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1. 发明申请

WO2008074017A3 POLYMER CHARGE TRANSPORT MATERIAL FOR OPTOELECTRONIC DEVICES 审中-公开
公开(公告)号：WO2008074017A3
公开(公告)日：2008-06-19
申请号：PCT/US2007/087474
申请日：2007-12-13
申请人： UNIVERSITY OF WASHINGTON , JEN, Kwan-Yue , HUANG, Fei , NIU, Yuhua , ZHANG, Yong
发明人： JEN, Kwan-Yue , HUANG, Fei , NIU, Yuhua , ZHANG, Yong
IPC分类号： G03G15/02
摘要： Polymers that enable the use of high work-function metals as a cathode in optoelectronic devices and optoelectronic devices incorporating the polymers as an electron transport layer.

2. 发明申请

WO2010088419A3 CROSS-CONJUGATED POLYMERS FOR ORGANIC ELECTRONIC DEVICES AND RELATED METHODS 审中-公开
公开(公告)号：WO2010088419A3
公开(公告)日：2010-08-05
申请号：PCT/US2010/022444
申请日：2010-01-28
申请人： UNIVERSITY OF WASHINGTON , JEN, Kwan-Yue , HUANG, Fei , YIP, Hin-Lap
发明人： JEN, Kwan-Yue , HUANG, Fei , YIP, Hin-Lap
IPC分类号： C08G61/00 , C08G73/02 , H01L31/04 , H01L29/02
摘要： Cross-conjugated donor-acceptor polymers, methods for their preparation, devices that include polymers, and methods for the preparation and use of the devices.

3. 发明申请

WO2023004565A1 MACHINE LEARNING MODEL CONFIGURATION FOR REDUCED CAPABILITY USER EQUIPMENT 审中-公开
公开(公告)号：WO2023004565A1
公开(公告)日：2023-02-02
申请号：PCT/CN2021/108576
申请日：2021-07-27
申请人： QUALCOMM INCORPORATED , XU, Huilin , NAMGOONG, June , REN, Yuwei , HUANG, Fei , ZHANG, Duo
发明人： XU, Huilin , NAMGOONG, June , REN, Yuwei , HUANG, Fei , ZHANG, Duo
IPC分类号： H04W8/22 , H04L41/16
摘要： Certain aspects of the present disclosure provide techniques for configuring machine learning models on user equipment, including reduced capability user equipment.

4. 发明申请

WO2011053779A2 METHODS FOR TREATING CANCER IN PATIENTS HAVING IGF-1R INHIBITOR RESISTANCE 审中-公开
标题翻译：治疗患有IGF-1R抑制剂抗性的患者的癌症的方法
公开(公告)号：WO2011053779A2
公开(公告)日：2011-05-05
申请号：PCT/US2010/054704
申请日：2010-10-29
申请人： BRISTOL-MYERS SQUIBB COMPANY , HUANG, Fei , CARBONI, Joan M.
发明人： HUANG, Fei , CARBONI, Joan M.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： A method for treating cancer comprising identifying a mammal that overexpresses breast cancer resistance protein; and administering to said mammal a pharmaceutical composition comprising a therapeutically effective amount of ixabepilone. In one aspect, the mammal is not administered an agent that is susceptible to breast cancer resistance protein overexpression resistance. In another aspect, the cancer is a solid tumor.
摘要翻译：治疗癌症的方法，包括鉴定过表达乳腺癌抗性蛋白质的哺乳动物; 并向所述哺乳动物施用包含治疗有效量的伊沙贝比隆的药物组合物。在一个方面，哺乳动物未被施用易受乳腺癌抗性蛋白质过表达抗性的药剂。另一方面，癌症是一种实体瘤。

5. 发明申请

WO2008144345A2 BIOMARKERS AND METHODS FOR DETERMINING SENSITIVITY TO INSULIN GROWTH FACTOR-1 RECEPTOR MODULATORS 审中-公开
标题翻译：生物标记物和确定胰岛素生长因子-1受体调节剂敏感性的方法
公开(公告)号：WO2008144345A2
公开(公告)日：2008-11-27
申请号：PCT/US2008/063621
申请日：2008-05-15
申请人： BRISTOL-MYERS SQUIBB COMPANY , HUANG, Fei , HAN, Xia , HAFEZI, Rameh , CHEN, Jiwen , ROBINSON, Douglas, Michael , WITTENBERG, Gayle, M. , DONGRE, Ashok, Ramesh , CARBONI, Joan, M. , ATTAR, Ricardo, M. , HURLBURT, Warren , GOTTARDIS, Marco, M.
发明人： HUANG, Fei , HAN, Xia , HAFEZI, Rameh , CHEN, Jiwen , ROBINSON, Douglas, Michael , WITTENBERG, Gayle, M. , DONGRE, Ashok, Ramesh , CARBONI, Joan, M. , ATTAR, Ricardo, M. , HURLBURT, Warren , GOTTARDIS, Marco, M.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： IGF1R biomarkers useful in a method for identifying and monitoring a mammal that will respond therapeutically to a method of treating cancer comprising administering an IGF1R modulator, wherein the method comprises (a) exposing the mammal to the IGF1R modulator and (b) measuring in the mammal the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in (b) compared to the level of the biomarker in a mammal that has not been exposed to the IGF1R modulator indicates that the mammal will respond therapeutically to the method of treating cancer and (c) wherein the level of the biomarker in a mammal after exposure to a IGF1R modulator indicates that the mammal has responded therapeutically to the method of treating cancer.
摘要翻译： IGF1R生物标志物可用于鉴定和监测将对治疗癌症治疗的治疗反应的哺乳动物的方法，其包括施用IGF1R调节剂，其中所述方法包括（a）将哺乳动物暴露于IGF1R调节剂和（b）在哺乳动物中测量所述至少一种生物标志物的水平，其中在（b）中测量的至少一种生物标志物的水平的差异与尚未暴露于IGF1R调节剂的哺乳动物中的生物标志物的水平相比表明哺乳动物将对治疗癌症的方法进行反应和（c）其中暴露于IGF1R调节剂后哺乳动物中的生物标志物的水平指示哺乳动物对治疗癌症的方法有治疗反应。

6. 发明申请

WO2008100522A1 DOCUMENT MATCHING ENGINE USING ASYMMETRIC SIGNATURE GENERATION 审中-公开
标题翻译：使用不对称签名生成的文件匹配引擎
公开(公告)号：WO2008100522A1
公开(公告)日：2008-08-21
申请号：PCT/US2008/001868
申请日：2008-02-12
申请人： PROVILLA, INC. , REN, Liwei , HUANG, Shu , HUANG, Fei , LIN, Yingqiang
发明人： REN, Liwei , HUANG, Shu , HUANG, Fei , LIN, Yingqiang
IPC分类号： G06F7/00
CPC分类号： G06F17/30943 , G06F17/30722 , G06F17/30864 , G06Q50/22
摘要： An automated method of matching an input document to a set of documents from a document repository. A signature database (224) is stored, the signature database (224) including a document identifier and signatures generated by a first signature generator (215-A) for each of the set of documents. The input document is received and signatures are generated for the input document using a second signature generator (215-B), and the signature database is searched using the signatures generated for the input document. The first (215-A) and second (215-B) signature generators are configured such that different numbers of signatures are generated for a same document. Other embodiments, aspects and features are also disclosed.
摘要翻译：将输入文档与文档库中的一组文档进行匹配的自动化方法。存储签名数据库（224），所述签名数据库（224）包括文档标识符和由所述一组文档中的每一个由第一签名生成器（215-A）生成的签名。接收输入文档，并使用第二签名生成器（215-B）为输入文档生成签名，并且使用为输入文档生成的签名来搜索签名数据库。第一（215-A）和第二（215-B）签名生成器被配置为使得为同一文档生成不同数量的签名。还公开了其它实施例，方面和特征。

7. 发明申请

WO2006005035A2 IDENTIFICATION OF POLYNUCLEOTIDES FOR PREDICTING ACTIVITY OF COMPOUNDS THAT INTERACT WITH AND/OR MODULATE PROTEIN TYROSINE KINASES AND/OR PROTEIN TYROSINE PATHWAYS IN LUNG CANCER CELLS 审中-公开
标题翻译：识别用于预测与肺癌细胞相互作用和/或调节蛋白酪氨酸激酶和/或蛋白质酪氨酸途径的化合物的活性的多核苷酸的鉴定
公开(公告)号：WO2006005035A2
公开(公告)日：2006-01-12
申请号：PCT/US2005/023687
申请日：2005-06-29
申请人： BRISTOL-MYERS SQUIBB COMPANY , HUANG, Fei , REEVES, Karen A. , HAN, Xia , FAIRCHILD, Craig R. , SHAW, Peter
发明人： HUANG, Fei , REEVES, Karen A. , HAN, Xia , FAIRCHILD, Craig R. , SHAW, Peter
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158
摘要： The present invention describes polynucleotides that have been discovered to correlate to the relative intrinsic sensitivity or resistance of cells, e.g., lung cell lines, to treatment with compounds that interact with and modulate, e.g., inhibit, protein tyrosine kinases, such as, for example, members of the Src family of tyrosine kinases, e.g., Src, Fgr, Fyn, Yes, Blk, Hck, Lck and Lyn, as well as other protein tyrosine kinases, including, Bcr-abl, Jak, PDGFR, c-kit and Ephr. These polynucleotides have been shown, through a weighted voting cross validation program, to have utility in predicting the resistance and sensitivity of lung cell lines to the compounds. The expression level of some polynucleotides is regulated by treatment with a particular protein tyrosine kinase inhibitor compound, thus indicating that these polynucleotides are involved in the protein tyrosine kinase signal transduction pathway, e.g., Src tyrosine kinase. Such polynucleotides, whose expression levels correlate highly with drug sensitivity or resistance and which are modulated by treatment with the compounds, comprise polynucleotide predictor or marker sets useful in methods of predicting drug response, and as prognostic or diagnostic indicators in disease management, particularly in those disease areas, e.g., lung cancer, in which signaling through the protein tyrosine kinase pathway, such as the Src tyrosine kinase pathway, is involved with the disease process.
摘要翻译：本发明描述了已经发现与将细胞（例如肺细胞系）的相对固有敏感性或抗性相关联的化合物与与蛋白酪氨酸激酶相互作用并调节，例如抑制蛋白质酪氨酸激酶（例如，，Src家族酪氨酸激酶的成员，例如Src，Fgr，Fyn，Yes，Blk，Hck，Lck和Lyn，以及其他蛋白酪氨酸激酶，包括Bcr-abl，Jak，PDGFR，c-kit和 EPHR。已经通过加权投票交叉验证程序显示了这些多核苷酸可用于预测肺细胞系对化合物的抵抗力和敏感性。一些多核苷酸的表达水平通过用特定蛋白酪氨酸激酶抑制剂化合物的治疗来调节，因此表明这些多核苷酸参与蛋白酪氨酸激酶信号转导途径，例如Src酪氨酸激酶。这些多核苷酸的表达水平与药物敏感性或抗性高度相关并且通过用化合物处理而被调节的多核苷酸包括用于预测药物反应的方法中的多核苷酸预测物或标志物组，以及疾病管理中的预后或诊断指标，特别是在那些疾病领域，例如肺癌，其中通过蛋白酪氨酸激酶途径的信号，例如Src酪氨酸激酶途径参与疾病过程。

8. 发明申请

WO2006122091A2 CASCADING SECURITY ARCHITECTURE 审中-公开
标题翻译： CASCADING安全建筑
公开(公告)号：WO2006122091A2
公开(公告)日：2006-11-16
申请号：PCT/US2006/017851
申请日：2006-05-08
申请人： DGATE TECHNOLOGIES, INC. , HUANG, Fei , HUANG, Shu , REN, Liwei
发明人： HUANG, Fei , HUANG, Shu , REN, Liwei
IPC分类号： G06F17/30
CPC分类号： G06F17/30011 , G06F21/554
摘要： A system and a method are disclosed for sensitive document management. The system includes one or more agents, a behavior analysis engine, a local policy engine, and a local matching service. The method identifies whether a document is sensitive, identifies behaviors applied to the document, determines whether the document contains sensitive information and determines whether to allow the identified behavior to continue based on security policies.
摘要翻译：公开了一种用于敏感文件管理的系统和方法。系统包括一个或多个代理，行为分析引擎，本地策略引擎和本地匹配服务。该方法识别文档是否敏感，识别应用于文档的行为，确定文档是否包含敏感信息，并确定是否允许基于安全策略继续识别的行为。

9. 发明申请

WO2004097030A2 PROGNOSTIC BREAST CANCER BIOMARKERS 审中-公开
公开(公告)号：WO2004097030A2
公开(公告)日：2004-11-11
申请号：PCT/US2004/013076
申请日：2004-04-28
申请人： BRISTOL-MYERS SQUIBB COMPANY , KAROLINSKA INNOVATIONS AB , BERGH, Jonas , PAWITAN, Yudi , HALL, Per , AMLER, Lukas, C. , HAN, Xia , HUANG, Fei , SHAW, Peter
发明人： BERGH, Jonas , PAWITAN, Yudi , HALL, Per , AMLER, Lukas, C. , HAN, Xia , HUANG, Fei , SHAW, Peter
IPC分类号： C12Q
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118
摘要： A method of identifying a mammal at increased risk for developing breast cancer comprising the steps of obtaining a biological sample from the mammal, measuring in said biological sample the level of at least one biomarker, correlating said level of at least one biomarker with a baseline level, identifying a mammal at increased risk for developing breast cancer based on said correlation.
摘要翻译：一种识别发展中的乳腺癌风险增加的哺乳动物的方法，包括以下步骤：从所述哺乳动物获得生物样品，在所述生物样品中测量至少一种生物标志物的水平，将所述至少一种生物标志物的水平与基线水平相关联基于所述相关性鉴定发生乳腺癌风险增加的哺乳动物。

10. 发明申请

WO2018165198A1 CELL-BASED METHODS AND COMPOSITIONS FOR THERAPEUTIC AGENT DELIVERY AND TREATMENTS USING SAME 审中-公开
公开(公告)号：WO2018165198A1
公开(公告)日：2018-09-13
申请号：PCT/US2018/021206
申请日：2018-03-06
申请人： UNIVERSITY OF WASHINGTON , SEATTLE CHILDREN'S RESEARCH INSTITUTE , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
发明人： STAYTON, Patrick, S. , CONVERTINE, Anthony , DAS, Debobrato , SON, Hye-Nam , SRINIVASAN, Selvi , MONTGOMERY, Katherine , BLUMENTHAL, Ian , CRANE, Courtney , JENSEN, Michael , MATTHAEI, James , CHIEFARI, John , DANIAL, Maarten , HUANG, Fei , MACDONALD, James , POSTMA, Almar , TURNER, Kathleen
IPC分类号： C12N5/10 , C12N15/67 , A61K47/50 , C07K16/28
摘要： Provided herein are engineered cells and methods for engineering cells to deliver a therapeutic agent, e.g., a small molecule, peptide or other drug, to a cell or tissue to be treated.

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