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1. 发明申请

WO2009043320A3 SUBSTITUTED 6-(ALKYLBENZYLAMINO)PURINE DERIVATIVES FOR USE AS CYTOKININ RECEPTOR ANTAGONISTS AND PREPARATIONS CONTAINING THESE DERIVATIVES 审中-公开
标题翻译：用作细胞因子受体拮抗剂的6-（亚苄基兰氨基）嘌呤衍生物和含有这些衍生物的制剂
公开(公告)号：WO2009043320A3
公开(公告)日：2009-05-28
申请号：PCT/CZ2008000118
申请日：2008-10-03
申请人： UNIVERZITA PALACKEHO V OLOMOUC , UNIV BERLIN FREIE , SPICHAL LUKAS , POPA IGOR , VOLLER JIRI , DOLEZAL KAREL , STRNAD MIROSLAV , WERNER TOMAS , SCHMULLING THOMAS
发明人： SPICHAL LUKAS , POPA IGOR , VOLLER JIRI , DOLEZAL KAREL , STRNAD MIROSLAV , WERNER TOMAS , SCHMULLING THOMAS
IPC分类号： C07D473/34 , A01N43/00 , A61K31/52
CPC分类号： A01N43/90 , C07D473/34
摘要： The invention relates to 6-(alkylbenzylamino)purine derivatives of the general formula I for use as cytokinin receptor antagonists, wherein R1 is selected from the group comprising hydroxyl, amino, nitro, thio and alkyl group, and R2 denotes one to four alkyl groups. The invention also relates to preparations containing these derivatives.
摘要翻译：本发明涉及用作细胞分裂素受体拮抗剂的通式I的6-（烷基苄基氨基）嘌呤衍生物，其中R1选自羟基，氨基，硝基，硫代和烷基，R2表示一至四个烷基。本发明还涉及含有这些衍生物的制剂。

2. 发明申请

WO2009003428A3 SUBSTITUTED 6-ANILINOPURINE DERIVATIVES AS INHIBITORS OF CYTOKININ OXIDASE/DEHYDROGENASE AND PREPARATIONS CONTAINING THESE DERIVATIVES 审中-公开
标题翻译：用作细胞因子氧化酶/脱氢酶抑制剂的取代6-苯氨基嘌呤衍生物及含有这些衍生物的制剂
公开(公告)号：WO2009003428A3
公开(公告)日：2009-09-03
申请号：PCT/CZ2008000074
申请日：2008-07-02
申请人： UNIVERZITA PALACKEHO V OLOMOUC , UNIV BERLIN FREIE , SPICHAL LUKAS , GEMROTOVA MARKETA , ZATLOUKAL MAREK , FREBORTOVA JITKA , GALUSZKA PETR , WERNER TOMAS , SCHMULLING THOMAS , DOLEZAL KAREL , STRNAD MIROSLAV
发明人： SPICHAL LUKAS , GEMROTOVA MARKETA , ZATLOUKAL MAREK , FREBORTOVA JITKA , GALUSZKA PETR , WERNER TOMAS , SCHMULLING THOMAS , DOLEZAL KAREL , STRNAD MIROSLAV
IPC分类号： A01N43/713 , A61K31/52 , A61P35/00 , C07D473/16 , C07D473/34
CPC分类号： C07D473/16 , A01N43/90 , C07D473/34
摘要： The invention relates to substituted 6-anilinopurine derivatives of the general formula I, wherein R denotes one to five substituents independently selected from the group consisting of hydrogen, halogen, hydroxyl, amino, alkyloxy and alkyl group, and R2 denotes amino, halogen, nitro, thio, alkylthio or alkyl group for use as inhibitors of cytokinin oxidase/dehydrogenase. The invention also relates to the compositions containing these derivatives.
摘要翻译：本发明涉及通式I的取代的6-氨基嘌呤衍生物，其中R代表1至5个独立地选自氢，卤素，羟基，氨基，烷氧基和烷基的取代基，并且R 2表示氨基，卤素，硝基，硫代，烷硫基或烷基，用作细胞分裂素氧化酶/脱氢酶的抑制剂。本发明还涉及含有这些衍生物的组合物。

3. 发明专利

AU2008271800A1 Substituted 6-anilinopurine derivatives as inhibitors of cytokinin oxidase/dehydrogenase and preparations containing these derivatives 未知
公开(公告)号：AU2008271800A1
公开(公告)日：2009-01-08
申请号：AU2008271800
申请日：2008-07-02
申请人： UNIVERZITA PALACKEHO V OLOMOUC , UNIV BERLIN FREIE
发明人： GEMROTOVA MARKETA , STRNAD MIROSLAV , DOLEZAL KAREL , WERNER TOMAS , SPICHAL LUKAS , SCHMULLING THOMAS , ZATLOUKAL MAREK , FREBORTOVA JITKA , GALUSZKA PETR
IPC分类号： A01N43/713 , A61K31/52 , A61P35/00 , C07D473/16 , C07D473/34
摘要： The invention relates to substituted 6-anilinopurine derivatives of the general formula I, wherein R denotes one to five substituents independently selected from the group consisting of hydrogen, halogen, hydroxyl, amino, alkyloxy and alkyl group, and R2 denotes amino, halogen, nitro, thio, alkylthio or alkyl group for use as inhibitors of cytokinin oxidase/dehydrogenase. The invention also relates to the compositions containing these derivatives.

4. 发明专利

CA2691625A1 SUBSTITUTED 6-ANILINOPURINE DERIVATIVES AS INHIBITORS OF CYTOKININ OXIDASE/DEHYDROGENASE AND PREPARATIONS CONTAINING THESE DERIVATIVES 未知
公开(公告)号：CA2691625A1
公开(公告)日：2009-01-08
申请号：CA2691625
申请日：2008-07-02
申请人： UNIVERZITA PALACKEHO V OLOMOUC
发明人： SPICHAL LUKAS , GEMROTOVA MARKETA , ZATLOUKAL MAREK , STRNAD MIROSLAV , GALUSZKA PETR , DOLEZAL KAREL , FREBORTOVA JITKA , SCHMULLING THOMAS , WERNER TOMAS
IPC分类号： A01N43/713 , A61K31/52 , A61P35/00 , C07D473/16 , C07D473/34
摘要： The invention relates to substituted 6-anilinopurine derivatives of the g eneral formula I, wherein R denotes one to five substituents independently s elected from the group consisting of hydrogen, halogen, hydroxyl, amino, alk yloxy and alkyl group, and R2 denotes amino, halogen, nitro, thio, alkylthio or alkyl group for use as inhibitors of cytokinin oxidase/dehydrogenase. Th e invention also relates to the compositions containing these derivatives.

5. 发明专利

ES2392190T3 Método para modificar la morfología, bioquímica y fisiología de plantas que comprende la expresión de citoquinina oxidasa de plantas 未知
公开(公告)号：ES2392190T3
公开(公告)日：2012-12-05
申请号：ES07113288
申请日：2002-12-10
申请人： SCHMULLING THOMAS , WERNER TOMAS
发明人： SCHMULLING THOMAS , WERNER TOMAS
IPC分类号： A01H1/00 , C12N9/06 , A01H5/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N15/09 , C12N15/29 , C12N15/53 , C12N15/82 , C12Q1/26 , G01N33/15 , G01N33/50 , G01N33/566
摘要： Un método para incrementar el tamaño o peso de las semillas que comprende incrementar el nivel o actividad deuna citoquinina oxidasa en las semillas en una planta.

6. 发明专利

AU2002361037A1 METHOD FOR MODIFYING PLANT MORPHOLOGY, BIOCHEMISTRY AND PHYSIOLOGY 未知
公开(公告)号：AU2002361037A1
公开(公告)日：2003-06-23
申请号：AU2002361037
申请日：2002-12-10
申请人： WERNER TOMAS , SCHMULLING THOMAS
发明人： WERNER TOMAS , SCHMULLING THOMAS
IPC分类号： A01H1/00 , A01H5/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N9/06 , C12N15/09 , C12N15/29 , C12N15/53 , C12N15/82 , C12Q1/26 , G01N33/15 , G01N33/50 , G01N33/566 , A01H5/04 , A01H5/06 , A01H5/10

7. 发明申请

WO2005123926B1 METHOD FOR MODIFYING PLANT MORPHOLOGY, BIOCHEMISTRY AND PHYSIOLOGY COMPRISING EXPRESSION OF CYTOKININ OXYDASE IN THE SEEDS 审中-公开
标题翻译：用于修饰植物形态学，生物化学和生理学的方法，其包括在种子中的细胞因子氧化酶的表达
公开(公告)号：WO2005123926B1
公开(公告)日：2006-02-16
申请号：PCT/EP2005006620
申请日：2005-06-20
申请人： SCHMULLING THOMAS , WERNER TOMAS
发明人： SCHMULLING THOMAS , WERNER TOMAS
IPC分类号： A01H5/10 , C12N9/06 , C12N15/29 , C12N15/82 , A01H5/00 , C12N15/53 , C12N15/63
CPC分类号： C12N9/0032 , C12N15/8261 , C12N15/8271 , C12N15/8287 , C12N15/8295 , Y02A40/146
摘要： The present invention relates to methods and compositions for increasing seed yield of a plant. The methods comprise expression of a cytokinin oxidase in the aleurone and/or embryo of a seed. The invention also relates to vectors comprising a nucleic acid encoding a cytokinin oxidase that is operably linked to a promoter capable of driving expression in the aleurone and/or embryo of a seed, and to host cells, transgenic cells and plants comprising such sequences. The use of these sequences for increasing yield is also provided.
摘要翻译：本发明涉及用于提高植物种子产量的方法和组合物。所述方法包括在种子的糊粉和/或胚胎中表达细胞分裂素氧化酶。本发明还涉及包含编码细胞分裂素氧化酶的核酸的载体，其与可驱动种子的糊粉和/或胚胎中的表达的启动子有效连接，以及宿主细胞，转基因细胞和包含该序列的植物。还提供了这些序列用于增加产量的用途。

8. 发明申请

WO03050287A2 METHOD FOR MODIFYING PLANT MORPHOLOGY, BIOCHEMISTRY AND PHYSIOLOGY 审中-公开
标题翻译：用于修饰植物形态学，生物化学和生理学的方法
公开(公告)号：WO03050287A2
公开(公告)日：2003-06-19
申请号：PCT/EP0213990
申请日：2002-12-10
申请人： SCHMULLING THOMAS , WERNER TOMAS
发明人： SCHMULLING THOMAS , WERNER TOMAS
IPC分类号： A01H1/00 , A01H5/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N9/06 , C12N15/09 , C12N15/29 , C12N15/53 , C12N15/82 , C12Q1/26 , G01N33/15 , G01N33/50 , G01N33/566 , A01H5/04 , A01H5/06 , A01H5/10
CPC分类号： C12N9/0032 , C12N15/8295
摘要： The present invention relates to methods for stimulating root growth and/or enhancing the formation of lateral or adventitious roots and/or altering root geotropism comprising expression of a plant cytokinin oxidase or comprising expression of another protein that reduces the level of active cytokinins in plants or plant parts.Also provided by the present invention are methods for increasing seed size and/or weight, embryo size and/or weight, and cotyledon size and/or weight. The methods comprise expression of a plant cytokinin oxidase or expression of another protein that reduces the level of active cytokinins in plants or plant parts.The invention also relates to novel plant cytokinin oxidase proteins, nucleic acid sequences encoding cytokinin oxidase proteins as well as to vectors, host cells, transgenic cells and plants comprising said sequences. The invention also relates to the use of said sequences for improving root-related characteristics including increasing yield and/or enhancing early vigor and/or modifying root/shoot ratio and/or improving resistance to lodging and/or increasing drought tolerance and/or promoting in vitro propagation of explants and/or modifying cell fate and/or plant development and/or plant morphology and/or plant biochemistry and/or plant physiology. The invention also relates to the use of said sequences in the above-mentioned methods.The invention also relates to methods for identifying and obtaining proteins and compounds interacting with cytokinin oxidase proteins. The invention also relates to the use of said compounds as a plant growth regulator or herbicide.
摘要翻译：本发明涉及用于刺激根生长和/或增强侧根或不定根的形成和/或改变根地貌的方法，包括植物细胞分裂素氧化酶的表达或包括降低植物中活性细胞分裂素水平的另一种蛋白质的表达或植物部分。本发明还提供了增加种子大小和/或重量，胚胎大小和/或重量以及子叶大小和/或重量的方法。所述方法包括植物细胞分裂素氧化酶的表达或另一种降低植物或植物部分活性细胞分裂素水平的蛋白质的表达。本发明还涉及新型植物细胞分裂素氧化酶蛋白，编码细胞分裂素氧化酶蛋白的核酸序列以及载体，宿主细胞，转基因细胞和包含所述序列的植物。本发明还涉及所述序列用于改善根相关特征的用途，包括增加产量和/或增强早期活力和/或改善根/芽比率和/或改善抗倒伏和/或增加耐旱性和/或促进作用外植体的体外繁殖和/或修饰细胞命运和/或植物发育和/或植物形态和/或植物生物化学和/或植物生理学。本发明还涉及上述方法中所述序列的用途。本发明还涉及用于鉴定和获得与细胞分裂素氧化酶蛋白相互作用的蛋白质和化合物的方法。本发明还涉及所述化合物作为植物生长调节剂或除草剂的用途。

9. 发明申请

WO0196580A3 METHOD FOR MODIFYING PLANT MORPHOLOGY, BIOCHEMISTRY AND PHYSIOLOGY USING CYTOKININ OXIDASES 审中-公开
标题翻译：使用细胞因子氧化修饰植物形态学，生物化学和生理学的方法
公开(公告)号：WO0196580A3
公开(公告)日：2002-07-11
申请号：PCT/EP0106833
申请日：2001-06-18
申请人： SCHMULLING THOMAS , WERNER TOMAS
发明人： SCHMULLING THOMAS , WERNER TOMAS
IPC分类号： A01H5/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N9/06 , C12N15/09 , C12N15/53 , C12N15/82 , C12Q1/26 , C12Q1/68
CPC分类号： C12N15/8261 , C12N9/0032 , C12N15/8271 , C12N15/8287 , C12N15/8295 , Y02A40/146
摘要： The present invention relates to methods for stimulating root growth and/or enhancing the formation of lateral or adventitious roots and/or altering root geotropism comprising expression of a plant cytokinin oxidase or comprising expression of another protein that reduces the level of active cytokinins in plants or plant parts. The invention also relates to novel plant cytokinin oxidase proteins, nucleic acid sequences encoding cytokinin oxidase proteins as well as to vectors, host cells, transgenic cells and plants comprising said sequences. The invention also relates to the use of said sequences for improving root-related characteristics including increasing yield and/or enhancing early vigor and/or modifying root/shoot ratio and/or improving resistance to lodging and/or increasing drought tolerance and/or promoting in vitro propagation of explants and/or modifying cell fate and/or plant development and/or plant morphology and/or plant biochemistry and/or plant physiology. The invention also relates to the use of said sequences in the above-mentioned methods.The invention also relates to methods for identifying and obtaining proteins and compounds interacting with cytokinin oxidase proteins. The invention also relates to the use of said compounds as a plant growth regulator or herbicide.
摘要翻译：本发明涉及用于刺激根生长和/或增强侧根或不定根的形成和/或改变根地貌的方法，包括植物细胞分裂素氧化酶的表达或包括降低植物中活性细胞分裂素水平的另一种蛋白质的表达或植物部位。本发明还涉及新型植物细胞分裂素氧化酶蛋白，编码细胞分裂素氧化酶蛋白的核酸序列以及包含所述序列的载体，宿主细胞，转基因细胞和植物。本发明还涉及所述序列用于改善根相关特征的用途，包括增加产量和/或增强早期活力和/或改善根/芽比率和/或改善抗倒伏和/或增加耐旱性和/或促进作用外植体的体外繁殖和/或修饰细胞命运和/或植物发育和/或植物形态和/或植物生物化学和/或植物生理学。本发明还涉及上述方法中所述序列的用途。本发明还涉及用于鉴定和获得与细胞分裂素氧化酶蛋白相互作用的蛋白质和化合物的方法。本发明还涉及所述化合物作为植物生长调节剂或除草剂的用途。

10. 发明专利

ES2469590T3 Procedimiento de modificación de la morfología, la fisiología y la bioquímica de plantas que comprende la expresión de citoquinina oxidasa en las semillas 未知
公开(公告)号：ES2469590T3
公开(公告)日：2014-06-18
申请号：ES05756097
申请日：2005-06-20
申请人： SCHMULLING THOMAS , WERNER TOMAS
发明人： SCHMULLING THOMAS , WERNER TOMAS
IPC分类号： C12N15/82 , A01H5/00 , A01H5/10 , C12N9/06 , C12N15/29 , C12N15/53 , C12N15/63
摘要： Un procedimiento para aumentar el número de semillas llenas de una planta, consistiendo dicho procedimiento en (i) introducir en una célula vegetal una molécula de ácido nucleico aislada que codifica una citoquinina oxidasa unida operablemente a un promotor que dirige específicamente la expresión en el embrión y/o la aleurona de una semilla, y (ii) aumentar el nivel y/o la actividad de dicha citoquinina oxidasa en el embrión y/o la aleurona de la semilla de una planta, en el que dicha molécula de ácido nucleico aislada que codifica una citoquinina oxidasa es un ácido nucleico que codifica la proteína representada por SEQ ID NO:36, o es una molécula de ácido nucleico que codifica CKX2 que se hibrida específicamente en 0,1 a 1x SSC y SDS al 0,1% en p/v a 60 ºC con dicho ácido nucleico que codifica la proteína de SEQ ID NO:36, y en el que dicho promotor comprende los nucleótidos 1-1256 de SEQ ID NO:41.

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