active compound of the formula or of the mirror image thereof with an optically active ephedrine. The bicyclo[3,1,0]hex-2-ene- 6-carboxaldehyde acetals of the above formula are obtained by reacting the aldehyde with the appropriate alcohols or glycols, and the resulting acetals may be then reacted with ketenes of the formula R 10 R 11 C=C=O to give tricyclooctanones of the above formula in which R 12 is Br or Cl and R 13 is H, Br or Cl, which may be converted to tricyclooctanones of the same formula in which R 12 and R 13 are H by treatment with zinc dust, and a racemic mixture so obtained may be resolved by reacting with an optically ephedrine, separating the resulting oxazolidines and hydrolysing the separated oxazolidine. Optically active bicyclo[3,1,0]hex-2-ene-6-carboxaldehyde is prepared in a similar manner. dl - Endo - bicyclo[3,1,0]hex - 2 - ene - 6 - carboxaldehyde is reacting bicyclo[2,2,1]hepta-2,5- diene with peracetic acid.

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