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1. 发明申请

WO2011089386A1 ELECTRO-OPTICE DEVICE COMPRISING A RIDGE WAVEGUIDE AND A PN JUNCTION AND METHOD OF MANUFACTURING SAID DEVICE 审中-公开
标题翻译：包含一个波峰波形和一个PN结的电选装置和制造装置的方法
公开(公告)号：WO2011089386A1
公开(公告)日：2011-07-28
申请号：PCT/GB2011/000060
申请日：2011-01-20
申请人： UNIVERSITY OF SURREY , THOMSON, David , GARDES, Frédéric , REED, Graham
发明人： THOMSON, David , GARDES, Frédéric , REED, Graham
IPC分类号： G02F1/025
CPC分类号： G02F1/025 , G02B6/134 , G02B6/1347 , G02B6/136 , G02B2006/12173 , G02F2001/0152 , G02F2201/063
摘要： An electro-optic device (10), comprising an insulating layer (14) and a layer (16, 18a, 18b, 20a, 20b) of light-carrying material adjacent the insulating layer. The layer of light-carrying material, such as silicon, comprises a first doped region (18a, 18b) of a first type and a second doped region (20a, 20b) of a second, different type abutting the first doped region to form a pn junction. The first doped region has a first thickness at the junction, and the second doped region has a second thickness at the junction, the first thickness being greater than the second thickness the two regions thereby, defining a waveguide rib (21) in the first doped region for propagating optical signals. Since the position of the junction coincides with the sidewall of the waveguide rib (21) a self-aligned process can be used in order to simplify the fabrication process and increase yield.
摘要翻译：一种电光器件（10），包括绝缘层（14）和邻近绝缘层的轻载体材料层（16,18a，18b，20a，20b）。光载体材料如硅的层包括第一类型的第一掺杂区域（18a，18b）和与第一掺杂区域邻接的第二不同类型的第二掺杂区域（20a，20b），以形成 pn结。所述第一掺杂区在所述结处具有第一厚度，并且所述第二掺杂区在所述结处具有第二厚度，所述第一厚度大于所述第二厚度，从而限定所述第一掺杂区中的波导肋（21）用于传播光信号的区域。由于接头的位置与波导肋（21）的侧壁重合，所以可以使用自对准工艺来简化制造工艺并提高产量。

2. 发明申请

WO2011101632A1 ELECTRO-OPTIC DEVICE 审中-公开
标题翻译：电光设备
公开(公告)号：WO2011101632A1
公开(公告)日：2011-08-25
申请号：PCT/GB2011/000216
申请日：2011-02-17
申请人： UNIVERSITY OF SURREY , GARDES, Frederic , THOMSON, David , REED, Graham
发明人： GARDES, Frederic , THOMSON, David , REED, Graham
IPC分类号： G02F1/025
CPC分类号： H01L33/58 , G02F1/025 , G02F1/218 , G02F1/29 , G02F1/35 , G02F2001/0152 , G02F2001/212
摘要： An electro - optic device (110), comprising a layer of light - carrying material; and a rib (121), projecting from the layer of light - carrying material, for guiding optical signals propagating through the device (110). The layer of light - carrying material comprises a first doped region (118) of a first type extending into the rib, and a second doped region (121) of a second, different type extending into the rib such that a pn junction is formed within the rib (121). The pn junction extends substantially parallel to at least two contiguous faces of the rib (121), resulting in a more efficient device. In addition, a self-aligned fabrication process can be used in order to simplify the fabrication process and increase reliability and yield.
摘要翻译：一种电光器件（110），包括一层轻载材料; 以及从所述载光材料层突出的用于引导通过所述装置（110）传播的光信号的肋（121）。载光材料层包括延伸到肋中的第一类型的第一掺杂区域（118）和延伸到肋中的第二不同类型的第二掺杂区域（121），使得在其内部形成pn结肋（121）。 pn结基本上平行于肋（121）的至少两个邻接面延伸，导致更有效的装置。此外，可以使用自对准制造工艺以简化制造工艺并提高可靠性和产率。

3. 发明申请

WO2011045290A2 MICROFLUIDIC MIXER 审中-公开
标题翻译： MICROFLUIDIC混合器
公开(公告)号：WO2011045290A2
公开(公告)日：2011-04-21
申请号：PCT/EP2010/065228
申请日：2010-10-11
申请人： ITI SCOTLAND LIMITED , LOW, Nicol , THOMSON, David , SALMON, Jonathan
发明人： LOW, Nicol , THOMSON, David , SALMON, Jonathan
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01F7/1605 , B01F11/0258 , B01F13/0059 , B01F13/0827 , B01F15/00006 , B01F2215/0431 , B01L3/5027 , B01L2300/0832 , Y10T137/0402 , Y10T436/143333 , Y10T436/25
摘要： Provided is a microfluidic or nanofluidic apparatus which comprises: (a) a reservoir for one or more fluids; (b) a mixing device configured to mix the one or more fluids within the reservoir; and (c) a microfluidic or nanofluidic device in fluid connection with the reservoir; wherein the reservoir is suitable for containing a total volume of fluid of from 100 microliters to 100 milliliters. Also provided is a method of manufacturing the apparatus and the use of the apparatus to detect an analyte in a fluid.
摘要翻译：提供了微流体或纳流体装置，其包括：（a）用于一种或多种流体的储存器; （b）经配置以混合所述贮存器内的所述一种或一种以上流体的混合装置; 和（c）与所述贮存器流体连接的微流体或纳流体装置; 其中所述贮存器适于容纳100微升至100毫升的总体积的流体。还提供了制造该设备的方法和该设备用于检测流体中的分析物的用途。

4. 发明申请

WO2008092859A1 ANALYTE MANIPULATION AND DETECTION 审中-公开
标题翻译：分析操作和检测
公开(公告)号：WO2008092859A1
公开(公告)日：2008-08-07
申请号：PCT/EP2008/051040
申请日：2008-01-29
申请人： ITI SCOTLAND LIMITED , BARRAULT, Denise , POLWART, Stuart , THOMSON, David
发明人： BARRAULT, Denise , POLWART, Stuart , THOMSON, David
IPC分类号： G01N33/543 , G01N33/569 , G01N33/558 , G01N33/52 , B01L3/00
CPC分类号： G01N33/54313 , B01L3/5027 , G01N33/54326 , G01N33/558
摘要： Provided is a method for separating two or more analytes in a fluid, which method comprises: (a) binding each different analyte to a different particle in a binding zone, to produce two or more bound analytes; (b) allowing the bound analytes to move through a separating conduit to two or more separate functional conduits; wherein each different particle has, or can be controlled to have, a different buoyancy in the fluid as compared with the other particles; and wherein the separating conduit is in fluid communication with the two or more functional conduits, each functional conduit being situated at a different height from the other functional conduits; and each functional conduit containing a fluid having a different fluid density from the fluids in the other functional conduits such that each different particle when attached to an analyte has neutral buoyancy in at least one of the functional conduits, thereby allowing separation of the bound analytes by means of the neutral buoyancies of the different particles in the different functional conduits.
摘要翻译：提供了一种用于在流体中分离两种或更多种分析物的方法，该方法包括：（a）将各种不同分析物结合到结合区域中的不同颗粒，以产生两种或更多种结合的分析物; （b）允许结合的分析物通过分离导管移动到两个或更多个分离的功能导管; 其中与其它颗粒相比，每个不同的颗粒具有或可以被控制为具有与流体中不同的浮力; 并且其中所述分离导管与所述两个或更多个功能导管流体连通，每个功能导管位于与其它功能导管不同的高度处; 并且每个功能导管包含与其它功能导管中的流体具有不同流体密度的流体，使得当附着到分析物上的每个不同颗粒在至少一个功能导管中具有中性浮力，从而允许通过以下方式分离结合的分析物：不同功能导管中不同颗粒的中性浮力的方法。

5. 发明申请

WO2005095401A1 ALPHA-TRIFLUOROMETHYL ALCOHOLS OR AMINES AS GLUCOCORTICOID MIMETICS 审中-公开
标题翻译： ALPHA-三氟甲基醇或氨基酸作为葡萄糖聚糖
公开(公告)号：WO2005095401A1
公开(公告)日：2005-10-13
申请号：PCT/US2005/006975
申请日：2005-03-04
申请人： BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. , REGAN, John, Robinson , LEE, Thomas, Wai-Ho , THOMSON, David , KIRRANE, Thomas, Martin , KUZMICH, Daniel , PROUDFOOT, John, Robert , BEKKALI, Younes , ZINDELL, Renee
发明人： REGAN, John, Robinson , LEE, Thomas, Wai-Ho , THOMSON, David , KIRRANE, Thomas, Martin , KUZMICH, Daniel , PROUDFOOT, John, Robert , BEKKALI, Younes , ZINDELL, Renee
IPC分类号： C07D471/04
CPC分类号： C07D491/04 , C07D471/04 , C07D495/04 , C07D513/04
摘要： Compounds of Formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and X are as defined herein for Formula (IA) and Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammtory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译：其中R 1，R 2，R 3，R 4，R 5，R 6和X的式（I）化合物如本文对于式（IA）和式 IB）或其互变异构体，前药，溶剂合物或其盐; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。

6. 发明申请

WO2004075864A2 GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF 审中-公开
标题翻译：葡萄糖酸化物质，其制备方法，药物组合物及其用途
公开(公告)号：WO2004075864A2
公开(公告)日：2004-09-10
申请号：PCT/US2004/006015
申请日：2004-02-27
申请人： BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. , CYWIN, Charles, Lawrence , MORWICK, Tina, Marie , PROUDFOOT, John, Robert , THOMSON, David
发明人： CYWIN, Charles, Lawrence , MORWICK, Tina, Marie , PROUDFOOT, John, Robert , THOMSON, David
IPC分类号： A61K
CPC分类号： C07D213/75 , C07C235/38 , C07D213/80 , C07D239/42 , C07D261/14 , C07D277/46 , C07D285/135
摘要： Compounds of Formula (I) wherein R 1 , R 2 , R 3 , and R 4 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译：其中R 1，R 2，R 3和R 4如本文所定义的式（I）化合物或其互变异构体，前药，溶剂合物或其盐; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。

7. 发明申请

WO2012066340A1 REMOTELY OPERABLE CONNECTING DEVICE 审中-公开
标题翻译：远程可操作的连接设备
公开(公告)号：WO2012066340A1
公开(公告)日：2012-05-24
申请号：PCT/GB2011/052251
申请日：2011-11-17
申请人： BALFOUR BEATTY PLC , MIDSON, Christopher , THOMSON, David
发明人： MIDSON, Christopher , THOMSON, David
IPC分类号： B66C1/66
CPC分类号： F16G15/06 , B66C1/66
摘要： Disclosed is a remotely operable connecting device (1) for attaching a chain to a rigid lifting eye, comprising a body (3), a shooting pin (5) and a locking carriage (7). The body has a pair of parallel, spaced apart legs (15a, 15b) for receiving the lifting eye therebetween, each of the legs having a hole (17a, 17b) formed therein along a common axis. The shooting pin is arranged to engage each of the holes formed in the legs of the body, is slidable between an open position and a closed position and is provided with locking and actuation recesses spaced apart from each other. The locking carriage is slidably mounted to one of the legs of the body and is provided at a first end with an opening for receiving the head (45) of an actuation tool (41) and at a second end with a locking feature (21).The locking carriage is slidable along the leg between: a locked position and an unlocked position in which the head of the actuation tool is held captive by the device and cannot be removed.
摘要翻译：公开了一种用于将链条附接到刚性起重眼的远程操作的连接装置（1），包括主体（3），射击销（5）和锁定支架（7）。主体具有用于在其间接收提升眼的一对平行的间隔开的腿部15a，15b，每个腿部具有沿公共轴线形成在其中的孔（17a，17b）。射击销布置成接合形成在主体的腿部中的每个孔，其可以在打开位置和关闭位置之间滑动，并且设置有彼此间隔开的锁定和致动凹部。锁定滑架可滑动地安装到主体的一个腿部，并且在第一端处设置有用于接收致动工具（41）的头部（45）的开口，并且在具有锁定特征（21）的第二端处，锁定托架可沿着腿部滑动：锁定位置和解锁位置，致动工具的头部由设备固定在该解锁位置并且不能被移除。

8. 发明申请

WO2008020228A1 ANALYTE MANIPULATION AND DETECTION 审中-公开
标题翻译：分析操作和检测
公开(公告)号：WO2008020228A1
公开(公告)日：2008-02-21
申请号：PCT/GB2007/003142
申请日：2007-08-17
申请人： ITI SCOTLAND LIMITED , BARRAULT, Denise , POLWART, Stuart , THOMSON, David , PRITCHARD, David , SUNDREHAGEN, Erling
发明人： BARRAULT, Denise , POLWART, Stuart , THOMSON, David , PRITCHARD, David , SUNDREHAGEN, Erling
IPC分类号： B01L3/00 , B03C1/00 , G01N33/543
CPC分类号： G01N33/54313 , B01L3/502761 , B01L2200/0647 , B01L2300/0864 , B01L2400/0487 , G01N33/54326 , G01N33/54333 , G01N33/56988 , G01N33/56994
摘要： Provided is a method for separating two or more analytes in a fluid, which method comprises: (a) binding each different analyte to a different functional particle in one or more binding zones, to produce two or more bound analytes; (b) allowing the bound analytes to move through a separating conduit to two or more separate functional zones; wherein, each different functional particle has, or can be controlled to have, a different function in the fluid as compared with the other functional particles; and wherein the separating conduit separates into two or more functional conduits, such that the separating conduit serves to separate the bound analytes into the separate functional conduits by means of the different functions of the different functional particles. Also provided is an apparatus for separating two or more analytes in a fluid, which apparatus comprises: (a) a binding zone; (b) two or more functional conduits; (c) a separating conduit connecting the binding zone to the two or more functional conduits; (d) a transporter for transporting the analyte through the separating conduit from the binding zone to the two or more functional conduits; and (e) optionally one or more concentrating zones in connection with at least one of the functional conduits.
摘要翻译：提供了一种用于在流体中分离两种或更多种分析物的方法，该方法包括：（a）将每种不同分析物结合到一个或多个结合区域中的不同功能颗粒，以产生两种或更多种结合的分析物; （b）允许结合的分析物通过分离管道移动到两个或更多个分离的功能区域; 其中，与其他功能性颗粒相比，每种不同的功能性颗粒具有或可以控制在流体中具有不同的功能; 并且其中所述分离管道分离成两个或更多个功能导管，使得所述分离管道用于通过所述不同功能性颗粒的不同功能将结合的分析物分离成分离的功能导管。还提供了一种用于在流体中分离两种或更多种分析物的装置，该装置包括：（a）结合区; （b）两个或多个功能导管; （c）将结合区域连接到两个或更多个功能导管的分离导管; （d）用于将分析物通过分离管道从结合区输送到两个或更多个功能导管的运送器; 和（e）可选地与至少一个功能导管连接的一个或多个浓缩区。

9. 发明申请

WO2008114031A1 IMPROVEMENTS IN AND RELATING TO PILE DRIVING 审中-公开
标题翻译：改进和相关的驱动
公开(公告)号：WO2008114031A1
公开(公告)日：2008-09-25
申请号：PCT/GB2008/001009
申请日：2008-03-20
申请人： DEMAREST, Vincent, Michael , THOMSON, David , DEMAREST, Paul, R.
发明人： DEMAREST, Vincent, Michael , THOMSON, David , DEMAREST, Paul, R.
IPC分类号： E02D7/06 , E04H17/26
CPC分类号： E04H17/263 , E02D7/02 , E02D7/06
摘要： A pile driving device comprising: a yoke selectively clampable at any position along the length of an elongate rigid pile, post or the like to be driven into the ground; a vibrator or percussion device in contact with or forming part of the yoke and a support, supporting the yoke in use and operable in use to adjust the initial position of the pile, post or the like.
摘要翻译：一种打桩装置，其特征在于，包括：可沿着细长刚性桩，立柱等长度的任何位置选择性地夹紧的轭，以驱动到地面中; 与磁轭接触或形成磁轭的一部分的振动器或冲击装置和支撑件，其支撑使用中的磁轭并且在使用中可操作地调节桩，支柱等的初始位置。

10. 发明申请

WO2009149139A1 GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF 审中-公开
标题翻译：葡萄糖酸化物质，其制备方法，药物组合物及其用途
公开(公告)号：WO2009149139A1
公开(公告)日：2009-12-10
申请号：PCT/US2009/046058
申请日：2009-06-03
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , BETAGERI, Rajashekhar , BOSANAC, Todd , BURKE, Michael, Jason , HARCKEN, Christian , KIM, Soojin , KUZMICH, Daniel , LEE, Thomas, Wai-ho , LI, Zhibin , LIU, Pingrong , LORD, John , RAZAVI, Hossein , REEVES, Jonathan, Timothy , THOMSON, David
发明人： BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , BETAGERI, Rajashekhar , BOSANAC, Todd , BURKE, Michael, Jason , HARCKEN, Christian , KIM, Soojin , KUZMICH, Daniel , LEE, Thomas, Wai-ho , LI, Zhibin , LIU, Pingrong , LORD, John , RAZAVI, Hossein , REEVES, Jonathan, Timothy , THOMSON, David
IPC分类号： C07D471/04 , A61K31/437 , A61P5/44 , A61P5/46
CPC分类号： C07D471/04
摘要： Compounds of Formula I wherein R 1 , R 2 , X, and Y are as defined herein, or a tautomer, optical isomer, prodrug, co-crystal, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译：其中R1，R2，X和Y如本文所定义的式I化合物或其互变异构体，旋光异构体，前药，共结晶或其盐; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。

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